CN104208551A - Traditional Chinese medicine composition for treatment of infectious hepatitis of duck - Google Patents
Traditional Chinese medicine composition for treatment of infectious hepatitis of duck Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treatment of infectious hepatitis of duck, the traditional Chinese medicine composition comprises the following components by weight: 60-90g of radix paeoniae alba, 60-90g of purslane, 60-90g of achyranthes, 60-90g of radix aristolochiae, 30-50g of polygonum cuspidatum, 30-50g of centella asiatica, 30-50g ofparasitic loranthus, 30-50g of katsumadai seed, 30-50g of caulis trachelospermi, 30-50g of menispermaceae, 30-50g of sweet wormwood, 30-50g of cornu bubali, 30-50g of cortex fraxini, 30-50g of honeysuckle flower, 15-30g of sophora flavescens, 15-30g of phellodendron bark, 15-30g of the root of kudzu vine, 15-30g of anemarrhena, 10-20g of jujube and 10-20g of licorice root. The traditional Chinese medicine composition has the advantages of simple ratio, convenient use, effects of invigorating liver and spleen, clearing heat and detoxification, anti inflammation and hepatoprotection, and good effect of treatment of duck virus hepatitis.
Description
technical field:
The present invention relates to veterinary drug technical field, particularly relate to a kind of Chinese medicine composition for the treatment of infectious hepatitis of duck.
background technology:
Infectious hepatitis of duck and duck viral hepatitis are a kind of Acute exposure sexually transmitted diseases being caused duckling by DHV.Clinically with fall ill anxious, propagate fast, mortality rate is high, cuing open inspection liver has obvious petechia and ecchymosis to be feature.Clinically with fall ill anxious, propagate fast, mortality rate is high, cuing open inspection liver has obvious petechia and ecchymosis to be feature.Duck viral hepatitis is that the kind of duckling is propagated rapidly and highly lethal infectious disease.The characteristics of lesion of liver is that volume increases and has hemorrhage speckle, starts mortality rate when falling ill up to more than 90%, causes very large loss.Primary disease mainly betides the duckling in below 3 week age, and more than 4 week age there is not yet morbidity report, do not affect adult duck, chicken and goose also have resistance.Someone discovery virulent duck enteritis virus artificial challenge's age in days and the poult in 1 week age, young goose and galeeny, can produce the symptom of primary disease, pathological change and serum neutralizing antibody, and be separated to virus from the liver of poult.Primary disease is propagated very fast in duckling group, above will pass through digestive tract infection.Duck liver inflammation is caused by 3 kinds of different virus, and be DHV (DHV) I, II, III type respectively, modal is DHVI type, belongs to enterovirus.
Chinese traditional treatment birds has certain advantage, as low in drug residue etc.In prior art, the prescription for the treatment of duck viral hepatitis is as square l, each 250 grams of prescription fresh Folium Isatidis blade root, Radix Serissae, each 100 grams of Radix glochidionis puberi, Yellow Fructus Gardeniae root (500 duckling therapeutic doses).Clean adopting the fresh herbal root come, section, adds water 2 liters, and with the medicinal liquid to about 1 liter at a simmer, often only sick duck gavages 1 ~ 2 milliliter.Not yet there is the duckling of symptom, cut off the water supply a few hours before administration, when duckling feels thirsty, allow its drink-service.Observation of curative effect prince learns, and [" traditional Chinese veterinary medicine magazine " is introduced, and adopts antibiotic and sulfa drugs to fail to respond to any medical treatment, and with sick 10 groups of this side treatment duck viral hepatitis, have received satisfied therapeutic effect.Side 2, prescription Radix Scutellariae, Cortex Phellodendri, Rhizoma Coptidis, Fructus Forsythiae, Flos Lonicerae, Herba Ardisiae Japonicae, Herba Artemisiae Scopariae, Fructus Aurantii, each 25 grams of Radix Glycyrrhizae (for 500 duckling consumptions).Decoct juice to mix meal and feed.The duckling do not eaten, drips clothes by medicine juice, 3 times on the 1st, serve on 2 days.