CN103169836A - Medicament for preventing and treating viral hepatitis of ducklings - Google Patents
Medicament for preventing and treating viral hepatitis of ducklings Download PDFInfo
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- CN103169836A CN103169836A CN2013101118129A CN201310111812A CN103169836A CN 103169836 A CN103169836 A CN 103169836A CN 2013101118129 A CN2013101118129 A CN 2013101118129A CN 201310111812 A CN201310111812 A CN 201310111812A CN 103169836 A CN103169836 A CN 103169836A
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Abstract
The invention relates to a medicament for preventing and treating viral hepatitis of ducklings and belongs to the technical field of medicine and medical engineering. The medicament consists of the following components in parts by weight: 5-15 parts of radix gentianae, 5-15 parts of flos lonicerae, 5-15 parts of cyrtomium rhizome, 5-15 parts of selfheal, 4-12 parts of uncaria, 4-12 parts of notopterygium, 4-12 parts of radix angelicae pubescentis, 4-12 parts of herba artemisiae scopariae, 3-10 parts of radix paeoniae alba, 3-10 parts of turtle shell, 3-10 parts of rhizoma dioscoreae colletii, 3-10 parts of pericarpium citri reticulatae viride, 2-6 parts of rhubarb, 2-6 parts of gardenia, 2-6 parts of jujube and 2-6 parts of liquorice. The Chinese herbal medicines are dried, weighed, ground, sieved by using a 60-80-mesh sieve, and mixed and stirred evenly. In clinical application, the medicament is soaked by using boiling water for 30-60 minutes to sufficiently dissolve and precipitate effective components of the medicament so as to be beneficial to the absorption in bodies of infected ducks, simultaneously a small amount of saccharides and Vc is added, and lysine, somatotropin and yeast powder are added into a feed for the ducklings according to the instructions, so that the medicament efficacy can be improved. The medicament is high in clinical cure rate without adverse reaction or drug resistance hidden trouble, easily available in raw materials, simple in preparation and convenient to use, and can be widely applied in the duck breeding industry.
Description
Technical field:
The invention belongs to medicine and engineering in medicine technical field, particularly a kind of medicine that relates to control Duck Hepatitis Virus disease.
Background technology:
Since reform and opening-up; along with improving constantly of people's living standard; demand to animal derived food is diversified trend; daily diet structure also quietly changes; increasingly raise as the consumption figure to Ovum Anas domestica, duck meat, under the potential demand in market, support the duck industry and also be able to fast development; transfer scale, intensive modern breeding way to by traditional mode of raising scattered, its production efficiency and cultivation income all have significantly raising.Foster duck had become the column support type industry of shaking off poverty and setting out on the road to prosperity some rural area already, yet the duck disease is still the key factor of harm and the foster duck industry healthy and sustainable development of restriction.As sick in Duck Hepatitis Virus, this is a kind of acute infectious disease of duckling, and this cause of disease is a kind of picornavirus, spreads all over both at home and abroad.3 ages in week, five ages in week were multiple with interior young duck with the easy infection of interior duckling, and general winter-spring season is easily sent out, and sickness rate is up to 100%, and mortality rate can be up to more than 90%, and often provisions duck industry is brought serious economic loss.This virus is many infects duckling by respiratory tract and two route of infection of digestive tract, and incubation period is short, and morbidity is anxious, dead fast, and opisthotonus is the peculiar symptom of primary disease.Primary disease shows as clinically that the disease duck peels off, necking down, the back of a bow, the wing that hangs down, thirsty, body temperature front low after high, lie on one's side and pedal ground, spasm rotation, opisthotonus, some ducks are suffered from diarrhoea, dead front-seat white or green loose stool.Pathology cuts open that inspection one's own judgment hepatomegaly, matter are soft, subcapsular hemorrhage, and gallbladder, kidney, splenomegaly, cardiac muscle are soft, pulmonary venous pleonaemia, intestinal mucosa swelling, hyperemia etc.In prior art, disclosed medicine for the control Duck Hepatitis Virus mainly contains biological preparation for animals (as vaccine, serum and egg yolk), Western medicine (as moroxydine, virazole etc.) and herbal medicine three major types, although the three all has certain prevention effect to this disease, also exist such or such problem.As use the vaccine control primary disease to carry out active immunity or when using serum (or egg yolk) to carry out passive immunity, often affect immune effect because of factors such as immunity time, immunizing dose, inoculation positions, so far fail large scale application, what have does not even do immunity; The control primary disease such as Western medicine commonly used such as moroxydine, virazole, certain curative effect is arranged when beginning to use, but along with prolonged application, even abuse the reasons such as abuse, its curative effect descends year by year, the drug resistance strain constantly produces, and drug residue in animal body also constitutes a threat to food safety, and its drawback day by day highlights; Though other commercially available herbal medicine such as duckling health, the peaceful drawback without above-mentioned Western medicine of duckling, but consist of on and methods for using them at formula and also have some technological deficiency, not rigorous curative effect is not good enough because filling a prescription, often the direct spice of drug powder is fed on application process, delayed sick duck to the absorption rate of effective ingredient, prevention effect is also unsatisfactory.Therefore, on the basis of existing public technology, control Duck Hepatitis Virus disease is carried out technological innovation necessary.
