CN103055207A - Pure Chinese medicinal composition for treating infectious hemorrhagic disease of grass carp and preparation method thereof - Google Patents
Pure Chinese medicinal composition for treating infectious hemorrhagic disease of grass carp and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a pure Chinese medicinal composition for treating infectious hemorrhagic disease of grass carp. The composition is prepared by mixing the following components in part by weight: 15 to 35 parts of rhubarb, 15 to 35 parts of baikal skullcap root, 15 to 35 parts of isatis root, 15 to 35 parts of propolis, 15 to 35 parts of honeysuckle flower, 15 to 35 parts of amur corktree bark, 20 to 40 parts of quassia, 20 to 40 parts of malt, 20 to 40 parts of medicated leaven, and 20 to 40 parts of Chinese mugwort leaf. The pure Chinese medicinal composition is reasonable in formula, easy to prepare, and high in bioavailability, is the pure Chinese medicinal composition, does not have any toxic or side effects, can treat both symptoms and root causes, has a very obvious curative effect and is obtained through super fine crushing; the medicine residues and medicine resistance are avoided; and the clinical results prove that the pure Chinese medicinal composition has a special effect of treating infectious hemorrhagic disease of the grass carp.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof, belong to the animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof.
Background technology
Ctenopharyngodon idellus infectiousness hemorrhagic disease is a kind of infectious disease of serious harm Ctenopharyngodon idellus, and this is a kind of popular wide, season is long, sickness rate is high, mortality rate is high a kind of disease.Production to Grass Carp Juveniles causes heavy losses.This disease pathogen is GCHV, generally still has popularly in late June to early October, and be epidemic peak season August.This disease shows as the mottled or block hyperemia of each Organ and tissue of Ctenopharyngodon idellus inside and outside, and congested phenomenon appears in the organs such as oral cavity, the gill cover, fin base, muscle, intestinal, liver,spleen,kidney, is " red muscularity ".Ctenopharyngodon idellus kind more than 10～15 centimetres is " the thin gill cover type of red fin " or " intestinal type " take intestinal, fin base, the gill cover and oral cavity hyperemia as main, and an age, in various degree hemorrhage appearred in above Ctenopharyngodon idellus.
The disease of primary disease is rapid, and General Symptoms worsens fast, and malpractice causes death easily, already causes serious economic loss for fish culture, and mortality rate is generally between 50%-80%.
This disease almost spreads all over all fish culture countries of the world, is widely distributed.The primary disease western medical treatment mainly uses antiviral agents and antibiosis anti-inflammatory drug, though receive certain effect, because its toxic and side effects by force, easily produces the problems such as drug resistance and drug residue, clinical practice is very limited or bans use of.And therapeutic principle of traditional Chinese medicine is take heat-clearing and toxic substances removing, removing heat from blood, harmonizing yingfen and weifen as the rule for the treatment of.At present, treat the most frequently used Chinese medicine of this disease because its prescription is unreasonable or just simple pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine.
Therefore research and develop a kind of pure Chinese prescription for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease, micronizing, bioavailability height, the specific medicament for the treatment of both the principal and secondary aspects of a disease is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide a kind of reasonable recipe, preparation simply, micronizing, high, the treating both the principal and secondary aspects of a disease of bioavailability, pure Chinese medicine composition of effective treatment Ctenopharyngodon idellus infectiousness hemorrhagic disease of successful and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease, by following component by weight mixed preparing form: Radix Et Rhizoma Rhei 15-35 part, Radix Scutellariae 15-35 part, Radix Isatidis 15-35 part, propolis 15-35 part, Flos Lonicerae 15-35 part, Cortex Phellodendri 15-35 part, Ramulus Et Folium Picrasmae 20-40 part, Fructus Hordei Germinatus 20-40 part, Massa Medicata Fermentata 20-40 part, Folium Artemisiae Argyi 20-40 part.
Described various component optimum ratio amount is: 25 parts of Radix Et Rhizoma Rhei, 25 parts of Radix Scutellariaes, 25 parts of Radix Isatidis, 25 parts of propolis, 25 parts of Flos Loniceraes, 25 parts of Cortex Phellodendris, 30 parts of Ramulus Et Folium Picrasmaes, 30 parts in Fructus Hordei Germinatus, 30 parts of Massa Medicata Fermentata, 30 parts of Folium Artemisiae Argyis.