[" traditional Chinese veterinary medicine magazine " this disease is at present without specific treatment medicine for observation of curative effect Hu Xuanwen.Adopt this side to feed afternoon on the same day, do not find dead duck next day, then take 1 dose, the whole rehabilitation of remaining duck.This side on probation only controls duckling more than 1.500, good results.Side's 3 Yiganlings, the prescription Radix Rehmanniae, Radix Et Rhizoma Rhei, Radix Paeoniae Rubra, Radix Gentianae, Rhizoma Imperatae, Caulis Akebiae, Cortex Phellodendri, Fructus Gardeniae, Herba Artemisiae Scopariae, Radix Isatidis, Herba Lysimachiae, Herba Hyperici Japonici, Herba Abri.Decocting takes orally.Every part of adult human dose can feed 40 ~ 50 ducklings, every day 1 dose.Serve on 3 ~ 5 days.Observation of curative effect Ke Yi [introduce, and apply this side only with 3 ~ 5 days, its effect is very satisfied by " traditional Chinese veterinary medicine magazine ".Add Yiganling as injected duck liver egg yolk liquid, effect is better, protective rate 100% simultaneously.Side's 4 " the lucid yang sending up soup " add taste prescription Radix Isatidis 50 grams, Folium Isatidis 50 grams, Radix Arnebiae (Radix Lithospermi) 50 grams, Rhizoma Cimicifugae 40 grams, Radix Puerariae 30 grams, Radix Bupleuri 30 grams, Fructus Gardeniae 30 grams, Radix Et Rhizoma Rhei 25 grams, dried Alumen 20 grams, 40 grams, Radix Glycyrrhizae (being 200 duckling consumptions above).Usage grinds to the powder or decocts soup mix fodder and feeds, and every day 1 dose, every 2 ~ 3 hours 1 time, serve on 3 ~ 5 doses.Observation of curative effect Zhang Zhaolun [" Chinese veterinarian's medical magazine "] introduces, and application the lucid yang sending up Tonga taste, point different condition of illness addition or subtraction of changes, carries out examination to 2 558 sick ducks and the duck that carries disease germs and control, effective 1 988, effective 221, invalid 349, satisfactory effect.For duck viral hepatitis, the experience that Chinese veterinarian among the people develops in practice, treatment also has certain effect.As: each 12 grams of Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Rhizoma Atractylodis, Herba Schizonepetae, Herba Menthae, Radix Angelicae Pubescentis, Pericarpium Citri Reticulatae, each 10 grams of Rhizoma Zingiberis Recens, each 6 grams of Radix Peucedani, Flos Lonicerae, Fructus Hordei Germinatus, each 30 grams of six song, Fructus Crataegi 15 grams (every 100 duckling consumptions).Decoct water to mix meal and feed.For another example: LIUYI SAN 30 grams, six songs 1 piece, Spica Prunellae, Radix Glycyrrhizae, each 15 grams of Flos Lonicerae, each 7 grams of Pericarpium Citri Reticulatae, Cortex Phellodendri, Herba Lophatheri, Radix Angelicae Sinensis, Rhizoma Osmundae, Radix Codonopsis, Radix Et Rhizoma Rhei, each 10 grams of Radix Scutellariae.Decoct water to feed (100 duckling consumptions).And for example: Radix Scutellariae 30 grams, Cortex Phellodendri 50 grams, Fructus Forsythiae 30 grams, Indigo Naturalis 30 grams, Flos Lonicerae 20 grams, Herba Ardisiae Japonicae 40 grams, Herba Artemisiae Scopariae 30 grams, Herba Lysimachiae 40 grams, Fructus Mume 30 grams.Decoct juice, spice is fed.Medicine does not instill in mouth by trencherman, every day 3 times.The record of periodical literature is as ' mattress Pu Liver-Clearing Powder is to the prevention effect of Duck Hepatitis Virus ', " Chinese veterinarian's medical magazine ", prescription disclosed in 05 year the 5th phase: mattress Pu Liver-Clearing Powder: Herba Artemisiae Scopariae 200 g, Herba Taraxaci 200 g, Herba Hedyotidis Diffusae 200 g, Radix Isatidis 50 g, Flos Lonicerae 60 g, Rhizoma Coptidis 35 g, Fructus Gardeniae 35 g, Radix Gentianae 35 g, Radix Bupleuri 30 g, Radix Saposhnikoviae 30 g, Ramulus Uncariae Cum Uncis 30 g, the Radix Astragali 40 g, Fructus Hordei Germinatus 35 g, Radix Glycyrrhizae 20 g.For another example, ' Chinese medicinal formulae is to the test of Duck Hepatitis Virus prevention effect ', prescription Herba Artemisiae Scopariae 50g, Radix Gentianae 20g disclosed in the phase " traditional Chinese veterinary medicine magazine " calendar year 2001 the 1st, Radix Scutellariae 20g, Rhizoma Coptidis 20g, Radix Astragali 20g, Radix Isatidis 20g, Radix Bupleuri Seedling 20g, Massa Medicata Fermentata 50g, Pericarpium Citri Reticulatae 30g, Radix Glycyrrhizae 20g.Found by retrieval, it is more with Herba Artemisiae Scopariae to be that monarch drug treats the prescription of this type of disease, and Herba Artemisiae Scopariae is damp-excreting anti-icteric medicinal, eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice.
