CN103169900A - Chinese herba preparation for treating gout - Google Patents
Chinese herba preparation for treating gout Download PDFInfo
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- CN103169900A CN103169900A CN2013101309126A CN201310130912A CN103169900A CN 103169900 A CN103169900 A CN 103169900A CN 2013101309126 A CN2013101309126 A CN 2013101309126A CN 201310130912 A CN201310130912 A CN 201310130912A CN 103169900 A CN103169900 A CN 103169900A
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Abstract
The invention relates to Chinese herba preparation for treating gout. The Chinese herba preparation is prepared from the following traditional Chinese medicine materials in parts by weight: 200-240 parts of phellodendron chinense schneid, 270-350 parts of sabia japonica, 400-500 parts of glabrous sarcandra herbs, 600-700 parts of rhizoma smilacis glabrae, 400-500 parts of longhairy antenoron herbs, 300-350 parts of fourstamen stephania roots, 200-250 parts of roots of largeleaf gentian. 200-250 parts of rhizoma atractylodis and 300-350 parts of medicinal cyathula roots. According to the Chinese herba preparation disclosed by the invention, pure natural Chinese herbal medicines are selected, strictly screened and processed respectively, combined with the modern production process according to the traditional Chinese medicine theoretical formulation to form the Chinese herba preparation for treating gout. The Chinese herba preparation for treating gout has a small toxic and side effect and action of treating gout according to the tests.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of gout.
Background technology
Gout is a kind of because the biosynthesis of purine metabolism increases, and uric acid produces too much or because uric acid in the bad hyperamization of urate excretion raises, urate crystal is deposited on the repeated relapsing inflammatory diseases that causes in synovium of joint, synovial bursa, cartilage and hetero-organization thereof.Primary disease can find in joint fluid and the tophus has the crystallization of single water uric acid sodium of two-fold photosensitiveness as its characteristics.Its Clinical symptoms is: the characteristic acute arthritis due to hyperuricemia and urate crystal, deposition, tophus, interstitial nephritis, severe patient are seen joint deformity and dysfunction, often accompany the uric acid lithangiuria.Along with economic development and lifestyle change, its prevalence rises gradually.
In view of medicine and the method for the treatment gout that there is no at present better curative effect, thus a kind of good effect of demand still, taking convenience, the Chinese medicine for oral administration that side effect is little.Chinese medicine preparation of the present invention is selected the pure natural Chinese herbal medicine, by the theory of Chinese medical science prescription, concocts respectively through strict screening, combines in conjunction with the modern production process recipes, and toxic and side effects is little, and empirical tests has the effect for the treatment of gout.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of gout.
The raw material of Chinese medicine formula of described Chinese medicine preparation is comprised of following by weight:
200～240 parts of Cortex Phellodendris, 270～350 parts of Caulis Sinomenii, 400～500 parts of Herba Sarcandraes, 600～700 parts of Rhizoma Smilacis Glabraes, 400～500 parts of Herba Lysimachiaes, 300～350 parts of Radix Stephaniae Tetrandrae, 200～250 parts of Radix Gentianae Macrophyllae, 200～250 parts of Rhizoma Atractylodis, 300～350 parts of Radix Cyathulaes.
Preferably, the raw material of Chinese medicine formula of described Chinese medicine preparation is comprised of following by weight:
220 parts of Cortex Phellodendris, 331 parts of Caulis Sinomenii, 441 parts of Herba Sarcandraes, 662 parts of Rhizoma Smilacis Glabraes, 441 parts of Herba Lysimachiaes, 331 parts of Radix Stephaniae Tetrandrae, 220 parts of Radix Gentianae Macrophyllae, 220 parts of Rhizoma Atractylodis, 331 parts of Radix Cyathulaes.
