CN103142771B - Medicine for controlling coccidiosis in chicken - Google Patents
Medicine for controlling coccidiosis in chicken Download PDFInfo
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- CN103142771B CN103142771B CN201310111815.2A CN201310111815A CN103142771B CN 103142771 B CN103142771 B CN 103142771B CN 201310111815 A CN201310111815 A CN 201310111815A CN 103142771 B CN103142771 B CN 103142771B
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Abstract
The invention provides a medicine for controlling coccidiosis in chicken, belonging to the technical field of pharmaceutical and medical engineering. The medicine comprises the following components in parts by weight: 5-15 parts of antifebrile dichroa root, 5-15 parts of sweet wormwood herb, 5-15 parts of amur corktree bark, 5-15 parts of Tokyo violet herb, 4-12 parts of Chinese wolfberry root-bark, 4-12 parts of figwortflower picrorhiza rhizome, 4-12 parts of lightyellow sophora root, 4-12 parts of red peony root, 3-10 parts of plantain seed, 3-10 parts of radix rehmanniae, 3-10 parts of belvedere fruit, 3-10 parts of lilac pink herb, 2-6 parts of sanqi and 2-6 parts of medicinal cyathula root. The medicine is prepared by drying the above Chinese herbal medicines in the sun, weighing the dried medicines, grinding the weighed medicines, sieving the powder with a 60-80-mesh sieve and mixing the powder uniformly. During clinical application, the medicine is soaked in boiling water for 30-60 minutes so that the active ingredients of the medicine are fully dissolved and precipitated to be beneficial to internal absorption of sick chicken, and at the same time, the medicine efficacy can be improved by reducing the content of the crude proteins in the feed to about 10-15% and adding specified dosages of VA and VK. The medicine has higher clinical cure rate, does not have adverse reactions, does not generate medicine resistance easily, avoids medicine residues in chicken bodies, has easily obtained needed raw materials, is simple to prepare and convenient to use and can be widely applied in the poultry industry.
Description
Technical field:
The invention belongs to medicine and engineering in medicine technical field, particularly a kind of medicine of preventing and treating chicken coccidiosis that relates to.
Background technology:
The aquaculture of China has been developed rapidly since reform and opening-up, especially poultry husbandry, and chicken livestock on hand total amount occupies first place in the world, becomes genuine poultry big country.But, along with poultry husbandry popularization, flowing frequent, density increases, and fowl disease has become the key factor of impact or restriction poultry husbandry healthy and sustainable development.As chicken coccidiosis is still a kind of important diseases of chicken so far.Research both at home and abroad shows that none is escaped by luck as long as poultry just has chicken coccidiosis all over the world; Be everlasting age in 4-6 week chickling group of this disease breaks out, and does not cause 20-80% mortality rate not etc., and economic loss is huge, sometimes or even destructive, and far above the loss to other poultry.For this reason, the control of this disease has been caused domestic and international veterinary scientific worker's great attention.In prior art, the medicine of disclosed control chicken coccidiosis has vaccine, Western medicine and herbal medicine three major types.Although three has prevention effect in various degree, also exist such or such technical problem, await technological innovation.As the egg capsule suspensoid vaccine-Coccivac of external sale, in production practices, though can make chicken group produce immunity, but result chicken group's immunity is uneven or be not enough to produce immunity, or cause a disease too much because taking in egg capsule amount, thereby this kind of vaccine fail generally to apply so far, so far the immunologic mechanism of coccidiosis be there is no to gratifying explanation, commercially available Western medicine is as antibiotics (penicillin, oxytetracycline, chlortetracycline etc.), sulfonamides (sulfadimethoxine, sulfamonomethoxine etc.), furans (nitrofural, furazolidone etc.) and other chemical synthesis preparation (Robenidine, Amprolium etc.) about kind more than 100, although above-mentioned Western medicine all has good prevention effect to control chicken coccidiosis, but along with prolonged application for many years, even abuse abuse, its curative effect reduced year by year, consumption increases year by year, the continuous formation of Drug resistance worm strain has become common recognition, and there is the hidden danger of drug residue, to meat, egg food constitutes a threat to safely, as just isolated the coccidiosis strain of anti-sulfonamide as far back as 1954, prove that subsequently nearly all coccidiostat has the strain of drug resistance worm to occur, and show cross-resistance to a certain degree, troubling, even some Western medicine is fed continuously and can be made meat as Robenidine, egg produces abnormal flavour, cannot eat, furazolidone and Maduramicin toxicity are too large, the normal poisoning case that two kinds of medicines occur in veterinary clinic practice, thereby cause damage, though other commercially available herbal medicine is as loose in coccidiosis health, gram ball etc. without the drawback of above-mentioned Western medicine, but form on and methods for using them and also have some technological deficiency at formula, because filling a prescription, not rigorous curative effect is not good enough, on application process, direct herbal medicine powder spice is fed, delayed the absorption rate of sick chicken to effective ingredient, prevention effect is also unsatisfactory.Therefore, the medicine of control chicken coccidiosis is carried out to technological innovation necessary.