Primary disease analyzes the cause of disease with theory of Chinese medical science, duckling " the spleen tending to insufficiency usually ", appetite is by force prosperous, and digestive function is poor in addition, easy trouble enteritis, the diseases such as diarrhoea, and " the liver being liable to excess ", heat-transformation in ill rear easy biography, Chang Yindong liver-wind, easy ill virus hepatitis, other internal organs are ill also often causes mixed infection, harm liver, intestinal, spleen, each internal organs of stomach.The ill virus hepatitis of duckling, card belongs to epidemic febrile disease scope, for experience epidemic disease heresy caused by.According to differentiation of disease according to pathological changes of the viscera and their analysis, duck experiences virus attack liver, causes deficiency of heart-QI, can not preside over blood circulation and to circulate each warp, YIN nourishing whole body, alluvial heat-dissipating, heat in blood is then withered, as now of a specified duration, its Therapeutic Principle then causes death, so should be " heat-clearing and toxic substances removing, antiinflammatory protects the liver ".
summary of the invention:
The object of the invention is to based on prior art, provide a kind of proportioning simple, easy to use, invigorating liver and spleen, heat-clearing and toxic substances removing, antiinflammatory protects the liver, the Chinese medicine composition of the treatment infectious hepatitis of duck that treatment duck viral hepatitis is effective.
To achieve these goals, the invention provides a kind of Chinese medicine composition for the treatment of infectious hepatitis of duck, wherein, according to the following each component of unit of weight configuration:
The Radix Paeoniae Alba, Herba Portulacae, Radix Achyranthis Bidentatae, each 60-90g of Radix Aristolochiae, Rhizoma Polygoni Cuspidati, Herba Centellae, Herba Taxilli, Semen Alpiniae Katsumadai, Caulis Trachelospermi, Radix Stephaniae Tetrandrae, Herba Artemisiae Annuae, Cornu Bubali, Cortex Fraxini, each 30-50g of Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Puerariae, each 15-30g of the Rhizoma Anemarrhenae, Fructus Jujubae, each 10-20g of Radix Glycyrrhizae.
Or, according to the following each component of unit of weight configuration:
The Radix Paeoniae Alba, Herba Portulacae, Radix Achyranthis Bidentatae, each 60-80g of Radix Aristolochiae, Rhizoma Polygoni Cuspidati, Herba Centellae, Herba Taxilli, Semen Alpiniae Katsumadai, Caulis Trachelospermi, Radix Stephaniae Tetrandrae, Herba Artemisiae Annuae, Cornu Bubali, Cortex Fraxini, each 30-40g of Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Puerariae, each 15-20g of the Rhizoma Anemarrhenae, Fructus Jujubae, each 10-15g of Radix Glycyrrhizae.
Or, according to the following each component of unit of weight configuration:
The Radix Paeoniae Alba, Herba Portulacae, Radix Achyranthis Bidentatae, each 80-90g of Radix Aristolochiae, Rhizoma Polygoni Cuspidati, Herba Centellae, Herba Taxilli, Semen Alpiniae Katsumadai, Caulis Trachelospermi, Radix Stephaniae Tetrandrae, Herba Artemisiae Annuae, Cornu Bubali, Cortex Fraxini, each 40-50g of Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Puerariae, each 20-30g of the Rhizoma Anemarrhenae, Fructus Jujubae, each 15-20g of Radix Glycyrrhizae.
