CN103142766B - Medicine for controlling coccidiosis in rabbits - Google Patents
Medicine for controlling coccidiosis in rabbits Download PDFInfo
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- CN103142766B CN103142766B CN201310111813.3A CN201310111813A CN103142766B CN 103142766 B CN103142766 B CN 103142766B CN 201310111813 A CN201310111813 A CN 201310111813A CN 103142766 B CN103142766 B CN 103142766B
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Abstract
The invention provides a medicine for controlling coccidiosis in rabbits, belonging to the technical field of pharmaceutical and medical engineering. The medicine comprises the following components in parts by weight: 1.5-4.5 parts of java brucea fruit, 5-15 parts of radix bupleuri, 5-15 parts of antifebrile dichroa root, 5-15 parts of sweet wormwood herb, 4-12 parts of radix gentianae macrophyllae, 4-12 parts of flying squirrels droppings, 10-20 parts of dahurian patrinia herb, 10-20 parts of callicarpa bodinieri, 3-10 parts of white hyacinth bean, 3-10 parts of garden burnet root, 3-10 parts of pagoda tree flower, 3-10 parts of largehead atractylodes rhizome, 3-10 parts of agrimony and 3-10 parts of talc. The medicine is prepared by drying the above Chinese herbal medicines in the sun, weighing the dried medicines, grinding the weighed medicines, sieving the powder with a 60-80-mesh sieve and mixing the powder uniformly. During application, the medicine is soaked in boiling water for 30-60 minutes so that the active ingredients of the medicine are fully dissolved and precipitated to be beneficial to absorption of rabbit bodies, and at the same time, the condition can be alleviated, recovery can be accelerated and the medicine efficacy can be improved by adding a few sugars and Vc, reducing the content of the crude proteins in the rabbit concentrated feed to 10-15% and adding vitamin A and vitamin K. The medicine has higher clinical cure rate, does not have adverse reactions, does not generate medicine resistance easily, avoids medicine residues in rabbit bodies, has easily obtained needed raw materials, is simple to prepare and convenient to use and can be widely applied in rabbitry.
Description
Technical field:
The invention belongs to medicine and engineering in medicine technical field, particularly a kind of medicine of preventing and treating rabbit coccidiosis that relates to.
Background technology:
China is since reform and opening-up, and rabbit keeping is able to flourish, becomes an effective way of vast wealth accumulation in rural areas, the column support type industry that becomes local economic development having, and China has become Yang Tu big country.But; along with scale, the intensive degree of rabbit keeping improve constantly; rabbit has become the important restriction factor of rabbit keeping sustainable and healthy development; if rabbit coccidiosis is exactly the protozoacide of serious harm rabbit keeping; this disease is caused by the various coccidiosis in sporozoa Eucoccida Eimeriidae; spread all over all over the world; host type is a lot; 4 monthly ages very easily infected with interior young rabbit; under the mode of intensive raising, very easily occur, often cause impaired development, even large quantities of death; case fatality rate approximately 80%, thus serious economic loss caused.This sick clinical manifestation has three kinds of visible peristalsis visible intestinal peristalsis, liver type and Combination, but common with mixed type, its clinical symptoms main manifestations is for subtracting food or useless food, stupefied, fever, saliva and eye nasal discharge increase, diarrhoea, hepatalgia, frequent micturition, there is the nervous symptoms such as spasm or paralysis in the later stage, head and neck layback, tic of the limbs, screams and die.Cut open inspection visible intestinal bleeding inflammation, liver enlargement, adularescent or the faint yellow focus differing in size.Disclosedly in prior art mainly contain Western medicine and the large class of herbal medicine two for preventing and treating the medicine of rabbit coccidiosis, although the two all has certain prevention effect to this disease, also exist such or such technical problem.Conventional Western medicine is as Robenidine, sulfadimethoxine (SDM), sulfaclozine (E
3b
3), sulfadimidine (SM
2), the treatment primary disease such as Salinomycin, Amprolium, while starting to apply, curative effect is fair, but along with prolonged application for many years, application, even abuses the reasons such as abuse repeatedly, and its curative effect declines year by year, drug-resistant worm plant constantly produces, strengthening dose had both increased cost, and medicine is in animal body residual again food safety is constituted a threat to for it, and its drawback day by day shows especially; Other commercially available herbal medicine is as loose in gram ball, though gram ball health etc. are without the drawback of above-mentioned Western medicine, but form on and methods for using them and also have some technological deficiency at formula, because filling a prescription, not rigorous curative effect is not good enough, on application process, often direct drug powder spice is fed, delayed the absorption rate of sick rabbit to effective ingredient, prevention effect is also unsatisfactory.Therefore, on the basis of existing public technology, necessary to control rabbit coccidiosis carry out technological innovation.