Goal of the invention:
Purpose of the present invention to provide exactly a kind of determined curative effect, cure rate higher, have no side effect, the pure Chinese herbal medicine of drug residue free, the control Duck Hepatitis Virus disease that is difficult for developing immunity to drugs.
Summary of the invention:
for realizing purpose of the present invention, the inventor has carried out experimental study and checking repeatedly for many years, paid hard work, filter out a plurality of Chinese herbal medicine formulas, finally determined formula of the present invention through optimal design, its composition is expressed as with mass fraction: Radix Gentianae 5-15 part, Flos Lonicerae 5-15 part, Rhizoma Osmundae 5-15 part, Spica Prunellae 5-15 part, Ramulus Uncariae Cum Uncis 4-12 part, Rhizoma Et Radix Notopterygii 4-12 part, Radix Angelicae Pubescentis 4-12 part, Herba Artemisiae Scopariae 4-12 part, Radix Paeoniae Alba 3-10 part, Carapax Trionycis 3-10 part, Rhizoma Dioscoreae Septemlobae 3-10 part, Pericarpium Citri Reticulatae Viride 3-10 part, Radix Et Rhizoma Rhei 2-6 part, Fructus Gardeniae 2-6 part, Fructus Jujubae 2-6 part, Radix Glycyrrhizae 2-6 part.The 60-80 mesh sieve is dried, weighs, was crushed to said herbal medicine, puddle and evenly namely get finished product of the present invention.
The usage and dosage of medicine of the present invention is as follows:
A, usage: claim medicated powder to pour in Porcelain Jar or pottery urn (avoid with canisters such as ferrum, aluminum, to avoid reaction, affect the treatment) according to duck group quantity, the state of an illness, consumption, then add 5-10 times of boiling water of medicated powder amount, the lid mouth soaked stewing 30-60 minute.Can make like this effective ingredient of medicine fully dissolve and separate out, when the medicine temperature is down to room temperature, take to duck group disposable throwing before at dusk after the former powder of Vc that adds 10% white sugar and 200pp by the medicine juice amount is mixed thoroughly, the medicinal residues spice is used in conjunction 3-5 days.Simultaneously, add commercially available lysine, auxin and yeast powder by operation instruction in feedstuff, be intended to slow down the state of an illness, reduce death, impel duck group rehabilitation.
B, consumption: therapeutic dose 1-2g/ is only. day, preventive dose 0.5-1g/ is only. day, be used in conjunction 3-5 days.
