CN104162063A - Traditional Chinese medicine compound preparation for treating hyperuricemia and production method thereof - Google Patents
Traditional Chinese medicine compound preparation for treating hyperuricemia and production method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine compound preparation for treating hyperuricemia and a production method thereof. The traditional Chinese medicine compound preparation is characterized by being prepared from scabrous elephantfoot herb as a main material, and blended with selfheal, rhizoma smilacis glabrae, semen coicis and hawthorn in a certain weight ratio. The traditional Chinese medicine compound preparation has the effects of promoting diuresis and removing obstruction of qi and blood circulation, and dispersing blood stasis and eliminating turbid liquid, and specially is used for the hyperuricemia induced by the stasis of dampness and turbid liquid. The traditional Chinese medicine compound preparation has the pharmacological actions of obviously reducing blood uric acid and accelerating uric acid metabolism.
Description
Technical field
[001] the present invention relates to medical technical field, specifically, relate to a kind of compound Chinese medicinal preparation for the treatment of hyperuricemia and preparation method thereof, a kind of pure compound Chinese medicinal preparation of take the treatment hyperuricemia that natural Chinese medicinal herb Scabrous Elephantfoot Herb makes as principal agent raw material and preparation method thereof.
Background technology
[002] from the viewpoint of the traditional Chinese medical science, hyperuricemia, belongs to " arthromyodynia ", and the category of " severe and migratory arthralgia ", is common clinical, frequently-occurring disease.Think weakness of the spleen and stomach, eating and drinking without temperance, exopathogen invasion and attack are Etiologicals.Weakness of the spleen and stomach causes transporting mistake department, endogenous damp formation, and with the passing of time heat-transformation, multiple abscess passages through which vital energy circulates is disease.Modern Chinese medicine thinks that too much uric acid belongs to that expectorant is turbid, turbid damp, strengthens the control to hyperuricemia, can effectively prevent developing of gout, has embodied the importance of traditional Chinese medical science preventive treatment of disease.[003] from the viewpoint of doctor trained in Western medicine, uric acid height can cause gout, and the acute attack of gout is that urate is in joint and the acute inflammatory reaction that causes with crystal form deposition of periarticular tissue.If gout untreated, urate increases in intraarticular deposition, and inflammation is repeatedly shown effect and entered chronic phase.
[004] in treatment, doctor trained in Western medicine is commonly used allopurinol tablet at present, and the medicine that adds probenecid sheet inhibition uricopoiesis reduces uric acid, and curative effect is pretty good substantially, but the side effect of allergic constitution and gastrointestinal upset is rather common.And the traditional Chinese medical science also has many side's medicines can treat hyperuricemia, can select Baihu Jia Guizhi Tang, SIMIAO WAN, clear numbness Medicine wine for activating the channels, Fufangshenjin capsules etc. according to the state of an illness, dialectical application can obtain certain curative effect, but raw material numerous and complicated, expensive and curative effect is still not ideal enough.
