CN102764308A - Drug for preventing bacterial diseases of fish and preparation method thereof - Google Patents

Drug for preventing bacterial diseases of fish and preparation method thereof Download PDF

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Publication number
CN102764308A
CN102764308A CN2012102873785A CN201210287378A CN102764308A CN 102764308 A CN102764308 A CN 102764308A CN 2012102873785 A CN2012102873785 A CN 2012102873785A CN 201210287378 A CN201210287378 A CN 201210287378A CN 102764308 A CN102764308 A CN 102764308A
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parts
medicine
radix
rhizoma rhei
weight
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伦艳霞
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Tianjin Shengji Group Co Ltd
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Tianjin Shengji Group Co Ltd
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Abstract

The invention relates to a drug for preventing bacterial diseases of fish and a preparation method thereof. The drug is composed of, by weight, 100-1000 parts of Chinese gall, 100-1000 parts of rhubarb and 100-1000 parts of andrographis paniculata. The drug and the preparation method thereof have the advantages that compatibility of functions of each component is used for organic combination, synergistic action and supplementation of one another, bacterial diseases can be effectively prevented and cured, the incidence rate of aquatic animals is reduced, and cultivation incomes are increased; and the preparation method is simple and environment-friendly, water is not polluted, and unlike chemicals such as antibiotics, the method brings no toxic and side effects on aquatic products and is beneficial to human health.