Goal of the invention:
Object of the present invention be just to provide a kind of determined curative effect, cure rate higher, have no side effect, pure Chinese herbal medicine that drug residue free, chicken group are taken the rear control chicken coccidiosis that is difficult for developing immunity to drugs.
Summary of the invention:
For realizing object of the present invention, inventor has carried out experimental study and checking repeatedly for many years, pay hard work, filter out multiple Chinese herbal medicine formulas, finally determined formula of the present invention through optimal design, its composition is expressed as with mass fraction: Radix Dichroae 5-15 part, Herba Artemisiae Annuae 5-15 part, Cortex Phellodendri 5-15 part, Herba Violae 5-15 part, Cortex Lycii 4-12 part, Rhizoma Picrorhizae 4-12 part, Radix Sophorae Flavescentis 4-12 part, Radix Paeoniae Rubra 4-12 part, Semen Plantaginis 3-10 part, Radix Rehmanniae 3-10 part, Fructus Kochiae 3-10 part, Herba Dianthi 3-10 part, Radix Notoginseng 2-6 part, Radix Cyathulae 2-6 part.60-80 mesh sieve is dried, weighs, was crushed to said herbal medicine, puddle and evenly obtain finished product of the present invention.
The usage and dosage of medicine of the present invention is as follows:
A, usage: claim medicated powder to pour in Porcelain Jar or pottery urn (avoid with canisters such as ferrum, aluminum, to avoid reaction, affect the treatment) according to chicken group quantity, the state of an illness, consumption, then add 5-10 times of boiling water of medicated powder amount, lid mouth soaks stewing 30-60 minute.Can make like this effective ingredient of medicine fully dissolve and separate out, in the time that medicine temperature is down to room temperature, before the dusk, once throw clothes to chicken group, be used in conjunction 5-7 days.Reduce the content (being advisable with 10-15%) of crude protein in chicken feedstuff simultaneously, add and feed vitamin A, vitamin K by explanation, object is to slow down the state of an illness, reduces death, accelerates chicken group rehabilitation.
B, consumption: therapeutic dose 1-2g/ is only. day, be used in conjunction 5-7 days; Preventive dose 0.5-1g/ is only. day, be used in conjunction 3 weeks from age week in 3 week age to 6.
Prescription is resolved:
Medicament composing prescription of the present invention is according to traditional traditional Chinese veterinary medicine theory, in conjunction with the characteristic of chicken coccidiosis through dialectical and design.This disease refers to the common protozoacide that one or more coccidiosis ovum of chicken intestinal infection cause, mainly attacks for 3 monthly ages with interior chickling, and becoming chicken is generally carrier, and other poultry all can infection morbidity.But under the condition of warm and moist, the easy infection of 20-40 Japanese instar chickling breaks out, quite serious to the harm of poultry husbandry.Clinical manifestation is that the necking down of disease chicken is slow-witted vertical, feather is fluffy and disorderly, fear of cold flocks together, does not eat or few food, and characteristic pathological changes is the loose stool of drawstring blood, and severe one is drawn blood completely, anemia stupor, convulsion death; Diseased region is mainly at caecum and small intestinal hypomere, inflammation swelling, and than normal large several times, content mostly is blood, sludged blood or strip sphacelus.Chinese veterinarian thinks, chicken sense exopathogen eats extraneous tool aggressive coccidian oocyst, and schizont is amount reproduction in Intestinum Gallus domesticus epithelial cell; Cause chicken failure of defensive QI to protect the body against pathogen, intestinal mucosa is destroyed and cause inflammation and epithelial cell disintegrate, the first natural cover for defense in body causes breakage, exopathogen is availed oneself of the opportunity to get in, and invasion and attack nutrient blood, causes digestive function disorder, enterogenous endotoxin is constantly accumulated, damp and hot malicious heresy is gradually contained, and finally causes the autointoxication of chicken body, and clinical manifestation is the symptoms such as collapse, anemia, dysentery.Be typical damp and hot deficient syndrome through dialectical this disease.Therefore, should establish heat-clearing and toxic substances removing, removing dampness dysentery relieving, promoting the circulation of blood hemostasis is the rule for the treatment of.Therefore first establishing Radix Dichroae, Herba Artemisiae Annuae, Cortex Phellodendri, Herba Violae four Chinese medicine combination among the strong ones composition main force square formation in the present invention formula is monarch drug, ensures that the present invention presses down protozoacide, clearing away deficiency-heat, separates the poison of acute appendicitis, except damp and hot effective efficacy of a drug