Summary of the invention
[0005] the object of this invention is to provide a kind of compound Chinese medicinal preparation of take the treatment hyperuricemia that Scabrous Elephantfoot Herb is principal agent.[0006] another object of the present invention is to provide the preparation method that antihyperuricemic compound Chinese medicinal preparation is controlled in a kind for the treatment of.[0007] compound Chinese medicinal preparation of the present invention is to take Scabrous Elephantfoot Herb as primary raw material, by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizoma Smilacis Glabrae, Semen Coicis, Fructus Crataegi, is made.[0008] compound Chinese medicinal preparation of the present invention has the effect of dampness removing dredging collateral, dissipating stasis and purging turbidity, is mainly used in treating hyperuricemia, and Syndrome Differentiation of Chinese Medicine is damp-heat arthralgia resistance type.Compound Chinese medicinal preparation of the present invention has remarkable reduction blood uric acid, accelerates the pharmacological action of urate excretion.[0009] preparation method of compound Chinese medicinal preparation of the present invention, it is prepared from by following weight portion proportioning by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizoma Smilacis Glabrae, Semen Coicis, Fructus Crataegi:
[0010] Scabrous Elephantfoot Herb 15-50
[0011] Semen Coicis 9-35
[0012] Spica Prunellae 9-20
[0013] Rhizoma Smilacis Glabrae 10-60
[0014] Fructus Crataegi 5-15
[0015] preparation method of preferred Chinese medicine composition of the present invention, it is prepared from by following weight portion proportioning by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizoma Smilacis Glabrae, Semen Coicis, Fructus Crataegi: [0016] Scabrous Elephantfoot Herb 15-50
[0017] Semen Coicis 9-35
[0018] Spica Prunellae 9-20
[0019] Rhizoma Smilacis Glabrae 10-60
[0020] preparation method of the further preferred compound Chinese medicinal preparation of the present invention of Fructus Crataegi 5-15 [0021], it is prepared from by following weight portion proportioning by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizoma Smilacis Glabrae, Semen Coicis, Fructus Crataegi: [0022] Scabrous Elephantfoot Herb 20-40
[0023] Semen Coicis 12-30
[0024] Spica Prunellae 12-18
[0025] Rhizoma Smilacis Glabrae 15-45
The preparation method of the compound Chinese medicinal preparation of the present invention that [0026] Fructus Crataegi 8-12 [0027] is best, it is prepared from by following weight portion proportioning by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizoma Smilacis Glabrae, Semen Coicis, Fructus Crataegi: [0028] Scabrous Elephantfoot Herb 30
[0029] Semen Coicis 15
[0030] Spica Prunellae 15
[0031] Rhizoma Smilacis Glabrae 10
[0032] Fructus Crataegi 9 [0033] a kind of compound Chinese medicinal preparation of controlling hyperuricemia of the present invention, it can make various dosage forms according to a conventional method, comprises the oral solid formulations such as granule, oral liquid, tablet, capsule, pill, decoction, powder.[0034] in various dosage forms, preferred a kind of granule of being made by following method, this preparation method is: [0035] A adds 4-8 times of water gaging by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizoma Smilacis Glabrae, Semen Coicis, Fructus Crataegi and decocts twice, for the first time 2-3 hour, for the second time 1-2 hour; [0036] B filters, merging filtrate;
[0037] centrifugal, the remove impurity of C, is condensed into relative density 1.2-1.3; [0038] D adds cane sugar powder, and soft material processed is granulated, and dry, granulate, is distributed into granule finished product.[0039] concrete instructions of taking and consumption: oral, every day 3 times, each 10ml.7 days acute stages were a course for the treatment of, and chronic phase one month is a course for the treatment of.[0040] in various dosage forms, preferred a kind of capsule of being made by following method also, this preparation method is: [0041] A adds 4-8 times of water gaging by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizoma Smilacis Glabrae, Semen Coicis, Fructus Crataegi and decocts twice, for the first time 2-3 hour, for the second time 1-2 hour; [0042] B filters, merging filtrate, and concentrated;
