CN102389499A - Traditional Chinese medicinal extract used for controlling viral diseases in aquiculture and preparation method thereof - Google Patents
Traditional Chinese medicinal extract used for controlling viral diseases in aquiculture and preparation method thereof Download PDFInfo
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- CN102389499A CN102389499A CN2011103446256A CN201110344625A CN102389499A CN 102389499 A CN102389499 A CN 102389499A CN 2011103446256 A CN2011103446256 A CN 2011103446256A CN 201110344625 A CN201110344625 A CN 201110344625A CN 102389499 A CN102389499 A CN 102389499A
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Abstract
The invention relates to a traditional Chinese medicinal extract used for controlling viral diseases in aquiculture and a preparation method thereof. The traditional Chinese medicinal extract used for controlling viral diseases is prepared by the following major materials according the part by weight: 40 to 60 of rhubarb, 20 to 40 of membranous milkvetch root, 15 to 25 of pilose asiabell root, 20 to 25 of pomegranate bark, 15 to 25 of indigowoad leaf, 20 to 30 of indigowoad root, 15 to 25 of Epimedium, 20 to 30 of divaricate saposhnikovia, 15 to 25 of Peucedanum, 10 to 20 of liquorice root and 20 to 30 of peppermint. The preparation method comprises the steps as follows: weighing the materials, grinding, extracting with an ethanol aqueous solution twice, collecting filtrates, and distilling the filtrates under reduced pressure to obtain the traditional Chinese medicinal extract. The extract can regulate the color of water and improve feed attractant in aquatic animals, has the characteristics of removing heat and toxic substances and improving immunity of aquatic animals, can inhibit the growth and reproduction of bacteria and viruses, and is used for treating various diseases caused by bacteria and viruses. The extract is convenient to administrate and has no drug residues or toxic side effects.
Description
Technical field
The present invention relates to Chinese medicine extraction liquid of a kind of viral disease control and preparation method thereof, particularly a kind of Chinese medicine extraction liquid that is used for the viral disease control of aquaculture and preparation method thereof belongs to viral disease control technical field of pharmaceuticals.
Background technology
In recent years, the aquaculture scale enlarges rapidly, and cultural technique improves maturation gradually.Along with the large-scale development of culture fishery, cultured area, culture intensity and constantly increase, the ecological environment of breed constantly worsens, disease also becomes increasingly conspicuous, wherein especially with virosis for very.Break out and popular still not being controlled effectively of water body animal virosis solve with basic, and the influence that causes is big, weight losses.Influence serious common prawn ' s virus and mainly contain white spot virus, taura syudrome, hepatopancreatic parvovirus, the Fish virosis has hemorrhagic disease of grass carp, spring viremia, infectious pancreatic necrosis, eel virus property opening disease etc.Because the virus that infects parasitizes in the somatic cell, treatment is difficulty relatively, and in order to prevent and treat the virosis of aquaculture effectively, scientific research and breed personnel have carried out various explorations.A large amount of researchs show that under suitable condition, the water body animal can be carried viral healthy growth, just can fall ill under the degradation situation under environmental catastrophe, the water body animal immunizing power.So, should prevent and treat the water body animal virosis targetedly, the growing environment that establishment and stable water body animal are suitable improves the water body animal immunizing power, kill virus or inhibition virus replication etc.
Present research shows that cause that the principal element of virosis has: virus possibly propagated in the following manner:
1. horizontal transmission: propagate through source of disease such as viruliferous sick fish and shrimp, dead fish and shrimp, sea water, mud, after the water body zoogenetic infection virus, virus is bred in cell; Destroy prawn blood regulating liver-QI pancreatic cell function; Cause aquatic animal dead, virus is discharged in the water then, infects new host.Its main path has: 1. culture pond mud; 2. the sea water of non-sterile; 3. media is biological, as culturing other crustacean (comprising wild shrimps, Eriocheir sinensis class) and Copepods etc. in the pond; 4. culture sick fish and shrimp in the pond, dead fish and shrimp; 5. flying bird, pool side muroid of viruliferous fish and shrimp etc. ingested; 6. by viral pollution bait etc.