Description

A kind of medicine of preventing and treating fish bacterial disease and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine class veterinary drug, particularly relate to a kind of medicine of preventing and treating fish bacterial disease and preparation method thereof.
Background technology
Along with the development of China's culture fishery, the disease species of aquatic product fishery and disease hazard degree are on the rise, and its reason has a lot, mainly are the reasons of degradation aspect under water pollution, germplasm degeneration, medicine, the feeding quality.About degradation factor majority under water pollution, germplasm degeneration, the feeding quality is whole industry problem, and medicine, we then have more how selectable leeway.
Because the relation, particularly antibiotic of Drug abuse make pathogen produce drug resistance, the curative effect of medicine reduced greatly in the past; Similar disease more and more refractory is treated, and the speed that new drug is released does not catch up with the speed that cause of disease is evolved, in addition, and along with the expansion of pharmaceutical factory production capacity; Assurance ability does not but catch up with, and causes drug quality to descend, and also has; People require increasingly highly to aquatic product quality, and healthy aquaculture more and more comes into one's own, and the use of medicine is restricted; A lot of in the past effectively medicines because high residue, to the human harm use that is under an embargo greatly, withdraw from the market the effective types of drugs minimizing that the raiser can select; But since the development of healthy aquaculture technology that is that all right is ripe, or the like these all can cause disease to increase, mortality rate rises.
The common chemical synthetic drug causes residually under life-time service or situation about using with easily in animal body, has a strong impact on product quality, be detrimental to health, and toxicity is big, and residual height is easy to generate drug resistance.
Chinese herbal and crude drugs preparations is then taken from the natural animal-plant product, keeps the naturalness and the biological activity of its constituent structure, and low toxicity, low-residual, drug resistance are not remarkable; And throw something and feed as feed mixing and also have to supplement the nutrients; Promote growth, health invigorating, the effect that improves fish body immunity; Effect preventing and treating aspect the fish diseases is very important, and some often can play excellent curative with the not good disease of chemical synthetic drug therapeutic effect with Chinese herbal medicine.
Research shows that polysaccharide, alkaloid, volatile ingredient and organic acid are the main effectively active component of many Chinese herbal medicine, and wherein polysaccharide has the ability of obvious enhancing animal body cell immune response; Other has data to show, nearly 200 kinds of Chinese herbal medicine have immunocompetence, except that strengthening the body resistance class, YANG invigorating class, yin nourishing class; Activation is become silted up type, heat clearing away class medicine and minority detoxifcation, astringent or styptic treatment for spontaneous sweating, hemostasis is rushed down down, anthelmintic class medicine also has enhance immunity effect; This this medicine is from different link challenges, and spice is thrown something and fed and can effectively be improved fish body body constitution, builds up resistance; Kill pathogen in the body, and also have certain growth promoting function.
In fish production reality, Chinese herbal medicine is widely used in preventing and treating all kinds of aquatic economic animal diseases, has obtained certain effect, has accumulated rich experience.Chinese herbal medicine is " a green fisheries drug "; Have efficiency natural, advantage such as the medicine source is wide, cost is low, good effect, safety are good; Neither can pollute to water quality, the product that also is not easy as the chemical drugs pesticide, to feed water brings toxic and side effects, but also helps the health of human body.
In recent years, the bacterial disease that is caused by Aeromonas sobria, Aeromonas hydrophila, Bacillus proteus etc. was acute popular more, and morbidity back mortality rate is very high, has caused serious economy loss to fish production.When preventing and treat, use chemical synthetic drugs such as antibiotic at present for these bacterial diseasees more; Though obtained certain effect; But also brought the Drug resistance of pathogen to grow with each passing day simultaneously, therapeutic effect descends, cost improves, water environment is destroyed even threaten human health.The bacterial disease disease is the common disease in culturing, and the aquatic animal bacterial disease that China has confirmed at present has kind more than 30, discovers and seizes 26 kinds of cause of diseases, mainly contains to have a liking for aqueous vapor pseudomonas bacillus, pseudomonas, subdue bacillus, vibrio etc.Therefore, a kind of medicine for preparing simple, obvious results control fish bacterial disease and preparation method thereof being provided, is that this field scientific research technical staff needs one of technical problem of solution badly.
Summary of the invention
Technical problem to be solved by this invention is that a kind of reasonable recipe is provided, prepares medicine simple, easy to use, obvious results control fish bacterial disease.
Another technical problem to be solved by this invention is to provide a kind of method for preparing of preventing and treating the fish bacterial disease medicine,
Technical scheme of the present invention:
A kind of medicine of preventing and treating fish bacterial disease is made up of Galla Chinensis, Radix Et Rhizoma Rhei and Herba Andrographis, by 100~1000 parts of its parts by weight Galla Chinensiss, 100~1000 parts of Radix Et Rhizoma Rhei, 100~1000 parts of Herba Andrographis.
