CN103385926A - Antibiosis gel for curing cervical and vaginal diseases of gynaecology - Google Patents
Antibiosis gel for curing cervical and vaginal diseases of gynaecology Download PDFInfo
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- CN103385926A CN103385926A CN2013102858953A CN201310285895A CN103385926A CN 103385926 A CN103385926 A CN 103385926A CN 2013102858953 A CN2013102858953 A CN 2013102858953A CN 201310285895 A CN201310285895 A CN 201310285895A CN 103385926 A CN103385926 A CN 103385926A
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Abstract
The invention discloses an antibiosis gel for curing cervical and vaginal diseases of gynaecology. Each 100 grams of gel is composed of following raw materials: 0.1 to 1 gram of chitosan, 0.1 to 5 grams of tea tree essential oil, 0.1 to 3 grams of borneol, 0.1 to 2 grams of borax, 0.25 to 2 grams of carbomer, 4 to 10 grams of ethanol and the balance of purified water. The antibiosis gel for curing cervical and vaginal diseases of gynaecology has a bacteriostasis rate not smaller than 90%, and has a strong bacteriostatic action. The antibiosis gel has a good biocompatibility, has cytotoxicity smaller than 2 grades, generates little stimulation to vagina, and does not have delayed type hypersensitivity. Each detection parameter of the antibiosis gel meets the corresponding national criterions or regulations. The antibiosis gel is safe during the using process, is capable of satisfying the needs of clinical application, and has the advantages of safety, high-efficiency, no side or toxic effect, and user-friendliness.
Description
Technical field
The present invention relates to medicine for external use, refer to particularly a kind of antibacterial gel for the treatment of Gynecological cervical and vagina.
Background technology
Show according to World Health Organization's incomplete statistics result, in the women, various gynaecopathia sickness rate are more than 65%.In continuous change, the prevalence of reproductive tract infection, menoxenia and mastopathy etc. is increasing gradually along with the development of society, people's life style and behavior.Gynecological infectious diseases is that class commonly encountered diseases and a frequently-occurring disease, particularly colpitis mycotica, cervical erosion and senile vaginitis sickness rate are very high.
In the Epidemiological study result of common gynecological disease, the order of reproductive tract infection prevalence is followed successively by: vaginitis 15.9%, Chlamydial Infection in Female Genital Tract 5.4%, chronic pelvic inflammatory disease 4.1%, vulvitis 1.5% etc. due to chronic cervicitis 39.3%, a variety of causes.
The early treatment of Gynecological cervical and vagina, typically use washing liquid, and washing liquid is when killing harmful bacteria, also can kill the bacterium vaginae useful to health, destroy intravaginal balance environment, life-time service will reduce local resistivity greatly, increases again the chance of bacteria infection.Inflammation severe patient drug administration is many, the oral Pharmaceutical dosage forms main component be in, Western medicine, through the intestines and stomach absorption, very big to actual bodily harm, particularly Liver and kidney injury, onset time is slow, its mechanism of action is that medicine enters vagina position and killing bacteria through the blood circulation, generally must just show curative effect by long-term taking, and toxic and side effects is strong.The preferred local application of the treatment of Gynecological cervical and vagina, still, existing vagina medicine for external use bactericidal effect is poor, and zest is large, skin allergy, easily repeatedly, therapeutic effect is not good enough.
Summary of the invention
Purpose of the present invention is exactly the defect for prior art, uses modern biotechnology, the treatment Gynecological cervical that provide a kind of good antimicrobial effect, has no side effect and the antibacterial gel of vagina.
For achieving the above object, the present invention treats the antibacterial gel of Gynecological cervical and vagina, and every 100 gram gels are made by the raw material of following weight proportioning:
Chitosan 0.1 ~ 1g, tea tree ethereal oil 0.1 ~ 5g, Borneolum Syntheticum 0.1 ~ 3g, Borax 0.1 ~ 2g, carbomer 0.25 ~ 2g, ethanol 4 ~ 10g, surplus are pure water.
Preferably, every 100 gram gels are made by the raw material of following weight proportioning:
Chitosan 0.5 ~ 1g, tea tree ethereal oil 2 ~ 4g, Borneolum Syntheticum 0.5 ~ 2g, Borax 0.5 ~ 1g, carbomer 0.5 ~ 1.2g, ethanol 6 ~ 8g, surplus are pure water.