2. vertical transmission: promptly give seedling with virus disseminating through viruliferous parent.Exist bigger possibility for this route of transmission, but still lack positive evidence at present.
Virus can not be lived on one's own life because of it; Must parasitize in the cell, and a large amount of in vivo breeding duplicates, virus propagates into other cells through the cell rupture or the mode of sprouting from aquatic animal somatic cell film surface; The aquatic animal that also can infect other through the approach of horizontal transmission is individual; Aquatic animal by viral infection after, its tissue organ function reduces or forfeiture, causes aquatic animal dead subsequently.To its treatment, must kill cell theoretically, thereby reach the purpose of elimination virus, this obviously is unpractical.Controlling virus through raising aquatic animal autoimmunity is a more satisfactory approach, but the aquatic animal immunologic function that has is very low, and these all make virosis lack the efficacious therapy means.
Also having viral epiphytotics breaking out in earlier stage possibly be to be infected earlier by vibrio, and the water body animal immunizing power descends, and this moment, virus can be bred in short several hours or tens hours in a large number.Also there is the scholar to think and for bacterial infection condition is provided then by first viral infection.In a word, the situation that infects in the time of virus, antibacterial, infects each other is very general, has increased the weight of the state of an illness of virosis.
The growth conditions of water body animal has determined that antibacterial and viral propagation medium are water; If regulation and control through water quality; In antibacterial and virus disseminating process, implement to kill, and the administered through oral extracting solution improves the immunity of prawn, inhibition antibacterial and viral breeding; Breaking out of control virosis is a very effective approach.Grope through years of researches and practice, we sum up strick precaution, the Therapeutic Method of a cover system, set up an office through the large tracts of land multizone and instruct the aquaculture family, all prove successfully effective.
Summary of the invention
The purpose of this invention is to provide a kind of immunity of organisms, the resistance against diseases that can regulate cultivation water and raising aquatic animal, reduce the infection of bacterial virus, improve Chinese medicine extraction liquid of aquatic animal bacterial virus prevention effect and preparation method thereof.
In order to address the above problem, the technical scheme that the present invention adopted is:
Chinese medicine extraction liquid of the present invention mainly is to be processed by the raw material of following weight portion:
40～60 parts of Radix Et Rhizoma Rhei, 20～40 parts of the Radixs Astragali, 15～25 parts of Radix Codonopsis, 20～25 parts of Pericarpium Granatis, 15～25 parts of Folium Isatidiss, 20～30 parts of Radix Isatidis, 15～25 parts of Herba Epimedii, windproof 20～30 parts, 15～25 parts of Radix Peucedanis, 10～20 parts in Radix Glycyrrhizae, 20～30 parts of Herba Menthaes.
The preferred feedstock proportioning is:
48 parts of Radix Et Rhizoma Rhei, 30 parts of the Radixs Astragali, 22 parts of Radix Codonopsis, 20 parts of Pericarpium Granatis, 23 parts of Folium Isatidiss, 25 parts of Radix Isatidis, 20 parts of Herba Epimedii, windproof 26 parts, 20 parts of Radix Peucedanis, 12 parts in Radix Glycyrrhizae, 25 parts of Herba Menthaes.
Be used to prepare the method for the Chinese medicine extraction liquid of the viral disease control of aquaculture, may further comprise the steps:
(1) takes by weighing each raw material for 20～30 parts by 40～60 parts of Radix Et Rhizoma Rhei, 20～40 parts of the Radixs Astragali, 15～25 parts of Radix Codonopsis, 20～25 parts of Pericarpium Granatis, 15～25 parts of Folium Isatidiss, 20～30 parts of Radix Isatidis, 15～25 parts of Herba Epimedii, windproof 20～30 parts, 15～25 parts of Radix Peucedanis, 10～20 parts in Radix Glycyrrhizae, Herba Menthae, pulverize subsequent use;
(2) raw material of step (1) being pulverized soaks twice with 50% ethanol water, and the amount that adds ethanol water for the first time was not advisable soaking at room temperature 20 ~ 30 hours to have former charge level; Filter out filtrating, filtering residue adds ethanol water again, and the addition of ethanol water was not advisable to have former charge level; Soaking at room temperature 20 ~ 30 hours filters out filtrating, merges filtrating twice; Then in the filtrating suction vacuum distillation tower, it is that 1.3 extractum gets final product that 50 ~ 70 ℃ of constant temperature concentrating under reduced pressure become proportion.