Prescription is resolved:
The present invention is that the traditional Chinese veterinary medicine traditional according to motherland is theoretical, in conjunction with the characteristic of Duck Hepatitis Virus through dialectical and design.This disease is a kind of acute contagious disease of duckling, anxious to fall ill, propagate fast, case fatality rate is high and the remarkable enlargement of liver, hemorrhage, kidney, spleen, lung, intestinal mucosa swelling in various degree are hemorrhage, gallbladder swelling, myocardium deliquescing and tic, opisthotonus is principal character.Chinese veterinarian thinks, the epidemic febrile disease category that during this disease belongs to, beast is learned.It is characterized by the state of an illness anxious, change many, thermal image weight, injuring YIN due to production of dryness.Dialectical with defensive-qi-nutrient-blood, and think that at first duck hepatitis virus invade respiratory tract and digestive tract and violate and defend, defend minute admittedly, then violate gas, edema caused by disorder of QI is not understood, and joins the army minute, and battalion is minute puzzled, enters blood system.Blood stored in the liver, kidney storing essence, therefore the blood system disease becomes the master with liver-kidney diseases, Clinical symptoms is that heating, coma, body of the tongue are fallen deeply, stiffness of the nape and back, a burst of tic, the hemorrhage blood system disease that waits of internal organs organ swelling is waited.Carefully distinguish according to card, this disease belongs to typical stirring of wind due to liver-heat pattern of syndrome in blood system disease (totally four kinds of pattern of syndrome), therefore should establish heat-clearing and toxic substances removing, suppressing the hyperactive liver to relieve the wind syndrome is the rule for the treatment of.To form main force's square formation be monarch drug therefore at first establish Radix Gentianae, Flos Lonicerae, Rhizoma Osmundae, Spica Prunellae combination among the strong ones in formula, guarantees effective efficacy of a drug of removing fire from the liver of the present invention, Disperse hepatic depression, clear distemper, solution epidemic disease poison; The Ramulus Uncariae Cum Uncis of calming liver and clearing heat, endogenous wind stopping relieving convulsion is good in inferior choosing, and curing mainly rigidity of the neck, spasm of the limbs, wind dispelling and obstruction eliminating has the famous medicine Herba Artemisiae Scopariae of Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis and the clearing away damp-heat of large merit, sharp jaundice to be altogether ministerial drug, assists monarch drug to strengthen drug effect; Transfer again kind easing the affected liver to relieve pain the Radix Paeoniae Alba, be longer than softening liver spleen Carapax Trionycis, control nephritis expelling pathogenic factors from muscles convulsion and have large merit De Rhizoma Dioscoreae Septemlobae and dispersing the depressed liver-QI for alleviating pain, promoting QI to circulate and dispersing the agglomeration of the pathogens famous medicine Pericarpium Citri Reticulatae Viride to be altogether adjuvant drug, jointly assist a ruler in governing a country the monarch and his subjects to get rid of evils; The Radix Glycyrrhizae of the Fructus Jujubae of the Radix Et Rhizoma Rhei of the kind heat-clearing and toxic substances removing of group, Fructus Gardeniae, kind nourishing blood to tranquillize the mind, invigorating the spleen and replenishing QI is altogether for making medicine again, and double righting is intended to get rid of evils.Be that Radix Et Rhizoma Rhei, Fructus Gardeniae can heal heresy in external from digestive tract and urinary tract respectively, exempt " close door and stay the bandit " and suffer from afterwards; Fructus Jujubae and Radix Glycyrrhizae not only coordinating the actions of various ingredients in a prescription but also harmonizing yingfen and weifen relax the suddenly high of antidote, just hinder in case capture too far.
Take a broad view of full side, the present invention fills a prescription rigorous, monarch, minister, helps, makes that Each performs its own functions, coordination linkage, plays the medicine merit altogether.In addition, also increased by two foreign aid's medicines of saccharide and Vc when clinical practice, can fast supply support with strong muscle power, power heals; Add lysine, auxin and yeast powder by explanation again in the duck material, more strengthened the centralizing function of getting rid of evils of the present invention.Therefore, the present invention has higher clinical cure rate than other related drugs.
The specific embodiment: following examples are in order to illustrate the present invention.
Embodiment 1:
Supply the examination time: in December, 2006.
For trying the place: Fan Jing mountain, Shahe City, Hebei province duckery.
For examination duck group: 18 ages in days, 2600 Kang Beier commercial generation laying ducks, because not doing immunity, very cold, the factors such as improper ventilation are broken out the Duck Hepatitis Virus disease, with the group with giving up.
For the reagent thing: i.e. pure Chinese herbal and crude drugs preparations of the present invention, each crude drug of distinguishing the flavor of is all available from oriental drug city, Anguo City, Hebei province, and its composition is expressed as by mass fraction: 5 parts of Radix Gentianaes, 5 parts of Flos Loniceraes, 5 parts of Rhizoma Osmundae, 5 parts of Spica Prunellaes, 4 parts of Ramulus Uncariae Cum Uncis, 4 parts of Rhizoma Et Radix Notopterygiis, 4 parts of Radix Angelicae Pubescentiss, 4 parts of Herba Artemisiae Scopariaes, 3 parts of the Radix Paeoniae Albas, 3 parts of 3 parts of, Rhizoma Dioscoreae Septemlobae of Carapax Trionycis, 3 parts, Pericarpium Citri Reticulatae Viride, 2 parts of Radix Et Rhizoma Rhei, 2 parts of Fructus Gardeniaes, 2 parts, Fructus Jujubae, 2 parts, Radix Glycyrrhizae.80 mesh sieves are dried, weigh, pulverized to said herbal medicine, and stirring gets final product to get finished product of the present invention.