[0043] centrifugal, the remove impurity of C concentrated solution, filtrate is concentrated, is spray dried to fine powder; [0044] D fine powder adds appropriate amount of starch, microcrystalline Cellulose, and mix homogeneously is distributed in capsule, capsule finished product.[0045] each taste Chinese medicine in compound Chinese medicinal preparation of the present invention is crude drug.Scabrous Elephantfoot Herb in side is the rhizome of dicotyledon medicine feverfew Scabrous Elephantfoot Herb Herba Elephantopi.Nature and flavor toil, cold in nature.There is removing heat from blood, heat clearing away, dehumidifying, diuretic, detoxicating functions.Modern pharmacological research finds that Scabrous Elephantfoot Herb is except having anti inflammation and heat resolution effect, also thering is obvious antitumor action and leukocyte is had to obvious inhibitory action. its main component is lupeol, stigmasterol and sesquiterpenoids-Scabrous Elephantfoot Herb lactone, and its effective ingredient is Scabrous Elephantfoot Herb lactone.Scabrous Elephantfoot Herb (Elephantopus scaber L.), another name Herba Elephantopi scaberis, garden heliotrope, chicken disease are sticky, native Radix Bupleuri, horse are driven hundred emerging, Scabrous Elephantfoot Herb, mill Herba Sonerilae cantonensis.Perennial vertical herbage is high 30～60 centimetres.Sometimes the coarse wool of being all close to by white.Stem dichotomous branch, branch less and firmly, coarse.The large portion of single leaf base is raw, and cochlear or oval shape fall lanceolar, and long 5～15 centimetres, wide 2～4.5 centimetres, base portion is gradually narrow, the blunt or short point of tip, and edge is tool crenation slightly: stem leaf is few and thin, long 5～15 millimeters of petiole, base portion expands embraces a stem, or near stockless.Head inflorescence approximately has 4 of little Hua, is born in Zhi Ding; Conventionally have 3 phyllaries, bract is avette or oval shape is avette, long 1～1.5 centimetre; Head inflorescence has a plurality of in each bouquet, intensive; 8～10 millimeters of involucre lengths of a film; Holder is without hair; little Hua is tubulose entirely, both sexes, and lavender, long 7～9 millimeters, tip 4 splits, on one side cracking, the slightly wealthy exhibition of sliver; Stamen 4～5, slightly outside protruded tube; Ovary is the next, Room 1.Achene has rib, the long hard seta 4～6 of top tool.
[0046] a kind of compound Chinese medicinal preparation for the treatment of hyperuricemia of the present invention is to take Scabrous Elephantfoot Herb as principal agent, by five kinds of Chinese herbal medicine, be prepared from, its prescription science, reasonable, belong to the specially good effect side for the treatment of hyperuricemia, curative effect highly significant, existing prescription flavour of a drug have been overcome many, the shortcoming such as complex process, curative effect are not significantly, side effect is many.[0047] below, by clinical trial, further illustrate the drug action that the present invention treats hyperuricemia:
[0048] method: adopt Chinese medicine compound Scabrous Elephantfoot Herb granule (Scabrous Elephantfoot Herb, Spica Prunellae, Rhizoma Smilacis Glabrae, Semen Coicis, Fructus Crataegi) treatment metabolic arthritis 43 examples, and establish matched group (allopurinol tablet adds probenecid sheet) 38 examples and contrast.[0049] result: treatment group total effective rate 98.2%; Matched group total effective rate 84.0%, learns and processes by statistics, and difference is very significant (P < 0.01).
[0050] prompting: this method has the effect of dampness removing dredging collateral, dissipating stasis and purging turbidity to primary disease.
[0051] specific as follows:
[0052] clinical data observes that case is that Wengyuan County institute of traditional Chinese medicine tcm internal medicine is in hospital for 2011 and out-patient's totally 81 examples, and employing digital watch method is divided into two groups at random.Treatment group 43 examples, male's 36 examples, women's 7 examples, age 34-69 year, average 45.6 years old, course of disease 2d～18 year, average 3.11 years.Overweight people's 15 examples.Heating person's 2 examples before treatment, fast 11 examples of erythrocyte sedimentation rate, hyperuricemia 43 examples, leucocytosis 13 examples, hyperlipemia 18 examples, B is super: renal calculus 5 examples, fatty liver 11 examples; Matched group 38 examples, male 31 examples, female's 7 examples, 29～70 years old age, average 46.2 years old, course of disease 1d～16 year, average 2.9 years.Overweight people's 13 examples.Heating person's example before treatment, fast 3 examples of 5 erythrocyte sedimentation rates, hyperuricemia 38 examples, leucocytosis 9 examples, hyperlipemia 12 examples, B ultrasonic: renal calculus 3 examples, fatty liver 7 examples.2 groups of clinical datas, basic identical, there is stronger comparability.Diagnostic criteria according to American Rheumatism Association in 1997 about acute gouty arthritis criteria for classification.Differentiation of symptoms and signs for classification of syndrome pyretic arthralgia: redness and swelling of joints burning pain, generate heat thirsty, red tongue with yellow fur, slippery and rapid pulse.Arthralgia due to cold: arthralgia is miserable, or enlargement distortion, meet cold increasing the weight of, or tophus, or ulceration stream white paste, and tongue is greasy in vain, stringy and tense pulse.