Chinese medicine of the present invention is got the method for preparing of liquid, may further comprise the steps:
1, described preferably weight ratio takes by weighing each raw material: 48 parts of Radix Et Rhizoma Rhei, 30 parts of the Radixs Astragali, 22 parts of Radix Codonopsis, 20 parts of Pericarpium Granatis, 23 parts of Folium Isatidiss, 25 parts of Radix Isatidis, 20 parts of Herba Epimedii, windproof 26 parts, 20 parts of Radix Peucedanis, 12 parts in Radix Glycyrrhizae, 25 parts of Herba Menthaes, pulverize subsequent use;
2, the raw material of pulverizing is soaked twice with 50% ethanol water, add ethanol water for the first time and be not advisable soaking at room temperature 24 hours to have former charge level; Filter out filtrating, add ethanol water again and do not have former charge level, soaking at room temperature 24 hours; Merge filtrating twice; With six layers of filtered through gauze twice, then in the filtrating suction vacuum distillation tower, it is that 1.3 extractum gets final product that 60 ℃ of constant temperature concentrating under reduced pressure become proportion.
The invention has the beneficial effects as follows:
The present invention selects the above-mentioned raw materials combination to make each component and effect produce synergism, thereby can improve immunity of organisms, the resistance against diseases of aquatic animal, reduces the infection of bacterial virus, improves the prevention effect of water body animal bacteria virus.
Wherein selecting Radix Et Rhizoma Rhei for use is because of its purging heat to relax the bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass clots absorbing.Selecting the Radix Astragali for use is because of its tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation.Selecting Radix Codonopsis for use is because of its invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting.Select for use Pericarpium Granati to be because its relieving diarrhea with astringents stops blooding anthelmintic.Selecting Folium Isatidis for use is because of its heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Selecting Radix Isatidis for use is because of its heat-clearing and toxic substances removing, the removing heat from blood sore-throat relieving.Selecting Herba Epimedii for use is because of its kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Selecting for use windproof is because its inducing diaphoresis to dispel wind wins and wets, spasmolytic.Selecting Radix Peucedani for use is because of its lowering the adverse-rising QI to resolve phlegm, wind and heat dispersing.Selecting Radix Glycyrrhizae for use is because of its invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong.Selecting Herba Menthae for use is because of its wind-dispelling heat-dissipating, the clear sharp head, sore-throat relieving, rash.This prescription has antiviral, antibacterium, heat-clearing and toxin-vanquishing, removing heat from the liver, antibiotic and sterilizing, disease resistance enhancemen, stop virus invade host cell, suppress its DNA and RNA synthetic, suppress the viral growth breeding and play antiviral effect.
Chinese medicine extraction liquid of the present invention can be regulated water quality, suppresses antibacterial and breeds with the growth of virus, and convenient drug administration distributes extensively, and drug residue free has no side effect, and safety range is wide.
The specific embodiment
Through embodiment the present invention is explained further details below, these embodiment only are used for explaining the present invention, do not limit the scope of the invention.
Embodiment 1
No. 1 preparation of Chinese medicine extraction liquid of the present invention
1, takes by weighing 40 parts of raw material Radix Et Rhizoma Rhei, 25 parts of the Radixs Astragali, 20 parts of Radix Codonopsis, 18 parts of Pericarpium Granatis, 20 parts of Folium Isatidiss, 22 parts of Radix Isatidis, 16 parts of Herba Epimedii, windproof 22 parts, 18 parts of Radix Peucedanis, 10 parts in Radix Glycyrrhizae, 21 parts of Herba Menthaes, pulverize subsequent use;
2, the raw material of pulverizing is soaked twice with 50% ethanol water, add ethanol water for the first time and be not advisable soaking at room temperature 24 hours to have former charge level; Filter out filtrating, add ethanol water again and do not have former charge level, soaking at room temperature 24 hours; Merge filtrating twice; With six layers of filtered through gauze twice, then in the filtrating suction vacuum distillation tower, it is that 1.3 extractum gets final product that 50 ℃ of constant temperature concentrating under reduced pressure become proportion.