Goal of the invention:
Object of the present invention be exactly to provide a kind of determined curative effect, cure rate higher, have no side effect, drug residue free, rabbit take and be difficult for developing immunity to drugs afterwards, technical support be provided safely and be convenient to the pure Chinese herbal medicine of the control rabbit coccidiosis of application for rabbit meat.
Summary of the invention:
For realizing object of the present invention, inventor has carried out experimental study for many years and has repeatedly verified and paid hard work, filter out multiple Chinese herbal medicine formulas, finally determined formula of the present invention through optimal design, its composition is expressed as with mass fraction: Fructus Bruceae 1.5-4.5 part, Radix Bupleuri 5-15 part, Radix Dichroae 5-15 part, Herba Artemisiae Annuae 5-15 part, Radix Gentianae Macrophyllae 4-12 part, Oletum Trogopterori 4-12 part, Herba Patriniae 10-20 part, Folium Callicarpae Formosanae 10-20 part, Semen Lablab Album 3-10 part, Radix Sanguisorbae 3-10 part, Flos Sophorae 3-10 part, Rhizoma Atractylodis Macrocephalae 3-10 part, Herba Agrimoniae 5-10 part, Talcum 5-10 part.60-80 mesh sieve is dried, weighs, was crushed to said herbal medicine, stir and get final product to obtain finished product of the present invention.
Usage and dosage of the present invention is as follows:
A. usage: claim medicated powder of the present invention to pour in Porcelain Jar or porcelain urn according to rabbit group quantity, the state of an illness, consumption and (avoid with canisters such as ferrum, aluminum, to avoid reaction, affect the treatment), add again 5-10 times of boiling water of medicated powder amount, lid mouthful rapidly, soak stewing 30-60 minute, can make like this active ingredient of medicine fully dissolve and separate out, in the time that fluid temperature is down to 20-25 DEG C, add 10% white sugar or the former powder of Vc of glucose and 200ppm by boiling water amount or amount of liquid medicine again, object is to supplement in time rabbit physical ability, has certain detoxicating adhesive concurrently.The medicinal liquid so preparing was once thrown clothes before the dusk to rabbit group, being used in conjunction 5-7 days is a course for the treatment of.Reduce crude protein content in feedstuff to 10-15% simultaneously, admix vitamin A and vitamin K by explanation, be intended to suppress coccidiosis breeding and reduce intestinal wall breakage hemorrhage, slow down the state of an illness, accelerate rehabilitation.
B. consumption: therapeutic dose 1-2g/ is day only; Preventive dose 0.5-1.0g/ is only. day, be used in conjunction 5-7 days.
Prescription is resolved:
The present invention is the traditional Chinese veterinary medicine theory traditional according to motherland, designs in conjunction with the feature of rabbit coccidiosis.Chinese veterinarian thinks: coccidiosis extensively exists at nature, rabbit body is had to natural aggressive, particularly larger at rabbit population density, a run of wet weather, under the environment of warm moist, its exophytic growth is very active, rabbit body is eaten after the Sporulated Oocysts of coccidiosis, due to the young rabbit in 4 monthly ages to the resistance of coccidiosis a little less than, it is not solid that rabbit body is defended gas (the natural physiologic barrier of first), the take advantage of a weak point epithelial cell of intestinal wall or liver of evil poison (rabbit coccidiosis) is bred rapidly, it is Endogenous stages, under the situation of pathogen being excessive but vital QI weak, enter again gas, battalion, blood system, therefore clinical manifestation diarrhoea or constipation, the clinical symptoms such as liver enlargement.Through comprehensively dialectical, primary disease belongs to damp and hot deficiency syndrome.Therefore, should establish heat-clearing and toxic substances removing, removing heat from blood tonifying liver, hemostasis and dysentery-stopping to primary disease is the rule for the treatment of.Therefore established Fructus Bruceae, Radix Bupleuri, Radix Dichroae in we, Herba Artemisiae Annuae four Chinese medicine combination among the strong ones composition main force square formation is monarch drug, is intended to guarantee effect that presses down protozoacide, heat-clearing and toxic substances removing of the present invention; Catching and can solve under the prerequisite of this principal contradiction, alternative Radix Gentianae Macrophyllae, Oletum Trogopterori, Herba Patriniae, Folium Callicarpae Formosanae are ministerial drug, increase that clearing away heat-damp and promoting diuresis, anti-inflammatory analgesic, relaxing muscles and tendons protect the liver, effect of hemostasis and dysentery-stopping, assist monarch drug with the strengthening efficacy of a drug; Adjusting to white Seem Lablab Album, Radix Sanguisorbae, Flos Sophorae, the Rhizoma Atractylodis Macrocephalae is adjuvant drug again, is intended to, except damp and clearing heat, safeguard epithelial cell, and spleen invigorating hemostasis, helps the monarch and his subjects' a helping hand altogether; Send again Herba Agrimoniae, Talcum for making medicine, to bring into play its removing toxic substances hemostasis, protection intestinal wall, can drive residual hazard in external characteristic, exempt the melancholy of " close door and stay bandit ".
