CN102370687A - Compound Chinese medicinal preparation for treating colonitis and preparation method thereof - Google Patents
Compound Chinese medicinal preparation for treating colonitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a compound Chinese medicinal preparation for treating colonitis. The compound Chinese medicinal preparation comprises the following Chinese medicinal raw materials in weight by percentage: 8-12 percent of codonopsis pilosula, 13-17 percent of astragalus mongholicus, 8-12 percent of large-head atractylodes rhizome, 13-17 percent of tuckahoe, 5-7 percent of liquoric root, 8-12 percent of angelica, 5-7 percent of tangerine peel, 5-7 percent of costus root and 8-12 percent of coptis root. A preparation method of the compound Chinese medicinal preparation comprises the following steps of: cleaning the 9 medicinal materials; mixing in proportion; adding water in an amount which is 4-6 times the total weight of the medicinal materials or ethanol in an amount which is 70 percent of the volume ratio to decoct for 3 times, 40 minutes each time; combining decoction for 3 times; filtering; and concentrating to obtain liquid extract with specific gravity of 1.09 at the temperature of 60 DEG C. By adopting the conventional reparation process, the preparation can be prepared into any one pharmaceutically said formulation, such as tablets, capsules, granules, oral liquid, pills and syrup. The compound Chinese medicinal preparation prepared by the invention has an obvious curative effect, does not have an adverse effect and is suitable to be applied on a large scale in treatment of colonitis.
Description
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation of treating colitis and preparation method thereof, belong to field of traditional Chinese.
Background technology
Colitis is claimed nonspecific ulcerative colitis again, and how slow onset is, and state of an illness weight differs, and diarrhoea is cardinal symptom, discharges bloody purulent stool, mucosanguineous feces or hemafecia etc.
Chinese medicine thinks that primary disease is how evil by weakness of the spleen and stomach or infection poison, causes dysfunction of the spleen in transportation, the liver failing to maintain the normal flow of QI, and deficiency of spleen and stomach accumulates in the damp and hot turbid pathogen, injures due to the intestinal network.Or because of natural endowment is not enough, transporting and transforming function of the spleen and stomach mistake department, indigestion, small intestinal divide Qinghua turbid and the large intestine conduction function is not normal, and water-damp not being transformed then closes dirt and descends, so see increased borborygmus and diarrhea; Mechanism of qi is hindered, and sees that breast gastral cavity painful abdominal mass is vexed.
Antibiotic therapy colitis effect is not good enough at present, also has big side effect.
Summary of the invention
The object of the present invention is to provide a kind of Chinese traditional compound medicine of treating colitis and preparation method thereof.
The present invention provides the compound Chinese medicinal preparation of a kind of Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, the Radix Aucklandiae, Rhizoma Coptidis compatibility to be used to treat colitis, and is evident in efficacy, has no adverse reaction.
Technical scheme of the present invention is following:
A kind of Chinese traditional compound medicine of treating colitis comprises the following weight Chinese medicinal raw materials: Radix Codonopsis 8-12, Radix Astragali 13-17, Rhizoma Atractylodis Macrocephalae 8-12, Poria 13-17, Radix Glycyrrhizae 5-7, Radix Angelicae Sinensis 8-12, Pericarpium Citri Reticulatae 5-7, Radix Aucklandiae 5-7, Rhizoma Coptidis 8-12.
Wherein method for preparing is that above-mentioned 9 flavor medical materials are cleaned, and proportional mixing, the 4-6 that adds medical material gross weight water or volume ratio doubly is that 70% ethanol decocts 3 times; Each 40 minutes, merge 3 times decoction liquor, filter; And concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃, adopts conventional preparation technology; Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
The Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae replenishing QI to invigorate the spleen tonify deficiency in the present invention's prescription; The Poria promoting diuresis with drugs of tasteless flavour; All medicines share, and the temper benefit is strong, and it is logical that internal organs is so incensed that, all disease spontaneous recovery.So the Chinese traditional compound medicine that the present invention makes is evident in efficacy, has no adverse reaction.
