CN108524923A - A kind of gynaecologic antibiotic gel and its production method - Google Patents
A kind of gynaecologic antibiotic gel and its production method Download PDFInfo
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- CN108524923A CN108524923A CN201810758493.3A CN201810758493A CN108524923A CN 108524923 A CN108524923 A CN 108524923A CN 201810758493 A CN201810758493 A CN 201810758493A CN 108524923 A CN108524923 A CN 108524923A
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- glue
- gynaecologic antibiotic
- antibiotic gel
- vinyl ether
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
Abstract
A kind of gynaecologic antibiotic gel and its production method, it is related to the production technical field of the medical dressing in medical sanitary technology field, the present invention is by QM glues, AVC glues are alternately added in HPMC glues, agitated uniformly mixed gelled, the speciality of various composition is not only played to greatest extent, and form good addition effect, to make gel become highly transparent, low vicidity, good dispersibility, permeability and active ingredient quickly absorb, the good characteristics such as be not easy to form a film, so as to avoid the film forming of exclusive use HPMC, active ingredient is not easy the defects of absorbing.
Description
Technical field
The present invention relates to the medical dressing in medical sanitary technology field, more particularly to the life for the antibacterial gel that gynaecology uses
Produce technical field.
Background technology
Current various gynaecologic antibiotic gel a multitude of names.According to market survey, almost 100% gynaecologic antibiotic is solidifying
The matrix of glue is cellulose, especially based on hydroxypropyl methylcellulose.Though this cellulose matrix has relatively good lubricity,
With significant film forming, therefore, a kind of film of white can be formed in use and is covered on skin and mucosa, not only can
The absorption of mucocutaneous gas permeability and active ingredient is influenced, it can also be in the white clast of mucocutaneous upper residual and sheet white films
The thing of sample, to cause very big puzzlement and the unplessantness displeasure of user, so that after many consumers using this gel use
Have to clean part.
Use benzalkonium chloride, chlorohexidene etc. as the sterilization component of gel by the antibacterial gel majority of matrix of cellulose,
And benzalkonium chloride, chlorohexidene are decoloriz ation, and bactericidal effect is lost quickly when contacting anion surfactant.
Benzalkonium chloride, chlorohexidene, i.e., could be maximum in weakly alkaline environment when pH value is more than 7 as cationic surfactant
Its bactericidal effect is played, its bactericidal effect weakens quickly in acidic environment, and especially when pH value is less than 4, dosage will increase
Add 20 times or more bactericidal effects when can be only achieved pH value 7, and the disinfection that so high concentration is promulgated considerably beyond the Ministry of Public Health
The limit standard and mucocutaneous tolerance that agent uses.
And the pH value of vagina is 4.0, for acidity, antibacterial gel made of benzalkonium chloride, chlorohexidene etc. is pushed into cloudy
Antibacterial effect is reduced rapidly or lost behind road, furthermore, women cleans perineum commonly using bath foam or perfumed soap, these bath foams and
Perfumed soap is anion surfactant, is neutralized rapidly after encountering the cationic surfactants such as benzalkonium chloride, chlorohexidene, makes benzene
It pricks oronain, chlorohexidene etc. and loses bactericidal effect.
In conclusion there are many defects for the cellulose antibacterial gel of existing market.
Invention content
The object of the present invention is to provide a kind of novel gynaecologic antibiotic gels, to overcome current cellulose antibacterial on the market solidifying
Glue above shortcomings.
The present invention includes disinfection sanitizer, water, it is characterised in that further includes Copolymer of Methyl Vinyl Ether/Maleic Anhydride
（QM）, acrylic acid dimethyltaurine ammonium/VP copolymers（AVC）And hydroxypropyl methylcellulose（HPMC）.
QM, i.e. Copolymer of Methyl Vinyl Ether/Maleic Anhydride（PVM/MA）, it is water-soluble electrolytes polymer, is artificial
Synthesize a few the substance nontoxic to human body and animal in compound.Because product have good chemical stability,
Hypotoxicity, complexing, sequestering, adhesiveness, coherency, has hydrophilic and hydrophobic special performance concurrently at biocompatibility, the product
There is extensive purposes in modern industry, dispersant, coupling agent, stabilizer, thickener can be played.QM have conveniently make
With, it efficiently thickens, good rheological behavior, resistant to shearing stability, resistance to ionic and photostability, wide scope PH adaptability,
It is not easy to form a film under the conditions of existing for organic solvent glycerine, propylene glycol.
