CN102335462A - Nano iodine-chitosan cervical disease treating membrane agent and preparation method of membrane - Google Patents
Nano iodine-chitosan cervical disease treating membrane agent and preparation method of membrane Download PDFInfo
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- CN102335462A CN102335462A CN2011102729385A CN201110272938A CN102335462A CN 102335462 A CN102335462 A CN 102335462A CN 2011102729385 A CN2011102729385 A CN 2011102729385A CN 201110272938 A CN201110272938 A CN 201110272938A CN 102335462 A CN102335462 A CN 102335462A
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- chitosan
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- quaternary ammonium
- iodine
- ammonium salt
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Abstract
The invention discloses a nano iodine-chitosan cervical disease treating membrane agent and a preparation method of the membrane. The treating membrane is prepared by adding plasticizer and adsorbent to chitosan, povidone iodine, dialkyl quaternary ammonium salt and chlorhexidine acetate used as main effective ingredients. The treating membrane disclosed by the invention has killing activity to multiple pathogenic microorganisms, has no irrigation to mucosa, can relieve itching, arrest bleeding and promote the growth of epidermic tissues, can be used for treating colpitis, trichomonas vaginalis, cervicitis, cervical erosion and other gynecological diseases, has better repair action on vaginal and cervical injury, and can effectively prevent the propagation of venereal diseases such as gonorrhoea, syphilis, AIDS (acquired immunodeficiency syndrome) and the like.
Description
Technical field
The present invention relates to a kind of medical material and preparation method thereof, the method for preparing of specifically a kind of nanometer iodine chitosan uterus-neck treatment membrane and film.
Technical background
Gynecological inflammation is common gynecological disease, frequently-occurring disease, sees so that vaginitis, cervicitis, cervical erosion, pelvic inflammatory disease more.In recent years, the sickness rate of female gynecological disease is the trend of obvious rising and rejuvenation, occupies World Health Organization's statistics, and the various gynaecopathia sickness rate of China women make people worried more than 70%.
The oral drugs of treatment gynaecopathia, not high like frequencies of utilization such as antibacterials, the patient is more prone to use external medication, and external used medicine can directly act on affected part, untoward reaction is few, easy is accepted by doctor and patient.The main external used medicine of existing market is divided into three types of lotion, suppository and effervescent tablets, and ointment, gel, capsule etc. are also arranged, and this type amount of drug is bigger, and medicine and substrate are prone to flow out from vagina, affect the treatment.
Summary of the invention
The present invention's technical problem at first to be solved provides a kind of nanometer iodine chitosan uterus-neck treatment film, and its consumption is little, biocompatibility is strong, easy to use and carry, is fit to the treatment of female patient and daily nursing at ordinary times.For this reason, the present invention adopts following technical scheme: it is main effective ingredient with povidone iodine, dialkyl quaternary ammonium salt, chlorhexidine acetate; Said membrane also comprises chitosan as the auxiliary treatment composition, is used to stop blooding and promotes the reparation of cervix uteri epidermal tissue; Said membrane also comprises cellulose derivative, plasticizer, adsorbent, and filmogen is chitosan and cellulose derivative, and adsorbent is a carbon nano-fiber.
On the basis of adopting technique scheme, the present invention also can adopt following further technical scheme:
Plasticizer is glycerol or sorbitol.
The weight content of povidone iodine in membrane is 1%-20%.
Dialkyl quaternary ammonium salt in membrane weight content be 0.01%-5%; Described dialkyl quaternary ammonium salt is selected from two dodecyl quaternary ammonium salts, two decyl quaternary ammonium salt, two nonyl quaternary ammonium salt, two octyl group quaternary ammonium salt, and it can adopt one or more the combination in these materials.
The weight content of chlorhexidine acetate in membrane is 0.01%-5%.
The weight content of chitosan in membrane is 20%-60%, and described chitosan is selected from carboxymethyl chitosan, sulphuric acid carboxymethyl chitosan, sulphuric acid chitosan, using carboxyl chitosan, sulfuration chitosan, hydroxylating chitosan or chitosan quaternary ammonium salt.