Specific embodiment
Embodiment 1:
A kind of Chinese traditional compound medicine of treating colitis comprises the following weight Chinese medicinal raw materials: Radix Codonopsis 8, the Radix Astragali 13, the Rhizoma Atractylodis Macrocephalae 8, Poria 13, Radix Glycyrrhizae 5, Radix Angelicae Sinensis 8, Pericarpium Citri Reticulatae 5, the Radix Aucklandiae 5, Rhizoma Coptidis 8.
Wherein method for preparing is that above-mentioned 9 flavor medical materials are cleaned, proportional mixing, and 4 times the decocting that adds the medical material gross weight boils 3 times, and each 40 minutes, merge 3 times decoction liquor, to filter, and concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃.
Embodiment 2:
A kind of Chinese traditional compound medicine of treating colitis comprises the following weight Chinese medicinal raw materials: Radix Codonopsis 10, the Radix Astragali 15, the Rhizoma Atractylodis Macrocephalae 10, Poria 15, Radix Glycyrrhizae 6, Radix Angelicae Sinensis 10, Pericarpium Citri Reticulatae 6, the Radix Aucklandiae 6, Rhizoma Coptidis 10.
All the other are with embodiment 1.
Embodiment 3:
A kind of Chinese traditional compound medicine of treating colitis comprises the following weight Chinese medicinal raw materials: Radix Codonopsis 12, the Radix Astragali 17, the Rhizoma Atractylodis Macrocephalae 12, Poria 17, Radix Glycyrrhizae 7, Radix Angelicae Sinensis 12, Pericarpium Citri Reticulatae 7, the Radix Aucklandiae 7, Rhizoma Coptidis 12.
Wherein method for preparing is that above-mentioned 9 flavor medical materials are cleaned, proportional mixing, and 4 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 3 times, each 40 minutes, merges 3 times decoction liquor, filter, and concentrated, proportion is 1.09 fluid extract when obtaining 60 ℃.
Embodiment 4:
A kind of Chinese traditional compound medicine of treating colitis, wherein method for preparing is the prescription Chinese crude drug to be cleaned proportional mixing; 5 times of volume ratios that add the medical material gross weight are that 70% ethanol 5 decocts 3 times; Each 40 minutes, merge 3 times decoction liquor, filter; And concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃.
All the other are with embodiment 1.
Embodiment 5:
A kind of Chinese traditional compound medicine of treating colitis, wherein method for preparing is the prescription Chinese crude drug to be cleaned proportional mixing; 5 times the water 5 that adds the medical material gross weight decocts 3 times, each 40 minutes, merges 3 times decoction liquor; Filter, and concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃.
All the other are with embodiment 2.
Embodiment 6:
A kind of Chinese traditional compound medicine of treating colitis, wherein method for preparing is the prescription Chinese crude drug to be cleaned proportional mixing; 5 times the decocting that adds the medical material gross weight boils 3 times, each 40 minutes, merges 3 times decoction liquor; Filter, and concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃.
All the other are with embodiment 3.
Embodiment 7:
A kind of Chinese traditional compound medicine of treating colitis, wherein method for preparing is the prescription Chinese crude drug to be cleaned proportional mixing; 6 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 3 times; Each 40 minutes, merge 3 times decoction liquor, filter; And concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃.
All the other are with embodiment 2.
Embodiment 8:
A kind of Chinese traditional compound medicine of treating colitis comprises the following weight Chinese medicinal raw materials: Radix Codonopsis 15, the Radix Astragali 18, the Rhizoma Atractylodis Macrocephalae 15, Poria 18, Radix Glycyrrhizae 5, Radix Angelicae Sinensis 3, Pericarpium Citri Reticulatae 2, the Radix Aucklandiae 2, Rhizoma Coptidis 3.
Wherein method for preparing is that the prescription Chinese crude drug is cleaned, proportional mixing, and 6 times the decocting that adds the medical material gross weight boils 3 times, and each 40 minutes, merge 3 times decoction liquor, to filter, and concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃.
Embodiment 9:
A kind of Chinese traditional compound medicine of treating colitis comprises the following weight Chinese medicinal raw materials: Radix Codonopsis 5, the Radix Astragali 10, the Rhizoma Atractylodis Macrocephalae 6, Poria 10, Radix Glycyrrhizae 10, Radix Angelicae Sinensis 15, Pericarpium Citri Reticulatae 10, the Radix Aucklandiae 8, Rhizoma Coptidis 6.
