CN104646343A - Washing mechanism for reaction cups of chemiluminescence immunity analyzer - Google Patents
Washing mechanism for reaction cups of chemiluminescence immunity analyzer Download PDFInfo
- Publication number
- CN104646343A CN104646343A CN201410848906.9A CN201410848906A CN104646343A CN 104646343 A CN104646343 A CN 104646343A CN 201410848906 A CN201410848906 A CN 201410848906A CN 104646343 A CN104646343 A CN 104646343A
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- China
- Prior art keywords
- washing
- reaction cup
- pin
- needle
- transfer dolly
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/20—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought
- B08B9/22—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by soaking alone
- B08B9/24—Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by soaking alone and having conveyors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a washing mechanism for reaction cups of a chemiluminescence immunity analyzer. The washing mechanism comprises a support standing plate, an aspirating needle, a washing liquor needle and a horizontal transfer dolly, wherein the support standing plate is provided with a lifting device; the lifting device is provided with an aspirating arm; the upper part of the aspirating needle is connected onto the aspirating arm in a penetrating manner; the upper end of the aspirating needle is connected with a negative-pressure air source; the horizontal transfer dolly is located below the aspirating needle; the horizontal transfer dolly is driven by a horizontal conveyer; the washing liquor needle is fixedly arranged above the horizontal transfer dolly; the upper end of the washing liquor needle is connected with washing liquor. According to the scheme adopted by the invention, the washing mechanism has the remarkable effects that each reaction cup is washed by the single washing liquor needle and the aspirating needle, so that all the reaction cups are consistent in washing effect, and therefore the accuracy of a detection result is ensured; meanwhile, luminescent substrate filling is combined with a washing system, and thus, an support structure and an installation structure which are independent do not need to be arranged aiming at a substrate needle, a process of transferring the reaction cups to a substrate filling system from the washing system is not needed, a complete machine mechanism is simplified, and the efficiency is increased.
Description
Technical field
The invention belongs to technical field of medical instruments, be specifically related to a kind of chemical illumination immunity analysis instrument reaction cup washing mechanism.
Background technology
Full-automatic chemiluminescence immunoassay analysis meter is by detection patients serum thus human body is carried out to the medical laboratory instrument of immunoassay.Quantitative patients serum and horseradish peroxidase (HRP) are joined solid-phase coating to be had in the White-opalescent microwell plate of antibody, antibody specific binding on testing molecule in serum and the bond of horseradish peroxidase and solid phase carrier, the unreacted free composition of separating, washing; Then, add liquid of the luminous end, the free energy utilizing chemical reaction to discharge excites intermediate, gets back to excitation state from ground state, and energy discharges with the form of photon; Now, microwell plate is inserted in analyzer, by the three-dimensional transmission system of instrument internal, read the number of photons in each hole successively by photon counter, and carry out quantitative analysis according to the Mathematical Modeling that standard items are set up, just can draw detection analysis result.
Wherein after seroreaction, need to clean reactant, after having washed, then add luminescence-producing reaction substrate and react; What traditional analyzer adopted is board-like reaction cup, add washing lotion when cleaning, adopt many washing lotion pins to annotate washing lotion simultaneously, and when washing completes absorption waste liquid, also be adopt many aspirating needles to draw waste liquid simultaneously, repeatedly after washing, filling luminescence-producing reaction substrate is then adopt another independently loading system, and existing washing scheme mainly contains following shortcoming:
(1), often the systematic error of root washing lotion pin generation is inconsistent, and during filling washing lotion, the washing lotion amount of every root pin filling is inconsistent, the washing lotion consumption of each reaction cup is inconsistent, cause residue unequal, after adding luminous substrate reaction, the detection of number of photons can be affected;
(2), many aspirating needles wash multiple reaction cup simultaneously, many aspirating needles are connected with same negative pressure source of the gas, but affect by length of pipe, caliber etc., and the absorption effect of every root aspirating needle to waste liquid is inconsistent, the residual quantity of washing lotion is uncontrollable, affects testing result;
(3), luminous substrate of annotate after the washing of reactant and washing is separate, and one side slow down the circulation speed of reaction cup; Increasing the volume of a whole set of analyzer on the other hand, is that the structure of complete machine becomes complicated.
