CN106822321B - Application of Curcuma water of traumatology in preparing medicine for treating keratosis pilaris - Google Patents
Application of Curcuma water of traumatology in preparing medicine for treating keratosis pilaris Download PDFInfo
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- CN106822321B CN106822321B CN201710134600.0A CN201710134600A CN106822321B CN 106822321 B CN106822321 B CN 106822321B CN 201710134600 A CN201710134600 A CN 201710134600A CN 106822321 B CN106822321 B CN 106822321B
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- traumatology
- yellow water
- keratosis pilaris
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
Abstract
The invention discloses a new application of traumatology yellow water, and particularly relates to an application of traumatology yellow water in preparing a medicine for treating keratosis pilaris. The medicine of the invention consists of a compound extract of the yellow water of the traumatology and pharmaceutically acceptable auxiliary materials. Wherein, the content of the compound extract of the yellow water of the traumatology is 1 to 99.5 percent by weight percentage. The medicament dosage form of the invention is external preparations such as lotion, spray, ointment, gel and the like. The invention has definite function and no toxic or side effect, widens the disease prevention range of the yellow water of the traumatology, and has considerable market prospect.
Description
Technical Field
The invention relates to the technical field of dermatology, in particular to application of traumatology yellow water in preparing a medicine for treating keratosis pilaris.
Background
The yellow water of the traumatology department is a typical medicine in the external treatment formula of the traditional Chinese medicine. The Chinese medicine compound of 'Shangkuang water' has been used for over 50 years in clinic, and is created by Chenwei Liankhun TCM doctors of TCM college in the city of famous family of orthopedics and traumatology, famous family of Shanghai, of contemporary Lingnan. The preparation of the yellow water of traumatology department is developed and shaped on the basis of the formula, and related patents (patent publication number: 96123078.9) are obtained in 2000, and the preparation is taken as a preparation in hospital in the traditional Chinese medical institute of Foshan City, is mainly used for traumatic injury, soft tissue and bone injury, and the like, has the effects of resisting inflammation and diminishing swelling, promoting blood circulation and removing blood stasis, and removing putrefaction and promoting tissue regeneration, is popular with patients, and has the average annual usage amount of hundreds of thousands of bottles.
Perifollicular keratosis, also known as perifollicular keratosis, keratosis pilaris, chicken skin, etc., is caused by keratosis of hair follicle mouths, has a large relationship with fat metabolism, and is expressed as follicular keratotic papules with multiple pinpoint sizes. Keratosis pilaris is mainly distributed in the upper arm, lateral femoral region and hip, and facial lesions are sometimes seen, especially in children. Facial damage is usually evident in winter and better in summer. The keratosis pilaris easily affects the beauty and brings great trouble to patients. Since it is well developed in adolescents to 40 years, and then gradually fades away with age, but the good hair stage is the most noticeable stage. Some patients feel ugly and wear long-sleeve trousers even in hot days to hide unnecessary embarrassment. More seriously, a single protruding part is a acne or pox, which can cause the idea of removing and then quickly, and the part is squeezed or scratched by fingers, thus causing more serious inflammation and pigmentation.
At present, no relevant journal literature reports that the traumatology yellow water can be used for treating skin diseases such as keratosis pilaris, and through search, no patent literature that the traumatology yellow water is used for treating keratosis pilaris is disclosed, and no preparation using the traumatology yellow water as a medicine for treating the skin diseases such as keratosis pilaris is on the market.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides the application of the yellow water of traumatology department in preparing the medicine for treating the keratosis pilaris. The yellow water for traumatology has good functions of improving microcirculation, resisting inflammation and reducing swelling, and has a special effect on treating skin diseases such as keratosis pilaris and the like.
In order to achieve the purpose, the invention adopts the following technical scheme:
the Chinese medicinal compound of the yellow water for the traumatology department comprises coptis chinensis, golden cypress, gardenia, lithospermum, alum and mint.
The following are the common specific efficacies of the components in the yellow water of traumatology:
coptis chinensis: it has antibacterial, antifungal, antiviral, amebic resisting, antiinflammatory, diarrhea resisting, antipyretic, blood sugar lowering, blood lipid reducing, antioxidant, blood system influencing, and antiulcer effects. The external application combines the efficacies of phellodendron bark, rhubarb and the like to be multiplied.
Phellodendron bark: has effects in clearing away heat, eliminating dampness, purging pathogenic fire, removing steam, removing toxic materials, and treating sore. The main treatment is as follows: dysentery due to damp-heat, jaundice with dark urine, pruritus vulvae, stranguria with damp-heat, tinea pedis with atrophy cramped, hectic fever due to yin-deficiency, night sweat, spermatorrhea, and external use for treating pyocutaneous disease, toxic swelling, eczema, and eczema.