Or, according to the following each component of unit of weight configuration:
The Radix Paeoniae Alba, Herba Portulacae, Radix Achyranthis Bidentatae, each 65-85g of Radix Aristolochiae, Rhizoma Polygoni Cuspidati, Herba Centellae, Herba Taxilli, Semen Alpiniae Katsumadai, Caulis Trachelospermi, Radix Stephaniae Tetrandrae, Herba Artemisiae Annuae, Cornu Bubali, Cortex Fraxini, each 35-45g of Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Puerariae, each 18-28g of the Rhizoma Anemarrhenae, Fructus Jujubae, each 12-18g of Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition for the treatment of infectious hepatitis of duck is as follows:
Each crude drug component in above-mentioned Chinese medicine composition is ground to form fine powder respectively, mixing, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, through ultraviolet radiation disinfection 10 seconds after stirring, obtain the Chinese medicine composition that the present invention treats infectious hepatitis of duck.
Using method, mixing in water for oral taking, the Chinese medicine composition warm water of the treatment infectious hepatitis of duck of powdery is taken after mixing it with water, and the mass ratio of protective agents and water is 1:15-20.Rush to obtain aqueous solution, gavage according to every duckling 2-5ml, three times on the one.
The present invention with the Radix Paeoniae Alba, Herba Portulacae, Radix Achyranthis Bidentatae, Radix Aristolochiae for monarch drug, with Rhizoma Polygoni Cuspidati, Herba Centellae, Herba Taxilli, Semen Alpiniae Katsumadai, Caulis Trachelospermi, Radix Stephaniae Tetrandrae, Herba Artemisiae Annuae, Cornu Bubali, Cortex Fraxini, Flos Lonicerae for ministerial drug, with Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Puerariae, the Rhizoma Anemarrhenae for adjuvant drug, with Fructus Jujubae, Radix Glycyrrhizae tying-in for making medicine.This proportioning is simple, easy to use, invigorating liver and spleen, heat-clearing and toxic substances removing, and antiinflammatory protects the liver, and treatment duck viral hepatitis is effective.
detailed description of the invention:
Experimental data:
One, medicine grouping:
Group 1, the Radix Paeoniae Alba, Herba Portulacae, Radix Achyranthis Bidentatae, each 90g of Radix Aristolochiae, Rhizoma Polygoni Cuspidati, Herba Centellae, Herba Taxilli, Semen Alpiniae Katsumadai, Caulis Trachelospermi, Radix Stephaniae Tetrandrae, Herba Artemisiae Annuae, Cornu Bubali, Cortex Fraxini, each 50g of Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Puerariae, each 30g of the Rhizoma Anemarrhenae, Fructus Jujubae, each 20g of Radix Glycyrrhizae.Each crude drug component in above-mentioned Chinese medicine composition grinds to form fine powder respectively, mixing, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, through ultraviolet radiation disinfection 10 seconds after stirring, obtain the Chinese medicine composition that the present invention treats infectious hepatitis of duck.The Chinese medicine composition warm water of the treatment infectious hepatitis of duck of powdery is taken after mixing it with water, and the mass ratio of protective agents and water is 1:20.Often only gavage 3ml.
Group 2, the Radix Paeoniae Alba, Herba Portulacae, Radix Achyranthis Bidentatae, each 60g of Radix Aristolochiae, Rhizoma Polygoni Cuspidati, Herba Centellae, Herba Taxilli, Semen Alpiniae Katsumadai, Caulis Trachelospermi, Radix Stephaniae Tetrandrae, Herba Artemisiae Annuae, Cornu Bubali, Cortex Fraxini, each 30g of Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Puerariae, each 15g of the Rhizoma Anemarrhenae, Fructus Jujubae, each 10g of Radix Glycyrrhizae.Each crude drug component in above-mentioned Chinese medicine composition grinds to form fine powder respectively, mixing, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, through ultraviolet radiation disinfection 10 seconds after stirring, obtain the Chinese medicine composition that the present invention treats infectious hepatitis of duck.The Chinese medicine composition warm water of the treatment infectious hepatitis of duck of powdery is taken after mixing it with water, and the mass ratio of protective agents and water is 1:18.Often only gavage 4ml.