The weight content of cellulose derivative is 20%-60%, and described cellulose derivative is selected from methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose.
Another technical problem to be solved of the present invention provides a kind of method for preparing of nanometer iodine chitosan uterus-neck treatment film; It adopts aforesaid prescription, and povidone iodine, dialkyl quaternary ammonium salt and chlorhexidine acetate are added in the suitable quantity of water, is heated with stirring to 30-100 ℃; Make its dissolving; Add filmogen, plasticizer,, make the dissolving mixing in 80-100 ℃ of heated and stirred 1 hour; Be cooled to 40-60 ℃ and slowly stir, add adsorbent, continue to stir, the aerofluxus bubble, bed board is dried 20-50 minute film forming in 50-100 ℃ while hot.
The present invention is the main pharmacodynamics composition with the povidone iodine; Povidone iodine is the disinfectant of a kind of wide spectrum, efficient, low toxicity, safety; Antibacterial, fungus, virus, protozoon etc. all there are good killing action, can be used for treating skin ulcer, gynaecopathia, prevention and auxiliary treatment sexually transmitted disease (STD).The dosage form of existing povidone iodine has washing liquid, suppository, gel, ointment etc., and the consumption of these dosage forms is big, and foreign body sensation is arranged, and medicine is prone to flow out from vagina.The preparation of povidone iodine membrane agent has been described in " povidone iodine membrane agent " in the past (the Chinese invention patent application of application number 9811192.2) and " highly-water-soluble povidone iodine membrane agent " (Chinese invention patent application of application number 03117635.6); With the povidone iodine is main component; The filmogen of using mainly is polyvinyl alcohol, polyvinylpyrrolidone, sodium alginate, cellulose etc., and these filmogens are biologically active not.The present invention uses chitosan as adjuvant therapy medicaments and filmogen, but antibacterial, hemostasis, promotion injured tissues are repaired.
Chitosan is the product of chitin N-deacetylation, is a kind of natural straight chain shape aminopolysaccharide.Chitosan has characteristics such as good film property, permeability, adsorptivity, biological degradability, biocompatibility and Bioabsorbable, widely pays close attention to.Chitosan can promote fibrocellular migration, and stromal cell is had chemotactic, migration, activated effect, and quickens cell proliferation and tissue remodeling process, promotes skin tissue recovering, and accelerating wound healing and anastalsis are arranged.The network structure of chitosan makes it to have the prevention tissue adhesion, suppresses physiological functions such as cicatrization and protection articular cartilage.
Except povidone iodine and chitosan, the present invention has also used an amount of dialkyl quaternary ammonium salt and chlorhexidine acetate as antibacterial, has strengthened bactericidal effect greatly, and antibacterial, fungus, virus, protozoon, mycoplasma etc. are all killed activity.The present invention has also used carbon nano-fiber as a kind of adsorbent in prescription, be used to adsorb vaginal secretions, reduces the sense of discomfort that patient's excess secretion causes.
Chitosan, dialkyl quaternary ammonium salt, povidone iodine three fill a prescription simultaneously and can manage it into a part of chitosan quaternary ammonium salt chelated iodine, can improve bactericidal property, increase to promote wound healing,
The present invention kills activity to the several diseases pathogenic microorganism; And to the mucosa nonirritant; Can be antipruritic, hemostasis, promote epidermal tissue's growth; Can be used for treating gynaecopathias such as vaginitis, trichomonas vaginitis, cervicitis, cervical erosion, and have repair function preferably, and can be used for preventing sexually transmitted disease (STD) such as propagation such as gonorrhea, syphilis, AIDS and hepatitis B.
The specific embodiment
Embodiment 1:
The membrane prescription:
Povidone iodine 20g
Two octyldimethyl ammonium chloride 1g
Chlorhexidine acetate 1g
Carboxymethyl chitosan 30g
Hydroxypropyl emthylcellulose 40g
Glycerol 10g
Carbon nano-fiber 2g
Water 400mL
Povidone iodine, two octyldimethyl ammonium chloride and chlorhexidine acetate add in the suitable quantity of water, and 80 ℃ of agitating heating make its dissolving, add carboxymethyl chitosan, hydroxypropyl emthylcellulose, glycerol, in 80 ℃ of heated and stirred 1 hour, make the dissolving mixing; Be cooled to 50 ℃ and slowly stir, add adsorbent, continue to stir, the aerofluxus bubble, bed board was dried 50 minutes in 60 ℃ while hot.Skinning, cutting.
