CN102406707B - Normal-temperature preparation method of ultramicro Scutellaria baicalensis powder and special bidirectional airflow screening machine thereof - Google Patents
Normal-temperature preparation method of ultramicro Scutellaria baicalensis powder and special bidirectional airflow screening machine thereof Download PDFInfo
- Publication number
- CN102406707B CN102406707B CN 201110382940 CN201110382940A CN102406707B CN 102406707 B CN102406707 B CN 102406707B CN 201110382940 CN201110382940 CN 201110382940 CN 201110382940 A CN201110382940 A CN 201110382940A CN 102406707 B CN102406707 B CN 102406707B
- Authority
- CN
- China
- Prior art keywords
- powder
- screen drum
- air
- scutellaria baicalensis
- ultramicro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a normal-temperature preparation method of ultramicro Scutellaria baicalensis powder. The preparation method comprises the following steps of: firstly preparing and washing Chinese herbal medicine Scutellaria baicalensis and drying in the air till the water content is not more than 10%; crushing the dried Scutellaria baicalensis at normal temperature to obtain coarse powder with granularity of 60-80 meshes; crushing the obtained coarse powder in a rod mill, and then blowing the crushed coarse powder into a special bidirectional airflow screening machine by air and screening by using a 500-mesh screen so as to obtain powder material with granularity not more than 25 microns, conveying the powder material into a cyclone material collector for collecting by airflow generated by a draught fan so as to finally obtain the finished product of ultramicro Scutellaria baicalensis powder; and collecting powder material which is not screened by the 500-mesh screen by usinga funnel and conveying the collected powder material into the rod mill for cyclic crushing by a pipeline. The preparation method has the advantages that the whole preparation process is performed at normal temperature in no need of low temperature or special additional conditions; the granularity of finished product of ultramicro Scutellaria baicalensis powder is not more than 25 microns, therefore the cell-wall breaking ratio and bioavailability are improved greatly and pharmacological action of the medicine is enhanced remarkably. By the adoption of the bidirectional airflow screening machine in the preparation method, the preparation process of the ultramicro Scutellaria baicalensis powder is simplified, and the quality standard of Chinese herbal medicine powder can be controlled.
Description
Technical field
The present invention relates to veterinary additive, especially relate to normal-temperature preparation method of ultramicro Scutellaria baicalensis powder; The invention still further relates to the special bilateral airflow sieving machine for the method.
Background technology
In long-term animal husbandry was produced, Drug resistance and the serious harm human health of drug residue of generally using generation of antibiotic etc had also caused destruction to environment.So research is green, non-harmful feed additive, improve the utilization rate of immunity of livestock and nutrient, the livestock products of producing green safety are inexorable trends of efficient, the low consumption in the 21 century whole world, of low pollution aquaculture development, Chinese medicine feed additive is antibiotic first-selected product as an alternative, solving drug residue, production safety food aspect is to become the focus of feed additive industrial research.
Radix Scutellariae begins to be stated from Shennong's Herbal, is the dry root of Labiatae herbaceos perennial Radix Scutellariae, main product is in northeast, Hebei, Shaanxi, the Inner Mongol, Henan, the provinces and regions such as Shaanxi, mostly be wild, the grower also has in recent years, and the property of medicine is bitter, cold, return lung, stomach, gallbladder, large intestine channel, contain flavonoid, take baicalin as main component, has heat-clearing and toxic substances removing, the effects such as pathogenic fire purging dampness arresting bleeding and miscarriage prevention.The Radix Scutellariae additive that is used at present poultry is the powder of coarse powder, exists using dosage large, and dosage form is thick, appearance poor, and the problem such as effective ingredient can not fully discharge, and bioavailability is low has had a strong impact on the quality of Chinese medicine and clinical health-care effect.
The Study on Supermicro-pulverization of Traditional Chinese Drugs technology is to the renewal of traditional crushing technology and development; it had both kept the advantage of Chinese medicine technology of preparing; injected new vitality for the modern production of Chinese medicine again; have a extensive future, but remain in actual production in some problems and a difficult problem: (1) production efficiency is low, the power consumption height is the principal element of restriction veterinary Chinese medicine superfine powder large-scale production.In traditional closed circuit method crushing process, when most of material has reached fineness requirement, always there is the small part coarse powder to be mixed in wherein, make this part coarse powder further be crushed to institute's granularity that requires needs significantly to prolong grinding time, so that crush efficiency reduces, power consumption significantly increases; (2) it is poor that there are the material particular diameter uniformity after the classification in selecting crude drugs with winnower classification and grading wheel classification, greatly affected the quality of production of herbal medicine compound recipe superfine powder, especially when being applied to the use of drinking water for animals or particulate material spice, because a large amount of not existence of breaking cellular wall cell are difficult to reach instructions for use.(3) traditional one-way gas flow screening is because Chinese medicine is when carrying out micronizing, along with reducing of particle diameter, material particles surface area and surface energy increase, adsorptivity increases, and mobile variation easily is gathered into bulky grain etc. and causes the sieve classification of crossing that surpasses 200 order fineness medicated powder to be difficult to carry out.The existence of above-mentioned factor has had a strong impact on standardization, the large-scale production of herbal medicine superfine powder, and the popularization on veterinary clinic and use.
