CN102319354A - Heat clearing and detoxication oral liquid, and preparation method thereof - Google Patents
Heat clearing and detoxication oral liquid, and preparation method thereof Download PDFInfo
- Publication number
- CN102319354A CN102319354A CN201110292558A CN201110292558A CN102319354A CN 102319354 A CN102319354 A CN 102319354A CN 201110292558 A CN201110292558 A CN 201110292558A CN 201110292558 A CN201110292558 A CN 201110292558A CN 102319354 A CN102319354 A CN 102319354A
- Authority
- CN
- China
- Prior art keywords
- radix
- hour
- add
- carrying
- clarifier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a heat clearing and detoxication oral liquid, and a preparation method thereof. The preparation method comprises: adding ten traditional Chinese drugs of gypsum, figwort, rehmannia, weeping forsythia fruit, cape jasmine, manyflower gueldenstaedtid herb, rough gentian root, indigowoad root, common anemarrhena and creeping liriope to water, wherein the ten traditional Chinese drugs are assistant raw materials; then carrying out warm immersing for 1 hour, boiling for 1 hour until the solution is boiled; adding two traditional Chinese drugs comprising honeysuckle and baikal skullcap root after the solution is slightly cold, carrying out immersing for 1 hour, then carrying out the second boiling, wherein the boiling time is 40 minutes; carrying out filtering, condensing the filtrate, adding ethanol when the filtrate has the relative density of about 1.17 at a temperature of 80 DEG C to enable the alcohol content to be 70%; carrying out cold preservation for 48 hours; carrying out filtering; recovering the ethanol; adding saccharin sodium, adjusting the pH value to 6.0; then adding a first-class cleaning agent and stirring, then standing for 30 minutes to obtain the supernatant; then adding a second-glass cleaning agent and stirring, adding water until the total volume of the solution is 1000 ml; carrying out filtering (400 mesh filter cloth), potting, sterilization to obtain the heat clearing and detoxication oral liquid. The heat clearing and detoxication oral liquid has high active ingredient content and good product stability; the preparation period of the product is short, the quality of the product is stable.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of QINGRE JIEDU KOUFUYE and preparation method thereof.
Background technology
The compound preparation that QINGRE JIEDU KOUFUYE is made up of 12 herbal medicines such as Gypsum Fibrosum, Flos Lonicerae, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Scutellariae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae, Radix Ophiopogonis.Have heat-clearing and toxic substances removing, treatment influenza, upper respiratory tract infection and various fever diseases.Be used for the heating flushed complexion due to the hyperactivity of toxic heat, irritated thirsty, laryngopharynx swelling and pain; Influenza, upper respiratory tract infection see that above-mentioned card Hou Zhejun has better curative effect, and according to clinical observation, the intramuscular injection of heat-clearing and toxic substances removing liquid has fashion good not as good as oral result.
The preparation technology of traditional QINGRE JIEDU KOUFUYE just adopts simple aqueous extraction-alcohol precipitation technology route, but the impurity that adopts this route to make is many, and the extraction and application rate is low, and the production cycle is long, so preparation technology remains to be improved.In Chinese patent CN101406617 B, use ultrafiltration membrance filter, though clarifying effect is remarkable, the loss of effective ingredient such as baicalin etc. is bigger.In traditional heat-clearing and toxic substances removing kind, also there is the adding of employing Pulvis Talci to solve the clarifier problem, if but the Pulvis Talci consumption is uncomfortable, and it is improper to operate, and can have a strong impact on the medical filtration effect.
For a short time by the king of Chongwen branch office of Beijing Drug Administration in 2010, be and Chongwen District, Beijing institute for drug control Zhao Ming " the 6 producer's QINGRE JIEDU KOUFUYE quality analysis " article with the Zhao Xixian issue that relaxes that wherein disclosing the QINGRE JIEDU KOUFUYE that records Jiangxi Sanjiu Pharmaceutical Co., Ltd, to contain the content of baicalin average be 2.24mg.
In the Chinese medicine oral liquid actual production, it is a paradox that the clarity of raising product keeps higher content of baicalin simultaneously with stability.Because the continuous employing of a plurality of clarification steps can sharply cause content of baicalin to descend, cause drug effect not good.
Therefore this is the difficult problem extremely important and urgent need solves, because it affects the overall pharmacy quality of oral liquid.