Embodiment 2:
The membrane prescription:
Povidone iodine 15g
Two dodecyl dimethyl ammonium chloride 2g
Chlorhexidine acetate 2g
Using carboxyl chitosan 30g
Methylcellulose 40g
Glycerol 10g
Carbon nano-fiber 3g
Water 400mL
Povidone iodine, two dodecyl dimethyl ammonium chloride and chlorhexidine acetate add in the suitable quantity of water, and 80 ℃ of agitating heating make its dissolving, add using carboxyl chitosan, methylcellulose, glycerol, in 80 ℃ of heated and stirred 1 hour, make the dissolving mixing; Be cooled to 50 ℃ and slowly stir, add adsorbent, continue to stir, the aerofluxus bubble, bed board was dried 50 minutes in 60 ℃ while hot.Skinning, cutting.
Embodiment 3:
The membrane prescription:
Povidone iodine 10g
Two decyl alkyl dimethyl ammonium chloride 2g
Chlorhexidine acetate 2g
Using carboxyl chitosan 25g
Sodium carboxymethyl cellulose 45g
Sorbitol 10g
Carbon nano-fiber 3g
Water 500mL
Povidone iodine, two decyl alkyl dimethyl ammonium chloride and chlorhexidine acetate add in the suitable quantity of water, and 80 ℃ of agitating heating make its dissolving, add using carboxyl chitosan, sodium carboxymethyl cellulose, sorbitol, in 80 ℃ of heated and stirred 1 hour, make the dissolving mixing; Be cooled to 50 ℃ and slowly stir, add adsorbent, continue to stir, the aerofluxus bubble, bed board was dried 50 minutes in 60 ℃ while hot.Skinning, cutting.
Above-mentioned embodiment is merely and is used for illustrative explanation the present invention, rather than limits the invention, and any modification that the present invention is made, is equal to replacement, improvement etc., all falls into protection scope of the present invention.
Claims (8)
1. a nanometer iodine chitosan uterus-neck treatment membrane is characterized in that it is main effective ingredient with povidone iodine, dialkyl quaternary ammonium salt, chlorhexidine acetate; Said membrane also comprises chitosan as the auxiliary treatment composition, is used to stop blooding and promotes the reparation of cervix uteri epidermal tissue; Said membrane also comprises cellulose derivative, plasticizer, adsorbent, and filmogen is chitosan and cellulose derivative, and adsorbent is a carbon nano-fiber.
2. nanometer iodine chitosan uterus-neck treatment membrane according to claim 1 is characterized in that plasticizer is glycerol or sorbitol.
3. nanometer iodine chitosan uterus-neck treatment membrane according to claim 1 is characterized in that the weight content of povidone iodine in membrane is 1%-20%.
4. nanometer iodine chitosan uterus-neck treatment membrane according to claim 1; It is characterized in that dialkyl quaternary ammonium salt in membrane weight content be 0.01%-5%, described dialkyl quaternary ammonium salt is selected from two dodecyl quaternary ammonium salts, two decyl quaternary ammonium salt, two nonyl quaternary ammonium salt, two octyl group quaternary ammonium salt.
5. nanometer iodine chitosan uterus-neck treatment membrane according to claim 1 is characterized in that the weight content of chlorhexidine acetate in membrane is 0.01%-5%.
6. nanometer iodine chitosan uterus-neck treatment membrane according to claim 2; It is characterized in that the weight content of chitosan in membrane is 20%-60%, described chitosan is selected from carboxymethyl chitosan, sulphuric acid carboxymethyl chitosan, sulphuric acid chitosan, using carboxyl chitosan, sulfuration chitosan, hydroxylating chitosan or chitosan quaternary ammonium salt.
