CN104644771A

CN104644771A - Method for preparing agent for treating gout in internal medicine room

Info

Publication number: CN104644771A
Application number: CN201510111915.4A
Authority: CN
Inventors: 侯苏
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-03-15
Filing date: 2015-03-15
Publication date: 2015-05-27

Abstract

The invention relates to a method for preparing an agent for treating gout in an internal medicine room. The method comprises the following steps: weighing the following raw materials: 280g of manyflower fissistigma root or stem, 230g of Chinese goldsaxifrage herb, 250g of Chinese osbeckia herb, 200g of cynanchum amplexicaule, 180g of euonymus oxyphyllus, 160g of root of threeangleabranch clovershrub, 150g of lethariella cladonioides, 170g of herb of himalayan willow weed, 150g of dregea sinensis var. corrugata, 130g of sweet clover, 140g of celastrus orbiculatus, 120g of cynoglossum officinale, 110g of calmus, 120g of herb of marsh horsetail, 100g of lanceleaf magnoliavine herb and 80g of swallowwortlike knotweed root; adding 12000ml of water, heating under the refluxing condition for 6 hours, and filtering, thereby obtaining the filter residue 1 and filtrate 1; adding 8000ml of water into the filter residue 1, heating under the refluxing condition for 3 hours, and filtering, thereby obtaining the filter residue 2 and filtrate 2; merging the filtrate 1 and the filtrate 2, concentrating to 5000ml, cooling to room temperature, adding 2000ml of absolute ethyl alcohol, standing under the room temperature and sealed conditions for 24 hours, and filtering, thereby obtaining the filtrate 3; and recycling ethanol in the filtrate 3, thereby obtaining the aqueous solution.

Description

A kind of preparation method being used for the treatment of the medicament of gout in internal medicine room

Technical field

The present invention relates to field of medicaments, relate in particular to a kind of preparation method being used for the treatment of the medicament of gout in internal medicine room.

Background technology

Gout is the systemic disease caused by one group of purine metabolic disturbance, its clinical characters is hyperuricemia, companion's gouty arthritis recurrent exerbation, tophaceous deposition, tophaceous chronic arthritis and joint deformity, often involve kidney and cause chronic interstitial nephritis and urate calculus to be formed.The medicine such as colchicine of often treatment, can produce the untoward reaction such as diarrhoea at present.

Summary of the invention

The object of this invention is to provide a kind of preparation method being used for the treatment of the medicament of gout in internal medicine room.

In order to realize object of the present invention, the invention provides a kind of preparation method being used for the treatment of the medicament of gout in internal medicine room, the method comprises the following steps: to take Caulis Fissistigmatis 280 grams, Herba Chrysosplenii Sinici 230 grams, to look up to heaven 250 grams, clock, Radix Cynanchi Amplexicaulis 200 grams, Cortex seu Radix Euonymi oxyphyllae 180 grams, Radix Campylotropis Trigonocladae 160 grams, 150 grams, spun gold brush, Herba Epilobii Himalayensis 170 grams, pass through 150 grams, muscle rattan, melilotus 130 grams, Celastrus orbiculatus Thunb. 140 grams, Radix Cynoglossi Officinalis 120 grams, economize 110 grams, rattan, Herba Equiseti Palustris 120 grams, Herba Schisandrae lancifoliae 100 grams and Polygonum cynanchoides Hemsl. 80 grams, add 12000 milliliters, water, heating 6 hours under the condition of backflow, filter, obtain filtering residue 1 and filtrate 1, in described filtering residue 1, add 8000 milliliters, water, heating 3 hours under the condition of backflow, filter, obtain filtering residue 2 and filtrate 2, merge described filtrate 1 and described filtrate 2, be concentrated into 5000 milliliters, be cooled to room temperature, add dehydrated alcohol 2000 milliliters, in room temperature, place 24 hours under the condition of sealing, filter, obtain filtrate 3, reclaim the ethanol in described filtrate 3, obtain aqueous solution.