Summary of the invention
For solving above technical problem, the object of the present invention is to provide a kind of washing lotion filling controllable precise, waste liquid draws the good chemical illumination immunity analysis instrument reaction cup washing mechanism of effect stability.
Technical scheme is as follows:
A kind of chemical illumination immunity analysis instrument reaction cup washing mechanism, its key is: comprise supporting vertical plate, aspirating needle and washing lotion pin and level transfer dolly, wherein in supporting vertical plate, be provided with lowering or hoisting gear, this lowering or hoisting gear is provided with liquid absorbing arm, the top cross-under of described aspirating needle is on this liquid absorbing arm, the upper termination negative pressure source of the gas of this aspirating needle, described level transfer dolly is positioned at below described aspirating needle, described level transfer dolly is driven by horizontal conveyance device, described washing lotion pin is fixed on above described level transfer dolly, the upper termination washing lotion of this washing lotion pin.The remarkable result of above technical scheme is, single needle filling washing lotion and single needle is used to draw waste liquid, the systematic error that single washing lotion pin and aspirating needle produce is certain, can control systematic error through debugging, to ensure that in each reaction cup, the addition of washing lotion and the residual quantity of waste liquid are consistent, repeatedly clean result can be ensured after cyclic washing, the reaction cup of washing is needed to be arranged on level transfer dolly, horizontal conveyance device drives level transfer dolly at washing lotion pin and aspirating needle moved beneath, washing lotion pin and aspirating needle point to reaction cup different in reaction cup respectively, after putting in place, washing lotion pin is annotated washing lotion in the reaction cup immediately below it, lowering or hoisting gear drives aspirating needle to decline, waste liquid is drawn in the reaction cup making aspirating needle sink to immediately below it, the filling of washing lotion and the absorption of waste liquid are carried out simultaneously, accelerate washing progress.
The middle part of above-mentioned supporting vertical plate is provided with cantilever mounted, described washing lotion pin is located in the external part of this cantilever mounted, substrate pin is equipped with at the external part of this cantilever mounted, the upper termination reaction substrate of this substrate pin, described washing lotion pin and substrate pin lay respectively at described aspirating needle both sides, and described substrate pin is positioned at above described level transfer dolly.In above scheme, substrate pin is for luminescence-producing reaction substrate of annotating, substrate pin is set directly at washing system, do not need like this to arrange independently supporting construction and mounting structure for substrate pin, can to annotate after completing washing luminous substrate, simplify the structure, eliminate reaction cup from washing system to the transfer process of substrate loading system simultaneously, improve efficiency.
Above-mentioned lowering or hoisting gear comprises the first line slideway and lead screw motor, wherein the first line slideway is vertically arranged in described supporting vertical plate, one end of described liquid absorbing arm is arranged on this first line slideway, described lead screw motor is arranged on the top of described supporting vertical plate, and the screw mandrel of described lead screw motor is threaded with the middle part of described liquid absorbing arm.Adopt above technical scheme, lead screw motor rotarily drives liquid absorbing arm lifting, and the first line slideway play the guiding role and position-limiting action, and liquid absorbing arm is elevated more steady, liquid absorbing arm height is even, and controlled precision is higher, aspirating needle better handling.
Above-mentioned horizontal conveyance device comprises the second line slideway, this second line slideway is arranged on base plate, described level transfer dolly is arranged on described second line slideway, described supporting vertical plate is provided with horizontal feeding motor, the output shaft of this horizontal feeding motor is provided with the first belt pulley, described base plate is provided with the second belt pulley, described first belt pulley and the second belt pulley are set with on same transfer band, this transfer band is parallel with described second line slideway, described level transfer dolly and this transfer band affixed, the lower end of described base plate and described supporting vertical plate is affixed.Transfer band drives the reaction cup be arranged on level transfer dolly to slide on the second line slideway, differential responses cup in reaction cup is alignd with the lower end of aspirating needle, washing lotion pin and substrate pin respectively, level transfer dolly moves steadily, fast, the material in reaction cup can not spill.