Take a broad view of full side, the present invention fills a prescription rigorous, monarch, minister, helps, makes that Each performs its own functions, coordination linkage, plays altogether medicine merit.In addition, in the time of clinical practice, two foreign aid's medicines of saccharide and Vc are increased again, can fast supply support, disperse virulence, reduce crude protein content in rabbit feedstuff simultaneously and use vitamin A and vitamin K with adding, more strengthened the centralizing function of getting rid of evils of the present invention, therefore, the present invention has higher clinical cure rate than other related drugs.
Detailed description of the invention: following examples are in order to illustrate the present invention.
Embodiment 1:
Supply the examination time: in July, 2009.
For trying place: Linzhang County, Hebei province Li Huan English rabbit warren.
For trying rabbit group: 80-95 age in days, 800 commercial generation California Rabbits, because the factors such as weather is damp and hot, improper ventilation are broken out rabbit coccidiosis, with the same house of group.
Supply reagent thing: i.e. pure Chinese herbal and crude drugs preparations of the present invention, each taste crude drug is all purchased from oriental drug city, Anguo City, Hebei province, and its composition is expressed as by mass fraction: 1.5 parts of Fructus Bruceaes, 5 parts of Radix Bupleuri, 5 parts of Radix Dichroaes, 5 parts of Herba Artemisiae Annuaes, 4 parts of Radix Gentianae Macrophyllae, 4 parts of Oletum Trogopteroris, 10 parts of Herba Patriniae, 10 parts of Folium Callicarpae Formosanaes, 3 parts of Semen Lablab Albums, 3 parts of Radix Sanguisorbaes, 3 parts, Flos Sophorae, 3 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Herba Agrimoniaes, 5 parts, Talcum.60 mesh sieves are dried, weigh, were crushed to said herbal medicine, stir and get final product to obtain finished product of the present invention.
Test group: 400, use Drug therapy of the present invention.
Matched group: 400, with Western medicine sulfadimidine (SM
2) treatment.
Test group step is as follows:
1. claim medicine: 1 gram of every rabbit medication, nominal is got 400 grams of medicines of the present invention and poured in Porcelain Jar.
2. soak: in cylinder, add boiling water 2000g, add a cover and soak stewing 30 minutes.
3. dosing: in the time that medicine juice temperature is down to 20-25 DEG C, add the former powder of 200g white sugar and 0.4gVc, stir.
4. throw clothes: before feeding, take this medicine (containing medicinal residues) to the disposable throwing of rabbit group between the lights, appoint the free drink-service of rabbit, search for food.
5. the course for the treatment of: continuous use 5 days.
6. other: adopt ancillary method simultaneously, reduce crude protein content to 10% left and right of rabbit concentrated feed, and add and mix vitamin A and vitamin K by operation instruction.
Matched group: take sulfadimidine (SM
2) former powder 4g, add in the clean drinking-water of 2000g, stir, concentration is 2000ppm, before at dusk, disposable throwing clothes, appoint the free drink-service of rabbit, continuous use 5 days.
Result of the test is listed in the table below: unit: a .%
Result shows: test group exceeds 11.25 percentage points than the cure rate of matched group.
Embodiment 2:
Supply the examination time: in August, 2011.
For trying place: Shahe City, Hebei province king two girl's rabbit warrens.
For examination rabbit group: the 75-113 monthly age, 1200 commercial generation rabbits, because the factors such as weather hectic fever, density be excessive are broken out rabbit coccidiosis, with group with house.
Supply reagent thing: i.e. the present invention, the purchasing of raw materials is with embodiment 1, and its composition is expressed as by mass fraction: 4.5 parts of Fructus Bruceaes, 15 parts of Radix Bupleuri, 15 parts of Radix Dichroaes, 15 parts of Herba Artemisiae Annuaes, 12 parts of Radix Gentianae Macrophyllae, 12 parts of Oletum Trogopteroris, 20 parts of Herba Patriniae, 20 parts of Folium Callicarpae Formosanaes, 10 parts of Semen Lablab Albums, 10 parts of Radix Sanguisorbaes, 10 parts, Flos Sophorae, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Herba Agrimoniaes, 10 parts, Talcum.Processing method is identical with embodiment 1.
Test group: 600, use Drug therapy of the present invention.
Matched group: 600, with the loose treatment of commercially available herbal medicine gram ball.
Test group step is as follows:
1. claim medicine: 2 grams of every rabbit medications, nominal is got 1200 grams of medicines of the present invention and poured in Porcelain Jar.