of the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels; Cortex Lycii, the Rhizoma Picrorhizae of the kind reducing the asthenic fever of choosing again, accumulates the damp and hot Radix Sophorae Flavescentis that has a large merit, is longer than removing heat from blood and promoting blood circulation, swollen clearly pain relieving can relax gastrointestinal smooth muscle and the Radix Paeoniae Rubra of alleviating its spasmic pain is ministerial drug altogether in removing, assistance monarch drug is with enhancing drug effect; Another tune is good at the Semen Plantaginis of relieving stranguria by diuresis, clearing away heat to stop bleeding, the Radix Rehmanniae of being longer than promoting the production of body fluid to quench thirst and clearing away heat and promoting diuresis to have Herba Dianthi, the Fructus Kochiae of large merit is adjuvant drug altogether, and four be all rich in vitamin A, very favourable to protection intestinal wall epithelial cell, jointly assists a ruler in governing a country the monarch and his subjects; Not only the famous medicine Radix Notoginseng of the kind hemostasis and pain-relieving of group and dissipating blood stasis, be longer than blood circulation promoting and blood stasis dispelling but also conducting blood to flow downwards Radix Cyathulae altogether for making medicine, coordinate monarch, minister, adjuvant drug to suppress, put down and kill chicken coccidiosis and body endogenous toxin heresy is excreted, exempt " close to fasten with a bolt or latch and stay bandit " and turn round and look at afterwards suffering.
Take a broad view of full side, the present invention fills a prescription rigorous, monarch, minister, helps, makes that the division of labor is clear and definite and Each performs its own functions, coordination linkage and play altogether drug effect.In addition, in the time of clinical practice according to principles such as animal nutritions, original high protein feed is reduced to Low protein diet, crude protein content is about 10-15%, in feedstuff, add with vitamin A and vitamin K by explanation simultaneously, like this can tonic power, loose virulence, more strengthened the present invention's centralizing function of getting rid of evils.Therefore, the present invention has higher clinical cure rate than the related drugs of other existing public technology.
Detailed description of the invention: following examples are in order to illustrate the present invention.
Embodiment 1:
Supply the examination time: in July, 2010.
For trying place: Yang Jiang swallow chicken farm, Longyao County, Hebei province.
For trying chicken group: the 35 blue brown laying hens in age in days commercial generations sea, 2400 of livestock on hands; Because weather is damp and hot, moist in house, the factors such as improper ventilation are broken out chicken coccidiosis, and same group is with house.
Supply reagent thing: i.e. pure Chinese herbal and crude drugs preparations of the present invention, each taste crude drug is all purchased from oriental drug city, Anguo City, Hebei province, and its composition is expressed as by mass fraction: 5 parts of Radix Dichroaes, 5 parts of Herba Artemisiae Annuaes, 5 parts of Cortex Phellodendris, 5 parts of Herba Violaes, 4 parts of Cortex Lycii, 4 parts of Rhizoma Picrorhizae, 4 parts of Radix Sophorae Flavescentiss, 4 parts of Radix Paeoniae Rubra, 3 parts of Semen Plantaginiss, 3 parts, the Radix Rehmanniae, 3 parts of the Fructus Kochiae, 3 parts of Herba Dianthis, 2 parts of Radix Notoginseng, 2 parts of Radix Cyathulaes.60 mesh sieves are dried, weigh, were crushed to said herbal medicine, stir and get final product to obtain finished product of the present invention.
Test group: 1200, use Drug therapy of the present invention.
Matched group: 1200, with the treatment of Western medicine Robenidine.
Test group step is as follows:
1. claim medicine: 1 gram of every chicken medication every day, nominal is got 1200 grams of medicines of the present invention and poured in Porcelain Jar.
2. soak: in cylinder, add boiling water 6kg, add a cover and soak stewing 30 minutes.
3. throw clothes: treat that medicine juice temperature is down to 20-25 DEG C, before dusk feeding, give this medicinal liquid of the disposable input of chicken group (containing medicinal residues), appoint the free drink-service of chicken, search for food.
4. other: reduce the crude protein content to 10% in feedstuff, by operation instruction interpolation vitamin A and Vitamin K preparation.
5. the course for the treatment of: continuous use 5 days.
Matched group: take Robenidine powder 6g, evenly admix 100kg powder, drug level is 60ppm, appoints chicken group free choice feeding, continuous use 5 days.
Result of the test is listed in the table below: unit: a .%
Result shows: test group exceeds 10.25 percentage points than the cure rate of matched group.
Embodiment 2:
Supply the examination time: in August, 2011.