Reaction cup slot is offered along the glide direction of described second line slideway at the upper surface of above-mentioned level transfer dolly, the one end open of this reaction cup slot, the other end is closed, described aspirating needle, washing lotion pin and substrate pin are all positioned at directly over this reaction cup slot, and the openend of this reaction cup slot is provided with chamfering.Above scheme provides a kind of easy quick attach structure reacting cup, reaction cup is arranged in the reaction cup of strip, the reaction cup of strip is sent into level by outer executing agency from the openend of reaction cup slot and is transferred dolly, after reaction cup completes the filling of washing and luminous substrate, send from the openend of reaction cup slot, reaction cup transfer running fast again.
The end face of above-mentioned cantilever mounted external part is provided with anti-flake, and described washing lotion pin and substrate pin are arranged on the end face of described cantilever mounted external part respectively by this anti-flake.Adopt the program, washing lotion pin and the easy installation and removal of substrate pin.
Syringe is set with on above-mentioned aspirating needle top, described liquid absorbing arm offers syringe fixed step hole, described syringe cross-under is in described syringe fixed step hole, matched in clearance between this syringe and described liquid absorbing arm, described liquid absorbing arm is provided with syringe pressing plate, and described syringe compresses by this syringe pressing plate.The program by syringe by aspirating needle cross-under on liquid absorbing arm, aspirating needle can be protected not to be damaged, ensure that simultaneously assembling and dismounting convenience.
Beneficial effect: the chemical illumination immunity analysis instrument reaction cup washing mechanism adopting above technical scheme, single washing lotion pin and single aspirating needle is adopted to clean each reaction cup, make the clean result of each reaction cup consistent, thus ensure the accuracy of testing result; The filling of luminous substrate is attached to washing system simultaneously, do not need to arrange independently supporting construction and mounting structure for substrate pin, can to annotate after completing washing luminous substrate, eliminate reaction cup from washing system to the transfer process of substrate loading system, simplify complete machine mechanism, improve efficiency.
Accompanying drawing explanation
Fig. 1 is the structural representation of chemical illumination immunity analysis instrument reaction cup washing mechanism of the present invention;
Fig. 2 is the A-A` sectional view of Fig. 1;
Fig. 3 is the B-B` sectional view of Fig. 1.
Detailed description of the invention
Below in conjunction with embodiment and accompanying drawing, the invention will be further described.
As shown in Fig. 1 to 3, a kind of chemical illumination immunity analysis instrument reaction cup washing mechanism, comprises supporting vertical plate 1, lowering or hoisting gear 2, horizontal conveyance device 3, aspirating needle 4 and washing lotion pin 5, substrate pin 6, level transfer dolly 8 and liquid absorbing arm 9, wherein:
Two cantilever mounted 11 are provided with at the middle part of supporting vertical plate 1, base plate 12 is connected with in the lower end of supporting vertical plate 1, described supporting vertical plate 1 is provided with described lowering or hoisting gear 2, described liquid absorbing arm 9 is arranged on this lowering or hoisting gear 2, described liquid absorbing arm 9 is between two described cantilever mounted 11, the top cross-under of described aspirating needle 4 is at the middle part of this liquid absorbing arm 9, the upper termination negative pressure source of the gas of this aspirating needle 4, described level transfer dolly 8 is positioned at below described aspirating needle 4, described level transfer dolly 8 is driven by described horizontal conveyance device 3, this horizontal conveyance device 3 is arranged on described base plate 12, described washing lotion pin 5 and substrate pin 6 are separately fixed in two described cantilever mounted 11, anti-flake 7 is respectively arranged with at the end face of two described cantilever mounted 11 external parts, described washing lotion pin 5 and substrate pin 6 are arranged on the end face of described cantilever mounted 11 external part respectively by this anti-flake 7, the upper termination washing lotion of described washing lotion pin 5, the upper termination reaction substrate of described substrate pin 6.
Described lowering or hoisting gear 2 comprises the first line slideway 21 and lead screw motor 22, wherein the first line slideway 21 is vertically arranged in described supporting vertical plate 1, one end of described liquid absorbing arm 9 is arranged on this first line slideway 21, described lead screw motor 22 is arranged on the top of described supporting vertical plate 1, the screw mandrel of described lead screw motor 22 down, the screw mandrel of described lead screw motor 22 is threaded with the middle part of described liquid absorbing arm 9, described aspirating needle 4 is located in the other end of described liquid absorbing arm 9, syringe 42 is set with on described aspirating needle 4 top, described liquid absorbing arm 9 offers syringe fixed step hole, the cross-under of described syringe 42 is in described syringe fixed step hole, matched in clearance between this syringe 42 and described liquid absorbing arm 9, described liquid absorbing arm 9 is provided with syringe pressing plate 41, described syringe 42 compresses by this syringe pressing plate 41.
