CN102421781A - 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用 - Google Patents

吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用 Download PDF

Info

Publication number
CN102421781A
CN102421781A CN2011800020688A CN201180002068A CN102421781A CN 102421781 A CN102421781 A CN 102421781A CN 2011800020688 A CN2011800020688 A CN 2011800020688A CN 201180002068 A CN201180002068 A CN 201180002068A CN 102421781 A CN102421781 A CN 102421781A
Authority
CN
China
Prior art keywords
acid
salt
methyl
bases
morpholines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800020688A
Other languages
English (en)
Inventor
邓炳初
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Priority to CN2011800020688A priority Critical patent/CN102421781A/zh
Publication of CN102421781A publication Critical patent/CN102421781A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

本发明涉及吡咯并N杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用。具体而言，本发明涉及式(I)所示的(R，Z)-2-(5-氟-2-氧代-1，2-二氢-吲哚-3-次甲基)-5-(2-羟基-3-***啉-4-基-丙基)-3-甲基-5，6，7，8-四氢-1H-吡咯并[3，2-c]吖庚因-4-酮的可药用的盐，其制备方法以及作为治疗剂特别是作为蛋白激酶抑制剂的用途。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN2011800020688A 2010-02-04 2011-01-07 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用 Pending CN102421781A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2011800020688A CN102421781A (zh) 2010-02-04 2011-01-07 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201010109068.5 2010-02-04
CN2010101090685A CN102146082A (zh) 2010-02-04 2010-02-04 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用
CN2011800020688A CN102421781A (zh) 2010-02-04 2011-01-07 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用
PCT/CN2011/070076 WO2011095068A1 (zh) 2010-02-04 2011-01-07 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用

Publications (1)

Publication Number Publication Date
CN102421781A true CN102421781A (zh) 2012-04-18

Family

ID=44354948

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2010101090685A Pending CN102146082A (zh) 2010-02-04 2010-02-04 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用
CN2011800020688A Pending CN102421781A (zh) 2010-02-04 2011-01-07 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN2010101090685A Pending CN102146082A (zh) 2010-02-04 2010-02-04 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用

Country Status (11)

Country Link
US (1) US20120295887A1 (zh)
EP (1) EP2532666A1 (zh)
JP (1) JP2013518828A (zh)
KR (1) KR20120130089A (zh)
CN (2) CN102146082A (zh)
AU (1) AU2011213440A1 (zh)
BR (1) BR112012018658A2 (zh)
CA (1) CA2786927A1 (zh)
MX (1) MX2012008611A (zh)
RU (1) RU2012136378A (zh)
WO (1) WO2011095068A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201402071D0 (en) * 2014-02-07 2014-03-26 Galapagos Nv Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
CN112778187B (zh) * 2021-01-06 2022-10-28 烟台舜康生物科技有限公司 一种海那替尼中间体的合成方法及所得的海纳替尼中间体

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064681A2 (en) * 2000-02-28 2001-09-07 Sugen, Inc. 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
WO2007085188A1 (en) * 2006-01-27 2007-08-02 Shanghai Hengrui Pharmaceutical Co. Ltd. Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase inhibitors
WO2008138184A1 (fr) * 2007-05-14 2008-11-20 Shanghai Hengrui Pharmaceutical Co.Ltd. Dérivés de pyrrolo-azacycles, leur procédé de fabrication et leur utilisation en tant qu'inhibiteurs de protéine kinases
WO2008138232A1 (fr) * 2007-05-14 2008-11-20 Shanghai Hengrui Pharmaceutical Co., Ltd. Dérivés pyrrolo-azotés hétérocycliques, leur préparation et leur utilisation pharmaceutique

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064681A2 (en) * 2000-02-28 2001-09-07 Sugen, Inc. 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
WO2007085188A1 (en) * 2006-01-27 2007-08-02 Shanghai Hengrui Pharmaceutical Co. Ltd. Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase inhibitors
WO2008138184A1 (fr) * 2007-05-14 2008-11-20 Shanghai Hengrui Pharmaceutical Co.Ltd. Dérivés de pyrrolo-azacycles, leur procédé de fabrication et leur utilisation en tant qu'inhibiteurs de protéine kinases
WO2008138232A1 (fr) * 2007-05-14 2008-11-20 Shanghai Hengrui Pharmaceutical Co., Ltd. Dérivés pyrrolo-azotés hétérocycliques, leur préparation et leur utilisation pharmaceutique

Also Published As

Publication number Publication date
CA2786927A1 (en) 2011-08-11
JP2013518828A (ja) 2013-05-23
AU2011213440A1 (en) 2012-08-09
BR112012018658A2 (pt) 2016-05-03
MX2012008611A (es) 2012-08-15
WO2011095068A1 (zh) 2011-08-11
CN102146082A (zh) 2011-08-10
US20120295887A1 (en) 2012-11-22
EP2532666A1 (en) 2012-12-12
KR20120130089A (ko) 2012-11-28
RU2012136378A (ru) 2014-03-10

Similar Documents

Publication Publication Date Title
CN102933574A (zh) (e)-n-[4-[[3-氯-4-(2-吡啶基甲氧基)苯基]氨基]-3-氰基-7-乙氧基-6-喹啉基]-3-[(2r)-1-甲基吡咯烷-2-基]丙-2-烯酰胺的可药用的盐、其制备方法及其在医药上的应用
RU2573633C2 (ru) Хинолил-содержащее соединение гидроксамовой кислоты, способ его получения, а также применение при лечении заболеваний, вызванных аномальной активностью протеинкиназы и/или гистондеацетилазы
CN105008355B (zh) 作为蛋白激酶抑制剂的氮杂吲哚衍生物
WO2018022761A1 (en) Substituted cyclopentane-amides for treating disorders related to ret
CN102471312A (zh) 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用
JP2021121597A (ja) 改善された特性を有するβ−グアニジノプロピオン酸の薬学的に許容される塩及びその使用
CN103987700A (zh) 4-喹唑啉胺类衍生物及其用途
CN107286130A (zh) 一种激酶选择性抑制剂
CN108341801A (zh) 多氟取代芳联杂环类衍生物、含其的药物组合物及其应用
CN107304210A (zh) 一种选择性fgfr4激酶抑制剂
EP3418277B1 (en) Substituted amino six-membered nitric heterocyclic ring compound and preparation and use thereof
CN108341815A (zh) 一种抑制激酶化合物及其用途
TW202311259A (zh) 化合物i的新形式及其應用
CN102421781A (zh) 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用
CN116496219A (zh) 六元并五元杂环类化合物及其药物组合物和应用
CA3199295A1 (en) New crystalline forms of a kras g12c inhibitor compound
CN109438362B (zh) 一种取代的苯并咪唑化合物及包含该化合物的组合物
CN107286107A (zh) 一种成纤维细胞生长因子受体选择性抑制剂
CN108117551B (zh) 取代(1H-吡唑[3,4-b]吡啶)脲类化合物及其抗肿瘤用途
JP7432739B2 (ja) アザインドール誘導体の結晶形及びその応用
CN108341837A (zh) 一种抑制激酶化合物及其在医学上的用途
KR102293709B1 (ko) 신규한 퀴놀린 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 약학적 조성물
TW201228664A (en) Pyrrolo-nitrogenous heterocyclic derivatives pharmaceutical salts, preparation process and pharmaceutical use thereof
TW202328138A (zh) 稠合二環類衍生物的可藥用鹽、晶型及其製備方法
CN117813288A (zh) 芳氨基衍生物***受体调节剂及其用途

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20120418