Group 3, the Radix Paeoniae Alba, Herba Portulacae, Radix Achyranthis Bidentatae, each 80g of Radix Aristolochiae, Rhizoma Polygoni Cuspidati, Herba Centellae, Herba Taxilli, Semen Alpiniae Katsumadai, Caulis Trachelospermi, Radix Stephaniae Tetrandrae, Herba Artemisiae Annuae, Cornu Bubali, Cortex Fraxini, each 40g of Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Puerariae, each 20g of the Rhizoma Anemarrhenae, Fructus Jujubae, each 15g of Radix Glycyrrhizae.Each crude drug component in above-mentioned Chinese medicine composition grinds to form fine powder respectively, mixing, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, through ultraviolet radiation disinfection 10 seconds after stirring, obtain the Chinese medicine composition that the present invention treats infectious hepatitis of duck.The Chinese medicine composition warm water of the treatment infectious hepatitis of duck of powdery is taken after mixing it with water, and the mass ratio of protective agents and water is 1:15.Often only gavage 5ml.
Group 4, in background technology, " Chinese veterinarian's medical magazine ", prescription disclosed in 05 year the 5th phase: mattress Pu Liver-Clearing Powder: Herba Artemisiae Scopariae 200 g, Herba Taraxaci 200 g, Herba Hedyotidis Diffusae 200 g, Radix Isatidis 50 g, Flos Lonicerae 60 g, Rhizoma Coptidis 35 g, Fructus Gardeniae 35 g, Radix Gentianae 35 g, Radix Bupleuri 30 g, Radix Saposhnikoviae 30 g, Ramulus Uncariae Cum Uncis 30 g, the Radix Astragali 40 g, Fructus Hordei Germinatus 35 g, Radix Glycyrrhizae 20 g.Be decocted in water for oral dose, every feeding 3-5ml.
Group 5, in background technology, ' Chinese medicinal formulae is to the test of Duck Hepatitis Virus prevention effect ', prescription Herba Artemisiae Scopariae 50g disclosed in phase " traditional Chinese veterinary medicine magazine " calendar year 2001 the 1st, Radix Gentianae 20g, Radix Scutellariae 20g, Rhizoma Coptidis 20g, Radix Astragali 20g, Radix Isatidis 20g, Radix Bupleuri Seedling 20g, Massa Medicata Fermentata 50g, Pericarpium Citri Reticulatae 30g, Radix Glycyrrhizae 20g.Be decocted in water for oral dose, every feeding 3-5ml.
Group 6, in background technology, " the lucid yang sending up soup " adds taste prescription Radix Isatidis 50 grams, Folium Isatidis 50 grams, Radix Arnebiae (Radix Lithospermi) 50 grams, Rhizoma Cimicifugae 40 grams, Radix Puerariae 30 grams, Radix Bupleuri 30 grams, Fructus Gardeniae 30 grams, Radix Et Rhizoma Rhei 25 grams, dried Alumen 20 grams, and 40 grams, Radix Glycyrrhizae, is decocted in water for oral dose, every feeding 3-5ml.
Group 7, folk remedy in background technology: each 12 grams of Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Rhizoma Atractylodis, Herba Schizonepetae, Herba Menthae, Radix Angelicae Pubescentis, Pericarpium Citri Reticulatae, each 10 grams of Rhizoma Zingiberis Recens, each 6 grams of Radix Peucedani, Flos Lonicerae, Fructus Hordei Germinatus, each 30 grams of six song, Fructus Crataegi 15 grams, is decocted in water for oral dose, every feeding 3-5ml.
Group 8, duck liver Trane Western medicine only carry out intramuscular injection 0.5ml/.
The grouping of experiment thing:
The nonimmune white duckling of test duck 3 age in days, before test, random its serum of sampling observation DVH antibody, checks maternal antibody with agar gel diffusion test, is feminine gender.
