CN102665733A - 用于治疗纤维性粘连和其它疾病的包含改性岩藻多糖的药物组合物 - Google Patents
用于治疗纤维性粘连和其它疾病的包含改性岩藻多糖的药物组合物 Download PDFInfo
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- 239000012925 reference material Substances 0.000 description 1
- 238000001448 refractive index detection Methods 0.000 description 1
- 239000004627 regenerated cellulose Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 108091092562 ribozyme Proteins 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229960002930 sirolimus Drugs 0.000 description 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 208000009056 telangiectasis Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 231100000607 toxicokinetics Toxicity 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000004704 ultra performance liquid chromatography Methods 0.000 description 1
- 229940035658 visco-gel Drugs 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A—HUMAN NECESSITIES
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- Medicinal Preparation (AREA)
Abstract
Description
糖单体 | 平均量(总碳水化合物的百分比) | 标准偏差(总碳水化合物的百分比) |
海藻糖 | 48.9 | 2.2 |
半乳糖 | 47.1 | 2.3 |
葡萄糖 | 1.4 | 0.4 |
甘露糖 | 1.1 | 0.3 |
木糖 | 0.8 | 0.2 |
鼠李糖 | 0.6 | 0.1 |
处理 | 总粘连评分 | 无粘连的部位(%) |
手术对照 | 3.1±0.4 | 5.0 |
对照LRS | 2.8±0.3 | 10.0 |
岩藻依聚糖提取物#AA | 2.2±0.6 | 20.0 |
岩藻依聚糖提取物#B | 1.5±0.4 | 32.5 |
岩藻依聚糖提取物#C | 1.4±0.8 | 40.0 |
岩藻依聚糖提取物#D | 1.6±0.4 | 25.0 |
岩藻依聚糖提取物#E | 1.2±0.3 | 42.5 |
岩藻依聚糖提取物#F | 2.0±0.6 | 17.5 |
岩藻依聚糖提取物#G | 1.3±1.4 | 37.5 |
岩藻依聚糖提取物#H | 1.8±0.4 | 22.5 |
岩藻依聚糖提取物#I | 1.7±0.6 | 15.0 |
测试 | 结果 |
外观 | 白色至灰白色粉末 |
总碳水化合物含量 | 61%w/w |
海藻糖含量 | 总碳水化合物的52%w/w |
半乳糖含量 | 总碳水化合物的48%w/w |
其它糖单体 | 小于总碳水化合物的1%w/w |
碳水化合物的分子量 | |
<5k g/mol | 8%w/w |
5k-20k g/mol | 2%w/w |
20k-60k g/mol | 11%w/w |
60k-200k g/mol | 27%w/w |
200k-1,100k g/mol | 35%w/w |
1,000k-1,600k g/mol | 4%w/w |
>1,600k g/mol | 13%w/w |
硫酸酯含量 | 31%w/w |
乙酰基∶海藻糖的比率(%) | 小于2% |
水含量 | 小于10%w/w |
0.1%w/v溶液的pH | 7 |
测试 | 结果 |
外观 | 白色至灰白色粉末 |
总碳水化合物含量 | 61%w/w |
海藻糖含量 | 总碳水化合物的52%w/w |
半乳糖含量 | 总碳水化合物的48%w/w |
其它糖单体 | 小于总碳水化合物的1%w/w |
碳水化合物的分子量 | |
<5k g/mol | 8%w/w |
5k-20k g/mol | 2%w/w |
20k-60k g/mol | 11%w/w |
60k-200k g/mol | 27%w/w |
200k-1,100k g/mol | 35%w/w |
1,000k-1,600k g/mol | 4%w/w |
>1,600k g/mol | 13%w/w |
硫酸酯含量 | 31%w/w |
乙酰基∶海藻糖的比率(%) | 小于2% |
水含量 | 小于10%w/w |
0.1%w/v溶液的pH | 7 |
测试 | 结果 |
外观 | 白色至灰白色粉末 |
总碳水化合物含量 | 61%w/w |
海藻糖含量 | 总碳水化合物的52%w/w |
半乳糖含量 | 总碳水化合物的48%w/w |
其它糖单体 | 小于总碳水化合物的1%w/w |
碳水化合物的分子量 | |
<5k g/mol | 8%w/w |
5k-20k g/mol | 2%w/w |
20k-60k g/mol | 11%w/w |
60k-200k g/mol | 27%w/w |
200k-1,100k g/mol | 35%w/w |
1,000k-1,600k g/mol | 4%w/w |
>1,600k g/mol | 13%w/w |
硫酸酯含量 | 31%w/w |