Summary of the invention
The object of the invention is to provide that a kind of rapid-action, good effect, bioavailability are high, the normal-temperature preparation method of ultramicro Scutellaria baicalensis powder of clinical good health care effect.
Another purpose of the present invention is to provide a kind of special bilateral airflow sieving machine that is applied to normal-temperature preparation method of ultramicro Scutellaria baicalensis powder.
Normal-temperature preparation method of ultramicro Scutellaria baicalensis powder of the present invention comprises the steps:
The first step, get baikal skullcap root and clean, dry, natural drying or dry to moisture≤10%;
Second step, under 20 ℃～25 ℃ Radix Scutellariae is pulverized, obtaining granularity is 60-80 purpose coarse powder;
The 3rd step, with second step gained coarse powder place in the rod mill pulverize after, be fed into special bilateral airflow sieving machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine is transported to collect in the tornado feeder set and namely gets superfine powder Radix Scutellariae finished product; The powder of not crossing 500 mesh sieves is transported to again circulation pulverizing in the described rod mill through the funnel collection and by pipeline.
Special bilateral airflow sieving machine of the present invention comprises casing and the downward screen drum of chamber intermediate openings that sets within it, the order number of described screen drum 〉=500 orders; The nozzle of screen drum is connected mutually with the funnel upper shed that is arranged on the casing bottom; Chassis cavity is connected with air-introduced machine by the negative pressure chamber on top; The door font rotation spray trachea that is made of transverse tube and standpipe is arranged at the region division between screen drum and casing, the puff prot of described door font rotation spray trachea is for axially being opened in groove on its tube wall along described transverse tube and standpipe respectively, described groove is offered towards the screen drum direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube and drive motors driving coupling; Be provided with blast pipe in the screen drum centre position, the air outlet of described blast pipe passes that screen drum is connected with the transverse tube middle part of door font rotation spray trachea and rolls by rolling bearing and is connected; The air inlet of blast pipe extends outside the described hopper side walls and is connected with the blast orifice of aerator; Be provided with feed pipe in screen drum, be provided with the buffering umbrella above the discharging opening of described feed pipe, the charging aperture of feed pipe extends outside the hopper side walls and is communicated with powder conveying fan air outlet through wind stopping device.
The air inducing of described air-introduced machine is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors is 155 rev/mins; The blast pressure of described aerator is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum and roof respectively with corresponding standpipe and transverse tube between distance be 25 millimeters.
The invention has the advantages that whole preparation process all carries out at normal temperatures, do not need low temperature or special additional conditions; The finished product Radix Scutellariae micropowder particle diameter of preparation≤25 microns has improved cell wall breaking rate (sporoderm-broken rate can reach more than 95%) and bioavailability greatly, has strengthened the pharmacological action of medicine, thereby has reduced dosage, has saved medical material; The bidirectional airflow sieving machine that uses in the inventive method has been simplified the preparation technology of superfine powder Radix Scutellariae greatly, has realized the purpose that the Chinese powder medicine quality standard is controlled, be suitable for large-scale industrial production.
Clinical health-care effect according to the superfine powder Radix Scutellariae of the inventive method preparation is verified by following test:
Test example: the Radix Scutellariae superfine powder is on the impact of meat chicken production performance
Test drug and material:
The Radix Scutellariae superfine powder adopts the present invention's preparation;
The Radix Scutellariae coarse powder: 80 order coarse powder, make by oneself at laboratory;
Experimental animal and packet transaction: 400 of healthy anosis 1 age in days AA broiler chicks, be divided at random 4 groups, every group of 5 repetitions, every group is repeated 20 plumages, be respectively the matched group of the basal diet of feeding, with add respectively 0.1%, 0.2%, 0.4% Radix Scutellariae superfine powder test group, cycle is conventional feeding and management in 4 days, free choice feeding is freely drunk water, and daily management and immune programme for children carry out routinely.