AVC, i.e. acrylic acid dimethyltaurine ammonium/VP copolymers are a kind of polymer of synthesis, for transparent system
The thickener of gelling agent and oil-in-water emulsion, which has neutralized in advance, easy to use, gives and is formulated splendid performance, very
To stability is also fine in the case of no emulsifier, the product containing Aristoflex AVC, appearance seems very frivolous,
But have centainly sticky, in addition to the above advantage, also and there are rheological characteristic, pleasant dermal sensation, low sticky sense, dispersibility
Good, wide scope PH adaptability absorbs soon, the features such as film forming.
HPMC, i.e. hydroxypropyl methylcellulose have thickening capabilities, salt discharge, PH stability, water-retaining property, dimensional stability, height
The features such as film forming and extensive resistance to enzymatic, dispersibility and caking property.Aqueous solution has surface-active, transparency height, performance
Stablize.
From said components：Cellulose instead QM, AVC are not used alone in the matrix components of the present invention
With HPMC mixed-matrixes.Due to the low vicidity of QM and AVC, the characteristics such as good dispersibility and absorption are fast, do not form a film are to divide
Dissipate the film forming for preventing HPMC.Such gel not only has high transparency, good dispersibility and rheological characteristic, and does not form a film
It easily absorbs, easily form a film the difficult defect absorbed so as to avoid cellulose gel in the market.
For the present invention using QM, AVC and HPMC as matrix components, permeability is strong, and mucocutaneous histocompatbility is good, not only
With extremely refreshing lubricity, and will not form a film；The antimicrobial component of this antibacterial gel of the present invention not only not with anionic surface
Neutralization reaction occurs for activating agent, even if similarly having superpower bactericidal effect in the acidic environment that vaginal pH is 4.0.
Further, in the gynaecologic antibiotic gel described in 100mL, QM, AVC and HPMC be respectively 0.1~10g, 0.1~
10g, 0.1~10g.Proportioning combination is carried out using the above ratio, dispersibility, the rheology of various composition can be played to greatest extent
Property, fast absorbability, lubricity, high transparency and not advantages such as film forming, avoid the skin and mucosa of HPMC not absorbability and
The defect of easy film forming.
The present invention disinfection sanitizer be made of lysozyme and chlorogenic acid, both sterilizing ingredients pH be 3.0~
Still superior bactericidal property is shown in 4.0 environment.It thus overcomes and uses benzalkonium chloride, chlorohexidene etc. raw on the market
The antibacterial gel of production bactericidal effect in acidic environment weaken quickly and easily by anion surfactant and and lose sterilization
The defect of effect.
Further, in the gynaecologic antibiotic gel described in 100mL, lysozyme is 0.1~5g, and chlorogenic acid is 0.05~3g.
The collaboration that the design of each ratio of the both the above composition in gynaecologic antibiotic gel can dramatically increase multiple sterilizing drugs is made
With not only making sterilizing effect enhancing at double, and dosage can be significantly reduced, eliminate its adverse reaction；The sterilization of the combination
Disinfecting drug energy high aggregation changes the permeability of bacteria cell wall in bacterium surface, influences the metabolism of bacterium, makes thalline
Rupture, protein overflow denaturation；It can also bind directly with negatively charged virus protein, be formed with DNA, RNA, apoprotein
Double salt makes virally inactivated.To play powerful killing bacterial virus effect, AIDS, venereal disease is prevented to be propagated by sexual behaviour,
The genital infection disease common to women has good efficacy simultaneously, even if with 4.0 identical ring of vagina PH value
In border, sterilizing effect is unaffected, is not also neutralized by anion surfactant, so as to avoid commercial antimicrobial gel
Bactericidal effect declines rapidly under acidic environment, and the defect of bactericidal effect is lost after being neutralized by anion.
It is another object of the present invention to propose the preparation method of above-mentioned gynaecologic antibiotic gel.