A kind of preparation method for the treatment of the pure Chinese medicine composition of Ctenopharyngodon idellus infectiousness hemorrhagic disease, carry out as follows:
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight Radix Et Rhizoma Rhei 15-35 part, Radix Scutellariae 15-35 part, Radix Isatidis 15-35 part, propolis 15-35 part, Flos Lonicerae 15-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Cortex Phellodendri 15-35 part, Ramulus Et Folium Picrasmae 20-40 part, Fructus Hordei Germinatus 20-40 part, Massa Medicata Fermentata 20-40 part, Folium Artemisiae Argyi 20-40 part, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
The medicinal property of each component is as follows:
Radix Scutellariae: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, have heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive function; Cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, high heat are greedyly drunk, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus, frequent fetal movement etc.
Propolis: bitter, hot, cold, return spleen, stomach warp, have anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, improve the function of immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa etc.
Radix Isatidis: bitter, cold, GUIXIN, stomach warp have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.
Radix Et Rhizoma Rhei: bitter, cold, return large intestine, spleen, stomach, liver, pericardium channel, have the function of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass blood stasis expelling; Cure mainly excess-heat constipation, combined symptoms, the yellow furunculosis of skin ulcer, conjunctival congestion and swelling pain, enteritis etc.
Flos Lonicerae: sweet, cold, attach to the lung and stomach meridians, have the function of heat-clearing and toxic substances removing, heat radiation dispelling wind; Cure mainly cough due to lung-heat, epidemic febrile disease heating, laryngopharynx swelling and pain, toxic-heat and blood stasis, carbuncle sore tumefacting virus etc.
Cortex Phellodendri: bitter, cold, return kidney, urinary bladder channel, have the function of heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever; Cure mainly damp-heat dysentery, jaundice, pyretic stranguria, sore swollen toxin, eczema, hyperactivity of fire caused by deficiency of YIN etc.
Ramulus Et Folium Picrasmae: bitter, cold, return lung, large intestine channel, have the function of heat-clearing and toxic substances removing, removing dampness and killing parasites; Cure mainly respiratory tract infection, pneumonia, acute gastroenteritis, dysentery, biliary tract infection, eczema etc.
Fructus Hordei Germinatus: sweet, flat, return spleen, stomach warp, have the function of spleen benefiting and stimulating the appetite, promote qi circulation digestion promoting; Cure mainly that food stagnation does not disappear, tripe is swollen etc.
Massa Medicata Fermentata: sweet, hot, warm, return stomach, spleen channel, have invigorating the spleen and regulating the stomach, function in transferring helps digestion; Cure mainly that food stagnation does not disappear, tripe is swollen, postnatal blood stasis stomachache etc.
Folium Artemisiae Argyi: hot, bitter, warm, return the liver,kidney,spleen warp, have the function of dispersing cold for relieving pain, warming the meridian for stopping bleeding; Cure mainly anemofrigid-damp arthralgia, tripe abdomen cold type of pain etc.
More than all herbal medicines according to the theoretical compatible combination of Chinese veterinarian, for paathogenic factor and the clinical symptoms of Ctenopharyngodon idellus infectiousness hemorrhagic disease, the effect of performance treating both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition, treating both the principal and secondary aspects of a disease, cost is low, and it is wide to draw materials, micronizing, bioavailability height, curative effect highly significant.The present invention is theoretical according to Chinese veterinarian, optimizes this ten herbal medicine, and they are formed according to optimum ratio, and clinical practice proves that treatment Ctenopharyngodon idellus infectiousness hemorrhagic disease is had specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 150 parts of Radix Et Rhizoma Rhei, 150 parts of Radix Scutellariaes, 150 parts of Radix Isatidis, 150 parts of propolis, 150 parts of Flos Loniceraes, mix 5-10 minute to even;
(3) take by weighing by weight 150 parts of Cortex Phellodendris, 200 parts of Ramulus Et Folium Picrasmaes, 200 parts in Fructus Hordei Germinatus, 200 parts of Massa Medicata Fermentata, 200 parts of Folium Artemisiae Argyis, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 250 parts of Radix Et Rhizoma Rhei, 250 parts of Radix Scutellariaes, 250 parts of Radix Isatidis, 250 parts of propolis, 250 parts of Flos Loniceraes, mix 5-10 minute to even;
(3) take by weighing by weight 250 parts of Cortex Phellodendris, 300 parts of Ramulus Et Folium Picrasmaes, 300 parts in Fructus Hordei Germinatus, 300 parts of Massa Medicata Fermentata, 300 parts of Folium Artemisiae Argyis, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 3
A kind of pure Chinese medicine Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 350 parts of Radix Et Rhizoma Rhei, 350 parts of Radix Scutellariaes, 350 parts of Radix Isatidis, 350 parts of propolis, 350 parts of Flos Loniceraes, mix 5-10 minute to even;
(3) take by weighing by weight 350 parts of Cortex Phellodendris, 400 parts of Ramulus Et Folium Picrasmaes, 400 parts in Fructus Hordei Germinatus, 400 parts of Massa Medicata Fermentata, 400 parts of Folium Artemisiae Argyis, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Clinical trial:
The clinical experiment animal selects 150 ages in days, body weight at 1.0kg-1.5kg, and Laboratory Diagnosed is the ill fish of Ctenopharyngodon idellus infectiousness hemorrhagic disease.Ill Ctenopharyngodon idellus isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and every group of 30 tails, 3 groups of feeding environments are identical, and experiment was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with " fish is precious loose " by specification; Present composition group can be for oral administration with product of the present invention (embodiment of the invention 1 prepared compositions), admixes bait feeding in 2.5% ratio, every day 2-3 time, is used in conjunction 3-5 days; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 5th day) when following table is the experiment end.