Described horizontal conveyance device 3 comprises the second line slideway 31, this the second line slideway 31 level is arranged on described base plate 12, described level transfer dolly 8 is arranged on described second line slideway 31, described supporting vertical plate 1 is provided with horizontal feeding motor, the output shaft of this horizontal feeding motor is provided with the first belt pulley, described base plate 12 is provided with the second belt pulley, described first belt pulley and the second belt pulley are set with same transfer band 32, this transfer band 32 is parallel with described second line slideway 31, described level transfer dolly 8 is affixed with this transfer band 32.
Reaction cup slot 8a is offered along the glide direction of described second line slideway 31 at the upper surface of described level transfer dolly 8, the one end open of this reaction cup slot 8a, the other end is closed, the openend of this reaction cup slot 8a is provided with chamfering, described aspirating needle 4, washing lotion pin 5 and substrate pin 6 are all positioned at directly over this reaction cup slot 8a, and described aspirating needle 4, washing lotion pin 5 and substrate pin 6 are successively along the arrangement of described level transfer dolly 8 moving direction.
Claims (7)
1. a chemical illumination immunity analysis instrument reaction cup washing mechanism, it is characterized in that: comprise supporting vertical plate (1), aspirating needle (4), with washing lotion pin (5) and level transfer dolly (8), wherein in supporting vertical plate (1), be provided with lowering or hoisting gear (2), this lowering or hoisting gear (2) is provided with liquid absorbing arm (9), the top cross-under of described aspirating needle (4) is on this liquid absorbing arm (9), the upper termination negative pressure source of the gas of this aspirating needle (4), described level transfer dolly (8) is positioned at described aspirating needle (4) below, described level transfer dolly (8) is driven by horizontal conveyance device (3), described washing lotion pin (5) is fixed on described level transfer dolly (8) top, the upper termination washing lotion of this washing lotion pin (5).
2. chemical illumination immunity analysis instrument reaction cup washing mechanism according to claim 1, it is characterized in that: the middle part of described supporting vertical plate (1) is provided with cantilever mounted (11), described washing lotion pin (5) is located in the external part of this cantilever mounted (11), substrate pin (6) is equipped with at the external part of this cantilever mounted (11), the upper termination reaction substrate of this substrate pin (6), described washing lotion pin (5) and substrate pin (6) lay respectively at described aspirating needle (4) both sides, described substrate pin (6) is positioned at described level transfer dolly (8) top.
3. chemical illumination immunity analysis instrument reaction cup washing mechanism according to claim 1 and 2, it is characterized in that: described lowering or hoisting gear (2) comprises the first line slideway (21) and lead screw motor (22), wherein the first line slideway (21) is vertically arranged in described supporting vertical plate (1), one end of described liquid absorbing arm (9) is arranged on this first line slideway (21), described lead screw motor (22) is arranged on the top of described supporting vertical plate (1), the screw mandrel of described lead screw motor (22) is threaded with the middle part of described liquid absorbing arm (9).
4. chemical illumination immunity analysis instrument reaction cup washing mechanism according to claim 1, it is characterized in that: described horizontal conveyance device (3) comprises the second line slideway (31), this second line slideway (31) is arranged on base plate (12), described level transfer dolly (8) is arranged on described second line slideway (31), described supporting vertical plate (1) is provided with horizontal feeding motor, the output shaft of this horizontal feeding motor is provided with the first belt pulley, described base plate (12) is provided with the second belt pulley, described first belt pulley and the second belt pulley are set with same transfer band (32), this transfer band (32) is parallel with described second line slideway (31), described level transfer dolly (8) is affixed with this transfer band (32), described base plate (12) is affixed with the lower end of described supporting vertical plate (1).
5. chemical illumination immunity analysis instrument reaction cup washing mechanism according to claim 4, it is characterized in that: offer reaction cup slot (8a) at the upper surface of described level transfer dolly (8) along the glide direction of described second line slideway (31), the one end open of this reaction cup slot (8a), the other end is closed, described aspirating needle (4), washing lotion pin (5) and substrate pin (6) are all positioned at directly over this reaction cup slot (8a), and the openend of this reaction cup slot (8a) is provided with chamfering.