乙酰基∶海藻糖的比率(%) | 小于2% |
水含量 | 小于10%w/w |
0.1%w/v溶液的pH | 7 |
测试 | 结果 |
外观 | 白色至灰白色粉末 |
总碳水化合物含量 | 61%w/w |
海藻糖含量 | 总碳水化合物的52%w/w |
半乳糖含量 | 总碳水化合物的48%w/w |
其它糖单体 | 小于总碳水化合物的1%w/w |
碳水化合物的分子量 | |
<5k g/mol | 8%w/w |
5k-20k g/mol | 2%w/w |
20k-60k g/mol | 11%w/w |
60k-200k g/mol | 27%w/w |
200k-1,100k g/mol | 35%w/w |
1,000k-1,600k g/mol | 4%w/w |
>1,600k g/mol | 13%w/w |
硫酸酯含量 | 31%w/w |
乙酰基∶海藻糖的比率(%) | 小于2% |
水含量 | 小于10%w/w |
0.1%w/v溶液的pH | 7 |
测试 | 结果 |
外观 | 白色至灰白色粉末 |
总碳水化合物含量 | 61%w/w |
海藻糖含量 | 总碳水化合物的52%w/w |
半乳糖含量 | 总碳水化合物的48%w/w |
其它糖单体 | 小于总碳水化合物的1%w/w |
碳水化合物的分子量 | |
<5k g/mol | 8%w/w |
5k-20k g/mol | 2%w/w |
20k-60k g/mol | 11%w/w |
60k-200k g/mol | 27%w/w |
200k-1,100k g/mol | 35%w/w |
1,000k-1,600k g/mol | 4%w/w |
>1,600k g/mol | 13%w/w |
硫酸酯含量 | 31%w/w |
乙酰基∶海藻糖的比率(%) | 小于2% |
水含量 | 小于10%w/w |
0.1%w/v溶液的pH | 7 |
测试 | 结果 |
外观 | 白色至灰白色粉末 |
总碳水化合物含量 | 61%w/w |
海藻糖含量 | 总碳水化合物的52%w/w |
半乳糖含量 | 总碳水化合物的48%w/w |
其它糖单体 | 小于总碳水化合物的1%w/w |
碳水化合物的分子量 | |
<5k g/mol | 8%w/w |
5k-20k g/mol | 2%w/w |
20k-60k g/mol | 11%w/w |
60k-200k g/mol | 27%w/w |
200k-1,100k g/mol | 35%w/w |
1,000k-1,600k g/mol | 4%w/w |
>1,600k g/mol | 13%w/w |
硫酸酯含量 | 31%w/w |
乙酰基∶海藻糖的比率(%) | 小于2% |
水含量 | 小于10%w/w |
0.1%w/v溶液的pH | 7 |
测试 | 结果 |
外观 | 白色至灰白色粉末 |
总碳水化合物含量 | 61%w/w |
海藻糖含量 | 总碳水化合物的52%w/w |
半乳糖含量 | 总碳水化合物的48%w/w |
其它糖单体 | 小于总碳水化合物的1%w/w |
碳水化合物的分子量 | |
<5k g/mol | 8%w/w |
5k-20k g/mol | 2%w/w |
20k-60k g/mol | 11%w/w |
60k-200k g/mol | 27%w/w |
200k-1,100k g/mol | 35%w/w |
1,000k-1,600k g/mol | 4%w/w |
>1,600k g/mol | 13%w/w |
硫酸酯含量 | 31%w/w |
乙酰基∶海藻糖的比率(%) | 小于2% |
水含量 | 小于10%w/w |
0.1%w/v溶液的pH | 7 |
测试 | 结果 |
外观 | 白色至灰白色粉末 |
总碳水化合物含量 | 61%w/w |
海藻糖含量 | 总碳水化合物的52%w/w |
半乳糖含量 | 总碳水化合物的48%w/w |
其它糖单体 | 小于总碳水化合物的1%w/w |
碳水化合物的分子量 | |
<5k g/mol | 8%w/w |
5k-20k g/mol | 2%w/w |
20k-60k g/mol | 11%w/w |
60k-200k g/mol | 27%w/w |
200k-1,100k g/mol | 35%w/w |
1,000k-1,600k g/mol | 4%w/w |
>1,600k g/mol | 13%w/w |
硫酸酯含量 | 31%w/w |
乙酰基∶海藻糖的比率(%) | 小于2% |
水含量 | 小于10%w/w |
0.1%w/v溶液的pH | 7 |
测试 | 结果 |
外观 | 白色至灰白色粉末 |
总碳水化合物含量 | 61%w/w |
海藻糖含量 | 总碳水化合物的52%w/w |
半乳糖含量 | 总碳水化合物的48%w/w |
其它糖单体 | 小于总碳水化合物的1%w/w |
碳水化合物的分子量 | |
<5k g/mol | 8%w/w |
5k-20k g/mol | 2%w/w |
20k-60k g/mol | 11%w/w |
60k-200k g/mol | 27%w/w |
200k-1,100k g/mol | 35%w/w |
1,000k-1,600k g/mol | 4%w/w |
>1,600k g/mol | 13%w/w |
硫酸酯含量 | 31%w/w |
乙酰基∶海藻糖的比率(%) | 小于2% |
水含量 | 小于10%w/w |
0.1%w/v溶液的pH | 7 |
测试 | 结果 |
外观 | 白色至灰白色粉末 |
总碳水化合物含量 | 61%w/w |
海藻糖含量 | 总碳水化合物的52%w/w |
半乳糖含量 | 总碳水化合物的48%w/w |
其它糖单体 | 小于总碳水化合物的1%w/w |
碳水化合物的分子量 | |
<5k g/mol | 8%w/w |
5k-20k g/mol | 2%w/w |
20k-60k g/mol | 11%w/w |
60k-200k g/mol | 27%w/w |