Test group: 1300, use Drug therapy of the present invention.
Matched group: 1300, with Western medicine moroxydine (moroxydine hydrochloride) treatment.
The test group step is as follows:
1. claim medicine: every duck medication 1 gram, nominal are got 1300 gram medicines of the present invention and are poured in Porcelain Jar.
2. soak: add boiling water 6500g in cylinder, add a cover and soak stewing 30 minutes.
3. dosing: when the medicine juice temperature is down to 20-25 ℃, add the former powder of 650g white sugar and 1.3gVc, stir.
4. throw clothes: before the dusk feeding, give this medicinal liquid of the disposable input of duck group, the medicinal residues spice is appointed the free drink-service of duck, is searched for food, and severe one gavages; Add lysine, auxin and yeast powder by operation instruction in former duck material simultaneously.
5. course for the treatment of: continuous use 3 days.
Matched group: press 0.1g/ only. inferior calculating, take the former powder of 130g moroxydine, to pour in 6500g drinking-water and stir, concentration is 2%, before the dusk feeding, gives this medicinal liquid of the disposable input of duck group, appoints the free drink-service of duck.Continuous use 3 days.
Result of the test is listed in the table below: unit: a .%
Result shows: test group exceeds 22.61 percentage points than the cure rate of matched group.
Embodiment 2:
Supply the examination time: in March, 2009.
For trying the place: Linzhang County, the Hebei province refined duckery of Song.
For examination duck group: 27 ages in days, 3000 commercial generation Growth of Cherry Valley laying ducks, because not doing immunity, climate change, the factors such as miscarriage are broken out the Duck Hepatitis Virus disease, with the group with giving up.
For the reagent thing: i.e. pure Chinese herbal and crude drugs preparations of the present invention, the crude drug buying is with embodiment 1, and its composition is expressed as by mass fraction: 15 parts of Radix Gentianaes, 15 parts of Flos Loniceraes, 15 parts of Rhizoma Osmundae, 15 parts of Spica Prunellaes, 12 parts of Ramulus Uncariae Cum Uncis, 12 parts of Rhizoma Et Radix Notopterygiis, 12 parts of Radix Angelicae Pubescentiss, 12 parts of Herba Artemisiae Scopariaes, 10 parts of the Radix Paeoniae Albas, 10 parts of 10 parts of, Rhizoma Dioscoreae Septemlobae of Carapax Trionycis, 10 parts, Pericarpium Citri Reticulatae Viride, 6 parts of Radix Et Rhizoma Rhei, 6 parts of Fructus Gardeniaes, 6 parts, Fructus Jujubae, 6 parts, Radix Glycyrrhizae.Processing method is with embodiment 1.
Test group: 1500, use Drug therapy of the present invention.
Matched group: 1500, with commercially available herbal medicine duckling health treatment.
The test group step is as follows:
1. claim medicine: every duck medication 2 grams, nominal are got 3000 gram medicines of the present invention and are poured in Porcelain Jar.
2. soak: add boiling water 30000g in cylinder, add a cover and soak stewing 60 minutes.
3. dosing: when the medicine juice temperature is down to 20-25 ℃, add the former powder of 3000g soft plantation white sugar and 6gVc, stir.
4. throw clothes: with embodiment 1.
5. course for the treatment of: continuous use 5 days.
Matched group: take duckling health 3000g, every same test group of duck consumption, direct spice, disposable throwing clothes, appoint the duck free choice feeding, continuous use 5 days before at dusk.
Result of the test is listed in the table below: unit: a .%
Result shows: test group exceeds 10.47 percentage points than the cure rate of matched group.