The preparation method of the antibacterial gel of above-mentioned treatment Gynecological cervical and vagina comprises the following steps:
A, carbomer is dispersed in pure water and soaks, treat fully to dissolve and obtain A phase solution;
B, chitosan is dissolved in pure water, obtains B phase solution;
C, Borneolum Syntheticum is dissolved in ethanol fully and dissolves, add tea tree ethereal oil to stir and obtain C phase solution;
D, Borax is dissolved in the pure water of remaining part, stirring and dissolving obtains D phase solution;
A, B, C, D four phase solution are all mixed, stirred 30 minutes, obtain.
Chitosan is a kind of natural cationic polysaccharide that chitin obtains through deacetylation.The interaction of negative charge on its positive charge and bacterial cell membrane, intracellular protease and other compositions are leaked, thereby play certain antibiotic and antitumor action, have degradability, good film property, good biocompatibility and wound repairing Healing.The present invention utilizes its film property, absorbability and antibiotic property, improves vaginal environment, at vaginal wall, forms one isolating membrane, stops the growth of pathogenic bacterium field planting and harmful bacteria, reaches antibacterial and bacteriostasis.
Tea tree ethereal oil is pure natural plant extract, is potent antibacterial, can effectively resist the strains such as dermatophytes, Candida albicans, little sporeformer, gram negative bacteria, staphylococcus aureus, escherichia coli.Composite with chitosan, can strengthen and extend sterilization, the antibacterial effect of product of the present invention.
The loose poison of Borneolum Syntheticum heat clearing away, promote the healing of erosion and ulcer,, to the mucosal injury due to antibacterial or other complicated factors, also can bring into play auxiliary therapeutic action.
Borax protection skin mucosa, sterilize anticorrosion, collaborative with Borneolum Syntheticum, and heat clearing and damp drying, convergence are antipruritic, the parasite killing that detoxifies, reducing swelling and alleviating pain.Mentioned component is composite, can anti-inflammation, and the convergence skin infection that can heal again, more fully strengthen the curative effect of product of the present invention.
Carbomer as the medicine carrying frame with various composition suspended dispersed in solvent, play drug effect evenly, control and slow releasing function.Ethanol, all compositions of pure water mediation.
Beneficial effect of the present invention is: the bacteriostasis rate of the treatment Gynecological cervical that the present invention makes and the antibacterial gel of vagina 〉=90% has stronger bacteriostasis.The antibacterial gel of Gynecological cervical of the present invention and vagina carries out heavy metal and detects, content of beary metal＜10ppm.The present invention has good biocompatibility, and cytotoxicity is less than 2 grades, and vaginal irritation is little, without delayed hypersensitivity.The every test rating of antibacterial gel of the treatment Gynecological cervical that the present invention makes and vagina all meets relevant national standard or regulation.Clinical trial shows that in use safety of product of the present invention is good, can meet the clinical practice requirement.The present invention have advantages of safety, efficient, have no side effect, simple and easy to use.
The specific embodiment
The present invention is described in further detail below in conjunction with specific embodiment.
Embodiment 1
Every 100 gram treatment Gynecological cervicals of the present embodiment and the antibacterial gel of vagina are made by the raw material of following weight proportioning: chitosan 0.5g, tea tree ethereal oil 4g, Borneolum Syntheticum 0.5g, Borax 0.5g, carbomer 0.5g, ethanol 6g, surplus are pure water.
Its preparation method comprises the following steps:
A, carbomer is dispersed in pure water and soaks, treat fully to dissolve and obtain A phase solution;
B, chitosan is dissolved in pure water, obtains B phase solution;
C, Borneolum Syntheticum is dissolved in ethanol fully and dissolves, add tea tree ethereal oil to stir and obtain C phase solution;
D, Borax is dissolved in the pure water of remaining part, stirring and dissolving obtains D phase solution;
A, B, C, D four phase solution are all mixed, stirred 30 minutes, obtain.
Embodiment 2
Every 100 gram treatment Gynecological cervicals of the present embodiment and the antibacterial gel of vagina are made by the raw material of following weight proportioning: chitosan 1g, tea tree ethereal oil 3g, Borneolum Syntheticum 2g, Borax 1g, carbomer 0.8g, ethanol 8g, surplus are pure water.