Table 1 basal diet forms and trophic level (%)
| Project | 1-21d | 22-42d |
| Semen Maydis | 56.05 | 65.94 |
| Bean cake | 36.46 | 26.04 |
| Soybean oil | 3.00 | 3.90 |
| Stone powder | 2.90 | 3.00 |
| Calcium hydrogen phosphate | 0.43 | 0.30 |
| Sal | 0.30 | 0.30 |
| 1B hydrochloric acid | 0.21 | 0.13 |
| DL-methionine | 0.20 | 0.19 |
| Vitamin premix | 0.20 | 0.05 |
| Choline chloride | 0.15 | 0.05 |
| Mineral substance premix | 0.10 | 0.10 |
| Metabolizable energy | 12.46 | 13.32 |
| Thick protein | 21.19 | 20.56 |
| Calcium | 0.90 | 0.85 |
| Phosphorus | 0.45 | 0.41 |
| Lysine | 1.18 | 1.02 |
| Methionine | 0.47 | 0.45 |
Table 2 Radix Scutellariae superfine powder is on the material anharmonic ratio impact of broiler
| Group | The 1-21 age in days | The 22-42 age in days | The 1-42 age in days |
| Matched group | 1.72±0.02 | 2.66±0.04 | 2.49±0.02 |
| Test group 1 | 1.73±0.02 | 2.64±0.01 | 2.52±0.01 |
| Test group 2 | 1.68±0.01 | 2.65±0.02 | 2.50±0.02 |
| Test group 3 | 1.71±0.02 | 2.63±0.01 | 2.51±0.02 |
As seen, the material anharmonic ratio of test group 2 is minimum from table 1,2, has reduced respectively 2.33%, 2.89% and 1.75% with respect to matched group and other two test group.This shows, add the material anharmonic ratio that 0.2% Radix Scutellariae superfine powder can obviously reduce broiler chicks, clinic is promoted.
Description of drawings
Fig. 1 is the production equipment system figure of the method for the invention.
Fig. 2 is the structural representation of special bilateral airflow sieving machine of the present invention.
The specific embodiment
As shown in Figure 1, 2, normal-temperature preparation method of ultramicro Scutellaria baicalensis powder of the present invention comprises the steps:
The first step, get the baikal skullcap root that bar is long, matter is solid, the yellow skin skin is clean and clean, dry, naturally dry or dry to moisture≤10%;
Second step, under 20 ℃～25 ℃ Radix Scutellariae is pulverized, obtaining granularity is 60-80 purpose coarse powder;
The 3rd goes on foot, at first opens powder conveying fan 15, air-introduced machine 5, aerator 11, drive motors 8.The blow pressure of powder conveying fan 15 is 24kpa, and the blowing amount is 150m
3/ h; The air inducing of air-introduced machine 5 is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The blast pressure of aerator 11 is 33kpa, blow rate required 320m
3/ h; The rotating speed of drive motors 8 is 155 rev/mins.
1, second step gained coarse powder is placed rod mill 16 interior pulverizing after, rod mill 16 interior powder body to be fractionated are arranged in the downward screen drum 2 of casing 1 inner chamber intermediate openings being brought into by high velocity air through wind stopping device 14, feed pipe 12 under the power of the blowing effect of powder conveying fan 15, and by the impulsive force of buffering umbrella 13 reduction powder body to be fractionated in screen drum 2, make powder body to be fractionated in screen drum 2 interior dispersions; The order number of screen drum 2 is 500 orders;
2, the powder body to be fractionated of screen drum 2 interior dispersions carries out classification by screen drum 2 under air-introduced machine 5 effect, and fine powder negative pressure chamber 4 through casing 1 top under the negative-pressure air-flow effect that air-introduced machine 5 produces of passing screen drum 2 is transported to and collects the superfine powder Radix Scutellariae finished product that namely gets particle diameter≤25 micron in the tornado feeder set 17.The powder body by screen drum 2 does not sink through collecting with the funnel 3 that screen drum 2 under sheds are connected mutually and being transported to again circulation pulverizing in the described rod mill 16 by pipeline 18;
3, door font rotation spray trachea rotates by rolling bearing 10 under drive motors 8 drives, the wind that aerator 11 is sent is in blast pipe 9 enters described transverse tube 6 and standpipe 7, and through be opened in vertically respectively the puff prot ejection that has the groove structure on transverse tube 6 and standpipe 7 tube walls towards screen drum 2 directions, form even blowback air-flow in screen drum 2 at screen drum 2 end faces and side, powder body in the screen drum 2 is further atomized, stop simultaneously powder body at screen drum 2 caking blocking screen mesh, make not powder body by screen drum 2 along with the air-flow whirlpool that forms sinks to entering in the funnel 3.The groove width that is opened in vertically respectively groove on transverse tube 6 and standpipe 7 tube walls is selected between 0.5 millimeter-2 millimeters as required, between the roof of transverse tube 6 and standpipe 7 and corresponding screen drum 2 and the sidewall apart from being respectively 25 millimeters.