Steps are as follows for the method for the present invention：
1）By Copolymer of Methyl Vinyl Ether/Maleic Anhydride, acrylic acid dimethyltaurine ammonium/VP copolymers and hypromellose
Element respectively with water dissolution, expansion, obtain Copolymer of Methyl Vinyl Ether/Maleic Anhydride glue, acrylic acid dimethyltaurine ammonium/
VP is copolymerized composition glue liquid and hydroxypropyl methylcellulose glue；
2）It is under stirring condition, Copolymer of Methyl Vinyl Ether/Maleic Anhydride glue, acrylic acid dimethyltaurine ammonium/VP is total
Polymers glue is alternately added in hydroxypropyl methylcellulose glue, obtains mixed glue solution；
3）By disinfection sanitizer with water dissolution, disinfection solution is obtained；
4）After disinfection solution is mixed with mixed glue solution, the pH value that mixed system is adjusted with citric acid or glycol acid solution is
4.0~4.5, then through standing to bubble-free, obtain gynaecologic antibiotic gel.
QM glues, AVC glues are alternately added in HPMC glues by the present invention, agitated uniformly mixed gelled, not only
The speciality of various composition is played to greatest extent, and forms good addition effect, to make gel become height thoroughly
Bright, low vicidity, good dispersibility, permeability and active ingredient quickly absorb, never the good characteristics such as film forming, to avoid
The film forming of HPMC is used alone, the defects of active ingredient is not easy to absorb.
Since QM, AVC, HPMC have wide scope pH adaptability, so even being adjusted the pH value of gel to 4.0 with acid
~4.5, the stability of gel is not interfered with not only, and keep the pH value of gel consistent with the pH value of vagina, can more be suitble to vagina
Normal physiological environment.
Preparation method of the present invention is simple, reasonable, facilitates production, can ensure the stability of product.
In addition, the present invention is in the step 1）In, first QM, AVC and HPMC are carried out respectively with glycerine or propylene glycol wet
Profit is disperseed and is stirred to after in homogeneous paste, and water is added, and agitated uniformly rear placement 48 hours obtain QM glues, AVC respectively
Glue and HPMC glues.Moistening dispersion is carried out to QM, AVC and HPMC respectively using glycerine or propylene glycol and is stirred in uniform
Paste, it is therefore an objective to prevent directly water-soluble caking from not readily dissolving.It is that glue is made fully to act on mixing to place 48 hours, eliminates stirring production
Raw bubble makes glue become more transparent.
When preparing QM glues, after addition of water, neutralized with sodium hydrate aqueous solution or triethanolamine, then place 48
Hour.The acidity of QM raw materials is very strong, and 5% pH value of water solution is 2, and its aqueous solution is dilute water sample, should not be with other raw materials
Compatibility.It is neutralized using sodium hydrate aqueous solution or triethanolamine, when its pH value being made to reach 6.5~7, its water will be made rapidly
Solution becomes sticky gel, and therefore, neutralization is in order to which QM aqueous solutions are transformed into glue.
A concentration of the 0.5~30% of the sodium hydrate aqueous solution.The use of neutralization agent concentration appropriate is to obtain high quality QM
The important link of gel, too low neutralization agent concentration may then not have neutralization, to generate gel；In excessively high
It so that gel is become yellow with agent concentration, and the pH value of gel can be caused to be alkalinity, can not only influence and other compositions
Compatibility but will destroy the normal physiological equilibrium of vagina.
In the gynaecologic antibiotic gel described in 100mL, the inventory of QM, AVC and HPMC be respectively 0.1~10g, 0.1~
10g, 0.1~10g.
The disinfection sanitizer is made of lysozyme and chlorogenic acid, in the gynaecologic antibiotic gel described in 100mL, lysozyme
Inventory is 0.1~5g, and chlorogenic acid inventory is 0.05~3g.The present invention uses lysozyme, chlorogenic acid for disinfection sanitizer, also
It is general in being that of avoiding even if good antibacterial action can also be played pH value 4 is even lower with wide scope pH adaptability
Disinfectant loses in low pH or weakens bactericidal effect.
Specific implementation mode
One, 100 mL gynaecologic antibiotic gels are prepared, preparation process is as follows：
1, the QM for taking 0.1~10g is gently stirred at homogeneous paste, then add with 5~10mL glycerine or the moistening dispersion of propylene glycol row
Enter 10~20 mL purified waters, stir evenly, is then adjusted with a concentration of 0.5~30% sodium hydrate aqueous solution or triethanolamine
The pH value of system, through standing 48 hours, makes system fully be expanded, obtains QM glues to 4~4.5.
2, the AVC for taking 0.1~10g is gently stirred with 5~10mL glycerine or the moistening dispersion of propylene glycol row at homogeneous paste,
5~10mL purified waters are added, through standing 48 hours after stirring evenly, so that system is fully expanded, obtains AVC glues.