Its preparation method such as embodiment 1.
Embodiment 3
Every 100 gram treatment Gynecological cervicals of the present embodiment and the antibacterial gel of vagina are made by the raw material of following weight proportioning: chitosan 1g, tea tree ethereal oil 5g, Borneolum Syntheticum 3g, Borax 2g, carbomer 2g, ethanol 10g, surplus are pure water.
Its preparation method such as embodiment 1.
The treatment Gynecological cervical that the embodiment of the present invention 1 ~ 3 is made and the antibacterial gel of vagina carry out the fungistatic effect experiment, and experimental result is as shown in table 1.
Table 1 fungistatic effect
| Project | Action time (min) | Bacteriostasis rate, % |
| Escherichia coli (8099) | 5 | ≥98 |
| Staphylococcus aureus (ATCC 6538) | 5 | ≥95 |
| Candida albicans (ATCC 10231) | 5 | ≥96 |
According to the evaluation criterion of GB15979-2002 appendix C 4 regulations, bacteriostasis rate 〉=50%～90%, product has bacteriostasis, and bacteriostasis rate 〉=90%, product have stronger bacteriostasis.
Therefore, the treatment Gynecological cervical that makes of the present invention and the antibacterial gel of vagina have stronger bacteriostasis.
Heavy metal:
The treatment Gynecological cervical that the embodiment of the present invention 1 ~ 3 is made and the antibacterial gel of vagina carry out heavy metal and detect, content of beary metal＜10ppm
Biocompatibility:
The treatment Gynecological cervical that the embodiment of the present invention 1 ~ 3 is made and the antibacterial gel of vagina are by the lixiviating solution method test of GB/T16886.5-2003 regulation, and cell toxicity test: cytotoxicity is less than 2 grades.
The treatment Gynecological cervical that the embodiment of the present invention 1 ~ 3 is made and the antibacterial gel of vagina are tested by the vaginal irritation test method(s) of stipulating in GB/T16886.10-2005, and irritant test: stimulation index is on average scored less than 4.
The treatment Gynecological cervical that the embodiment of the present invention 1 ~ 3 is made and the antibacterial gel of vagina stick test method(s) by the sealing of stipulating in GB/T16886.10-2005 and test, delayed hypersensitivity test: without delayed hypersensitivity.
Therefore, the treatment Gynecological cervical that makes of the present invention and the every test rating of antibacterial gel of vagina all meet relevant national standard or regulation.
Clinical trial:
The treatment Gynecological cervical that the embodiment of the present invention 1 ~ 3 is made and the antibacterial gel of vagina carry out clinical trial.
Result of the test shows: product of the present invention is reducing postoperative hemorrhage of cervix amount and bleeding time, neoplasm amount and drain time, promote the wound surface epithelization, it is smooth that cervix uteri recovers, reduce cervical ectropion, there is obvious clinical effectiveness reparation vaginal environment balance, prevention infection aspect, make healing time shorten, reduce post-operative complication.In use safety of product of the present invention simultaneously is good, can meet the clinical practice requirement.
Claims (3)
1. an antibacterial gel for the treatment of Gynecological cervical and vagina, is characterized in that, every 100 gram gels are made by the raw material of following weight proportioning:
Chitosan 0.1 ~ 1g, tea tree ethereal oil 0.1 ~ 5g, Borneolum Syntheticum 0.1 ~ 3g, Borax 0.1 ~ 2g, carbomer 0.25 ~ 2g, ethanol 4 ~ 10g, surplus are pure water.
2. the antibacterial gel for the treatment of Gynecological cervical according to claim 1 and vagina, is characterized in that, every 100 gram gels are made by the raw material of following weight proportioning:
Chitosan 0.5 ~ 1g, tea tree ethereal oil 2 ~ 4g, Borneolum Syntheticum 0.5 ~ 2g, Borax 0.5 ~ 1g, carbomer 0.5 ~ 1.2g, ethanol 6 ~ 8g, surplus are pure water.