The superfine powder Radix Scutellariae finished product that obtains is sub-packed in the aluminium foil bag, and every bag weighs 500g or 1000g.
Claims (2)
1. a normal-temperature preparation method of ultramicro Scutellaria baicalensis powder is characterized in that: comprise the steps:
The first step, get baikal skullcap root and clean, dry, natural drying or dry to moisture≤10%;
Second step, under 20 ℃～25 ℃ Radix Scutellariae is pulverized, obtaining granularity is 60-80 purpose coarse powder;
The 3rd step, with second step gained coarse powder place pulverize in the rod mill (16) after, be fed into special bilateral airflow sieving machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine (5) is transported to that collection namely gets superfine powder Radix Scutellariae finished product in the tornado feeder set (17); The powder of not crossing 500 mesh sieves is transported to again circulation pulverizing in the described rod mill (16) through funnel (3) collection and by pipeline (18);
Described special bilateral airflow sieving machine is characterized in that: comprise casing (1) and the downward screen drum of chamber intermediate openings (2) that sets within it, the order number of described screen drum (2) 〉=500 orders; The nozzle of screen drum (2) is connected mutually with funnel (3) upper shed that is arranged on casing (1) bottom; Casing (1) inner chamber is connected with air-introduced machine (5) by the negative pressure chamber (4) on top; At the region division that is positioned between screen drum (2) and the casing (1) the door font rotation spray trachea that is made of transverse tube (6) and standpipe (7) is arranged, the puff prot of described door font rotation spray trachea is for axially being opened in groove on its tube wall along described transverse tube (6) and standpipe (7) respectively, described groove is offered towards screen drum (2) direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube (6) and drive motors (8) driving coupling; Be provided with blast pipe (9) in screen drum (2) centre position, the air outlet of described blast pipe (9) passes screen drum (2) and is connected with transverse tube (6) middle part of door font rotation spray trachea and is connected by rolling bearing (10) rolling; The air inlet of blast pipe (9) extends outside described funnel (3) sidewall and is connected with the blast orifice of aerator (11); In screen drum (2), be provided with feed pipe (12), be provided with buffering umbrella (13) in the discharging opening of described feed pipe (12) top, the charging aperture of feed pipe (12) extends outside funnel (3) sidewall and is communicated with powder conveying fan (15) air outlet through wind stopping device (14).
2. normal-temperature preparation method of ultramicro Scutellaria baicalensis powder according to claim 1 is characterized in that: the air inducing of described air-introduced machine (5) is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors (8) is 155 rev/mins; The blast pressure of described aerator (11) is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan (15) is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum (2) and roof respectively with corresponding standpipe (7) and transverse tube (6) between distance be 25 millimeters.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110382940 CN102406707B (en) | 2011-11-28 | 2011-11-28 | Normal-temperature preparation method of ultramicro Scutellaria baicalensis powder and special bidirectional airflow screening machine thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110382940 CN102406707B (en) | 2011-11-28 | 2011-11-28 | Normal-temperature preparation method of ultramicro Scutellaria baicalensis powder and special bidirectional airflow screening machine thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102406707A CN102406707A (en) | 2012-04-11 |
| CN102406707B true CN102406707B (en) | 2013-10-23 |
Family
ID=45909244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110382940 Active CN102406707B (en) | 2011-11-28 | 2011-11-28 | Normal-temperature preparation method of ultramicro Scutellaria baicalensis powder and special bidirectional airflow screening machine thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102406707B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810791A (en) * | 2009-12-17 | 2010-08-25 | 河南省康星药业有限公司 | Preparation method of ultrafine powder for eliminating pestilence and relieving toxicity at normal temperature |
| CN102133355A (en) * | 2011-03-25 | 2011-07-27 | 江西核工业金品生物科技有限公司 | Screened traditional Chinese medicine preparation for preventing and treating high fever syndrome of livestock and preparation method thereof |
-
2011
- 2011-11-28 CN CN 201110382940 patent/CN102406707B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810791A (en) * | 2009-12-17 | 2010-08-25 | 河南省康星药业有限公司 | Preparation method of ultrafine powder for eliminating pestilence and relieving toxicity at normal temperature |
