CN113288925A - Traditional Chinese medicine composition for preventing and treating gout - Google Patents

Traditional Chinese medicine composition for preventing and treating gout Download PDF

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CN113288925A
CN113288925A CN202110804719.0A CN202110804719A CN113288925A CN 113288925 A CN113288925 A CN 113288925A CN 202110804719 A CN202110804719 A CN 202110804719A CN 113288925 A CN113288925 A CN 113288925A
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traditional chinese
chinese medicine
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管庆磊
张冰
林志健
王雨
赵晓玫
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Zhiqi Health Industry Shandong Group Co ltd
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Abstract

The invention relates to the field of traditional Chinese medicines, foods and health-care foods, in particular to a traditional Chinese medicine composition for preventing and treating gout, which is used for reducing uric acid, promoting uric acid excretion, diminishing inflammation and easing pain. The material is prepared from the following raw materials in parts by weight: 1-50 parts of chicory root, 20-70 parts of poria cocos and 1-30 parts of medicinal cyathula root. The selected classical medicinal materials of tuckahoe, chicory root and medicinal cyathula root are compounded and have synergistic effect, so that the composition has the effects of strengthening spleen and stomach, soothing liver and gallbladder and tonifying kidney, and also has the effects of detoxifying and promoting diuresis and accelerating the removal of metabolic wastes in vivo. The formulation of the formula is based on the theory of traditional Chinese medicine of 'integration treatment', has reasonable formula, smart medicine selection and unique and ingenious design, and realizes the functions of reducing uric acid, promoting uric acid excretion, diminishing inflammation and easing pain.

Description

Traditional Chinese medicine composition for preventing and treating gout
Technical Field
The invention relates to the field of traditional Chinese medicines, foods and health-care foods, in particular to a traditional Chinese medicine composition for preventing and treating gout, which is used for reducing uric acid, promoting uric acid excretion, diminishing inflammation and easing pain.
Technical Field
The number of hyperuricemia patients in China reaches 1.7 hundred million (13.3%), gout patients exceed 8000 ten thousand, and gout becomes the second major metabolic disease next to diabetes in China. The incidence of diseases in recent years is rising year by year, and the life and health of people are seriously affected. Experts point out that in the next 20 years, China faces large-scale epidemic diseases of hyperlipidemia, hypertension, hyperglycemia, hyperuricemia and apoplexy. In recent years, a great deal of clinical studies indicate that hyperuricemia is not only the biochemical center of gout, but also an independent risk factor of diseases such as type 2 diabetes, cardiovascular diseases, hypertension and the like, so prevention and treatment of hyperuricemia are in urgent need of solution. At present, the uric acid reducing chemical drugs commonly used in clinic are mostly concentrated in 2 categories, one is to achieve the effect of reducing uric acid by inhibiting the uric acid generation pathway, namely by inhibiting the activity of a key enzyme xanthine oxidase of the generation pathway, such as allopurinol; the other is to achieve the effect of reducing uric acid by promoting the excretion of uric acid, namely by promoting the excretion of uric acid by the kidney, such as benzbromarone. The research on the epidemiology of the medicines shows that although the medicines have clear action targets and definite uric acid reducing effect, serious adverse reactions such as gastrointestinal system damage, rash, bone marrow suppression, liver and kidney damage and the like are often caused after long-term administration. In view of the current situation of clinical use of uric acid lowering drugs in China, the study of safe drugs with clear effective action mechanisms is imperative.
Modern medicine considers that hyperuricemia is abnormal rise of blood uric acid level caused by in vivo purine metabolic disorder and/or uric acid excretion disorder, and is characterized by that under the normal diet state, the 2 times of non-same day of fasting blood uric acid level is above 420 mu mol/L. Gout is characterized in that when the blood uric acid level exceeds saturation, precipitated urate crystals are deposited on tissues and organs such as joints, cartilages, kidneys and the like to cause local inflammatory reaction and tissue damage, and the gout is clinically manifested by gouty arthritis and gouty nephropathy. In recent years, with the intensive clinical research and the wide application of advanced image examination techniques, it has been found that asymptomatic patients with hyperuricemia have no obvious clinical manifestations, but have the phenomena of urate deposition or even bone erosion in joints and tissues due to the increase of the levels of inflammatory response factors such as TNF-alpha, IL6 and IL-1 beta. Therefore, the elevated blood uric acid level is the root cause of the occurrence and development of hyperuricemia and gout and related complications thereof, and the hyperuricemia and the gout are suggested to be a continuous pathological process and to be different stages of the same disease.