Embodiment 2
No. 2 preparations of Chinese medicine extraction liquid of the present invention
1, takes by weighing 55 parts of raw material Radix Et Rhizoma Rhei, 35 parts of the Radixs Astragali, 25 parts of Radix Codonopsis, 25 parts of Pericarpium Granatis, 25 parts of Folium Isatidiss, 30 parts of Radix Isatidis, 25 parts of Herba Epimedii, windproof 30 parts, 25 parts of Radix Peucedanis, 16 parts in Radix Glycyrrhizae, 30 parts of Herba Menthaes, pulverize subsequent use;
2, the raw material of pulverizing is soaked twice with 50% ethanol water, add ethanol water for the first time and be not advisable soaking at room temperature 24 hours to have former charge level; Filter out filtrating, add ethanol water again and do not have former charge level, soaking at room temperature 24 hours; Merge filtrating twice; With six layers of filtered through gauze twice, then in the filtrating suction vacuum distillation tower, it is that 1.3 extractum gets final product that 60 ℃ of constant temperature concentrating under reduced pressure become proportion.
Embodiment 3
No. 3 preparations of Chinese medicine extraction liquid of the present invention
1, takes by weighing 48 parts of raw material Radix Et Rhizoma Rhei, 30 parts of the Radixs Astragali, 22 parts of Radix Codonopsis, 20 parts of Pericarpium Granatis, 23 parts of Folium Isatidiss, 25 parts of Radix Isatidis, 20 parts of Herba Epimedii, windproof 26 parts, 20 parts of Radix Peucedanis, 12 parts in Radix Glycyrrhizae, 25 parts of Herba Menthaes, pulverize subsequent use;
2, the raw material of pulverizing is soaked twice with 50% ethanol water, add ethanol water for the first time and be not advisable soaking at room temperature 24 hours to have former charge level; Filter out filtrating, add ethanol water again and do not have former charge level, soaking at room temperature 24 hours; Merge filtrating twice; With six layers of filtered through gauze twice, then in the filtrating suction vacuum distillation tower, it is that 1.3 extractum gets final product that 70 ℃ of degree constant temperature concentrating under reduced pressure become proportion.
Embodiment 4
Safety experiment of the present invention:
In three fishponds, carry out safety testing, Ctenopharyngodon idellus 50 tails are put in each fishpond in a suitable place to breed.First fishpond adds 5ml viral disease control extracting solution of the present invention No. 1 in the feedstuff of every day; Second fishpond adds 5ml viral disease control extracting solution of the present invention No. 2 in the feedstuff of every day; The 3rd fishpond adds 5ml viral disease control extracting solution of the present invention No. 3 in the feedstuff of every day.Observed 30 days.
In 30 days, the fish in three fishponds is all no abnormal, is a cup too low depressed or the phenomena of mortality, well-grown.Explain that viral disease control Chinese medicine extraction liquid security performance of the present invention is good.
Embodiment 5
The present invention is to the preventive effect of aquaculture viral disease:
In four fishponds, carry out viral prevention of damage by disease effect test.Each 30 tail of Ctenopharyngodon idellus, the heavily about 100～150g of every urosome are put in each pond.Normally feed every day in first fishpond; Throw something and feed with 5% amantadine hydrochloride soluble powder, 1 gram spice every day in second fishpond; The 3rd fishpond adds No. 1 1ml spice of viral disease control extracting solution of the present invention and throws something and feeds; The 4th pond adds No. 3 1ml spices of viral disease control extracting solution of the present invention and throws something and feeds;
After raising a week, in four fishponds, respectively put into a Ctenopharyngodon idellus of suffering from hemorrhagic disease of grass carp respectively, observe the growing state of fish in each fishpond.The result sees table 1.The result shows that viral disease control extracting solution of the present invention has tangible prevention and therapeutical effect to hemorrhagic disease of grass carp.