3. the preparation method of the antibacterial gel of a treatment Gynecological cervical according to claim 1 and vagina, is characterized in that, comprises the following steps:
A, carbomer is dispersed in pure water and soaks, treat fully to dissolve and obtain A phase solution;
B, chitosan is dissolved in pure water, obtains B phase solution;
C, Borneolum Syntheticum is dissolved in ethanol fully and dissolves, add tea tree ethereal oil to stir and obtain C phase solution;
D, Borax is dissolved in the pure water of remaining part, stirring and dissolving obtains D phase solution;
A, B, C, D four phase solution are all mixed, stirred 30 minutes, obtain.
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| CN201310285895.3A CN103385926B (en) | 2013-07-09 | 2013-07-09 | Antibiosis gel for curing cervical and vaginal diseases of gynaecology |
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| CN103385926B CN103385926B (en) | 2015-04-22 |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104224923A (en) * | 2014-07-07 | 2014-12-24 | 海南华拓天涯制药有限公司 | Tea tree essential oil antimicrobial gel for treating vaginal disease in gynecology |
| CN105477052A (en) * | 2014-09-19 | 2016-04-13 | 贵阳新天药业股份有限公司 | Kushen gel for treating mixed vaginal diseases and application thereof |
| CN106511374A (en) * | 2016-10-20 | 2017-03-22 | 安徽宇宁果胶股份有限公司 | Pectin gynecological antibacterial gel and preparation method thereof |
| CN107149619A (en) * | 2017-05-18 | 2017-09-12 | 四川悦艾健康科技有限公司 | Harmful bacteria breeding can be suppressed and the compound preparation of growth of probiotics can be promoted |
| CN107375384A (en) * | 2017-07-10 | 2017-11-24 | 广州暨南生物医药研究开发基地有限公司 | A kind of gynaecological gel containing P-Cymene and preparation method thereof |
| CN107836466A (en) * | 2017-11-10 | 2018-03-27 | 天津中澳嘉喜诺生物科技有限公司 | A kind of tea tree ethereal oil natural disinfectant agent for animals and preparation method thereof |
| CN108079120A (en) * | 2017-12-06 | 2018-05-29 | 常州三伊化工有限公司 | A kind of cow teats disinfectant |
| CN108524866A (en) * | 2018-05-08 | 2018-09-14 | 中商华夏物产（贵州）贵和堂药业有限公司 | A kind of Traditional Chinese medicine bacteriostatic gelling agent and preparation method thereof |
| CN108524923A (en) * | 2018-07-11 | 2018-09-14 | 江苏万可瑞科技实业有限公司 | A kind of gynaecologic antibiotic gel and its production method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104224923A (en) * | 2014-07-07 | 2014-12-24 | 海南华拓天涯制药有限公司 | Tea tree essential oil antimicrobial gel for treating vaginal disease in gynecology |
| CN105477052A (en) * | 2014-09-19 | 2016-04-13 | 贵阳新天药业股份有限公司 | Kushen gel for treating mixed vaginal diseases and application thereof |
| CN106511374A (en) * | 2016-10-20 | 2017-03-22 | 安徽宇宁果胶股份有限公司 | Pectin gynecological antibacterial gel and preparation method thereof |
| CN107149619A (en) * | 2017-05-18 | 2017-09-12 | 四川悦艾健康科技有限公司 | Harmful bacteria breeding can be suppressed and the compound preparation of growth of probiotics can be promoted |
| CN107375384A (en) * | 2017-07-10 | 2017-11-24 | 广州暨南生物医药研究开发基地有限公司 | A kind of gynaecological gel containing P-Cymene and preparation method thereof |
| CN107836466A (en) * | 2017-11-10 | 2018-03-27 | 天津中澳嘉喜诺生物科技有限公司 | A kind of tea tree ethereal oil natural disinfectant agent for animals and preparation method thereof |
| CN108079120A (en) * | 2017-12-06 | 2018-05-29 | 常州三伊化工有限公司 | A kind of cow teats disinfectant |
| CN108524866A (en) * | 2018-05-08 | 2018-09-14 | 中商华夏物产（贵州）贵和堂药业有限公司 | A kind of Traditional Chinese medicine bacteriostatic gelling agent and preparation method thereof |
| CN108524923A (en) * | 2018-07-11 | 2018-09-14 | 江苏万可瑞科技实业有限公司 | A kind of gynaecologic antibiotic gel and its production method |
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| CN103385926B (en) | 2015-04-22 |
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