The traditional Chinese medicine literature is studied and read, and the discussion of each pathological stage of gout is easily found. 1) The ancient books of traditional Chinese medicine have no definite record on the stage of hyperuricemia, and the traditional Chinese medicine has no uniform name on the hyperuricemia, but according to the clinical manifestation of the rise of blood uric acid, the ancient books of traditional Chinese medicine are better developed on the pathological characteristics of obese people who like to eat fat, sweet and thick taste, and are called as blood turbidity, turbid stagnation arthralgia, turbid plaster disease and the like by the scholars of traditional Chinese medicine. 2) The description of the inflammatory attack stage of joint gout can be seen in diseases such as arthralgia, gout, tiger, joint, beriberi and the like, and the disease names are mainly directed at the clinical manifestations of red swelling and hot pain. For example, recorded in the recorded records of the Yangyi university, gout patients with ancient famous arthralgia are commonly called as Baihu regular arthralgia, i.e. pain in the joints of the four limbs. The traditional Chinese medicine considers that the occurrence of joint gout is closely related to factors such as body weakness, diet irregularity, daily life irregularity, exogenous pathogenic factors and the like, and the gout is caused by dampness and turbidity obstruction in joints, muscles and tendons and muscles due to insufficiency of spleen and kidney, dysfunction of opening and closing, or overeating, so that the gout is caused. Such as Zhuzhenhunyun: for gout, it is usually due to weak constitution with open striae and interstice, so wind, cold and damp attack meridians and collaterals, entering tendons and vessels, muscles and bones, causing muscles to collapse and blood vessels to congeal, resulting in failure of circulation of joints and failure of all tendons to nourish. The book recorded in Wan Bing Hui Chun (Wan Bing Chun) states that patients with gout, malignant boil and carbuncle are most likely to suffer from the symptoms of gao Liang, polyphagia of , wine and hot food steaming viscera. 3) For the gout and gouty nephropathy caused by the continuous existence of hyperuricemia and the formation of urate crystals deposited in tissues and organs (mainly joints and kidneys), the traditional Chinese medicine does not have corresponding disease names, and the symptoms and clinical manifestations of the disease can be classified into the disease names of rheumatoid arthritis, renal arthralgia, edema, stranguria with stone, dysuria, obstruction, consumptive disease and the like. Therefore, TCM has a deeper understanding of the etiology and pathogenesis of this disease, but it is relatively dispersive, and does not unify and standardize the pathological stages into a definite medical concept.
Chicory (Cichorium intybus L.) also known as endive, French endive, chicory, coffee, etc., is a perennial plant of the family Cichorium, native to Mediterranean, Central Asia and North Africa, and has been cultivated as early as in ancient Rome and Greece. Chicory is cultivated in europe for many years and has been used for many years as a replacement for leafy vegetables, pasture, sugar-making raw materials and coffee. China also has distribution in Xinjiang, Shandong, inner Mongolia and other places. Chicory is a commonly used medicinal material in Uygur and Mongolian nationalities, and the record of the national medicinal material standard Uygur medicine records that the chicory can be used as a medicine and has slightly bitter, salty and cool properties; collected in the Xinjiang Chinese herbal handbook, the Chinese herbal medicine composition is slightly bitter, salty and cool in nature, has the effects of clearing liver and promoting bile flow, invigorating stomach and promoting digestion, and inducing diuresis to reduce edema, and is used for treating diseases such as damp-heat jaundice, stomachache and anorexia, edema and oliguria and the like. Injection of chicory flowers into animals can excite the central nervous system and enhance cardiac activity; the decoction has antibacterial and astringent effects. The root can improve appetite and promote digestion, and the high concentration infusion can improve gastric secretion without enhancing smooth muscle tone. Seeds have non-specific phytohemagglutinin ". The research and report of the chicory medicinal use are also reported abroad. Research shows that the chicory extract is not only an important source of inulin, chicoric acid, fructose and the like, but also has complex components, and polysaccharides, terpenoids (especially sesquiterpenes), flavonoids, phenolic acid compounds, various vitamins, metal elements and other chemical components are separated from the chicory at present. But also has many physiological activities such as immunity enhancement, anti-inflammatory action, uric acid reduction, cholesterol and blood sugar reduction, etc.