Get nonimmune white duckling 360 plumage of 3 age in days, be divided at random 9 groups (1 to 8 is test group, and 9 groups is blank group), often organize 40, isolation is conventional raises.Experimental group 1-8 counteracting toxic substances, with (500 ELD50/0.1ml) intramuscular injection of the strong poison of DHV D2000-1.Counteracting toxic substances is after 6 hours, and liver anatomical finds: hepatomegaly, and in yellowish red color or graniphyric, there are petechia and ecchymosis in surface, and gollbladder dilation is full of bile.Spleen is enlargement sometimes, the piebaldism of outward appearance also similar liver.Kidney is congested, swelling, and cardiac muscle is as boiled shape.External sign duckling twitches, wryneck, and foot spasm, head are to swinging back, having loose bowels.
Administration:
The medicine that experimental group 1-7 group uses medicine to divide into groups in 1-7 is respectively fed, and experimental group 8 uses duck liver Trane Western medicine only to carry out intramuscular injection 0.5ml/, observes after 3 days.Cure number of elements (duckling to the symptom of swinging back, having loose bowels, namely calculates healing without tic, wryneck, foot spasm, head)
Result:
Duckling sign after healing is consistent with blank group.To sum up, effective percentage of the present invention (medicine group 1-group 3) 85-90%, medicine group 4 effective percentage 72.5%, medicine group 5 effective percentage 67.5%.Medicine group 6 effective percentage 65%.Medicine group 7 effective percentage 65%.Medicine 8 effective percentage 80%.
Antiviral breeding data:
Experimental group 1-8 after DHV D2000-1 counteracting toxic substances, takes medicine 3 days, randomly draws one, fixing after taking body weight, dissects, and gets liver and calculates liver exponential quantity, calculates liver index suppression ratio.
Heavy (g)/body weight (g) × 100 of liver index=liver
Liver index suppression ratio=(virus control group liver Mean value of index-experimental group liver Mean value of index)/virus control group liver Mean value of index × 100%
Liver index is larger, represents that liver pathological changes degree is serious,
Hepatic tissue 10% formaldehyde is fixed, and ethanol series is dewatered, and dimethylbenzene is transparent, paraffin embedding, slice thickness 4-5 micron, and HE dyes, and observes blood lipid change with ordinary optical microscope, with the liver of Normal group as a comparison.
The impact (n=10) of liver's checking (virus is observed)
Can find, the present invention (experimental group 1-3) to viral DHV D2000-1 suppression ratio apparently higher than other experimental grouies, prove that effect of the present invention is better.
Toxicity is to the experiment of rat:
Acute oral (LD50) > 500mg/kg,
Acute percutaneous (LD 50) > 2000mg/kg,
Belong to low toxicity.
Object lesson 1
Plant of Liu family one, cultivation meat-type duck 1200, during 5 age in days, find that there is duckling dying time head swing back to back, spasm, in opisthotonus shape, spirit is depressed, and appetite is useless absolutely.Eyes semi-closure, stupor, diarrhoea, movement disorder, health swings to side, bipod spasm, a few hours back dead to layback.3-4 days dead more than 100, dissect and find hepatomegaly, in yellowish red color or graniphyric, there are petechia and ecchymosis in surface, and gollbladder dilation is full of bile.Spleen is enlargement sometimes, the piebaldism of outward appearance also similar liver.Kidney is congested, swelling, for viral duck liver is scorching, be suitable for the present invention: the Radix Paeoniae Alba, Herba Portulacae, Radix Achyranthis Bidentatae, each 90g of Radix Aristolochiae, Rhizoma Polygoni Cuspidati, Herba Centellae, Herba Taxilli, Semen Alpiniae Katsumadai, Caulis Trachelospermi, Radix Stephaniae Tetrandrae, Herba Artemisiae Annuae, Cornu Bubali, Cortex Fraxini, each 50g of Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Puerariae, each 30g of the Rhizoma Anemarrhenae, Fructus Jujubae, each 20g of Radix Glycyrrhizae.Each crude drug component in above-mentioned Chinese medicine composition grinds to form fine powder respectively, mixing, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, through ultraviolet radiation disinfection 10 seconds after stirring, obtain the Chinese medicine composition that the present invention treats infectious hepatitis of duck.The Chinese medicine composition warm water of the treatment infectious hepatitis of duck of powdery is taken after mixing it with water, and the mass ratio of protective agents and water is 1:20.