Gardenia: clear heat, purge fire, cool blood and remove toxicity. It is indicated for restlessness and insomnia due to deficiency of heat, jaundice, gonorrhea, diabetes, conjunctival congestion, pharyngalgia, and hematemesis. Epistaxis, bloody dysentery, hematuria, sores and ulcers due to heat-toxin, sprain, swelling and pain, and innominate swelling and pain.
Lithospermum: cool blood, activate blood, clear heat and remove toxicity. It can be used for treating warm heat macula, damp-heat jaundice, purpura, emesis, epistaxis, hematuria, stranguria with turbid urine, constipation due to heat accumulation, topical eruption, burn, eczema, erysipelas, and carbuncle and ulcer.
Alum: the external use can detoxify, kill parasites, eliminate dampness and relieve itching; internal use can stop bleeding, check diarrhea and resolve phlegm. Treating epilepsy, pharyngitis, acute and chronic saliva accumulation, hepatitis, jaundice, gastric ulcer, duodenal ulcer, uterine prolapse, leucorrhea, dysentery, epistaxis, aphtha, hemorrhoid, scabies, tinea, water, fire, and insect injury.
Mint: has effects of dispelling pathogenic wind, clearing heat away, removing toxic substances, etc., and can be used for treating affection of exogenous wind-heat, headache, conjunctival congestion, sore throat, dyspepsia, flatulence, aphtha, toothache, scabies, and hypochondriac pain due to stagnation of liver-qi.
The traditional Chinese medicine compound of the traumatic yellow water adopts coptis as a monarch drug, phellodendron, gardenia and lithospermum as a ministerial drug, alum and mint as an adjuvant drug, the compatibility of the components is proper, the drug effects have the synergistic and complementary effects, the absorption of active ingredients in the monarch drug and the ministerial drug is enhanced, the traditional Chinese medicine compound has the characteristics of clearing heat, diminishing swelling, promoting blood circulation, relaxing muscles and tendons, effectively improving skin blood circulation and the like, is used for treating skin diseases such as keratosis pilaris and the like, has definite functions, does not have toxic or side effects, achieves the effects of quick effect taking and remarkable curative effect, and widens the range of the traumatic yellow water disease prevention.
Further, the traditional Chinese medicine compound for the yellow water of the traumatology department is prepared from the following components in parts by weight: phellodendron bark: gardenia: lithospermum: alum: mint (1-100): (1-100): (1-100): (1-100): (1-100): (1-100). The weight proportion of the components is the formula weight proportion range of the Chinese medicinal compound for treating the traumatology yellow water for treating the keratosis pilaris, and the traumatology yellow water prepared by the value in the range can have the effect of treating the keratosis pilaris.
Further, the content of the compound extract of the yellow water of the traumatology department in the medicine is 1 to 99.5 percent by weight, and the balance is pharmaceutically acceptable auxiliary materials. The compound extract is prepared by concentrating the medicinal preparation of SHANGKE HUANGSHUI, and the adjuvant can be conventional auxiliary substances such as antiseptic, solvent, emulsifier or penetration enhancer.
In a further aspect, the medicament is in a dosage form that can be manufactured by conventional pharmaceutical equipment.
Further, the dosage forms are lotions, sprays, ointments and gels. The same medicine has different formulations, is suitable for different occurrence and development stages of diseases, and different formulations can be correctly selected according to symptoms and characteristics of diseases in different periods. For example, when the part of the skin disease has red swelling, blister and erosion in the acute stage, the solution is used for wet compress in many cases, which can play a role in diminishing inflammation; for those with seepage, the solution is used for wet compress firstly, and then the oil solution is used; when the skin lesion is in a subacute stage, the redness and swelling are reduced, the effusion is reduced, and lotion can be selected as appropriate to play the anti-inflammatory, itching relieving, astringing and protecting roles; the skin lesion is thickened in the chronic period, and the ointment or the gel is used for multiple purposes, has strong penetrating power and lasting effect, and has the functions of lubricating and protecting the skin.
The invention has the beneficial effects that: the Chinese herbal compound for the yellow water of the traumatology takes the coptis as a monarch drug, has the effects of clearing away heat and toxic materials, eliminating dampness and reducing swelling, and is supplemented with the golden cypress and the gardenia to enhance the effects of eliminating dampness and reducing swelling; the gardenia and the lithospermum have the functions of cooling blood and activating blood, and take stasis removing and pulse invigorating as ministerial drugs; then, alum is used for detoxifying, removing the necrotic tissue, astringing and promoting granulation; the pungent and cool property of Bo He is used to gently clear and disperse, dispel wind and alleviate pain, and help Zi Cao to resolve stasis. The invention provides a new traditional Chinese medicine preparation for treating skin diseases such as keratosis pilaris and the like, has definite functions and no toxic or side effect, and also widens the disease prevention range of the yellow water of traumatology.