Poria is dry sclerotium of Wolf of Polyporaceae fungus Poria Poriacos (Schw.); the Chinese medicinal material has the characteristics that the Chinese medicinal material is one of four traditional medicinal materials which are used as both medicine and food in clinic, the Chinese medicinal material has the theory of 'one hundred square nine-poria', the annual demand of dried poria cocos in China reaches more than 3 ten thousand tons, the dried poria cocos is a main raw material medicinal material of Chinese patent medicines, and the industrial output value of the poria cocos exceeds 100 hundred million yuan. The tuckahoe is mainly produced in Hubei, Anhui, Fujian, Yunnan, Hunan, Guizhou, Sichuan provinces and the like, has sweet and light taste, is neutral in nature and non-toxic, has the effects of promoting diuresis and excreting dampness, strengthening spleen and calming heart, is mainly used for treating edema and oliguria, phlegm and fluid retention and dizziness and palpitation, spleen deficiency and poor appetite, loose stool and diarrhea, uneasiness, palpitation and insomnia and the like, is compatible with proper medicaments, and can play the unique effect regardless of cold, warm, wind and dampness. Poria cocos is grown by pine roots, is called Fu Tu ancient times, and has the application of Poria cocos in the Chinese generation as early as more than 2000 years, and is listed as the ' top grade ' for reducing weight, tonifying qi and prolonging life ' in Shen nong Ben Cao Jing. For example, the traditional Chinese medicine composition can be used for treating adverse qi in chest and hypochondrium, palpitation caused by fright anger fright, palpitation, nodal pain under the heart, cold and heat, dysphoria, cough, dry mouth and tongue, and diuresis; recorded in Ben Cao gang mu, Fu Ling has a bland flavor and a weak nature to promote the circulation of body fluid, open the striae and nourish the water. The chemical components found in tuckahoe include polysaccharides, triterpenes, sterols, amino acids, fatty acids, etc. and the compounds with biological activity reported in tuckahoe are mainly concentrated in triterpenes and polysaccharides. At present, 84 triterpene components and more than 60 polysaccharide components are identified by coseparation. The chemical components of tuckahoe mainly play roles of tuckahoe polysaccharides and tuckahoe triterpenes, and the medicine effect is rich. Modern pharmacological research shows that the tuckahoe has pharmacological effects in various aspects such as tumor inhibition, immunity enhancement, anti-inflammation and the like. Modern medical research shows that tuckahoe can enhance the immune function of organisms, and pachyman has obvious anti-tumor and liver-protecting effects. It has been reported that pachyman is an immunopotentiator, and can improve only nonspecific immune functions and also specific immune system functions.
Radix Cyathulae is the dried root of Cy athula officinalis Kuan of Amaranthaceae. Mild in nature, sweet and slightly bitter in taste. It enters liver and kidney meridians. Has the functions of dispelling wind, promoting diuresis, dredging meridian and promoting blood circulation. Can be used for treating amenorrhea, abdominal mass, retention of exocytosis, arthralgia, flaccidity of feet, spasm of tendons, stranguria with hematuria and blood, traumatic injury, etc. Researches show that the achyranthes bidentata contains various medicinal components, such as saponins, sterones, polysaccharides, betaine and various trace elements. The chemical components of the compound mainly comprise alkaloid and steroid ketone, and the modern pharmacological research shows that the compound has the effects of improving microcirculation, resisting inflammation, resisting fertility, delaying senility, resisting tumor, regulating immunity and the like.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for preventing gout, which is used for reducing uric acid, promoting uric acid excretion, diminishing inflammation and easing pain;
the invention is realized by the following technical scheme:
a traditional Chinese medicine composition for preventing and treating gout is prepared from the following raw materials in parts by weight: 1-50 parts of tuckahoe, 20-70 parts of tuckahoe and 1-30 parts of medicinal cyathula root.