Preferably, the medicine of above-mentioned control fish bacterial disease is by 300~500 parts of its parts by weight Galla Chinensiss, 300~600 parts of Radix Et Rhizoma Rhei, 300~500 parts of Herba Andrographis.
Preferably, the medicine of above-mentioned control fish bacterial disease is by 400 parts of its parts by weight Galla Chinensiss, 300 parts of Radix Et Rhizoma Rhei, 500 parts of Herba Andrographis.
Preferably, the medicine of above-mentioned control fish bacterial disease is by 300 parts of its parts by weight Galla Chinensiss, 500 parts of Radix Et Rhizoma Rhei, 400 parts of Herba Andrographis.
Preferably, the medicine of above-mentioned control fish bacterial disease is by 500 parts of its parts by weight Galla Chinensiss, 600 parts of Radix Et Rhizoma Rhei, 300 parts of Herba Andrographis.
Preferably, the medicine of above-mentioned control fish bacterial disease is by 100 parts of its parts by weight Galla Chinensiss, 1000 parts of Radix Et Rhizoma Rhei, 100 parts of Herba Andrographis.
Preferably, the medicine of above-mentioned control fish bacterial disease is by 1000 parts of its parts by weight Galla Chinensiss, 100 parts of Radix Et Rhizoma Rhei, 1000 parts of Herba Andrographis.
The method for preparing of the medicine of above-mentioned control fish bacterial disease, concrete preparation process is following:
(1) takes by weighing medical material by above-mentioned parts by weight;
(2) with the water that adds 10~12 times of quality of medical material gross mass in the medical material that takes by weighing in the step (1), soak 20~30min;
(3) decoct twice according to conventional method; 30~the 40min of boiling back slow fire boiling for the first time crosses and filters decocting liquid; Water boiling back slow fire boiling 20~30min that filtering residue adds 6~8 times of amounts again crosses and filters decocting liquid; Merge twice decocting liquid and refilter, must filtrate; In temperature is that under 40 ℃~50 ℃ filtrating to be concentrated into relative density be 1.05~1.20 promptly to get.
Quality that above-mentioned relative density is meant described in the step (3) filtrating and ratio with the quality of water by volume.
The invention has the beneficial effects as follows: the drug utilization compatibility component of control fish bacterial disease is function separately, organic assembling, synergism; Complement each other, can effectively prevent and treat bacterial disease, reduce the aquatic animal sickness rate; Increase and culture income, and preparation technology is simple, environmental protection, neither can pollute to water quality; Also be not easy to bring toxic and side effects, but also help the health of human body as chemical drugss such as the antibiotic product that can feed water.
The specific embodiment
Below in conjunction with specific embodiment, technical scheme according to the invention is further specified.
Embodiment 1
A kind of medicine of preventing and treating fish bacterial disease is made up of Galla Chinensis, Radix Et Rhizoma Rhei and Herba Andrographis, by 400 parts of its parts by weight Galla Chinensiss, 300 parts of Radix Et Rhizoma Rhei, 500 parts of Herba Andrographis.
The method for preparing of the medicine of above-mentioned control fish bacterial disease, concrete preparation process is following:
(1) takes by weighing 300 parts of Galla Chinensiss, 300 parts of Radix Et Rhizoma Rhei, 500 parts of Herba Andrographis by weight;
(2) set by step the water of 12 times of (1) Chinese crude drug gross weights soaks 20min;
(3) decoct twice according to conventional method; The 30min of boiling back slow fire boiling for the first time crosses and filters decocting liquid; The water boiling back slow fire boiling 20min that filtering residue adds 6 times of amounts again crosses and filters decocting liquid; Merge twice decocting liquid refilter filtrating, be that under 40 ℃ filtrating to be concentrated into relative density be 1.05 promptly to get in temperature.
Embodiment 2
A kind of medicine of preventing and treating fish bacterial disease is made up of Galla Chinensis, Radix Et Rhizoma Rhei and Herba Andrographis, by 300 parts of its parts by weight Galla Chinensiss, and 500 parts of Radix Et Rhizoma Rhei, 400 parts of Herba Andrographis.
The method for preparing of the medicine of above-mentioned control fish bacterial disease, concrete preparation process is following:
(1) takes by weighing 300 parts of Galla Chinensiss by weight, 500 parts of Radix Et Rhizoma Rhei, 400 parts of Herba Andrographis;
(2) set by step the water of 10 times of (1) Chinese crude drug gross weights soaks 20min;
(3) decoct twice according to conventional method; The 30min of boiling back slow fire boiling for the first time crosses and filters decocting liquid; The water boiling back slow fire boiling 20min that filtering residue adds 6 times of amounts again crosses and filters decocting liquid; Merge twice decocting liquid refilter filtrating, be that under 40 ℃ filtrating to be concentrated into relative density be 1.10 promptly to get in temperature.
Embodiment 3
A kind of medicine of preventing and treating fish bacterial disease is made up of Galla Chinensis, Radix Et Rhizoma Rhei and Herba Andrographis, by 500 parts of its parts by weight Galla Chinensiss, and 600 parts of Radix Et Rhizoma Rhei, 300 parts of Herba Andrographis.
The method for preparing of the medicine of above-mentioned control fish bacterial disease, concrete preparation process is following:
(1) takes by weighing 500 parts of Galla Chinensiss by weight, 600 parts of Radix Et Rhizoma Rhei, 300 parts of Herba Andrographis;
(2) set by step the water of 11 times of (1) Chinese crude drug gross weights soaks 25min;
(3) decoct twice according to conventional method; The 35min of boiling back slow fire boiling for the first time crosses and filters decocting liquid; The water boiling back slow fire boiling 25min that filtering residue adds 7 times of amounts again crosses and filters decocting liquid; Merge twice decocting liquid refilter filtrating, be that under 45 ℃ filtrating to be concentrated into relative density be 1.15 promptly to get in temperature.