To sick duck 264 isolation of disease symptom be had, often only gavage 3ml treatment.Asymptomatic duckling often only gavages 1ml prevention.Every day 2 times, after 3 days, 264 sick ducks cure 234, dead 30, effective percentage 88.63%.After healthy duck feeding prevention, only have 26 to only have disease symptom, all the other are in good health.
Example 2, Feng Jia cultivation base, cultivation meat-type duck 1400 plumage, during 7 age in days, find that there is duckling dying time head swing back to back, spasm, in opisthotonus shape, spirit is depressed, and appetite is absolutely useless.Eyes semi-closure, stupor, diarrhoea, movement disorder, health swings to side, bipod spasm, a few hours back dead to layback, in 2 days therefore dead more than 200 only, dissect and find hepatomegaly, in yellowish red color or graniphyric, there are petechia and ecchymosis in surface, and gollbladder dilation is full of bile.Spleen is enlargement sometimes, the piebaldism of outward appearance also similar liver.Kidney is congested, swelling, is diagnosed as duck viral hepatitis.Use prescription: group 2, the Radix Paeoniae Alba, Herba Portulacae, Radix Achyranthis Bidentatae, each 60g of Radix Aristolochiae, Rhizoma Polygoni Cuspidati, Herba Centellae, Herba Taxilli, Semen Alpiniae Katsumadai, Caulis Trachelospermi, Radix Stephaniae Tetrandrae, Herba Artemisiae Annuae, Cornu Bubali, Cortex Fraxini, each 30g of Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Puerariae, each 15g of the Rhizoma Anemarrhenae, Fructus Jujubae, each 10g of Radix Glycyrrhizae.Each crude drug component in above-mentioned Chinese medicine composition grinds to form fine powder respectively, mixing, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, through ultraviolet radiation disinfection 10 seconds after stirring, obtain the Chinese medicine composition that the present invention treats infectious hepatitis of duck.The Chinese medicine composition warm water of the treatment infectious hepatitis of duck of powdery is taken after mixing it with water, and the mass ratio of protective agents and water is 1:18.To sick duck 259 isolation of disease symptom be had, often only gavage 4ml.Asymptomatic duckling often only gavages 1ml prevention.Every day 2 times, after 3 days, 259 sick ducks cure 233, dead 26, effective percentage 89.96%.After healthy duck feeding prevention, only have 28 to only have disease symptom, all the other are in good health.
Example 3, all family raisers, cultivation meat-type duck 1600, because cage house is moist dark, finds that there is duckling spasm during 8 age in days, in opisthotonus shape, spirit is depressed, and appetite is absolutely useless.Eyes semi-closure, stupor, diarrhoea, movement disorder, health swings to side, bipod spasm, a few hours back dead to layback, namely dead 100 to have a surplus within one day, dissect and find hepatomegaly, in yellowish red color or graniphyric, there are petechia and ecchymosis in surface, and gollbladder dilation is full of bile.Spleen is enlargement sometimes, the piebaldism of outward appearance also similar liver.Kidney is congested, swelling, for viral duck liver is scorching.Use prescription is as follows: the Radix Paeoniae Alba, Herba Portulacae, Radix Achyranthis Bidentatae, each 80g of Radix Aristolochiae, Rhizoma Polygoni Cuspidati, Herba Centellae, Herba Taxilli, Semen Alpiniae Katsumadai, Caulis Trachelospermi, Radix Stephaniae Tetrandrae, Herba Artemisiae Annuae, Cornu Bubali, Cortex Fraxini, each 40g of Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Puerariae, each 20g of the Rhizoma Anemarrhenae, Fructus Jujubae, each 15g of Radix Glycyrrhizae.Each crude drug component in above-mentioned Chinese medicine composition grinds to form fine powder respectively, mixing, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, add correctives (as sweeting agent), the mass ratio of correctives and powder is 0.5:100, through ultraviolet radiation disinfection 10 seconds after stirring, obtain the Chinese medicine composition that the present invention treats infectious hepatitis of duck.The Chinese medicine composition warm water of the treatment infectious hepatitis of duck of powdery is taken after mixing it with water, and the mass ratio of protective agents and water is 1:15.To sick duck 452 isolation of disease symptom be had, often only gavage 5ml.Asymptomatic duckling often only gavages 1ml prevention.Every day 2 times, after 3 days, 452 sick ducks cure 385, dead 67, effective percentage 85.17%.After healthy duck feeding prevention, only have 58 to only have disease symptom, all the other are in good health.