3, the HPMC for taking 0.1~10g is gently stirred with 5~10 mL glycerine or the moistening dispersion of propylene glycol row at uniformly paste
Shape adds 10~20mL purified waters, through standing 48 hours after stirring evenly, so that system is fully expanded, and keep system complete
All-transparent obtains HPMC glues without bubble.
4,0.1~5g lysozymes and 0.05~3g chlorogenic acids is taken to put into 10~20 mL room temperature purified waters, until completely molten
Solution obtains disinfection solution.
5, QM glues and AVC glues are divided three to four times and is alternately added in HPMC glues, it is stirring while adding, until becoming
Uniform mixed glue solution.
6, disinfection solution full dose is added in mixed glue solution, after stirring evenly, then with citric acid or glycol acid solution tune
The pH value of whole mixed system is to 4.0~4.5, and placement is fully transparent, and bubble-free is to get 100 mL gynaecologic antibiotic gels.
Two, application method, dosage, access times：
Lithotomy position position is used before sleeping（Lie low, two leg bucklings slightly abduction, padded 30 centimeters of buttocks）, antibacterial gel pencil is set
Enter vagina depths, all push-in vagina, holding position 30 minutes play a role so that drug enters vagina depths gel.Often
Secondary 3 mL is used primary every night.
Three, using effect：
1. the mixed-matrix using QM, AVC, HPMC as antibacterial gel avoids the simple film forming for using HPMC matrix gels
The puzzlement that defect and user bring.
2. disinfection sanitizer lysozyme is combined with chlorogenic acid, cation surface-active disinfectant is avoided in acidic environment
Middle bactericidal effect reduces rapidly and encounters the defect that anion surfactant neutralizes rapidly failure.
3, the rheological characteristic of the antibacterial gel significantly increased, dispersibility, absorbability and not film forming, it is anti-using the present invention
After bacterium gel, active ingredient can quickly absorb, and medication part epidermis moistens smooth, is not required to rinse.
Claims (10)
1. a kind of gynaecologic antibiotic gel, including disinfection sanitizer, water, it is characterised in that further include methyl vinyl ether/maleic acid
Anhydride copolymer, acrylic acid dimethyltaurine ammonium/VP copolymers and hydroxypropyl methylcellulose.
2. gynaecologic antibiotic gel according to claim 1, it is characterised in that methyl in the gynaecologic antibiotic gel described in 100mL
Vinyl ether/maleic anhydride copolymer, acrylic acid dimethyltaurine ammonium/VP copolymers and hydroxypropyl methylcellulose are respectively 0.1
~10g, 0.1~10g, 0.1~10g.
3. gynaecologic antibiotic gel according to claim 1 or claim 2, it is characterised in that the disinfection sanitizer is by lysozyme and green original
Acid composition.
4. gynaecologic antibiotic gel according to claim 3, it is characterised in that in the gynaecologic antibiotic gel described in 100mL, bacteriolyze
Enzyme is 0.1~5g, and chlorogenic acid is 0.05~3g.
5. the preparation method of gynaecologic antibiotic gel as described in claim 1, it is characterised in that include the following steps：
1）By Copolymer of Methyl Vinyl Ether/Maleic Anhydride, acrylic acid dimethyltaurine ammonium/VP copolymers and hypromellose
Element respectively with water dissolution, expansion, obtain Copolymer of Methyl Vinyl Ether/Maleic Anhydride glue, acrylic acid dimethyltaurine ammonium/
VP is copolymerized composition glue liquid and hydroxypropyl methylcellulose glue；
2）It is under stirring condition, Copolymer of Methyl Vinyl Ether/Maleic Anhydride glue, acrylic acid dimethyltaurine ammonium/VP is total
Polymers glue is alternately added in hydroxypropyl methylcellulose glue, obtains mixed glue solution；
3）By disinfection sanitizer with water dissolution, disinfection solution is obtained；
4）After disinfection solution is mixed with mixed glue solution, the pH value that mixed system is adjusted with citric acid or glycol acid solution is
4.0~4.5, then through standing to bubble-free, obtain gynaecologic antibiotic gel.
6. the preparation method of gynaecologic antibiotic gel according to claim 5, it is characterised in that in the step 1）In, first with third
Triol or propylene glycol respectively to Copolymer of Methyl Vinyl Ether/Maleic Anhydride, acrylic acid dimethyltaurine ammonium/VP copolymers and
Hydroxypropyl methylcellulose carries out moistening and is dispersed in water after homogeneous paste, is added, and agitated uniformly rear placement 48 hours take respectively
It obtains Copolymer of Methyl Vinyl Ether/Maleic Anhydride glue, acrylic acid dimethyltaurine ammonium/VP copolymerization composition glue liquids and hydroxypropyl first is fine
The plain glue of dimension.