Further, the feed additive is prepared from the following raw materials in parts by weight: 15-40 parts of chicory root, 35-70 parts of poria cocos and 5-25 parts of medicinal cyathula root.
Further, the feed additive is prepared from the following raw materials in parts by weight: 28 parts of chicory root, 56 parts of poria cocos and 16 parts of medicinal cyathula root.
Further, adding 10 times of purified water into chicory root, poria cocos and radix cyathulae, boiling, reflux-extracting at 100 ℃ for 6 hours, filtering the extract with a filter cloth plate frame to obtain a mixed liquid medicine;
concentrating the obtained mixed medicinal liquid under-0.09 Mpa at 80 deg.C under reduced pressure to obtain soft extract; spray drying the obtained soft extract with atomizer frequency of 15HZ-20HZ and air exhaust temperature of 80-100 deg.C, and sieving with 60 mesh sieve to obtain Chinese medicinal composition powder.
Further, the traditional Chinese medicine composition is added with pharmaceutically or physiologically acceptable auxiliary materials, wherein the auxiliary materials are one or more of a filling agent, a flavoring agent and a lubricating agent; making into granule, powder, capsule, tablet, pill or liquid.
Further, the traditional Chinese medicine composition is applied to preparation of medicines, health-care foods or functional foods for treating hyperuricemia and inflammation and pain induced by the hyperuricemia.
The invention has the advantages that: the compound preparation can generate mutual synergistic effect, and the gout disease is progressive metabolic disease closely related to multiple links such as hyperuricemia, urate deposition, inflammation and the like. Modern medicine treatment gout is mainly symptomatic treatment, uric acid is reduced in a hyperuricemia period, anti-inflammation and analgesia are performed in an acute attack period of gouty arthritis, besides operation treatment, no specific medicine can clear urate deposition, and therefore western medicines are single in effect and large in toxic and side effects. Western medicines have single action, and the intervention of the divided medicines can only aim at a certain link of the attack of the disease and is difficult to accord with the progressive pathological characteristics of the disease; anti-deposition drugs also have difficulty in blocking the recurrence of disease processes. By utilizing the theoretical advantages of the holistic concept of the traditional Chinese medicine and the action characteristics of multiple components, multiple targets and multiple ways of the traditional Chinese medicine, an 'integration treatment' strategy is innovatively provided for guiding the whole process of preventing and treating the gout and integrally regulating the progress of the gout. The 'integration treatment' strategy is a treatment strategy for integrating 3 different pathological stages, namely a hyperuricemia stage, a urate deposition stage and an acute gouty inflammation attack stage of the gout disease, relieving clinical symptoms, turning the pathological state, removing the source of the induced symptoms, cutting off the pathological process and intervening the gout disease in the whole process. Chicory and tuckahoe can both strengthen the spleen and eliminate dampness, and chicory also has the efficacies of clearing away heat and toxic material and easing joint movement, and is the core medicine composition for treating both symptoms and root causes of gout disease under the strategy of 'treatment integrated'. The two medicines can regulate metabolic disturbance by invigorating spleen and stomach, promote diuresis and discharge turbidity, accelerate the clearing of metabolic waste in vivo, and remove toxic substance and promote diuresis, and are suitable for the whole process of pathological progress of gout. Modern pharmacological research also shows that chicory and tuckahoe have definite functions of inhibiting the generation of uric acid, promoting the excretion of uric acid, resisting inflammation and easing pain, can obviously reduce the level of uric acid in blood and improve the inflammatory reaction state. Radix Cyathulae has effects of nourishing liver and kidney, strengthening tendons and bones, removing blood stasis, eliminating carbuncle and swelling, and moving lower limbs to remove uric acid deposition. The three medicines are combined to play roles in strengthening spleen and dissolving turbidity to reduce the level of blood uric acid, promoting blood circulation and removing obstruction in channels to dispel urate deposition, trying to cut off high blood uric acid, improving inflammatory reaction state, twisting urate deposition, and further blocking the progress of disease course to prevent gout acute inflammation attack. Chicory has the effects of clearing liver, promoting bile flow, invigorating stomach, promoting digestion, and inducing diuresis to alleviate edema; poria has effects in invigorating spleen and stomach, promoting diuresis, eliminating dampness, and tonifying kidney; cyathula root, radix Cyathulae has the effect of removing dampness and toxic materials. Has the effects of strengthening spleen and stomach, promoting diuresis and purging turbid pathogen. It has no incompatibility and mild property. Strengthen the body resistance and consolidate the constitution, remove dampness and eliminate pathogenic factors, take the root and symptoms into consideration and bring out the best in each other. Can effectively play the effects of reducing uric acid, promoting uric acid excretion, diminishing inflammation, relieving pain and simultaneously improving various metabolic disorders.