6. the chemical illumination immunity analysis instrument reaction cup washing mechanism according to claim 2 or 5, it is characterized in that: the end face of described cantilever mounted (11) external part is provided with anti-flake (7), described washing lotion pin (5) and substrate pin (6) are arranged on the end face of described cantilever mounted (11) external part respectively by this anti-flake (7).
7. the chemical illumination immunity analysis instrument reaction cup washing mechanism according to claim 1,2 or 5, it is characterized in that: be set with syringe (42) on described aspirating needle (4) top, described liquid absorbing arm (9) offers syringe fixed step hole, described syringe (42) cross-under is in described syringe fixed step hole, matched in clearance between this syringe (42) and described liquid absorbing arm (9), described liquid absorbing arm (9) is provided with syringe pressing plate (41), and described syringe (42) compresses by this syringe pressing plate (41).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410848906.9A CN104646343B (en) | 2014-12-31 | 2014-12-31 | Washing mechanism for reaction cup of chemiluminescence immunity analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410848906.9A CN104646343B (en) | 2014-12-31 | 2014-12-31 | Washing mechanism for reaction cup of chemiluminescence immunity analyzer |
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| CN104646343A true CN104646343A (en) | 2015-05-27 |
| CN104646343B CN104646343B (en) | 2016-08-24 |
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| CN201410848906.9A Active CN104646343B (en) | 2014-12-31 | 2014-12-31 | Washing mechanism for reaction cup of chemiluminescence immunity analyzer |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105834176A (en) * | 2016-05-20 | 2016-08-10 | 威海威高生物科技有限公司 | Convenient and fast cleaning device of full-automatic chemiluminescence tester |
| CN106199026A (en) * | 2016-03-09 | 2016-12-07 | 深圳雷杜生命科学股份有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN106383241A (en) * | 2016-08-23 | 2017-02-08 | 厦门市波生生物技术有限公司 | A micropore self-adaption independent washing mechanism |
| CN107626702A (en) * | 2017-08-28 | 2018-01-26 | 重庆科斯迈生物科技有限公司 | Cup strip suction type double-washing system and washing method thereof |
| WO2020168870A1 (en) * | 2019-02-20 | 2020-08-27 | 重庆科斯迈生物科技有限公司 | Chemiluminescence immunoassay instrument washing system with uniformly-mixing function |
| WO2022110574A1 (en) * | 2020-11-30 | 2022-06-02 | 苏州长光华医生物医学工程有限公司 | Liquid injection and suction device for measurement chamber |
| CN116060404A (en) * | 2023-02-28 | 2023-05-05 | 山东中鸿特检生物科技有限公司 | Reaction cup washing mechanism of chemiluminescent immunoassay analyzer |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106199026A (en) * | 2016-03-09 | 2016-12-07 | 深圳雷杜生命科学股份有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
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| CN106383241A (en) * | 2016-08-23 | 2017-02-08 | 厦门市波生生物技术有限公司 | A micropore self-adaption independent washing mechanism |
| CN106383241B (en) * | 2016-08-23 | 2019-05-17 | 厦门市波生生物技术有限公司 | The adaptive separate wash mechanism of micropore |
| CN107626702A (en) * | 2017-08-28 | 2018-01-26 | 重庆科斯迈生物科技有限公司 | Cup strip suction type double-washing system and washing method thereof |
| CN107626702B (en) * | 2017-08-28 | 2020-07-07 | 重庆科斯迈生物科技有限公司 | Cup strip suction type double-washing system and washing method thereof |
| WO2020168870A1 (en) * | 2019-02-20 | 2020-08-27 | 重庆科斯迈生物科技有限公司 | Chemiluminescence immunoassay instrument washing system with uniformly-mixing function |
| WO2022110574A1 (en) * | 2020-11-30 | 2022-06-02 | 苏州长光华医生物医学工程有限公司 | Liquid injection and suction device for measurement chamber |
| CN116060404A (en) * | 2023-02-28 | 2023-05-05 | 山东中鸿特检生物科技有限公司 | Reaction cup washing mechanism of chemiluminescent immunoassay analyzer |
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