Detailed Description
The present invention will be described in detail with reference to the following examples. It should be understood by those skilled in the art that the following examples are preferred embodiments, which are merely illustrative of the present invention, and that appropriate omissions of well-known techniques may be made therein, and that the present invention will be understood by those skilled in the art in conjunction with the description of well-known techniques and examples.
The vulnerary yellow water is a medicine known in the field, and the main effective components of the vulnerary yellow water are coptis chinensis, phellodendron, gardenia, lithospermum, alum and mint, and other components can be added to increase the efficacy. In the invention, for providing an exemplary illustration, the preparation method of the compound extract of the yellow water of the traumatology department is selected as follows: taking coptis chinensis, phellodendron, gardenia, lithospermum, alum and mint, wherein the weight compatibility proportion of the raw materials is that the coptis chinensis: phellodendron bark: gardenia: lithospermum: alum: mint (1-100): (1-100): (1-100): (1-100): (1-100): (1-100), adding 5-7 times of water, heating and decocting for 1-3 hours, and extracting for 1-3 times in total, wherein the obtained extracting solution is a compound extract of yellow water in the traumatology department.
Example 1 preparation of lotions
The formula is as follows: 10kg of compound yellow water extract (active ingredient) of traumatology department, 1kg of ethylparaben (preservative), 2kg of sodium benzoate (preservative) and a proper amount of distilled water (solvent).
The preparation method comprises the following steps: dissolving the active ingredient and other adjuvants in distilled water, diluting to 1000L, packaging, and sterilizing.
The using method comprises the following steps: the gauze or cotton swab is dipped in the medicinal liquid, and cleaned or applied to the affected part by wet application for 2 times a day.
Example 2 preparation of spray
The formula is as follows: 10kg of compound extract (active component) of yellow water of traumatology, 1kg of borneol (penetration enhancer) and a proper amount of distilled water (solvent).
The preparation method comprises the following steps: dissolving the active ingredient and other adjuvants (adjuvant can be pretreated) in distilled water, metering to volume of 1000L, packaging into sprayer, and sterilizing.
The using method comprises the following steps: it is applied to affected part for 2 times a day.
EXAMPLE 3 preparation of the ointment
The formula is as follows: 1.0kg of compound yellow water extract (active component) of traumatology department, 2.4kg of stearic acid (matrix), 1.4kg of glycerin monostearate (matrix), 0.2kg of white vaseline (matrix), 1.0kg of lanolin (matrix), 1.2kg of liquid paraffin (matrix), 800.08 kg of tween (emulsifier) and a proper amount of distilled water (solvent).
The preparation method comprises the following steps: putting stearic acid, glyceryl monostearate, white vaseline and liquid paraffin into a container, heating to about 80 deg.C, and stirring to melt (oil phase). Tween 80 and a calculated amount of distilled water are put into another container, heated to about 80 ℃, and stirred uniformly (water phase). The aqueous phase was added to the oil phase in a thin stream at the same temperature and stirred continuously in a water bath to a milky semisolid and then stirred at room temperature until near condensation. Placing active ingredients on an ointment plate and in a mortar, adding the prepared emulsifier matrix by times, and uniformly grinding to obtain the final product.
The using method comprises the following steps: applied to affected part uniformly 2 times a day.
EXAMPLE 4 preparation of gels
The formula is as follows: 1.0kg of compound extract (active component) of yellow water of traumatology, 1.2kg of sodium carboxymethylcellulose (matrix), 2.0kg of glycerin (humectant), 0.1kg of sodium benzoate (preservative) and a proper amount of distilled water.
The preparation method comprises the following steps: putting sodium carboxymethylcellulose into a grinder, adding glycerol, grinding, adding water solution containing sodium benzoate and active ingredients, swelling, and grinding.
The using method comprises the following steps: applied to affected part uniformly 2 times a day.
Clinical examples prove that the traumatology yellow water has the effect of treating skin diseases such as keratosis pilaris and the like. The clinical effect of the medicine of the present invention is observed in the experiment. The treatment effect of the yellow water of the traumatology department is observed and compared by counting the improvement condition of the patient.