7. nanometer iodine chitosan uterus-neck treatment membrane according to claim 2; The weight content that it is characterized in that cellulose derivative is 20%-60%, and described cellulose derivative is selected from methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose.
8. the method for preparing of nanometer iodine chitosan uterus-neck treatment film is characterized in that, it adopts the described prescription of claim 1; Povidone iodine, dialkyl quaternary ammonium salt and chlorhexidine acetate are added in the suitable quantity of water; Be heated with stirring to 30-100 ℃, make its dissolving, add filmogen, plasticizer; In 80-100 ℃ of heated and stirred 1 hour, make the dissolving mixing; Be cooled to 40-60 ℃ and slowly stir, add adsorbent, continue to stir, the aerofluxus bubble, bed board is dried 20-50 minute film forming in 50-100 ℃ while hot.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011102729385A CN102335462A (en) | 2011-09-15 | 2011-09-15 | Nano iodine-chitosan cervical disease treating membrane agent and preparation method of membrane |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011102729385A CN102335462A (en) | 2011-09-15 | 2011-09-15 | Nano iodine-chitosan cervical disease treating membrane agent and preparation method of membrane |
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| CN102335462A true CN102335462A (en) | 2012-02-01 |
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| CN2011102729385A Pending CN102335462A (en) | 2011-09-15 | 2011-09-15 | Nano iodine-chitosan cervical disease treating membrane agent and preparation method of membrane |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083711A (en) * | 2013-01-11 | 2013-05-08 | 浙江三创生物科技有限公司 | Chitosan-iodine composite biological medical film and preparation method thereof |
| CN104069124A (en) * | 2014-07-11 | 2014-10-01 | 天津嘉氏堂科技有限公司 | Composition and preparation for gynecologic infections |
| CN104739858A (en) * | 2015-01-14 | 2015-07-01 | 深圳市安多福消毒高科技股份有限公司 | Isolation ointment and preparation method thereof |
| CN108836951A (en) * | 2018-06-20 | 2018-11-20 | 中山万汉制药有限公司 | A kind of povidone iodine slow-release medicine-membrane and preparation method thereof |
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| CN1302606A (en) * | 1999-12-23 | 2001-07-11 | 强生消费者公司 | Method of preparing water soluble film |
| CN1709243A (en) * | 2005-07-02 | 2005-12-21 | 杨喜鸿 | Vagina medicine containing ebselen and its use |
| CN101987201A (en) * | 2010-02-11 | 2011-03-23 | 北京德存华盛医疗器械有限公司 | Medical ultrasonic probe sterilizing gel and preparation method thereof |
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2011
- 2011-09-15 CN CN2011102729385A patent/CN102335462A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1302606A (en) * | 1999-12-23 | 2001-07-11 | 强生消费者公司 | Method of preparing water soluble film |
| CN1709243A (en) * | 2005-07-02 | 2005-12-21 | 杨喜鸿 | Vagina medicine containing ebselen and its use |
| CN101987201A (en) * | 2010-02-11 | 2011-03-23 | 北京德存华盛医疗器械有限公司 | Medical ultrasonic probe sterilizing gel and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083711A (en) * | 2013-01-11 | 2013-05-08 | 浙江三创生物科技有限公司 | Chitosan-iodine composite biological medical film and preparation method thereof |
| CN103083711B (en) * | 2013-01-11 | 2014-05-07 | 浙江三创生物科技有限公司 | Chitosan-iodine composite biological medical film and preparation method thereof |
| CN104069124A (en) * | 2014-07-11 | 2014-10-01 | 天津嘉氏堂科技有限公司 | Composition and preparation for gynecologic infections |
| CN104739858A (en) * | 2015-01-14 | 2015-07-01 | 深圳市安多福消毒高科技股份有限公司 | Isolation ointment and preparation method thereof |
| CN108836951A (en) * | 2018-06-20 | 2018-11-20 | 中山万汉制药有限公司 | A kind of povidone iodine slow-release medicine-membrane and preparation method thereof |
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Application publication date: 20120201 |