The selected classical medicinal materials of tuckahoe, chicory and medicinal cyathula root are compounded to play roles of strengthening spleen and stomach, soothing liver and gallbladder and tonifying kidney, and also can detoxify and promote diuresis and accelerate the removal of metabolic wastes in vivo. The formulation of the formula is based on the theory of traditional Chinese medicine of 'integration treatment', has reasonable formula, smart medicine selection and unique and ingenious design, and realizes the functions of reducing uric acid, promoting uric acid excretion, diminishing inflammation and easing pain. The tuckahoe, the chicory and the medicinal cyathula root are compounded and have synergistic effect, and the synergistic effect can obviously reduce uric acid, promote the excretion of uric acid and diminish inflammation and relieve pain.
Chicory is slightly bitter, salty and cool. It enters liver, gallbladder and stomach meridians. The Chinese pharmacopoeia (2020 edition) carries the functions of clearing liver and promoting bile flow, invigorating stomach and promoting digestion, and inducing diuresis and reducing edema. Can be used for treating stomach ache, anorexia, edema and oliguria. Can assist tuckahoe to strengthen the functions of strengthening spleen and stomach, promoting diuresis and removing dampness. Can be used as principal drug.
Poria cocos, sweet, bland and neutral. It enters heart, spleen and kidney meridians. Shen nong Ben Cao Jing (Shen nong's herbal classic) means that: 'diuresis promoting'. Long-term administration of the product can relieve soul, nourish mind, prevent hunger, and prolong life. "Shibuzhai medical book" Yun: "Fu Ling is a Chinese herb, which is used as the main herb for treating phlegm, but also water can move water. The phlegm moving and dampness moving, but the tuckahoe also moves and dampness moves. The actions of benefiting water and eliminating dampness, invigorating spleen and calming heart are provided. The spleen is the acquired root. Fu Ling can strengthen the function of spleen and stomach, and also drain damp-turbidity. Is used as a monarch drug.
Cyathula root, radix Cyathulae is sweet, bland and neutral. It enters liver and stomach meridians. The compendium of materia Medica carries it: strengthening the spleen and stomach, strengthening the bones and muscles, removing rheumatism, benefiting joints and stopping diarrhea. The "materia medica justice" records: achyranthes root, radix Achyranthis bidentatae has the effects of removing dampness and heat, dredging collaterals, and eliminating accumulated toxicity of damp-heat. Has the functions of clearing heat and promoting diuresis. Used as adjuvant drug.
The specific implementation mode is as follows:
in order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention are described below clearly and completely, and it is obvious that the described embodiments are some, not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
By combining the traditional Chinese medicine theory and modern pathological research, the hyperuricemia, the gouty arthritis and the urate deposition are considered to be known in a whole process, and the concept of the gout disease is further provided, wherein the gout disease is a progressive metabolic disease closely related to the hyperuricemia and the urate deposition. Dysfunction of the spleen in transport and transformation and failure of the kidney in opening and closing due to improper diet and insufficient innate endowment, and endogenous dampness is the main etiology and pathogenesis of the rise of blood uric acid. The transformation of hyperuricemia to urate deposition is caused by dampness accumulation, aggravation of spleen and kidney dysfunction, formation of vicious circle, inability to discharge dampness out of body, and accumulation of dampness to produce phlegm. Phlegm turbidity obstruction obstructs the channels and collaterals, affects the circulation of qi and blood, causes pain due to obstruction, and has clinical manifestations of acute inflammation attack such as local severe pain, swelling, fever, limited activity, dysfunction and the like when the phlegm turbidity blood stasis is retained in joints and muscles and stimulated by factors such as cold, diet, severe exercise, emotion and the like.