Embodiment 4
A kind of medicine of preventing and treating fish bacterial disease is made up of Galla Chinensis, Radix Et Rhizoma Rhei and Herba Andrographis, by 100 parts of its parts by weight Galla Chinensiss, and 1000 parts of Radix Et Rhizoma Rhei, 100 parts of Herba Andrographis.
The method for preparing of the medicine of above-mentioned control fish bacterial disease, concrete preparation process is following:
(1) takes by weighing 100 parts of Galla Chinensiss by weight, 1000 parts of Radix Et Rhizoma Rhei, 100 parts of Herba Andrographis;
(2) set by step the water of 12 times of (1) Chinese crude drug gross weights soaks 30min;
(3) decoct twice according to conventional method; The 40min of boiling back slow fire boiling for the first time crosses and filters decocting liquid; The water boiling back slow fire boiling 30min that filtering residue adds 8 times of amounts again crosses and filters decocting liquid; Merge twice decocting liquid refilter filtrating, be that under 50 ℃ filtrating to be concentrated into relative density be 1.20 promptly to get in temperature.
Embodiment 5
A kind of medicine of preventing and treating fish bacterial disease is made up of Galla Chinensis, Radix Et Rhizoma Rhei and Herba Andrographis, by 1000 parts of its parts by weight Galla Chinensiss, and 100 parts of Radix Et Rhizoma Rhei, 1000 parts of Herba Andrographis.
The method for preparing of the medicine of above-mentioned control fish bacterial disease, concrete preparation process is following:
(1) takes by weighing 1000 parts of Galla Chinensiss by weight, 100 parts of Radix Et Rhizoma Rhei, 1000 parts of Herba Andrographis;
(2) set by step the water of 12 times of (1) Chinese crude drug gross weights soaks 30min;
(3) decoct twice according to conventional method; The 40min of boiling back slow fire boiling for the first time crosses and filters decocting liquid; The water boiling back slow fire boiling 30min that filtering residue adds 8 times of amounts again crosses and filters decocting liquid; Merge twice decocting liquid refilter filtrating, be that under 50 ℃ filtrating to be concentrated into relative density be 1.20 promptly to get in temperature.
Each amounts of components of the described Chinese crude drug of one of embodiment 1~5 is increased or reduces according to same ratio, and the parts by weight relation of each component of gained all belongs to protection scope of the present invention.
Embodiment 1~5 each component of said Chinese crude drug all meets " Chinese veterinary drug allusion quotation " version two ministerial standards in 2005.
The composition principle of control fish bacterial disease medicine according to the invention is:
Galla Chinensis: sour, salty, flat.Have another name called gall nut, Mass Galla chinesis et camelliae Fermentata, hundred worm storehouses etc.; Be the dry insect gall on the lacquer section plant salt skin leaf originally; Form by gallic aphid parasitism; Contain a large amount of tannic acids, the ability solidifying protein has stronger sterilizing ability; Gram-positive and negative bacteria all there are inhibitory action, are used to prevent and treat that white head and mouth fish disease, slime bacteria are sick, Aeromonas is sick, pseudomonas is sick, white skin disease, erythroderma, furunculosis etc.
Radix Et Rhizoma Rhei: bitter in the mouth, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Main effect has: heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Chemical constituent is mainly anthraquinone derivative in the Radix Et Rhizoma Rhei, mainly comprises anthraquinone glycoside and dianthracene quinone glycoside.Other contains tannin class material, organic acid and estrogen-like product etc.Radix Et Rhizoma Rhei has anti-infectious function, and multiple Gram-positive and negative bacteria are all had inhibitory action, and wherein the most responsive is staphylococcus and streptococcus.
Herba Andrographis: nature and flavor are bitter, and are cold.GUIXIN, lung, large intestine, urinary bladder channel.Main effect: heat-clearing and toxic substances removing, removing heat from blood, detumescence.Andrographolide is the effective constituent that mainly contains of Herba Andrographis, has the thermal detoxification of dispelling, and the effect of anti-inflammatory analgetic has special efficacy to bacillary with viral upper respiratory tract infection and dysentery, is described as the natural antibiotics medicine.
The clinical trial example:
The pond area that one raiser of Yutian County, Tangshan City cultures Ctenopharyngodon idellus is 50 mu, 1.7 meters of mean depths, and intensive culture, about Ctenopharyngodon idellus specification 400g, throw something and feed feed of grass carp and forage.On July 2nd, 2011, it is dead that the raiser finds that Ctenopharyngodon idellus occurs, and 4 of dead quantity, but fish material feeding situation is normal had death, dead quantity increase to every days 40~50 tails in several days afterwards continuously and do not wait; July 5, the raiser treats by conventional treatments, uses chlorine-containing disinfectant, glutaraldehyde preparation sterilizing during the treatment; And antibiotic such as spice enrofloxacin for oral administration, after 5 days, DeGrain; Ctenopharyngodon idellus death is more serious, and dead quantity obviously increases, and death every day is up to 400~500 tails; And the fish food is bad, does not eat food basically.At the medicine that uses the embodiment of the invention 1 preparation, according to the consumption of 5000ml/ mu Mi Shuishen, logotype 2~3 days, every day 1 time; The 4th day dead minimizing of sick fish, the 5th day, every day, dead 4~5 tails did not have later death in 8 days basically, and food is normal, suffers from the fish diseases feelings and also is effectively controlled.
Above-mentioned detailed description of the medicine and preparation method thereof of control fish bacterial disease being carried out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.