Claims (3)
1. medicine of preventing and treating the Duck Hepatitis Virus disease is characterized in that its composition is expressed as with mass fraction:
Radix Gentianae 5-15 part, Flos Lonicerae 5-15 part, Rhizoma Osmundae 5-15 part, Spica Prunellae 5-15 part, Ramulus Uncariae Cum Uncis 4-12 part, Rhizoma Et Radix Notopterygii 4-12 part, Radix Angelicae Pubescentis 4-12 part, Herba Artemisiae Scopariae 4-12 part, Radix Paeoniae Alba 3-10 part, Carapax Trionycis 3-10 part, Rhizoma Dioscoreae Septemlobae 3-10 part, Pericarpium Citri Reticulatae Viride 3-10 part, Radix Et Rhizoma Rhei 2-6 part, Fructus Gardeniae 2-6 part, Fructus Jujubae 2-6 part, Radix Glycyrrhizae 2-6 part.
2. by the medicine of control Duck Hepatitis Virus disease claimed in claim 1, it is characterized in that its composition is expressed as with mass fraction:
5 parts of Radix Gentianaes, 5 parts of Flos Loniceraes, 5 parts of Rhizoma Osmundae, 5 parts of Spica Prunellaes, 4 parts of Ramulus Uncariae Cum Uncis, 4 parts of Rhizoma Et Radix Notopterygiis, 4 parts of Radix Angelicae Pubescentiss, 4 parts of Herba Artemisiae Scopariaes, 3 parts of the Radix Paeoniae Albas, 3 parts of 3 parts of, Rhizoma Dioscoreae Septemlobae of Carapax Trionycis, 3 parts, Pericarpium Citri Reticulatae Viride, 2 parts of Radix Et Rhizoma Rhei, 2 parts of Fructus Gardeniaes, 2 parts, Fructus Jujubae, 2 parts, Radix Glycyrrhizae.
3. by the medicine of control Duck Hepatitis Virus disease claimed in claim 1, it is characterized in that its composition is expressed as with mass fraction:
15 parts of Radix Gentianaes, 15 parts of Flos Loniceraes, 15 parts of Rhizoma Osmundae, 15 parts of Spica Prunellaes, 12 parts of Ramulus Uncariae Cum Uncis, 12 parts of Rhizoma Et Radix Notopterygiis, 12 parts of Radix Angelicae Pubescentiss, 12 parts of Herba Artemisiae Scopariaes, 10 parts of the Radix Paeoniae Albas, 10 parts of 10 parts of, Rhizoma Dioscoreae Septemlobae of Carapax Trionycis, 10 parts, Pericarpium Citri Reticulatae Viride, 6 parts of Radix Et Rhizoma Rhei, 6 parts of Fructus Gardeniaes, 6 parts, Fructus Jujubae, 6 parts, Radix Glycyrrhizae.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310111812.9A CN103169836B (en) | 2013-04-02 | 2013-04-02 | Medicament for preventing and treating viral hepatitis of ducklings |
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| CN201310111812.9A CN103169836B (en) | 2013-04-02 | 2013-04-02 | Medicament for preventing and treating viral hepatitis of ducklings |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104208551A (en) * | 2014-08-17 | 2014-12-17 | 严中明 | Traditional Chinese medicine composition for treatment of infectious hepatitis of duck |
| CN107981089A (en) * | 2017-12-14 | 2018-05-04 | 安徽金冠农牧科技有限公司 | A kind of feed for preventing Duck Hepatitis Virus and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679898A (en) * | 2005-01-13 | 2005-10-12 | 刘桂香 | Chinese medicine composition for treating hepatitis and cancers |
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2013
- 2013-04-02 CN CN201310111812.9A patent/CN103169836B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679898A (en) * | 2005-01-13 | 2005-10-12 | 刘桂香 | Chinese medicine composition for treating hepatitis and cancers |
Non-Patent Citations (1)
| Title |
|---|
| 何永明: "探析鸭病毒性肝炎的中草药治疗", 《广东畜牧兽医科技》, vol. 21, no. 01, 31 March 1996 (1996-03-31) * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104208551A (en) * | 2014-08-17 | 2014-12-17 | 严中明 | Traditional Chinese medicine composition for treatment of infectious hepatitis of duck |
| CN107981089A (en) * | 2017-12-14 | 2018-05-04 | 安徽金冠农牧科技有限公司 | A kind of feed for preventing Duck Hepatitis Virus and preparation method thereof |
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| CN103169836B (en) | 2014-07-02 |
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