Table 1: Chinese medicine extraction liquid of the present invention is to the preventive effect of hemorrhagic disease of grass carp
Embodiment 6
The present invention is to the therapeutical effect of aquaculture viral disease
Ctenopharyngodon idellus 200 tails with suffering from hemorrhagic disease of grass carp are divided into four groups at random, every group 50 tail, and normally feed first group of every day; Second group adds 5% amantadine hydrochloride soluble powder, 2 grams, and spice is thrown something and fed; The 3rd group with viral disease control extracting solution of the present invention No. 22 gram, and spice is thrown something and fed; The 4th group with viral disease control extracting solution of the present invention No. 32 gram, and spice is thrown something and fed;
After raising a week, observe the growing state of all Ctenopharyngodon idellus.The result sees table 2: the result shows that medicine of the present invention has the obvious treatment effect to hemorrhagic disease of grass carp.
Table 2: viral disease control Chinese medicine of the present invention is got the therapeutical effect of liquid to hemorrhagic disease of grass carp
Claims (3)
1. Chinese medicine extraction liquid that is used for the viral disease control of aquaculture, it is characterized in that: it mainly is to be processed by the raw material of following weight portion:
20～30 parts of 40～60 parts of Radix Et Rhizoma Rhei, 20～40 parts of the Radixs Astragali, 15～25 parts of Radix Codonopsis, 20～25 parts of Pericarpium Granatis, 15～25 parts of Folium Isatidiss, 20～30 parts of Radix Isatidis, 15～25 parts of Herba Epimedii, windproof 20～30 parts, 15～25 parts of Radix Peucedanis, 10～20 parts in Radix Glycyrrhizae and Herba Menthaes.
2. a kind of Chinese medicine extraction liquid that is used for the viral disease control of aquaculture according to claim 1 is characterized in that: it mainly is to be processed by the raw material of following weight portion:
25 parts of 48 parts of Radix Et Rhizoma Rhei, 30 parts of the Radixs Astragali, 22 parts of Radix Codonopsis, 20 parts of Pericarpium Granatis, 23 parts of Folium Isatidiss, 25 parts of Radix Isatidis, 20 parts of Herba Epimedii, windproof 26 parts, 20 parts of Radix Peucedanis, 12 parts in Radix Glycyrrhizae and Herba Menthaes.
3. one kind is used to prepare the described method that is used for the Chinese medicine extraction liquid of the viral disease control of aquaculture of claim 1, it is characterized in that: may further comprise the steps:
(1) takes by weighing each raw material for 20～30 parts by 40～60 parts of Radix Et Rhizoma Rhei, 20～40 parts of the Radixs Astragali, 15～25 parts of Radix Codonopsis, 20～25 parts of Pericarpium Granatis, 15～25 parts of Folium Isatidiss, 20～30 parts of Radix Isatidis, 15～25 parts of Herba Epimedii, windproof 20～30 parts, 15～25 parts of Radix Peucedanis, 10～20 parts in Radix Glycyrrhizae and Herba Menthae, pulverize subsequent use;
(2) raw material of step (1) being pulverized soaks twice with 50% ethanol water, and the amount that adds ethanol water for the first time was not advisable soaking at room temperature 20 ~ 30 hours to have former charge level; Filter out filtrating, filtering residue adds ethanol water again, and the addition of ethanol water was not advisable to have former charge level; Soaking at room temperature 20 ~ 30 hours filters out filtrating, merges filtrating twice; Then in the filtrating suction vacuum distillation tower, it is that 1.3 extractum gets final product that 50 ~ 70 ℃ of constant temperature concentrating under reduced pressure become proportion.