200k-1,100k g/mol | 35%w/w |
1,000k-1,600k g/mol | 4%w/w |
>1,600k g/mol | 13%w/w |
硫酸酯含量 | 31%w/w |
乙酰基∶海藻糖的比率(%) | 小于2% |
水含量 | 小于10%w/w |
0.1%w/v溶液的pH | 7 |
Claims (27)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610545789.8A CN106176798A (zh) | 2009-07-27 | 2010-07-27 | 用于治疗纤维性粘连和其它疾病的包含改性岩藻多糖的药物组合物 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22892909P | 2009-07-27 | 2009-07-27 | |
US61/228,929 | 2009-07-27 | ||
PCT/CA2010/001175 WO2011011881A1 (en) | 2009-07-27 | 2010-07-27 | Pharmaceutical compositions comprising modified fucans for use in the treatment of fibrous adhesions and other disorders |
Related Child Applications (1)
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CN106943619A (zh) * | 2017-03-17 | 2017-07-14 | 清华大学 | 一种液体伤口敷料及其制备方法 |
CN112513104A (zh) * | 2018-07-27 | 2021-03-16 | Arc医疗器械股份有限公司 | 用于治疗纤维性粘连的高度硫酸酯化的褐藻糖胶 |
CN115746161A (zh) * | 2022-08-14 | 2023-03-07 | 湘潭大学 | 一种改性岩藻多糖化合物及其制备方法和应用 |
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EP1809303B1 (en) * | 2004-09-23 | 2019-03-06 | ARC Medical Devices, Inc. | Pharmaceutical compositions and methods relating to inhibiting fibrous adhesions or inflammatory disease using low sulphate fucans |
JO3676B1 (ar) * | 2009-07-27 | 2020-08-27 | Arc Medical Devices Inc | مركبات صيدلانية تضم فوكانات معدلة وطرق تتعلق بها |
WO2011109469A1 (en) * | 2010-03-03 | 2011-09-09 | Neocutis Sa | Compositions and methods for treatment of skin diseases and disorders using antimicrobial peptide sequestering compounds |
FR2984126B1 (fr) * | 2011-12-20 | 2014-08-22 | Oreal | Polysaccharides sulfates agent antipelliculaire |
CA2976142A1 (en) | 2015-02-16 | 2016-08-25 | Gilles Henri LASSERRE | Composition for prevention or treatment of cutaneous disorder |
CN105663154B (zh) * | 2016-01-18 | 2020-06-30 | 首都医科大学 | 褐藻多糖硫酸酯在制备预防和/或治疗下肢外周动脉血管病的产品中的应用 |
US20180056087A1 (en) * | 2016-08-26 | 2018-03-01 | Adolfo Ribeiro | Wearable Micro-LED Healing Bandage |
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CN106943619A (zh) * | 2017-03-17 | 2017-07-14 | 清华大学 | 一种液体伤口敷料及其制备方法 |
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CN112770763A (zh) * | 2018-07-27 | 2021-05-07 | Arc医疗器械股份有限公司 | 低内毒素褐藻糖胶组合物、***和方法 |
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CN112513165B (zh) * | 2018-07-27 | 2023-04-25 | Arc医疗器械股份有限公司 | 用于治疗纤维性粘连和其他疾病和病症的高分子量褐藻糖胶 |
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CN115746161A (zh) * | 2022-08-14 | 2023-03-07 | 湘潭大学 | 一种改性岩藻多糖化合物及其制备方法和应用 |
CN115746161B (zh) * | 2022-08-14 | 2024-06-07 | 湘潭大学 | 一种改性岩藻多糖化合物及其制备方法和应用 |
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