| CN102133355A (en) * | 2011-03-25 | 2011-07-27 | 江西核工业金品生物科技有限公司 | Screened traditional Chinese medicine preparation for preventing and treating high fever syndrome of livestock and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| "分级技术在中药超细粉体生产中的应用";王劲等;《中国粉体技术》;20080225;36-38 * |
| 王劲等."分级技术在中药超细粉体生产中的应用".《中国粉体技术》.2008, |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102406707A (en) | 2012-04-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102512520B (en) | Normal-temperature preparation method for ultrafine powder hawthorn | |
| CN102512545B (en) | Submicron powder bazheng powder normal temperature preparation method and special bidirectional airflow sieving machine thereof | |
| CN102512509B (en) | Normal-temperature preparation method for ultra-micro fine Chinese pulsatilla powder and special bidirectional airflow sieving machine thereof | |
| CN102511659B (en) | Normal-temperature ultrafine argy wormwood leaf powder preparation method | |
| CN102397488B (en) | Method for preparing submicron powder for legehenne at normal temperature, and two-way air flow screening machine special for method | |
| CN102430089B (en) | Method for preparing ultrafine powder Qiangzhuang San at normal temperature | |
| CN102429937B (en) | Superfine powder purslane powder normal-temperature preparation method and special double-direction air flow screening machine thereof | |
| CN102406781B (en) | Room temperature preparation method for ultrafine huoxiang zhengqi powder, and special bidirectional air flow screening device | |
| CN102406687B (en) | Normal-temperature preparation method of isatis root submicron powder and special bidirectional airflow sieving machine used by same | |
| CN102397452B (en) | Submicron powder cough powder normal temperature preparation method | |
| CN102488803B (en) | Preparation method for superfine bupleurum powder under normal temperature | |
| CN102397162B (en) | Method for preparing ultrafine honeysuckle and forsythia powder at normal temperature | |
| CN103070972A (en) | Normal temperature preparation method of Radix Scrophulariae and licorice submicron powder, and special bidirectional airflow screener therefor | |
| CN102397347B (en) | Submicron powder pulvis rhei normal temperature preparation method and special two-way airflow screen grader | |
| CN103071011A (en) | Normal temperature preparation method of chicken sexual maturity promotion ultrafine powder, and special bidirectional airflow screener therefor | |
| CN102406707B (en) | Normal-temperature preparation method of ultramicro Scutellaria baicalensis powder and special bidirectional airflow screening machine thereof | |
| CN102429963B (en) | Method for preparing ultrafine powder Houyanjing San at normal temperature | |
| CN102406546B (en) | Normal temperature preparation method of superfine asthma treatment powder | |
| CN102406701B (en) | Normal-temperature preparation method of ultramicro antidysenteric powder and special bidirectional airflow screening machine thereof | |
| CN102429992B (en) | Superfine powder houttuynia herb normal-temperature preparation method | |
| CN102406830B (en) | Room-temperature preparation method for submicron powder Qingshu powder and special bidirectional airflow screening machine | |
| CN102397321B (en) | Method for preparing ultra-micro lightyellow sophora root powder at normal temperature and special bidirectional airflow screening machine | |
| CN102406713B (en) | Normal-temperature preparation method for rheum franzenbachii munt. submicron powder and special bidirectional airflow sieving machine used by same | |
| CN102406688B (en) | Normal-temperature preparation method of codonopsis pilosula submicron powder | |
| CN102406741B (en) | Preparation method of ultrafine powder dried orange peel at normal temperature |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent for invention or patent application | ||
| CB02 | Change of applicant information |
Address after: 451464, No. 2, Hing Road, Baisha Industrial Park, Zhongmu County, Henan, Zhengzhou Applicant after: Henan Health Star Pharmaceutical Co., Ltd. Address before: 451464, No. 2, Hing Road, Baisha Industrial Park, Zhongmu County, Henan, Zhengzhou Applicant before: Henan Kangxing Pharmaceutical Co., Ltd. |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: HENAN KANGXING BIOTECHNOLOGY CO., LTD. Effective date: 20131213 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20131213 Address after: 451464, No. 2, Hing Road, Baisha Industrial Park, Zhongmu County, Henan, Zhengzhou Patentee after: Henan Health Star Pharmaceutical Co., Ltd. Patentee after: Henan Kang Xing Biotechnology Co., Ltd. Address before: 451464, No. 2, Hing Road, Baisha Industrial Park, Zhongmu County, Henan, Zhengzhou Patentee before: Henan Health Star Pharmaceutical Co., Ltd. |