The present invention also provides compositions to be used for the treatment of purposes in the medicine of gout being prepared in internal medicine room, described compositions is made up of the material of following weight portion: Caulis Fissistigmatis 250-300 part, Herba Chrysosplenii Sinici 200-250 part, to look up to heaven clock 230-270 part, Radix Cynanchi Amplexicaulis 200-240 part, Cortex seu Radix Euonymi oxyphyllae 150-200 part, Radix Campylotropis Trigonocladae 150-180 part, spun gold brush 130-170 part, Herba Epilobii Himalayensis 150-200 part, pass through muscle rattan 130-180 part, melilotus 100-150 part, Celastrus orbiculatus Thunb. 130-150 part, Radix Cynoglossi Officinalis 100-150 part, economize rattan 100-130 part, Herba Equiseti Palustris 100-150 part, Herba Schisandrae lancifoliae 80-120 part and Polygonum cynanchoides Hemsl. 50-100 part.

Preferably, described compositions is made up of the material of following weight portion: Caulis Fissistigmatis 280 parts, Herba Chrysosplenii Sinici 230 parts, 250 parts, clock of looking up to heaven, Radix Cynanchi Amplexicaulis 200 parts, Cortex seu Radix Euonymi oxyphyllae 180 parts, Radix Campylotropis Trigonocladae 160 parts, 150 parts, spun gold brush, Herba Epilobii Himalayensis 170 parts, pass through 150 parts, muscle rattan, melilotus 130 parts, Celastrus orbiculatus Thunb. 140 parts, Radix Cynoglossi Officinalis 120 parts, economize 110 parts, rattan, Herba Equiseti Palustris 120 parts, Herba Schisandrae lancifoliae 100 parts and Polygonum cynanchoides Hemsl. 80 parts.

More preferably, described medicament can be tablet, dispersible tablet, capsule, soft capsule or lotion.

In the present compositions, Caulis Fissistigmatis, Herba Chrysosplenii Sinici are monarch drug; Look up to heaven clock, Radix Cynanchi Amplexicaulis, Cortex seu Radix Euonymi oxyphyllae, Radix Campylotropis Trigonocladae, spun gold brush is ministerial drug; Herba Epilobii Himalayensis, pass through muscle rattan, melilotus, Celastrus orbiculatus Thunb., Radix Cynoglossi Officinalis, province rattan, Herba Equiseti Palustris, Herba Schisandrae lancifoliae be adjuvant drug; Polygonum cynanchoides Hemsl. coordinating the actions of various ingredients in a prescription, for making medicine.

Medicament of the present invention interacts, and synergism complements each other, and plays the merit of monarch altogether, and treatment gout Be very effective, clinic is promoted.

Detailed description of the invention

The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.

Embodiment lotion of the present invention

Take Caulis Fissistigmatis 280 grams, Herba Chrysosplenii Sinici 230 grams, to look up to heaven 250 grams, clock, Radix Cynanchi Amplexicaulis 200 grams, Cortex seu Radix Euonymi oxyphyllae 180 grams, Radix Campylotropis Trigonocladae 160 grams, 150 grams, spun gold brush, Herba Epilobii Himalayensis 170 grams, pass through 150 grams, muscle rattan, melilotus 130 grams, Celastrus orbiculatus Thunb. 140 grams, Radix Cynoglossi Officinalis 120 grams, economize 110 grams, rattan, Herba Equiseti Palustris 120 grams, Herba Schisandrae lancifoliae 100 grams and Polygonum cynanchoides Hemsl. 80 grams, add 12000 milliliters, water, heating 6 hours under the condition of backflow, filter, obtain filtering residue 1 and filtrate 1, 8000 milliliters, water is added in described filtering residue 1, heating 3 hours under the condition of backflow, filter, obtain filtering residue 2 and filtrate 2, merge described filtrate 1 and described filtrate 2, be concentrated into 5000 milliliters, be cooled to room temperature, add dehydrated alcohol 2000 milliliters, in room temperature, place 24 hours under the condition of sealing, filter, obtain filtrate 3, reclaim the ethanol in described filtrate 3, the aqueous solution obtained is lotion.

Experimental example

Physical data

Choose Patients with Fatty Liver 60 example of accepting for medical treatment, wherein man 35 example, female 25 example, age 23-58 year, average (31.5 ± 3.5) year; The shortest person of medical history 1 day, most elder 6 days, average 3 days.Patient's blood uric acid is all greater than 430 μm of ol/L, and soprano reaches 653 μm of ol/L.All patient's cards are shown in arthroncus, and sore spot is red scorching hot, and its pain is violent, and very, have heating, xerostomia concurrently, dysphoria, yellowish or reddish urine, constipation with dry stool is not well for hypnalgia, and red tongue, yellow and greasy fur, slippery and rapid pulse are strong.