For trying place: Zhang Gencheng chicken farm, Wei County, Hebei province.
For trying chicken group: 28 age in days commercial generation Luo Man laying hens, 3000 of livestock on hands, because weather is sultry, moist in house, the factors such as improper ventilation are broken out chicken coccidiosis, with giving up with group.
Supply reagent thing: i.e. the present invention, the purchasing of raw materials is with embodiment 1, and its composition is expressed as by mass fraction: 15 parts of Radix Dichroaes, 15 parts of Herba Artemisiae Annuaes, 15 parts of Cortex Phellodendris, 15 parts of Herba Violaes, 12 parts of Cortex Lycii, 12 parts of Rhizoma Picrorhizae, 12 parts of Radix Sophorae Flavescentiss, 12 parts of Radix Paeoniae Rubra, 10 parts of Semen Plantaginiss, 10 parts, the Radix Rehmanniae, 10 parts of the Fructus Kochiae, 10 parts of Herba Dianthis, 6 parts of Radix Notoginseng, 6 parts of Radix Cyathulaes.Processing method is with embodiment 1.
Test group: 1500, use Drug therapy of the present invention.
Matched group: 1500, with commercially available herbal medicine coccidiosis health treatment.
Test group step is as follows:
1. claim medicine: 2 grams of every chicken medications, nominal is got 3000 grams of medicines of the present invention and poured in Porcelain Jar.
2. soak: in cylinder, add boiling water 30kg, add a cover and soak stewing 60 minutes.
3. throw clothes: with embodiment 1.
4. other: reduce the crude protein content to 15% in feedstuff, vitamin A, vitamin K consumption usage are with embodiment 1.
5. the course for the treatment of: continuous use 7 days.
Matched group: take coccidiosis health 3000g, the same test group of dosage, directly the disposable throwing clothes of spice, appoint chicken free choice feeding, continuous use 7 days.
Result of the test is listed in the table below: unit: a .%
Result shows: test group exceeds 8.66 percentage points than the cure rate of matched group.
Claims (3)
1. prevent and treat a medicine for chicken coccidiosis, it is characterized in that its composition is expressed as with mass fraction:
Radix Dichroae 5-15 part, Herba Artemisiae Annuae 5-15 part, Cortex Phellodendri 5-15 part, Herba Violae 5-15 part, Cortex Lycii 4-12 part, Rhizoma Picrorhizae 4-12 part, Radix Sophorae Flavescentis 4-12 part, Radix Paeoniae Rubra 4-12 part, Semen Plantaginis 3-10 part, Radix Rehmanniae 3-10 part, Fructus Kochiae 3-10 part, Herba Dianthi 3-10 part, Radix Notoginseng 2-6 part, Radix Cyathulae 2-6 part.
2. by the medicine of control chicken coccidiosis claimed in claim 1, it is characterized in that its composition is expressed as with mass fraction:
5 parts of Radix Dichroaes, 5 parts of Herba Artemisiae Annuaes, 5 parts of Cortex Phellodendris, 5 parts of Herba Violaes, 4 parts of Cortex Lycii, 4 parts of Rhizoma Picrorhizae, 4 parts of Radix Sophorae Flavescentiss, 4 parts of Radix Paeoniae Rubra, 3 parts of Semen Plantaginiss, 3 parts, the Radix Rehmanniae, 3 parts of the Fructus Kochiae, 3 parts of Herba Dianthis, 2 parts of Radix Notoginseng, 2 parts of Radix Cyathulaes.
3. by the medicine of control chicken coccidiosis claimed in claim 1, it is characterized in that its composition is expressed as with mass fraction:
15 parts of Radix Dichroaes, 15 parts of Herba Artemisiae Annuaes, 15 parts of Cortex Phellodendris, 15 parts of Herba Violaes, 12 parts of Cortex Lycii, 12 parts of Rhizoma Picrorhizae, 12 parts of Radix Sophorae Flavescentiss, 12 parts of Radix Paeoniae Rubra, 10 parts of Semen Plantaginiss, 10 parts, the Radix Rehmanniae, 10 parts of the Fructus Kochiae, 10 parts of Herba Dianthis, 6 parts of Radix Notoginseng, 6 parts of Radix Cyathulaes.
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| CN102100788A (en) * | 2009-12-16 | 2011-06-22 | 青岛康地恩药业有限公司 | Chinese medicinal preparation for preventing and treating chicken coccidiosis |
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2013
- 2013-04-02 CN CN201310111815.2A patent/CN103142771B/en not_active Expired - Fee Related
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| CN102988769A (en) * | 2012-07-17 | 2013-03-27 | 张峰 | Traditional Chinese medicine composition for treating chicken coccidiosis and application |
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