[0053] Therapeutic Method treatment group: compound recipe Scabrous Elephantfoot Herb granule (forms: Scabrous Elephantfoot Herb, Spica Prunellae, Rhizoma Smilacis Glabrae, Semen Coicis, Fructus Crataegi.Usage: 1 dose of every day, decocting 2 times, sooner or later decoction being taken warmly; Matched group: allopurinol tablet, 100mg, every day 3 times, probenecid sheet (first 0.25g, every day 2 times), according to circumstances by-election Sodium Bicarbonate Tablets alkalized urine.2 groups all take treatment 7d be 1 course for the treatment of, finish to add up therapeutic outcome 4 courses for the treatment of.[0054] criterion of therapeutical effect clinical cure: in blood and urine, uric acid content is normal, follows up a case by regular visits to normal person in January.Effective: in blood and urine, uric acid content obviously reduces.Invalid: unchanged before and after blood and urine treatment.[0055] 2 groups of clinical cure rate comparisons of therapeutic outcome (P < 0.01), difference has highly significant meaning, and treatment group is obviously better than matched group.[0056] hyperuricemia being discussed, to cause the reason of gout be because purine metabolic disturbance causes uric acid metabolism not normal.In treatment, Western medicine adds uricosuric allopurinol tablet mainly with suppressing uricopoiesis, adds probenecid sheet, if desired, use alkalescent medicine alkalized urine, reduce uric acid, still lack radical cure measure, once the drug withdrawal state of an illness easily repeatedly, and said medicine side effect is all larger, has increased the difficulty of prolonged application.Use tcm syndrome differentiation and treatment, phlegm-damp turbid pathogen is got rid of external, hot and suffocating clearly, and interior environment is tended to balance, and hyperuricemia is removed and disease is fully recovered.This Study of Traditional Chinese Medicine treatment metabolic arthritis disease is different from traditional arthromyodynia Coryza Treated by Syndrome Differentiation, and tradition thinks that the many damp and hot evil numbness resistance joint stasis blocking QI and blood of exopathogen or interior life that wait because wind and cold is damp and hot of primary disease fall ill.The rule for the treatment of is with the effect of dampness removing dredging collateral, dissipating stasis and purging turbidity, and Syndrome Differentiation of Chinese Medicine is damp-heat arthralgia resistance type.Compound Chinese medicinal preparation of the present invention has remarkable reduction blood uric acid, accelerates the pharmacological action of urate excretion.
The specific embodiment
[057] form by the following examples further illustrates a kind of compound Chinese medicinal preparation and preparation method for the treatment of hyperuricemia of the present invention, but this should be interpreted as to restriction of the present invention.The technology that all genus foregoing of the present invention is realized all belongs to category of the present invention.
[0058] embodiment 1
[0059] treat a Chinese native medicine compound prescription pellet agent for hyperuricemia, it is prepared from by following weight portion proportioning by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizoma Smilacis Glabrae, Semen Coicis, Fructus Crataegi:
[0060] Scabrous Elephantfoot Herb 30
[0061] Semen Coicis 15
[0062] Spica Prunellae 15
[0063] Rhizoma Smilacis Glabrae 10
[0064] Fructus Crataegi 9
[0065] preparation method of above-mentioned granule is:
[0066] A adds 4-8 times of water gaging decoction twice, for the first time 2-3 hour, for the second time 1-2 hour by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizoma Smilacis Glabrae, Semen Coicis, Fructus Crataegi; [0067] B filters, merging filtrate;
[0068] centrifugal, the remove impurity of C, is condensed into relative density 1.2-1.3; [0069] D adds cane sugar powder, and soft material processed is granulated, and dry, granulate, is distributed into granule, 10 grams every bag.