Example 1:
28 parts of chicory root, 56 parts of tuckahoe and 16 parts of medicinal cyathula root are boiled and extracted by 10 times of hot water for 6 hours, and the obtained extract is concentrated and spray-dried to obtain dry paste powder of the traditional Chinese medicine composite extract.
Auxiliary materials: sorbitol, sucralose, magnesium stearate; adding sorbitol, sucralose and magnesium stearate into the dry extract powder of the traditional Chinese medicine composition, and preparing into granules by conventional methods such as dry granulation or wet granulation.
Example 2:
25 parts of chicory root, 60 parts of tuckahoe and 15 parts of medicinal cyathula root are boiled and extracted by 10 times of hot water for 6 hours, and the obtained extract is concentrated and spray-dried to obtain dry paste powder of the traditional Chinese medicine composite extract.
Auxiliary materials: maltodextrin, sorbitol; adding sorbitol and maltodextrin into the above dry extract powder, and making into oral liquid or functional beverage by conventional method.
Example 3:
28 parts of chicory root, 55 parts of tuckahoe and 17 parts of medicinal cyathula root are boiled and extracted by 10 times of hot water for 6 hours, and the obtained extract is concentrated and spray-dried to obtain dry paste powder of the traditional Chinese medicine composite extract.
Auxiliary materials: dextrin, magnesium stearate; adding dextrin and magnesium stearate into the dry extract powder of the Chinese medicinal composition extract, preparing into granules by a conventional method, and filling into capsules.
Example 4:
33 parts of chicory root, 52 parts of tuckahoe and 15 parts of medicinal cyathula root are boiled and extracted by 10 times of hot water for 6 hours, and the obtained extract is concentrated and spray-dried to obtain dry paste powder of the traditional Chinese medicine composite extract.
Auxiliary materials: maltodextrin, silicon dioxide, sorbitol, sucralose; adding maltodextrin, silicon dioxide, sorbitol and sucralose into the dry extract powder of the traditional Chinese medicine composition, and preparing into powder by a conventional method.
Example 5:
24 parts of chicory root, 64 parts of tuckahoe and 12 parts of medicinal cyathula root are boiled and extracted by 10 times of hot water for 6 hours, and the obtained extract is concentrated and spray-dried to obtain dry paste powder of the traditional Chinese medicine composite extract.
Auxiliary materials: CMS-Na, magnesium stearate; adding CMS-Na and magnesium stearate into the above dry extract powder, and making into tablet by conventional method.
Example 6:
23 parts of chicory root, 63 parts of tuckahoe and 14 parts of medicinal cyathula root are boiled and extracted by 10 times of hot water for 6 hours, and the obtained extract is concentrated and spray-dried to obtain dry paste powder of the traditional Chinese medicine composite extract.
Auxiliary materials: mannitol, silica; adding mannitol and silicon dioxide into the above dry extract powder, and making into tablet by conventional method.
Example 7:
26 parts of chicory root, 58 parts of tuckahoe and 16 parts of medicinal cyathula root are boiled and extracted by 10 times of hot water for 6 hours, and the obtained extract is concentrated and spray-dried to obtain dry paste powder of the traditional Chinese medicine composite extract.
Auxiliary materials: starch, magnesium stearate; adding starch and magnesium stearate into the above dry extract powder, and making into capsule by conventional method.
Example 8:
30 parts of chicory root, 56 parts of tuckahoe and 14 parts of medicinal cyathula root are boiled and extracted by 10 times of hot water for 6 hours, and the obtained extract is concentrated and spray-dried to obtain dry paste powder of the traditional Chinese medicine composite extract.
Auxiliary materials: stevioside, sucralose, silicon dioxide; adding stevioside, sucralose and silicon dioxide into the dry extract powder of the traditional Chinese medicine combination, and preparing the granules by the conventional methods such as dry granulation or wet granulation.
Example 9:
28 parts of chicory root, 58 parts of tuckahoe and 16 parts of medicinal cyathula root are boiled and extracted by 10 times of hot water for 6 hours, and the obtained extract is concentrated and spray-dried to obtain dry paste powder of the traditional Chinese medicine composite extract.
Auxiliary materials: stevioside, maltodextrin; adding stevioside and maltodextrin into the dry extract powder of the Chinese medicinal composition extract, and preparing oral liquid or functional beverage by a conventional method.