2. soak: in cylinder, add boiling water 12000g, add a cover and soak stewing 60 minutes.
3. dosing: when medicine juice temperature is down to 20-25 DEG C, add the former powder of 1200g glucose and 2.4gVc, stir.
4. throw clothes: with embodiment 1.
5. the course for the treatment of: continuous use 7 days.
6. other: reduce the crude protein content to 15% of rabbit concentrated feed, the other the same as in Example 1.
Matched group: take the loose 1200g of gram ball, every same test group of rabbit dosage, directly spice was once thrown clothes, continuous use 7 days before the dusk.
Result of the test is listed in the table below: unit: a .%
Result shows: test group exceeds 10.33 percentage points than the cure rate of matched group.
Claims (2)
1. prevent and treat a medicine for rabbit coccidiosis, it is characterized in that its composition is expressed as with mass fraction:
1.5 parts of Fructus Bruceaes, 5 parts of Radix Bupleuri, 5 parts of Radix Dichroaes, 5 parts of Herba Artemisiae Annuaes, 4 parts of Radix Gentianae Macrophyllae, 4 parts of Oletum Trogopteroris, 10 parts of Herba Patriniae, 10 parts of Folium Callicarpae Formosanaes, 3 parts of Semen Lablab Albums, 3 parts of Radix Sanguisorbaes, 3 parts, Flos Sophorae, 3 parts of the Rhizoma Atractylodis Macrocephalaes, 3 parts of Herba Agrimoniaes, 3 parts, Talcum.
2. prevent and treat a medicine for rabbit coccidiosis, it is characterized in that its composition is expressed as with mass fraction:
4.5 parts of Fructus Bruceaes, 15 parts of Radix Bupleuri, 15 parts of Radix Dichroaes, 15 parts of Herba Artemisiae Annuaes, 12 parts of Radix Gentianae Macrophyllae, 12 parts of Oletum Trogopteroris, 20 parts of Herba Patriniae, 20 parts of Folium Callicarpae Formosanaes, Semen Lablab Album l0 part, 10 parts of Radix Sanguisorbaes, 10 parts, Flos Sophorae, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Herba Agrimoniaes, Talcum l0 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310111813.3A CN103142766B (en) | 2013-04-02 | 2013-04-02 | Medicine for controlling coccidiosis in rabbits |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310111813.3A CN103142766B (en) | 2013-04-02 | 2013-04-02 | Medicine for controlling coccidiosis in rabbits |
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| Publication Number | Publication Date |
|---|---|
| CN103142766A CN103142766A (en) | 2013-06-12 |
| CN103142766B true CN103142766B (en) | 2014-09-03 |
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| CN201310111813.3A Expired - Fee Related CN103142766B (en) | 2013-04-02 | 2013-04-02 | Medicine for controlling coccidiosis in rabbits |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103830378B (en) * | 2014-03-25 | 2015-06-17 | 烟台金海药业有限公司 | Chinese veterinary medicine superfine powder for treating chicken caecal coccidiosis and preparation method thereof |
| CN103875986A (en) * | 2014-04-02 | 2014-06-25 | 陈迎霞 | Appetizing and parasite-expelling eutrophic pig feed and preparation method thereof |
| CN106234811A (en) * | 2016-08-04 | 2016-12-21 | 遵义县强芳养殖发展有限公司 | A kind of beaver rabbit feed |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1145791A (en) * | 1995-09-20 | 1997-03-26 | 山东省鲁西兽药厂 | Coccidiosis-resisting Chinese herbal veterinary medicine and its prepn |
| CN102327329A (en) * | 2011-09-30 | 2012-01-25 | 广东紫金正天药业有限公司 | Rhubarb-containing composition and application thereof |
-
2013
- 2013-04-02 CN CN201310111813.3A patent/CN103142766B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1145791A (en) * | 1995-09-20 | 1997-03-26 | 山东省鲁西兽药厂 | Coccidiosis-resisting Chinese herbal veterinary medicine and its prepn |
| CN102327329A (en) * | 2011-09-30 | 2012-01-25 | 广东紫金正天药业有限公司 | Rhubarb-containing composition and application thereof |
Non-Patent Citations (4)
| Title |
|---|
| 中兽药在抗兔球虫病上的应用研究与展望;韦田等;《中兽医医药杂志》;20051231(第5期);59-60 * |
| 中草药防治鸡球虫病研究进展;葛凯等;《动物医学进展》;20061231;第27卷(第2期);17-21 * |
| 葛凯等.中草药防治鸡球虫病研究进展.《动物医学进展》.2006,第27卷(第2期), |
| 韦田等.中兽药在抗兔球虫病上的应用研究与展望.《中兽医医药杂志》.2005,(第5期), |
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