1. Clinical data and methods
100 clinical cases were selected for diagnosis of keratosis pilaris. 45 men and 55 women among the above cases; age max 38 years, min 10 years; the affected part is the outer side of the upper arm. Randomly dividing into 2 groups, one group treated with tartaric acid as control group; the other group is used as experimental group for treating traumatic injury with yellow water preparation. The control group and the test group were compared for observation of the treatment effect. The judgment standard of the curative effect is as follows: the skin damage is completely removed and is level with the skin surface, and only a relatively shallow pigment spot is left for healing; the skin damage is removed by more than or equal to 60 percent, and the effect is obvious; the skin damage is effectively reduced by 20 to 59 percent; a total reduction of skin damage of < 20% is not effective.
2. Results
The experimental result shows that the effect of the yellow water of the traumatology department on treating the keratosis pilaris is better than that of the tartaric acid. The total effective rate of the test group was higher than that of the control group at 2 weeks, 4 weeks and 8 weeks of the drug administration, and the results are shown in table 1.
TABLE 1 comparison of the two groups of therapeutic effects
3. And (4) conclusion: the obtained yellow water can be used for treating dermatoses such as keratosis pilaris. Compared with tartaric acid, the yellow water of the traumatology has quick response, good curative effect and more clinical advantages.
In conclusion, the compound of the invention takes the coptis as the monarch drug, and has the effects of clearing away heat and toxic materials, eliminating dampness and reducing swelling. The golden cypress and the gardenia are added for enhancing the effect of drying dampness and reducing swelling; gardenia and lithospermum have the functions of cooling blood and activating blood circulation, and take stasis removing and pulse invigorating as ministerial drugs. Then, alum is used for detoxifying, removing the necrotic tissue, astringing and promoting granulation; the pungent and cool property of Bo He is used to gently clear and disperse, dispel wind and alleviate pain, and help Zi Cao to resolve stasis. The invention provides a new traditional Chinese medicine preparation for treating skin diseases such as keratosis pilaris and the like, has definite functions and no toxic or side effect, widens the disease prevention range of the yellow water of traumatology, and has considerable market prospect.
The embodiments described above are described to facilitate an understanding and use of the invention by those skilled in the art. It will be readily apparent to those skilled in the art that various modifications to these embodiments may be made, and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the above embodiments, and those skilled in the art should make improvements and modifications within the scope of the present invention based on the disclosure of the present invention.
Claims (4)
1. The Chinese medicinal compound of the yellow water for the traumatology department comprises coptis chinensis, golden cypress, gardenia, lithospermum, alum and mint.
2. The use of traumatology yellow water according to claim 1 for the preparation of a medicament for the treatment of keratosis pilaris, wherein the medicament comprises: the yellow water of the traumatology department and pharmaceutically acceptable auxiliary materials.
3. The use of traumatology yellow water according to claim 1 for the preparation of a medicament for the treatment of keratosis pilaris, wherein the medicament is in a form that can be prepared by conventional pharmaceutical equipment.
4. The use of the traumatological yellow water of claim 3 in the preparation of a medicament for treating keratosis pilaris, wherein the formulation is a lotion, a spray, an ointment, or a gel.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710134600.0A CN106822321B (en) | 2017-03-08 | 2017-03-08 | Application of Curcuma water of traumatology in preparing medicine for treating keratosis pilaris |
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| CN201710134600.0A CN106822321B (en) | 2017-03-08 | 2017-03-08 | Application of Curcuma water of traumatology in preparing medicine for treating keratosis pilaris |
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| CN108593785A (en) * | 2018-03-22 | 2018-09-28 | 佛山市中医院 | A kind of preparation method improving Trauma Yellow-water clarity |
| CN114230814B (en) * | 2021-12-30 | 2024-02-23 | 佛山市中医院 | Hydrogel carrying yellow water for wound department and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1215595A (en) * | 1996-12-31 | 1999-05-05 | 佛山市中医院 | External use medicine for treating soft tissue injury and its producing method |
| CN105012688A (en) * | 2015-06-30 | 2015-11-04 | 青岛海之星生物科技有限公司 | Traditional Chinese medicine ointment used for treating keratosis pilaris, and preparation method thereof |
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2017
- 2017-03-08 CN CN201710134600.0A patent/CN106822321B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1215595A (en) * | 1996-12-31 | 1999-05-05 | 佛山市中医院 | External use medicine for treating soft tissue injury and its producing method |
| CN105012688A (en) * | 2015-06-30 | 2015-11-04 | 青岛海之星生物科技有限公司 | Traditional Chinese medicine ointment used for treating keratosis pilaris, and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 伤科黄水纱湿敷治疗挫擦性感染创面护理与疗效观察;谭碧娆;《新中医》;20131031;第45卷(第10期);第177-178页 * |
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