The preparation technology of the Chinese medicine preparation of described treatment gout comprises the following steps:
Get Cortex Phellodendri, Radix Gentianae Macrophyllae, Caulis Sinomenii, Radix Stephaniae Tetrandrae four flavors, add the water of 8 times of volumes, soaked 0.5 ~ 1 hour, then transferring pH with hydrochloric acid is 1 ~ 2, and lixiviate 10 hours under 50 ℃ ~ 60 ℃ conditions, filtering, medicinal residues add the water of 6 times of volumes again, transferring pH with hydrochloric acid is 2 ~ 3, temperature 50 C ~ 60 ℃ lixiviate 8 hours is filtered, and merges twice filtrate, transfer pH7 ~ 8 with sodium hydroxide solution, obtain acid water extracting liquid;
Fetch earth Poria, Herba Sarcandrae, Rhizoma Atractylodis, Radix Cyathulae, the Herba Lysimachiae five tastes, with the 80wt% ethanol water reflux, extract, of 6 times of volumes 2 times, each 1.5 hours, filter, merging filtrate concentrates and reclaims ethanol, gets ethanol extract;
Merge above-mentioned acid water extracting liquid and ethanol extract, being concentrated into 80 ℃ of heat, to survey density be 1.28～1.30 extractum, contains the mass ratio of crude drug inventory: dextrin=10:1 by extractum, adds the dextrin mixing, spray drying, get dry extract, then add the dextrin mixing by the mass ratio of dry extract: dextrin=1:0.85, adding suitable quantity of water is wetting agent soft material processed, extrude granule, in 60 ℃～80 ℃ dryings, granulate, packing.
Modern pharmacological research proves: Cortex Phellodendri has antiinflammatory, suppresses central action; Caulis Sinomenii has the effects such as calmness, analgesia, adjusting immunity; Rhizoma Smilacis Glabrae has antiinflammatory, Detoxication, and special inflammatory reaction has inhibitory action for some non-bacterials; Radix Achyranthis Bidentatae has antiinflammatory, detumescence, analgesia and diuresis; Radix Stephaniae Tetrandrae has better analgesia, antiinflammatory and anti-allergic effects; Radix Gentianae Macrophyllae has the effects such as antiinflammatory, analgesia, calmness, antihistaminic; Rhizoma Atractylodis have calmness, analgesia and blood vessel dilating effect.From modern pharmacology, diuresis can promote urate excretion; Anti-inflammation detumescence is beneficial to the course of reaction of the inflammation that suppresses uric acid crystal; Blood vessel dilating helps to improve local sour environment; Analgesia, calmness can obviously improve symptom.All medicines share, and play altogether heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, can suppress the course of reaction of the inflammation of uric acid crystal, promote urate excretion, are mainly used in the treatment of gout.
Each herbal nature and pharmacological action are as follows:
The Cortex Phellodendri bitter in the mouth, cold.Function: heat clearing and damp drying, eliminating fire and detoxication is except the hectic fever due to YIN-deficiency clearind deficient heat.
Caulis Sinomenii is bitter in the mouth, suffering; Warm in nature.Function: expelling wind and removing dampness; Promoting blood circulation and detoxication.
The Herba Sarcandrae slightly warm in nature, bitter in the mouth, suffering.Function cures mainly: anti-inflammation, dispelling wind and removing obstruction in the collateral, blood circulation promoting and dispersing pathogen accumulation.
Rhizoma Smilacis Glabrae nature and flavor: sweet light, flat.Function: detoxifcation, dehumidifying, sharp joint.
Herba Lysimachiae sweet in the mouth, little hardship, cool in nature.Function cures mainly: relieving stranguria by diuresis; Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.
The Radix Stephaniae Tetrandrae acrid in the mouth is flat.Effect: inducing diuresis to remove edema, wind-expelling pain-stopping.
Radix Gentianae Macrophyllae acrid in the mouth, hardship are slightly cold.Function cures mainly: Eradicates rheumatism, Shujin network, clearind deficient heat.
Rhizoma Atractylodis acrid in the mouth, hardship, temperature.Return spleen, stomach, Liver Channel.Function cures mainly: drying damp and strengthening spleen, expelling wind and cold makes eye bright.
Radix Cyathulae property is flat, and sweet and slightly bitter taste is nontoxic.Cure mainly and dispel the wind, dampness removing, stimulate the menstrual flow.
The present invention discloses a kind of Chinese medicine preparation that is used for the treatment of gout, selects the pure natural Chinese herbal medicine: Cortex Phellodendri, Caulis Sinomenii, Herba Sarcandrae, Rhizoma Smilacis Glabrae, Herba Lysimachiae, Radix Stephaniae Tetrandrae, Radix Gentianae Macrophyllae, Rhizoma Atractylodis, Radix Cyathulae.By the theory of Chinese medical science prescription, concoct respectively through strict screening, combine in conjunction with the modern production process recipes.Preparation is pure Chinese herbal medicine, and toxic and side effects is little, and treating both the principal and secondary aspects of a disease is evident in efficacy.