[0070] embodiment 2
[0071] treat a Herbal compound capsule agent for hyperuricemia, it is prepared from by following weight portion proportioning by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizoma Smilacis Glabrae, Semen Coicis, Fructus Crataegi:
[0072] Scabrous Elephantfoot Herb 30
[0073] Semen Coicis 15
[0074] Spica Prunellae 15
[0075] Rhizoma Smilacis Glabrae 10
[0076] Fructus Crataegi 9
[0077] preparation method of above-mentioned capsule is:
[0078] A adds 4-8 times of water gaging decoction twice, for the first time 2-3 hour, for the second time 1-2 hour by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizoma Smilacis Glabrae, Semen Coicis, Fructus Crataegi; [0079] B filters, merging filtrate;
[0080] centrifugal, the remove impurity of C, is condensed into relative density 1.10-1.15, is spray dried to fine powder; [0081] D fine powder adds appropriate amount of starch, microcrystalline Cellulose, and mix homogeneously is distributed in capsule, 0.4 gram every.
[0082] embodiment 3
[0083] treat a traditional Chinese medicine compound oral liquid for hyperuricemia, it is prepared from by following weight portion proportioning by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizoma Smilacis Glabrae, Semen Coicis, Fructus Crataegi:
[0084] Scabrous Elephantfoot Herb 30
[0085] Semen Coicis 15
[0086] Spica Prunellae 15
[0087] Rhizoma Smilacis Glabrae 10
[0088] Fructus Crataegi 9
[0089] preparation method of above-mentioned oral liquid is:
[0090] A adds 4-8 times of water gaging decoction twice, for the first time 2-3 hour, for the second time 1-2 hour by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizoma Smilacis Glabrae, Semen Coicis, Fructus Crataegi; [0091] B filters, merging filtrate;
[0092] centrifugal, the remove impurity of C, adds purified water to 100ml.
[0093] D is distributed into every 10ml, 105 ° of C pressure sterilizings sterilizing 30 minutes.
Claims (6)
1. treat compound Chinese medicinal preparation of hyperuricemia and preparation method thereof for one kind, be characterised in that and take Scabrous Elephantfoot Herb as principal agent.
2. compound Chinese medicinal preparation described in the claims in the present invention, is characterized in that take that Scabrous Elephantfoot Herb is as principal agent, is equipped with Spica Prunellae, Rhizoma Smilacis Glabrae, Semen Coicis, Fructus Crataegi and is prepared from by certain part by weight proportioning.
3. according to the weight proportion described in claims 2, be Scabrous Elephantfoot Herb 15-50, Semen Coicis 9-35, Spica Prunellae 9-20, Rhizoma Smilacis Glabrae 10-60, Fructus Crataegi 5-15.
4. according to claims 3, optimum weight proportioning is, Scabrous Elephantfoot Herb 30, Semen Coicis 15, Spica Prunellae 15, Rhizoma Smilacis Glabrae 10, Fructus Crataegi 9.
5. according to claims 1, the dosage form comprising comprises the oral solid formulations such as granule, oral liquid, tablet, capsule, pill, decoction, powder.
6. the Scabrous Elephantfoot Herb of take of claims 1,2 any one is that main folk prescription or compound recipe or compositions reduce the application of the aspects such as high hematuria acid disease and gout.
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| CN110327434A (en) * | 2019-08-14 | 2019-10-15 | 吉林省特医食品生物科技有限公司 | A kind of Chinese medicine composition that treating gout, compound Chinese medicinal preparation and preparation method thereof |
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Cited By (3)
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| CN106039131A (en) * | 2016-08-10 | 2016-10-26 | 郑州大学第附属医院 | Traditional Chinese medicinal compound preparation for treating IgA nephrosis with hyperuricemia, and preparation method and use thereof |
| CN106039131B (en) * | 2016-08-10 | 2019-11-22 | 郑州大学第一附属医院 | A kind of compound Chinese medicinal preparation and its preparation method and application treated IgA nephrosis and merge hyperuricemia |
| CN110327434A (en) * | 2019-08-14 | 2019-10-15 | 吉林省特医食品生物科技有限公司 | A kind of Chinese medicine composition that treating gout, compound Chinese medicinal preparation and preparation method thereof |
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