CN108341801A - 多氟取代芳联杂环类衍生物、含其的药物组合物及其应用 - Google Patents
多氟取代芳联杂环类衍生物、含其的药物组合物及其应用 Download PDFInfo
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- CN108341801A CN108341801A CN201710053576.8A CN201710053576A CN108341801A CN 108341801 A CN108341801 A CN 108341801A CN 201710053576 A CN201710053576 A CN 201710053576A CN 108341801 A CN108341801 A CN 108341801A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Abstract
Description
激酶 | VII-12 | VII-30 | GSK2141795 |
Akt2 | 5.5-倍 | 5.9-倍 | 2-倍 |
Akt3 | 4.1-倍 | 4.5-倍 | 2.6-倍 |
PKA | 1.3-倍 | 1.77-倍 | 1.2-倍 |
PKC | 123-倍 | 101-倍 | 28-倍 |
Claims (11)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710053576.8A CN108341801B (zh) | 2017-01-24 | 2017-01-24 | 多氟取代芳联杂环类衍生物、含其的药物组合物及其应用 |
EP18744726.3A EP3575291A1 (en) | 2017-01-24 | 2018-01-19 | Polyfluoro-substituted aromatic heterocyclic compound derivative, pharmaceutical composition containing same, and applications thereof |
PCT/CN2018/073325 WO2018137555A1 (zh) | 2017-01-24 | 2018-01-19 | 多氟取代芳联杂环类衍生物、含其的药物组合物及其应用 |
US16/480,599 US11319300B2 (en) | 2017-01-24 | 2018-01-19 | Polyfluoro-substituted aromatic heterocyclic derivative, pharmaceutical composition containing same, and applications thereof |
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Cited By (4)
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CN108752318A (zh) * | 2018-07-11 | 2018-11-06 | 浙江大学 | 一种多氟取代芳联杂环类化合物的晶型、制备方法和应用 |
CN109384708A (zh) * | 2018-11-19 | 2019-02-26 | 浙江大学 | 一种Akt抑制剂中间体SM1及其制备方法 |
CN109574991A (zh) * | 2018-11-19 | 2019-04-05 | 浙江大学 | 一种多氟取代芳联杂环类化合物的制备工艺 |
CN112915086A (zh) * | 2021-01-27 | 2021-06-08 | 广州市力鑫药业有限公司 | 一种含有Akt靶向激酶抑制剂的药物组合物 |
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KR102343165B1 (ko) * | 2020-01-08 | 2021-12-24 | 숙명여자대학교산학협력단 | 생물학적 시료를 이용한 대장암 발암물질 노출 여부 진단방법 |
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CN101921268A (zh) * | 2010-08-27 | 2010-12-22 | 中山大学肿瘤防治中心 | 5-噻唑酰胺类化合物及生物学应用 |
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CN108752318A (zh) * | 2018-07-11 | 2018-11-06 | 浙江大学 | 一种多氟取代芳联杂环类化合物的晶型、制备方法和应用 |
CN109384708A (zh) * | 2018-11-19 | 2019-02-26 | 浙江大学 | 一种Akt抑制剂中间体SM1及其制备方法 |
CN109574991A (zh) * | 2018-11-19 | 2019-04-05 | 浙江大学 | 一种多氟取代芳联杂环类化合物的制备工艺 |
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CN112915086A (zh) * | 2021-01-27 | 2021-06-08 | 广州市力鑫药业有限公司 | 一种含有Akt靶向激酶抑制剂的药物组合物 |
CN112915086B (zh) * | 2021-01-27 | 2022-04-12 | 广州市力鑫药业有限公司 | 一种含有Akt靶向激酶抑制剂的药物组合物 |
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US20200165229A1 (en) | 2020-05-28 |
CN108341801B (zh) | 2020-05-12 |
US11319300B2 (en) | 2022-05-03 |
EP3575291A4 (en) | 2019-12-04 |
EP3575291A1 (en) | 2019-12-04 |
WO2018137555A1 (zh) | 2018-08-02 |
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