Table is the field applicable cases contrast of the present invention and other medicines treatment Ctenopharyngodon idellus infectiousness hemorrhagic disease:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 53.3 | 30.0 | 16.7 |
| II | The precious loose group of fish | 13.3 | 73.4 | 13.3 |
| III | Present composition group | 3.3 | 86.7 | 10.0 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P＜0.01) with the precious loose group of fish aspect the cure rate.
Safety testing:
Choose 80 age in days healthy grass carp, 30 tails, 5 times according to the embodiment of the invention 1 made compositions recommended dose took orally 10 days, during the medication, any bad or Deviant Behavior performance does not appear in healthy grass carp, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of pure Chinese medicine composition of this treatment Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease, it is characterized in that by following component by weight mixed preparing form: Radix Et Rhizoma Rhei 15-35 part, Radix Scutellariae 15-35 part, Radix Isatidis 15-35 part, propolis 15-35 part, Flos Lonicerae 15-35 part, Cortex Phellodendri 15-35 part, Ramulus Et Folium Picrasmae 20-40 part, Fructus Hordei Germinatus 20-40 part, Massa Medicata Fermentata 20-40 part, Folium Artemisiae Argyi 20-40 part.
2. the pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of Radix Et Rhizoma Rhei, 25 parts of Radix Scutellariaes, 25 parts of Radix Isatidis, 25 parts of propolis, 25 parts of Flos Loniceraes, 25 parts of Cortex Phellodendris, 30 parts of Ramulus Et Folium Picrasmaes, 30 parts in Fructus Hordei Germinatus, 30 parts of Massa Medicata Fermentata, 30 parts of Folium Artemisiae Argyis.
3. the preparation method of the pure Chinese medicine composition of a treatment Ctenopharyngodon idellus infectiousness hemorrhagic disease according to claim 1 and 2 is characterized in that carrying out as follows:
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight Radix Et Rhizoma Rhei 15-35 part, Radix Scutellariae 15-35 part, Radix Isatidis 15-35 part, propolis 15-35 part, Flos Lonicerae 15-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Cortex Phellodendri 15-35 part, Ramulus Et Folium Picrasmae 20-40 part, Fructus Hordei Germinatus 20-40 part, Massa Medicata Fermentata 20-40 part, Folium Artemisiae Argyi 20-40 part, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
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| CN201210549536.XA CN103055207B (en) | 2012-12-04 | 2012-12-04 | Pure Chinese medicinal composition for treating infectious hemorrhagic disease of grass carp and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728976A (en) * | 2017-03-06 | 2017-05-31 | 长沙瑞多康生物科技有限公司 | A kind of composition for preventing and treating hemorrhagic disease of grass carp |
| CN108938797A (en) * | 2018-09-21 | 2018-12-07 | 朱林 | It is a kind of for treating the Chinese herbal and crude drugs preparations of the disease of grass carp five |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401921A (en) * | 2008-10-30 | 2009-04-08 | 河南省龙腾高科实业有限公司 | Microbial ecological traditional Chinese medicine preparation for livestock and poultry from fermentation production of multiple bacterials and fermentation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401921A (en) * | 2008-10-30 | 2009-04-08 | 河南省龙腾高科实业有限公司 | Microbial ecological traditional Chinese medicine preparation for livestock and poultry from fermentation production of multiple bacterials and fermentation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王慧军等: "《中草药添加剂在我国养殖业的应用现状》", 《山东畜牧兽医》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728976A (en) * | 2017-03-06 | 2017-05-31 | 长沙瑞多康生物科技有限公司 | A kind of composition for preventing and treating hemorrhagic disease of grass carp |
| CN108938797A (en) * | 2018-09-21 | 2018-12-07 | 朱林 | It is a kind of for treating the Chinese herbal and crude drugs preparations of the disease of grass carp five |
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