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103494038A (en) * | 2013-09-30 | 2014-01-08 | 江苏省淡水水产研究所 | Chinese herbal medicine immunopotentiator for resisting white spot syndrome virus (WSSV) of procambarus clarkia, as well as preparation method and application thereof |
| CN103690617A (en) * | 2014-01-06 | 2014-04-02 | 四川德润通生物科技有限公司 | Antiviral powder capable of clearing heat and removing toxicity |
| CN103705588A (en) * | 2014-01-06 | 2014-04-09 | 四川德润通生物科技有限公司 | Preparation method of high-stability superfine powder for strengthening body resistance and detoxifying |
| CN105124201A (en) * | 2015-08-10 | 2015-12-09 | 浙江省海洋开发研究院 | Artificial formula feed for preventing and treating hemorrhagic disease of spagrus macrocephalus |
| CN105124200A (en) * | 2015-08-10 | 2015-12-09 | 浙江省海洋开发研究院 | Artificial formula feed for preventing and treating hemorrhagic disease of oplegnathidae |
| CN105146140A (en) * | 2015-08-10 | 2015-12-16 | 浙江省海洋开发研究院 | Artificial compound feed for preventing and treating haemorrhage of Japanese flounders |
| CN105726660A (en) * | 2014-01-06 | 2016-07-06 | 四川德润通生物科技有限公司 | Body resistance strengthening and toxin removing ultrafine powder for livestock and poultry |
| CN105770019A (en) * | 2014-01-06 | 2016-07-20 | 四川德润通生物科技有限公司 | Heat-clearing and detoxifying powder for livestock and poultry |
| CN105832828A (en) * | 2014-01-06 | 2016-08-10 | 四川德润通生物科技有限公司 | Preparation method of healthy-energy-strengthening and body-detoxifying ultrafine powder agent for livestock and poultry |
| CN107373045A (en) * | 2017-07-27 | 2017-11-24 | 张银花 | One kind prevention leukodermal solid feed of lobster and preparation method thereof |
| CN108740555A (en) * | 2018-05-04 | 2018-11-06 | 金寨县康王寨家庭农场 | A kind of nutrition additive for aquaculture |
| CN111587860A (en) * | 2020-06-02 | 2020-08-28 | 长春至应科技有限公司 | Fishing phagostimulant and low-temperature preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103494038B (en) * | 2013-09-30 | 2015-08-05 | 江苏省淡水水产研究所 | Anti-white spot syndrome virus Chinese medicine immunity enhancer of a kind of Procambius clarkii and its preparation method and application |
| CN103494038A (en) * | 2013-09-30 | 2014-01-08 | 江苏省淡水水产研究所 | Chinese herbal medicine immunopotentiator for resisting white spot syndrome virus (WSSV) of procambarus clarkia, as well as preparation method and application thereof |
| CN105832828A (en) * | 2014-01-06 | 2016-08-10 | 四川德润通生物科技有限公司 | Preparation method of healthy-energy-strengthening and body-detoxifying ultrafine powder agent for livestock and poultry |
| CN103705588A (en) * | 2014-01-06 | 2014-04-09 | 四川德润通生物科技有限公司 | Preparation method of high-stability superfine powder for strengthening body resistance and detoxifying |
| CN105726660A (en) * | 2014-01-06 | 2016-07-06 | 四川德润通生物科技有限公司 | Body resistance strengthening and toxin removing ultrafine powder for livestock and poultry |
| CN105770019A (en) * | 2014-01-06 | 2016-07-20 | 四川德润通生物科技有限公司 | Heat-clearing and detoxifying powder for livestock and poultry |
| CN103690617A (en) * | 2014-01-06 | 2014-04-02 | 四川德润通生物科技有限公司 | Antiviral powder capable of clearing heat and removing toxicity |
| CN105124201A (en) * | 2015-08-10 | 2015-12-09 | 浙江省海洋开发研究院 | Artificial formula feed for preventing and treating hemorrhagic disease of spagrus macrocephalus |
| CN105124200A (en) * | 2015-08-10 | 2015-12-09 | 浙江省海洋开发研究院 | Artificial formula feed for preventing and treating hemorrhagic disease of oplegnathidae |
| CN105146140A (en) * | 2015-08-10 | 2015-12-16 | 浙江省海洋开发研究院 | Artificial compound feed for preventing and treating haemorrhage of Japanese flounders |
| CN107373045A (en) * | 2017-07-27 | 2017-11-24 | 张银花 | One kind prevention leukodermal solid feed of lobster and preparation method thereof |
| CN108740555A (en) * | 2018-05-04 | 2018-11-06 | 金寨县康王寨家庭农场 | A kind of nutrition additive for aquaculture |
| CN111587860A (en) * | 2020-06-02 | 2020-08-28 | 长春至应科技有限公司 | Fishing phagostimulant and low-temperature preparation method thereof |
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