The specific embodiment
Be below several instantiation of the present invention, further describe the present invention, but the present invention be not limited only to this.
Most preferred embodiment 1
A kind of Chinese medicine preparation that is used for the treatment of gout, Chinese drug-treated group becomes:
Cortex Phellodendri 220g, Caulis Sinomenii 331.0g, Herba Sarcandrae 441g, Rhizoma Smilacis Glabrae 662.0g, Herba Lysimachiae 441g, Radix Stephaniae Tetrandrae 331.0g, Radix Gentianae Macrophyllae 220g, Rhizoma Atractylodis 220g, Radix Cyathulae 331.0g.
Preparation method is as follows:
Get Cortex Phellodendri, Radix Gentianae Macrophyllae, Caulis Sinomenii, Radix Stephaniae Tetrandrae four flavors, add the water of 8 times of amounts, soaked 0.5 ~ 1 hour, transferring pH with hydrochloric acid is 1 ~ 2, temperature 50 C ~ 60 ℃ lixiviate 10 hours is filtered, and medicinal residues add the water of 6 times of amounts again, transferring pH with hydrochloric acid is 2 ~ 3, temperature 50 C ~ 60 ℃ lixiviate 8 hours is filtered, and merges twice filtrate, transfer pH7 ~ 8 with sodium hydroxide solution, obtain acid water extracting liquid.Fetch earth Poria, Herba Sarcandrae, Rhizoma Atractylodis, Radix Cyathulae, the Herba Lysimachiae five tastes, with the ethanol water reflux, extract, of 6 times of amounts 80% 2 times, each 1.5 hours, filter, merging filtrate, concentrated, reclaim ethanol, get ethanol extract.Merge above-mentioned acid water extracting liquid and ethanol extract, be concentrated into relative proportion 1.298(80 ℃) extractum, contain the ratio of crude drug inventory-dextrin (10:1) in extractum, add the dextrin mixing, spray drying gets dry extract.In the ratio mixing of dry extract-dextrin (1:0.85), adding suitable quantity of water is wetting agent soft material processed, extrudes granule, in 60 ℃～80 ℃ dryings, granulate, packing.
Embodiment 2
A kind of Chinese medicine preparation that is used for the treatment of gout, Chinese drug-treated group becomes:
Cortex Phellodendri 240g, Caulis Sinomenii 350.0g, Herba Sarcandrae 500g, Rhizoma Smilacis Glabrae 700.0g, Herba Lysimachiae 500g, Radix Stephaniae Tetrandrae 500g, Radix Gentianae Macrophyllae 250g, Rhizoma Atractylodis 250g, Radix Cyathulae 350.0g.
Preparation method is with embodiment 1.
Embodiment 3
A kind of Chinese medicine preparation that is used for the treatment of gout, Chinese drug-treated group becomes:
Cortex Phellodendri 200g, Caulis Sinomenii 270.0g, Herba Sarcandrae 400g, Rhizoma Smilacis Glabrae 600.0g, Herba Lysimachiae 400g, Radix Stephaniae Tetrandrae 300.0g, Radix Gentianae Macrophyllae 200g, Rhizoma Atractylodis 200g, Radix Cyathulae 300.0g.
Preparation method is with embodiment 1.
The present invention has obvious curative effect through clinical observation for many years to the gout symptom, is below clinical observation material.
1, physical data
Treatment case 100 examples.
2, efficacy assessment standard
Transference cure or alleviate obviously that (it is normal that blood uric acid recovers for produce effects; urine is without crystal salt; person's tuberosity disappears the subcutaneous nodule; person's calculus is discharged the urinary stone, and drug withdrawal is the nothing recurrence more than 1 year), sx↓ (blood uric acid normal or obviously decline; in urine, crystallization reduces or basic the disappearance; person's tuberosity disappears substantially the subcutaneous nodule, and the person's calculus that has the urinary stone is discharged or moved down, and drug withdrawal half a year is without recurrence) be effective.