Wherein method for preparing is that the prescription Chinese crude drug is cleaned, proportional mixing, and 6 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 3 times, each 40 minutes, merges 3 times decoction liquor, filter, and concentrated, proportion is 1.09 fluid extract when obtaining 60 ℃.
Embodiment 10:
A kind of Chinese traditional compound medicine of treating colitis comprises the following weight Chinese medicinal raw materials: Radix Codonopsis 7, the Radix Astragali 18, the Rhizoma Atractylodis Macrocephalae 7, Poria 17, Radix Glycyrrhizae 4, Radix Angelicae Sinensis 12, Pericarpium Citri Reticulatae 4, the Radix Aucklandiae 8, Rhizoma Coptidis 7.
Wherein method for preparing is that above-mentioned 9 flavor medical materials are cleaned, proportional mixing, and 3 times the decocting that adds the medical material gross weight boils 3 times, and each 40 minutes, merge 3 times decoction liquor, to filter, and concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃.
Embodiment 11:
Be the Chinese medicine preparation of 99116308.7 the disclosed treatment colitis of patent according to application number, comprise the following weight Chinese medicinal raw materials: Radix Angelicae Sinensis 60, the Radix Paeoniae Alba 200, windproof 100, Rhizoma Coptidis 50, Fructus Toosendan 100, Rhizoma Corydalis 100, Fructus Aurantii 100, Pericarpium Citri Reticulatae 100, the Radix Aucklandiae 100, Radix Glycyrrhizae 60, Radix Bupleuri 100, the Rhizoma Atractylodis Macrocephalae 200, the Radix Astragali 300, Radix Codonopsis 150, Poria 120, Fructus Jujubae 40, the Radix Angelicae Dahuricae 100, Rhizoma Atractylodis 100, the Rhizoma Pinelliae 80, Pericarpium Papaveris 100.
Wherein method for preparing is that Radix Angelicae Sinensis, Radix Paeoniae Alba wine are fried, and the Rhizoma Atractylodis Macrocephalae, the Radix Aucklandiae, Rhizoma Coptidis, Rhizoma Atractylodis are fried, and Fructus Toosendan, Rhizoma Corydalis, Radix Bupleuri, Pericarpium Papaveris vinegar are used as medicine after frying, usefulness behind the Radix Astragali, the Radix Glycyrrhizae processed with honey, and other medical material is given birth to usefulness, processes water preparation.An oral 200ml, three times on the one
Embodiment 12:
According to application number is 00132727.5 the disclosed a kind of Chinese medicine of treating colitis of patent, comprises the following weight Chinese medicinal raw materials: the Radix Astragali 120, the Rhizoma Atractylodis Macrocephalae 100, Fructus Psoraleae 70, Radix Sangusorbae 100, Fructus Evodiae 50, Fructus Jujubae charcoal 80, Unguis Sus domestica 80, Radix Codonopsis 100, the Radix Aucklandiae 90, Poria 100, Radix Glycyrrhizae 60.
Wherein method for preparing is that said medicine is taken by weighing each component by ratio requirement is subsequent use; Radix Sangusorbae is worn into powder; Process the Fructus Jujubae charcoal to Fructus Jujubae; It is not burnt to process yellow to Unguis Sus domestica with the sandy soil race; Put into extraction pot to all the other medicines and add 10 times of water boils 3 times, mix, remove slag, concentrate, cold drying becomes dried cream; Radix Rehmanniae elm powder, Fructus Jujubae charcoal, the not burnt superfine powder that is mixed and made into of yellow, process the granule tabletting again; Packing, every heavy 0.2-0.3g, every bottle 100 is on chip.Oral each 2,3 times on the one.
Embodiment 13: adopt conventional preparation technology, Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
All the other are with embodiment 1-10.
Embodiment 14: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, and according to the operational approach of conventional tablet, adds pharmaceutic adjuvant; With each component mix homogeneously, wet granulation sieves; Adopt conventional tablet preparation method tabletting to process tablet, wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 50
Starch 22
Microcrystalline Cellulose 15
Pulvis Talci 10
Polyethylene Glycol 6
All the other are with embodiment 1-10.