7. the preparation method of gynaecologic antibiotic gel according to claim 6, it is characterised in that preparing methyl vinyl ether/horse
It when carrying out anhydride copolymers composition glue liquid, after addition of water, is neutralized with sodium hydrate aqueous solution or triethanolamine, then to place 48 small
When.
8. the preparation method of gynaecologic antibiotic gel according to claim 7, it is characterised in that the sodium hydrate aqueous solution
A concentration of 0.5~30%.
9. the preparation method of gynaecologic antibiotic gel according to claim 5, it is characterised in that the gynaecologic antibiotic described in 100mL
In gel, Copolymer of Methyl Vinyl Ether/Maleic Anhydride, acrylic acid dimethyltaurine ammonium/VP copolymers and hypromellose
The inventory of element is respectively 0.1~10g, 0.1~10g, 0.1~10g.
10. according to the preparation method of the gynaecologic antibiotic gel of claim 5 or 9, it is characterised in that the disinfection sanitizer by
Lysozyme and chlorogenic acid form, and in the gynaecologic antibiotic gel described in 100mL, lysozyme inventory is 0.1~5g, and chlorogenic acid is thrown
Doses is 0.05~3g.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810758493.3A CN108524923A (en) | 2018-07-11 | 2018-07-11 | A kind of gynaecologic antibiotic gel and its production method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810758493.3A CN108524923A (en) | 2018-07-11 | 2018-07-11 | A kind of gynaecologic antibiotic gel and its production method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110623919A (en) * | 2019-10-15 | 2019-12-31 | 江苏万可瑞科技实业有限公司 | Hydrogen-ion-rich acidic maintenance contraceptive gel for gynecology and preparation method thereof |
| CN111838177A (en) * | 2020-08-25 | 2020-10-30 | 广东省医疗器械研究所 | Preparation method and preparation system of gel disinfectant |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103385926A (en) * | 2013-07-09 | 2013-11-13 | 武汉烺祺生物科技有限公司 | Antibiosis gel for curing cervical and vaginal diseases of gynaecology |
| CN104224923A (en) * | 2014-07-07 | 2014-12-24 | 海南华拓天涯制药有限公司 | Tea tree essential oil antimicrobial gel for treating vaginal disease in gynecology |
| CN106619780A (en) * | 2017-02-24 | 2017-05-10 | 李忠泽 | Gynecological antibacterial gel |
| CN107184641A (en) * | 2017-05-23 | 2017-09-22 | 刘羽 | A kind of gynecological antimicrobial gel recipe and preparation method thereof |
| CN107375494A (en) * | 2017-07-18 | 2017-11-24 | 广东省阳春市信德生物科技发展有限公司 | A kind of An Bai gynaecology activity silver ion antimicrobial gel |
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2018
- 2018-07-11 CN CN201810758493.3A patent/CN108524923A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103385926A (en) * | 2013-07-09 | 2013-11-13 | 武汉烺祺生物科技有限公司 | Antibiosis gel for curing cervical and vaginal diseases of gynaecology |
| CN104224923A (en) * | 2014-07-07 | 2014-12-24 | 海南华拓天涯制药有限公司 | Tea tree essential oil antimicrobial gel for treating vaginal disease in gynecology |
| CN106619780A (en) * | 2017-02-24 | 2017-05-10 | 李忠泽 | Gynecological antibacterial gel |
| CN107184641A (en) * | 2017-05-23 | 2017-09-22 | 刘羽 | A kind of gynecological antimicrobial gel recipe and preparation method thereof |
| CN107375494A (en) * | 2017-07-18 | 2017-11-24 | 广东省阳春市信德生物科技发展有限公司 | A kind of An Bai gynaecology activity silver ion antimicrobial gel |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110623919A (en) * | 2019-10-15 | 2019-12-31 | 江苏万可瑞科技实业有限公司 | Hydrogen-ion-rich acidic maintenance contraceptive gel for gynecology and preparation method thereof |
| CN111838177A (en) * | 2020-08-25 | 2020-10-30 | 广东省医疗器械研究所 | Preparation method and preparation system of gel disinfectant |
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Application publication date: 20180914 |