3, Therapeutic Method
Take this granular preparation every day 3 times, taking medicine after meal, a 0.8-1.2g, being used in conjunction 1 month is 1 course for the treatment of, general two to three courses for the treatment of, and be careful in one's diet.Take the granular preparation of embodiment 1 preparation, can see effect in 8 days.
4, therapeutic outcome
Produce effects 62 examples, effective 35 examples, invalid 3 examples, total effective rate 97%.
Claims (3)
1. Chinese medicine preparation for the treatment of gout, it is characterized in that: the raw material of Chinese medicine formula of described Chinese medicine preparation is comprised of following by weight:
200～240 parts of Cortex Phellodendris, 270～350 parts of Caulis Sinomenii, 400～500 parts of Herba Sarcandraes, 600～700 parts of Rhizoma Smilacis Glabraes, 400～500 parts of Herba Lysimachiaes, 300～350 parts of Radix Stephaniae Tetrandrae, 200～250 parts of Radix Gentianae Macrophyllae, 200～250 parts of Rhizoma Atractylodis, 300～350 parts of Radix Cyathulaes.
2. the Chinese medicine preparation of the treatment gout described according to claim 1, it is characterized in that: the raw material of Chinese medicine formula of described Chinese medicine preparation is comprised of following by weight:
220 parts of Cortex Phellodendris, 331 parts of Caulis Sinomenii, 441 parts of Herba Sarcandraes, 662 parts of Rhizoma Smilacis Glabraes, 441 parts of Herba Lysimachiaes, 331 parts of Radix Stephaniae Tetrandrae, 220 parts of Radix Gentianae Macrophyllae, 220 parts of Rhizoma Atractylodis, 331 parts of Radix Cyathulaes.
3. preparation technology who treats as claimed in claim 1 or 2 the Chinese medicine preparation of gout, it is characterized in that: described preparation technology comprises the following steps:
Get Cortex Phellodendri, Radix Gentianae Macrophyllae, Caulis Sinomenii, Radix Stephaniae Tetrandrae four flavors, add the water of 8 times of volumes, soaked 0.5 ~ 1 hour, then transferring pH with hydrochloric acid is 1 ~ 2, and lixiviate 10 hours under 50 ℃ ~ 60 ℃ conditions, filtering, medicinal residues add the water of 6 times of volumes again, transferring pH with hydrochloric acid is 2 ~ 3, temperature 50 C ~ 60 ℃ lixiviate 8 hours is filtered, and merges twice filtrate, transfer pH7 ~ 8 with sodium hydroxide solution, obtain acid water extracting liquid;
Fetch earth Poria, Herba Sarcandrae, Rhizoma Atractylodis, Radix Cyathulae, the Herba Lysimachiae five tastes, with the 80wt% ethanol water reflux, extract, of 6 times of volumes 2 times, each 1.5 hours, filter, merging filtrate concentrates and reclaims ethanol, gets ethanol extract;
Merge above-mentioned acid water extracting liquid and ethanol extract, being concentrated into 80 ℃ of heat, to survey density be 1.28～1.30 extractum, contains the mass ratio of crude drug inventory: dextrin=10:1 by extractum, adds the dextrin mixing, spray drying, get dry extract, then add the dextrin mixing by the mass ratio of dry extract: dextrin=1:0.85, adding suitable quantity of water is wetting agent soft material processed, extrude granule, in 60 ℃～80 ℃ dryings, granulate, packing.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104644771A (en) * | 2015-03-15 | 2015-05-27 | 侯苏 | Method for preparing agent for treating gout in internal medicine room |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| IT201800004419A1 (en) * | 2018-04-12 | 2018-07-12 | Medicine to cure gout and procedure for its preparation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1927330A (en) * | 2006-09-05 | 2007-03-14 | 广州固志医药科技有限公司 | Chinese medicine composition for treating gout and preparing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1927330A (en) * | 2006-09-05 | 2007-03-14 | 广州固志医药科技有限公司 | Chinese medicine composition for treating gout and preparing method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 尹莲等: "四妙丸加味治疗急性痛风性关节炎概述", 《中国中医药科技》, vol. 11, no. 1, 31 December 2004 (2004-12-31) * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104644771A (en) * | 2015-03-15 | 2015-05-27 | 侯苏 | Method for preparing agent for treating gout in internal medicine room |
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