Example 10:
32 parts of chicory root, 54 parts of tuckahoe and 17 parts of medicinal cyathula root are boiled and extracted by 10 times of hot water for 6 hours, and the obtained extract is concentrated and spray-dried to obtain dry paste powder of the traditional Chinese medicine composite extract.
Auxiliary materials: lactose, CMC-Na, magnesium stearate; adding lactose into the above dry extract powder, adding CMC-Na and magnesium stearate, making into granule by conventional method, and making into capsule.
Example 11:
29 parts of chicory root, 56 parts of tuckahoe and 15 parts of medicinal cyathula root are boiled and extracted by 10 times of hot water for 6 hours, and the obtained extract is concentrated and spray-dried to obtain dry paste powder of the traditional Chinese medicine composite extract.
Auxiliary materials: dextrin, magnesium stearate; adding starch and magnesium stearate into the above dry extract powder, and making into capsule by conventional method.
Example 12:
26 parts of chicory root, 60 parts of tuckahoe and 14 parts of medicinal cyathula root are boiled and extracted by 10 times of hot water for 6 hours, and the obtained extract is concentrated and spray-dried to obtain dry paste powder of the traditional Chinese medicine composite extract.
Auxiliary materials: maltodextrin, silicon dioxide, sorbitol, sucralose; adding maltodextrin, silicon dioxide, sorbitol and sucralose into the dry extract powder of the traditional Chinese medicine composition, and preparing into powder by a conventional method.
Example 13:
29 parts of chicory root, 56 parts of tuckahoe and 15 parts of medicinal cyathula root are boiled and extracted by 10 times of hot water for 6 hours, and the obtained extract is concentrated and spray-dried to obtain dry paste powder of the traditional Chinese medicine composite extract.
Auxiliary materials: adding Mel and water into the above dry extract powder, adding water, making into pill, drying, and making into pill according to conventional process.
A traditional Chinese medicine preparation for preventing and treating gout is prepared by adding purified water with the mass ratio of 10 times of that of the traditional Chinese medicine composition in the embodiment 1-12, adopting a decoction method, and performing reflux extraction for 6 hours at 100 ℃ after boiling. Filtering the extractive solution with filter cloth plate frame to remove black residue to obtain mixed medicinal liquid, and concentrating under reduced pressure at-0.09 Mpa and 80 deg.C to obtain soft extract;
spray drying the obtained soft extract, slowly adjusting the frequency of the atomizer to a certain frequency, determining to be 15HZ-20HZ according to actual conditions, exhausting at 80-100 deg.C, and sieving with 60 mesh sieve to obtain Chinese medicinal composition paste powder; adding one or more of filler, correctant and lubricant according to required dosage form, sieving, mixing, and making into granule, powder, capsule, tablet, liquid, etc.
Case 1: liza, male, 47 years old. The main complaints are: blood uric acid is increased for more than 10 years, and ankle joint is interrupted for swelling and pain for half a year. The patient found elevated blood uric acid 10 years ago and was not treated regularly. The ankle joint swelling and pain of both sides appear half a year ago, and local hospitals diagnose the gouty arthritis and give medicines for reducing uric acid and diminishing inflammation and easing pain for treatment, which are not detailed specifically. The double ankle joint gall is taken 3 to 4 times in two months, each time lasts for one week, and the blood uric acid is about 474.6 mu mol/L. And (3) Western diagnosis: acute gouty arthritis, and the traditional Chinese medicine diagnosis: arthralgia syndrome, syndrome of obstruction of damp-heat. For treatment, it can clear heat and promote diuresis, invigorate spleen and resolve turbidity, and unblock collaterals to alleviate pain. The core medicines of the prescription, namely 6g of chicory root, 10g of tuckahoe and 2g of medicinal cyathula root are supplemented with blood-activating and arthralgia-relieving medicines, 1 dose of the medicine is taken every day by decocting with water, and the medicine is taken 2 times in the morning and at night. Order low-purine diet and refrain from drinking wine. After three weeks, the patient had no swelling and pain in both ankle joints, and after 3 months, uric acid was 246.7. mu. mol/L. Advising to maintain a low-purine diet, refraining from drinking wine, and making a double-check on the level of hematuria acid and the functions of liver and kidney at regular intervals. Gout does not reoccur half a year following. According to the following steps: in middle-aged men, blood uric acid rises for years, acute gout attack occurs, namely damp-heat phlegm is accumulated, meridians and collaterals are stagnated, joints are blocked, and pain is caused by obstruction. During treatment, chicory is used based on the basic principle of clearing heat and promoting diuresis, and dredging collaterals and relieving pain, poria is used for regulating qi activity of viscera to ensure that food essence is transported and distributed normally, and radix cyathulae is added to reduce accumulation of phlegm dampness and stasis and occurrence of arthralgia.