Claims (8)

1. medicine of preventing and treating fish bacterial disease is characterized in that it is made up of Galla Chinensis, Radix Et Rhizoma Rhei and Herba Andrographis, by 100~1000 parts of its parts by weight Galla Chinensiss, 100~1000 parts of Radix Et Rhizoma Rhei, 100~1000 parts of Herba Andrographis.
2. a kind of medicine of preventing and treating fish bacterial disease according to claim 1 is characterized in that: by 300~500 parts of its parts by weight Galla Chinensiss, 300~600 parts of Radix Et Rhizoma Rhei, 300~500 parts of Herba Andrographis.
3. a kind of medicine of preventing and treating fish bacterial disease according to claim 1 is characterized in that: by 400 parts of its parts by weight Galla Chinensiss, 300 parts of Radix Et Rhizoma Rhei, 500 parts of Herba Andrographis.
4. a kind of medicine of preventing and treating fish bacterial disease according to claim 1 is characterized in that: by 300 parts of its parts by weight Galla Chinensiss, 500 parts of Radix Et Rhizoma Rhei, 400 parts of Herba Andrographis.
5. a kind of medicine of preventing and treating fish bacterial disease according to claim 1 is characterized in that: by 500 parts of its parts by weight Galla Chinensiss, 600 parts of Radix Et Rhizoma Rhei, 300 parts of Herba Andrographis.
6. a kind of medicine of preventing and treating fish bacterial disease according to claim 1 is characterized in that: by 100 parts of its parts by weight Galla Chinensiss, 1000 parts of Radix Et Rhizoma Rhei, 100 parts of Herba Andrographis.
7. a kind of medicine of preventing and treating fish bacterial disease according to claim 1 is characterized in that: by 1000 parts of its parts by weight Galla Chinensiss, 100 parts of Radix Et Rhizoma Rhei, 1000 parts of Herba Andrographis.
8. the method for preparing of the medicine of the described control fish bacterial disease of one of claim 1~7 is characterized in that comprising following preparation process:
(1) taking by weighing medical material by said parts by weight is raw material;
(2) with the water that adds 10~12 times of quality of medical material gross mass in the medical material that takes by weighing in the step (1), soak 20~30min;
(3) decoct twice according to conventional method; 30~the 40min of boiling back slow fire boiling for the first time crosses and filters decocting liquid; Water boiling back slow fire boiling 20~30min that filtering residue adds 6~8 times of amounts again crosses and filters decocting liquid; Merge twice decocting liquid and refilter, must filtrate; In temperature is that under 40 ℃~50 ℃ filtrating to be concentrated into relative density be 1.05~1.20 promptly to get.
CN2012102873785A 2012-08-14 2012-08-14 Drug for preventing bacterial diseases of fish and preparation method thereof Pending CN102764308A (en)

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Cited By (6)

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Publication number Priority date Publication date Assignee Title
CN103272005A (en) * 2013-06-04 2013-09-04 江苏中洋集团股份有限公司 Preparation method and application of Chinese herbal medicine for ecologically preventing and treating Australia dragon spot saprolegniasis
CN104887843A (en) * 2014-03-03 2015-09-09 北京大北农动物保健科技有限责任公司 Chinese medicinal composition for prevention and treatment of fish gill rot disease and preparation method thereof
WO2016161534A1 (en) * 2015-04-08 2016-10-13 Maqui New Life S.A. Veterinary composition of marine algae and andrographis sp extracts, which can be used to treat infections in fish
CN106551176A (en) * 2016-10-31 2017-04-05 通化师范学院 A kind of Chinese herbal feed additive compositionss and application thereof
CN111388538A (en) * 2020-04-10 2020-07-10 江苏省淡水水产研究所 Liver-protecting and intestine-protecting immunity-enhancing composition for freshwater fish and preparation and application thereof
US10967035B1 (en) 2020-02-12 2021-04-06 HP Ingredients Corp. Aquaculture feed additive

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103272005A (en) * 2013-06-04 2013-09-04 江苏中洋集团股份有限公司 Preparation method and application of Chinese herbal medicine for ecologically preventing and treating Australia dragon spot saprolegniasis
CN104887843A (en) * 2014-03-03 2015-09-09 北京大北农动物保健科技有限责任公司 Chinese medicinal composition for prevention and treatment of fish gill rot disease and preparation method thereof
CN104887843B (en) * 2014-03-03 2020-12-22 北京大北农动物保健科技有限责任公司 Traditional Chinese medicine composition for preventing and treating fish gill rot disease and preparation method thereof
WO2016161534A1 (en) * 2015-04-08 2016-10-13 Maqui New Life S.A. Veterinary composition of marine algae and andrographis sp extracts, which can be used to treat infections in fish
US11439680B2 (en) 2015-04-08 2022-09-13 Maqui New Life S.A. Veterinary composition of marine algae and Andrographis sp extracts, which can be used to treat infections in fish
CN106551176A (en) * 2016-10-31 2017-04-05 通化师范学院 A kind of Chinese herbal feed additive compositionss and application thereof
US10967035B1 (en) 2020-02-12 2021-04-06 HP Ingredients Corp. Aquaculture feed additive
CN111388538A (en) * 2020-04-10 2020-07-10 江苏省淡水水产研究所 Liver-protecting and intestine-protecting immunity-enhancing composition for freshwater fish and preparation and application thereof

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