Embodiment 15: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, and according to the operational approach of conventional capsule, adds pharmaceutic adjuvant; With each component mix homogeneously; Granulate, adopt conventional capsule preparation method to fill and process capsule, wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 100
Pregelatinized Starch 25
Lactis Anhydrous 20
Microcrystalline Cellulose 15
Calcium hydrogen phosphate 8
All the other are with embodiment 1-10.
Embodiment 16: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, according to the operational approach of conventional oral liquid, ethanol precipitation 1-2 time; Filter, concentrate aqueous precipitation; Filter, add pharmaceutic adjuvant, filter; The packing sterilization adopts conventional oral liquid preparation method to prepare oral liquid, and wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 100
Ethanol 150
Sucrose 85
Sodium carboxymethyl cellulose 15
Oleum menthae 5
Sorbic acid 2
All the other are with embodiment 1-10.
The effectiveness study experiment:
Patient's data:
Totally 377 routine patients, male's 191 examples wherein, women's 186 examples; Minimum 20 years old, maximum 68 years old, average 40.7 years old; The course of disease is the shortest 2 years, and is the longest 22 years, average 10.3 years.All experimenters who meets each diagnostic criteria are divided into 13 groups according to the table of random number method; Every group 29 example, wherein 1 group as matched group, organizes as treatment for 12 groups; The sex of 13 groups of data, age, the course of disease have comparability through the equal not statistically significant of statistical procedures difference (P>0.05).
Therapeutic Method:
The oral sulfasalazine of matched group, just amount is a 1-1.5g, every 6-8 hour 1 time.Maintenance dose is a 0.5g, per 6 hours 1 time; 9 times by volume of the Chinese traditional compound medicine waters that embodiment 1-10 is made respectively take for respectively 10 groups of treatment groups, once oral 100ml, every day 3 times, the herbal mixture that the oral respectively embodiment 11 of two groups of remaining treatment groups and embodiment 12 make; Matched group and treatment group were all taken medicine 3 months continuously.
Criterion of therapeutical effect
Criterion of therapeutical effect with reference to national chronic noninfective intestinal tract disease academic discussion is formulated is evaluated.1. clinical cure: clinical symptom disappearance, feces symptom and microscopy are all normal, just time＜and 2 times/d, colonoscopy finding mucosa pathological changes disappears, and vascular lake is clear, and color and luster is normal, and intestinal mucosa does not have inflammatory cell infiltration, and body of gland is no abnormal, follows up a case by regular visits to and does not have recurrence in 1 year.2. take a turn for the better: clinical symptom relief, colonoscopy show that the mucosa pathological changes takes a turn for the better.3. invalid: clinical symptoms and colonoscopy do not have significant change or increase the weight of.
Therapeutic outcome respectively organized by table 1 and curative effect compares
2 routine drug eruption appear in matched group in therapeutic process, 1 routine aplastic anemia, 1 routine nausea and vomiting; Any untoward reaction does not appear in the treatment group in therapeutic process.
Can find out that from the effectiveness study experiment curative effect of the present invention obviously is superior to the oral western medicine of existing treatment colitis, and be superior to the curative effect of the Chinese medicine medicine that similar prescription makes in the prior art, wherein best with the therapeutic effect of embodiment 5; Therefore, the Chinese traditional compound medicine that the present invention makes is evident in efficacy, has no adverse reaction, and is adapted at the colitis treatment and goes up large-scale application.
Claims (5)
1. a Chinese traditional compound medicine of treating colitis comprises the following weight Chinese medicinal raw materials: Radix Codonopsis 8-12, Radix Astragali 13-17, Rhizoma Atractylodis Macrocephalae 8-12.
2. a Chinese traditional compound medicine of treating colitis comprises the following weight Chinese medicinal raw materials: Radix Codonopsis 8-12, Radix Astragali 13-17, Rhizoma Atractylodis Macrocephalae 8-12, Poria 13-17, Radix Glycyrrhizae 5-7, Radix Angelicae Sinensis 8-12, Pericarpium Citri Reticulatae 5-7, Radix Aucklandiae 5-7, Rhizoma Coptidis 8-12.