The present invention with the Radix Paeoniae Alba, Herba Portulacae, Radix Achyranthis Bidentatae, Radix Aristolochiae for monarch drug, with Rhizoma Polygoni Cuspidati, Herba Centellae, Herba Taxilli, Semen Alpiniae Katsumadai, Caulis Trachelospermi, Radix Stephaniae Tetrandrae, Herba Artemisiae Annuae, Cornu Bubali, Cortex Fraxini, Flos Lonicerae for ministerial drug, with Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Puerariae, the Rhizoma Anemarrhenae for adjuvant drug, with Fructus Jujubae, Radix Glycyrrhizae tying-in for making medicine.This proportioning is simple, easy to use, invigorating liver and spleen, heat-clearing and toxic substances removing, and antiinflammatory protects the liver, and treatment duck viral hepatitis is effective.
Claims (4)
1. treat a Chinese medicine composition for infectious hepatitis of duck, it is characterized in that, according to the following each component of unit of weight configuration:
The Radix Paeoniae Alba, Herba Portulacae, Radix Achyranthis Bidentatae, each 60-90g of Radix Aristolochiae, Rhizoma Polygoni Cuspidati, Herba Centellae, Herba Taxilli, Semen Alpiniae Katsumadai, Caulis Trachelospermi, Radix Stephaniae Tetrandrae, Herba Artemisiae Annuae, Cornu Bubali, Cortex Fraxini, each 30-50g of Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Puerariae, each 15-30g of the Rhizoma Anemarrhenae, Fructus Jujubae, each 10-20g of Radix Glycyrrhizae.
2. treat the Chinese medicine composition of infectious hepatitis of duck according to claim 1, it is characterized in that, according to the following each component of unit of weight configuration:
The Radix Paeoniae Alba, Herba Portulacae, Radix Achyranthis Bidentatae, each 60-80g of Radix Aristolochiae, Rhizoma Polygoni Cuspidati, Herba Centellae, Herba Taxilli, Semen Alpiniae Katsumadai, Caulis Trachelospermi, Radix Stephaniae Tetrandrae, Herba Artemisiae Annuae, Cornu Bubali, Cortex Fraxini, each 30-40g of Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Puerariae, each 15-20g of the Rhizoma Anemarrhenae, Fructus Jujubae, each 10-15g of Radix Glycyrrhizae.
3. treat the Chinese medicine composition of infectious hepatitis of duck according to claim 1, it is characterized in that, according to the following each component of unit of weight configuration:
The Radix Paeoniae Alba, Herba Portulacae, Radix Achyranthis Bidentatae, each 80-90g of Radix Aristolochiae, Rhizoma Polygoni Cuspidati, Herba Centellae, Herba Taxilli, Semen Alpiniae Katsumadai, Caulis Trachelospermi, Radix Stephaniae Tetrandrae, Herba Artemisiae Annuae, Cornu Bubali, Cortex Fraxini, each 40-50g of Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Puerariae, each 20-30g of the Rhizoma Anemarrhenae, Fructus Jujubae, each 15-20g of Radix Glycyrrhizae.
4. treat the Chinese medicine composition of infectious hepatitis of duck according to claim 1, it is characterized in that, according to the following each component of unit of weight configuration:
The Radix Paeoniae Alba, Herba Portulacae, Radix Achyranthis Bidentatae, each 65-85g of Radix Aristolochiae, Rhizoma Polygoni Cuspidati, Herba Centellae, Herba Taxilli, Semen Alpiniae Katsumadai, Caulis Trachelospermi, Radix Stephaniae Tetrandrae, Herba Artemisiae Annuae, Cornu Bubali, Cortex Fraxini, each 35-45g of Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Puerariae, each 18-28g of the Rhizoma Anemarrhenae, Fructus Jujubae, each 12-18g of Radix Glycyrrhizae.
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