Use the lotion prepared in embodiment to treat, every day 3 times, during treatment, get 100 milliliters of lotions, use sterile gauze to dip, cover painful area 10 minutes.Continuous treatment 5 days.

The standard of curative effect evaluation

Recovery from illness: redness and swelling of joints burning pain transference cure, movable normal, Level of Serum Uric Acid recovers normal, lower than 350 μm of ol/L.Take a turn for the better: arthroncus disappears, still have pain time movable, Level of Serum Uric Acid checks close to normal, is 400 μm of ol/L to 420 μm of ol/L.Invalid: symptom and lab testing are all unchanged.

Result

Through treatment, in 60 routine patients, recovery from illness 49 example, take a turn for the better 11 examples, and total effective rate is 100%.And there is not obvious untoward reaction over the course for the treatment of.

Claims

1. one kind is used for the treatment of the preparation method of the medicament of gout in internal medicine room, the method can comprise the following steps: to take Caulis Fissistigmatis 280 grams, Herba Chrysosplenii Sinici 230 grams, to look up to heaven 250 grams, clock, Radix Cynanchi Amplexicaulis 200 grams, Cortex seu Radix Euonymi oxyphyllae 180 grams, Radix Campylotropis Trigonocladae 160 grams, 150 grams, spun gold brush, Herba Epilobii Himalayensis 170 grams, pass through 150 grams, muscle rattan, melilotus 130 grams, Celastrus orbiculatus Thunb. 140 grams, Radix Cynoglossi Officinalis 120 grams, economize 110 grams, rattan, Herba Equiseti Palustris 120 grams, Herba Schisandrae lancifoliae 100 grams and Polygonum cynanchoides Hemsl. 80 grams, add 12000 milliliters, water, heating 6 hours under the condition of backflow, filter, obtain filtering residue 1 and filtrate 1, 8000 milliliters, water is added in described filtering residue 1, heating 3 hours under the condition of backflow, filter, obtain filtering residue 2 and filtrate 2, merge described filtrate 1 and described filtrate 2, be concentrated into 5000 milliliters, be cooled to room temperature, add dehydrated alcohol 2000 milliliters, in room temperature, place 24 hours under the condition of sealing, filter, obtain filtrate 3, reclaim the ethanol in described filtrate 3, obtain aqueous solution.

2. compositions is used for the treatment of purposes in the medicine of gout being prepared in internal medicine room, it is characterized in that, described compositions is made up of the material of following weight portion: Caulis Fissistigmatis 250-300 part, Herba Chrysosplenii Sinici 200-250 part, to look up to heaven clock 230-270 part, Radix Cynanchi Amplexicaulis 200-240 part, Cortex seu Radix Euonymi oxyphyllae 150-200 part, Radix Campylotropis Trigonocladae 150-180 part, spun gold brush 130-170 part, Herba Epilobii Himalayensis 150-200 part, pass through muscle rattan 130-180 part, melilotus 100-150 part, Celastrus orbiculatus Thunb. 130-150 part, Radix Cynoglossi Officinalis 100-150 part, economize rattan 100-130 part, Herba Equiseti Palustris 100-150 part, Herba Schisandrae lancifoliae 80-120 part and Polygonum cynanchoides Hemsl. 50-100 part.

3. purposes according to claim 2, it is characterized in that, described compositions is made up of the material of following weight portion: Caulis Fissistigmatis 280 parts, Herba Chrysosplenii Sinici 230 parts, 250 parts, clock of looking up to heaven, Radix Cynanchi Amplexicaulis 200 parts, Cortex seu Radix Euonymi oxyphyllae 180 parts, Radix Campylotropis Trigonocladae 160 parts, 150 parts, spun gold brush, Herba Epilobii Himalayensis 170 parts, pass through 150 parts, muscle rattan, melilotus 130 parts, Celastrus orbiculatus Thunb. 140 parts, Radix Cynoglossi Officinalis 120 parts, economize 110 parts, rattan, Herba Equiseti Palustris 120 parts, Herba Schisandrae lancifoliae 100 parts and Polygonum cynanchoides Hemsl. 80 parts.

4. purposes according to claim 3, is characterized in that, described medicament can be tablet, dispersible tablet, capsule, soft capsule or lotion.