3. a Chinese traditional compound medicine of treating colitis comprises the following weight Chinese medicinal raw materials: Radix Codonopsis 10, the Radix Astragali 15, the Rhizoma Atractylodis Macrocephalae 10, Poria 15, Radix Glycyrrhizae 6, Radix Angelicae Sinensis 10, Pericarpium Citri Reticulatae 6, the Radix Aucklandiae 6, Rhizoma Coptidis 10.
4. like claim 2 or 3 said a kind of method for preparinies of treating the Chinese traditional compound medicine of colitis, it is characterized by: 9 flavor medical materials are cleaned proportional mixing; The 4-6 that adds medical material gross weight water or volume ratio doubly is that 70% ethanol decocts 3 times, each 40 minutes, merges 3 times decoction liquor; Filter; And concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃, adopts conventional preparation technology; Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
5. a kind of method for preparing of treating the Chinese traditional compound medicine of colitis as claimed in claim 4 is characterized by: 9 flavor medical materials are cleaned proportional mixing; 5 times the decocting that adds the medical material gross weight boils 3 times, each 40 minutes, merges 3 times decoction liquor; Filter, and concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃; Adopt conventional preparation technology, Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102641486A (en) * | 2012-04-02 | 2012-08-22 | 王永刚 | Preparation method of traditional Chinese medicine for treating blood-deficiency-type colonitis |
| CN103070955A (en) * | 2013-01-12 | 2013-05-01 | 张石柱 | Traditional Chinese medicine powder for treating colonitis and preparation method of same |
| CN103301257A (en) * | 2013-05-16 | 2013-09-18 | 聂明明 | Traditional Chinese medicine plaster for treating colitis and preparation method thereof |
| CN104208230A (en) * | 2014-09-26 | 2014-12-17 | 禤燕华 | Chinese medicinal composition for treating chronic colitis |
| CN104887967A (en) * | 2015-06-10 | 2015-09-09 | 吴光付 | Traditional Chinese medicine composition for treating ulcerative colitis and preparation method thereof |
| CN105343687A (en) * | 2015-11-13 | 2016-02-24 | 张雯 | Traditional Chinese medicine for treating rectitis and colitis and its preparation method |
| CN107019774A (en) * | 2017-05-05 | 2017-08-08 | 广东农之道农牧科技有限公司 | A kind of Chinese medicine composition for treating livestock and poultry intestinal canal diseases and its application |
| KR20180119507A (en) * | 2017-04-25 | 2018-11-02 | 대구한의대학교산학협력단 | A composition comprising mixture of the herb extract and sulfasalazine for preventing or treating colitis |
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| CN1616041A (en) * | 2004-09-27 | 2005-05-18 | 简光富 | Chinese medicine composition for treating chronic ulcerative colitis |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641486A (en) * | 2012-04-02 | 2012-08-22 | 王永刚 | Preparation method of traditional Chinese medicine for treating blood-deficiency-type colonitis |
| CN103070955A (en) * | 2013-01-12 | 2013-05-01 | 张石柱 | Traditional Chinese medicine powder for treating colonitis and preparation method of same |
| CN103301257A (en) * | 2013-05-16 | 2013-09-18 | 聂明明 | Traditional Chinese medicine plaster for treating colitis and preparation method thereof |
| CN104208230A (en) * | 2014-09-26 | 2014-12-17 | 禤燕华 | Chinese medicinal composition for treating chronic colitis |
| CN104887967A (en) * | 2015-06-10 | 2015-09-09 | 吴光付 | Traditional Chinese medicine composition for treating ulcerative colitis and preparation method thereof |
| CN105343687A (en) * | 2015-11-13 | 2016-02-24 | 张雯 | Traditional Chinese medicine for treating rectitis and colitis and its preparation method |
| KR20180119507A (en) * | 2017-04-25 | 2018-11-02 | 대구한의대학교산학협력단 | A composition comprising mixture of the herb extract and sulfasalazine for preventing or treating colitis |
| CN107019774A (en) * | 2017-05-05 | 2017-08-08 | 广东农之道农牧科技有限公司 | A kind of Chinese medicine composition for treating livestock and poultry intestinal canal diseases and its application |
| CN107019774B (en) * | 2017-05-05 | 2020-05-19 | 欧显华 | Traditional Chinese medicine composition for treating intestinal diseases of livestock and poultry and application thereof |
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