The above examples are only examples to express the specific embodiments of the present invention, and the description thereof is more specific, but not to be construed as limiting the scope of the application of the present invention; it should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (7)

1. A traditional Chinese medicine composition for preventing and treating gout is characterized in that: the feed is prepared from the following raw materials in parts by weight: 1-50 parts of chicory root, 20-80 parts of poria cocos and 1-30 parts of medicinal cyathula root.
2. The traditional Chinese medicine composition for preventing and treating gout according to claim 1, wherein: the material is prepared from the following raw materials in parts by weight: 15-40 parts of chicory root, 35-70 parts of poria cocos and 5-25 parts of medicinal cyathula root.
3. The traditional Chinese medicine composition for preventing and treating gout according to claim 2, wherein: the material is prepared from the following raw materials in parts by weight: 28 parts of chicory root, 56 parts of poria cocos and 16 parts of medicinal cyathula root.
4. The Chinese medicinal composition according to any one of claims 1 to 3, wherein the preparation method of the Chinese medicinal composition comprises the following steps:
s1, adding 10 times of purified water into the chicory root, the poria cocos and the radix cyathulae in parts by weight, boiling, extracting under reflux for six hours at 100 ℃, and filtering the extract by using a filter cloth plate frame to obtain a mixed liquid medicine;
s2, concentrating: concentrating the obtained mixed medicinal liquid under-0.09 Mpa at 80 deg.C under reduced pressure to obtain soft extract;
s3, preparing medicinal powder: spray drying the obtained soft extract with atomizer frequency of 15Hz-20Hz, air exhaust temperature of 80-100 deg.C, and sieving to obtain Chinese medicinal composition.
5. The traditional Chinese medicine composition according to any one of claims 1 to 3, wherein a pharmaceutically or physiologically acceptable adjuvant is added to the traditional Chinese medicine composition, and the adjuvant is one or more of a filler, a flavoring agent and a lubricant.
6. The composition of claim 5, wherein the composition is in the form of granules, powders, capsules, tablets, pills, liquids.
7. Use of the Chinese medicinal composition according to any one of claims 1 to 3 in the preparation of a medicament, health food or functional food for treating hyperuricemia and inflammation and pain induced thereby.
CN202110804719.0A 2021-07-16 2021-07-16 Traditional Chinese medicine composition for preventing and treating gout Pending CN113288925A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114847479A (en) * 2022-04-25 2022-08-05 知岐健康产业(山东)集团有限公司 Health food preparation with blood sugar and blood fat reducing function
CN115518132A (en) * 2022-10-24 2022-12-27 北京擎天数康科技有限公司 Chinese medicinal compound composition for preventing and treating hyperuricemia
CN116746680A (en) * 2023-06-17 2023-09-15 广东善百年特医食品有限公司 Uric acid-reducing gout-relieving diglyceride composition and preparation method and application thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
李文静等: ""整合论治"策略下张冰教授标本兼治痛风病临床实践", 《世界中医药》 *
胡新林等: "《痛风居家调养全典》", 30 September 2017, 中国科学技术出版社 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114847479A (en) * 2022-04-25 2022-08-05 知岐健康产业(山东)集团有限公司 Health food preparation with blood sugar and blood fat reducing function
CN115518132A (en) * 2022-10-24 2022-12-27 北京擎天数康科技有限公司 Chinese medicinal compound composition for preventing and treating hyperuricemia
CN116746680A (en) * 2023-06-17 2023-09-15 广东善百年特医食品有限公司 Uric acid-reducing gout-relieving diglyceride composition and preparation method and application thereof

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