Summary of the invention
To the deficiency in the above-mentioned existing product Technology; The object of the present invention is to provide a kind of preparation technology of QINGRE JIEDU KOUFUYE; This technology has improved the extraction and application rate of QINGRE JIEDU KOUFUYE, shortens the production cycle, and in clarity that has improved product and stability; Also improved content of baicalin, this is an outstanding advantage of the present invention.
The present invention can guarantee when adopting decoction and alcohol sedimentation technique and secondary clarification technique that content of baicalin up to more than 3%, takes into account the clarifying effect excellence simultaneously.Little by the king of Chongwen branch office of Beijing Drug Administration in 2010 is to relax " 6 producer's QINGRE JIEDU KOUFUYE quality analysis " with the Zhao Xixian issue with Chongwen District, Beijing institute for drug control Zhao Ming, and wherein disclosing the QINGRE JIEDU KOUFUYE that records Jiangxi Sanjiu Pharmaceutical Co., Ltd, to contain the content of baicalin average be 2.24mg.Contrast can know that the present invention's content of baicalin on original " 6 producer's QINGRE JIEDU KOUFUYE quality analysis " basis obviously improves.
The present invention adopts decoction and alcohol sedimentation technique, and Chinese crude drug is carried out twice immersion and steaming and decocting, and adds clarifier; Compared with prior art; Outstanding advantage is: improves the extraction and application rate of QINGRE JIEDU KOUFUYE, shortened the production cycle, and in clarity that has improved product and stability; Kept the effective ingredient content of baicalin in higher level, integral body has improved the competitiveness of product on market.
The technical scheme that the present invention adopts is following:
A kind of raw material of Chinese medicine adjuvant weight proportion of QINGRE JIEDU KOUFUYE is following: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g, clarifier 32g, saccharin sodium 0.8g;
A kind of method for preparing of QINGRE JIEDU KOUFUYE: the Chinese crude drug of distinguishing the flavor of the Gypsum Fibrosum in the raw material adjuvant, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae and Radix Ophiopogonis ten is added water temperature earlier soaked 1 hour, decocted 1 hour, after waiting to seethe with excitement, cold rnning is gone into Flos Lonicerae slightly, Radix Scutellariae two flavor Chinese crude drugs soaked 1 hour; Carry out the steaming and decocting second time, the time is 40 minutes, filters, and relative density was about 1.17 when filtrating was concentrated into 80 ℃; Add ethanol, make to contain the alcohol amount and reach 65%-70%, cold preservation 48 hours filters; Reclaim ethanol, add saccharin sodium, adjust pH to 6.0 adds the one-level clarifier again; Stir, leave standstill after 30 minutes and get supernatant, add the secondary clarifier again, stir; Add water to 1000ml, filter (400 order filter cloth), embedding, sterilization, promptly get.
Wherein, saccharin sodium is a correctives; The one-level clarifier is 101 fruit juice clarifiers of 22g; The secondary clear liquor is the chitosan of 10g.
The present invention adopts decoction and alcohol sedimentation technique, and Chinese crude drug is carried out twice immersion and steaming and decocting, and adds clarifier; Compared with prior art; Outstanding advantage is: improves the extraction and application rate of QINGRE JIEDU KOUFUYE, shortened the production cycle, and in clarity that has improved product and stability; Kept the effective ingredient content of baicalin in higher level, integral body has improved the competitiveness of product on market.
Advantage of the present invention:
The QINGRE JIEDU KOUFUYE active constituent content that adopts prescription provided by the invention and method for preparing to make is high, and product stability is good.The manufacturing cycle of this product is short simultaneously, stay in grade.
The specific embodiment:
Embodiment 1
QINGRE JIEDU KOUFUYE, process by following weight Chinese medicinal raw materials adjuvant: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g, clarifier 32g, saccharin sodium 0.8g;
The method for preparing of QINGRE JIEDU KOUFUYE: the Chinese crude drug of distinguishing the flavor of the Gypsum Fibrosum in the raw material adjuvant, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae and Radix Ophiopogonis ten is added water temperature earlier soaked 1 hour, decocted 1 hour, after waiting to seethe with excitement, cold rnning is gone into Flos Lonicerae slightly, Radix Scutellariae two flavor Chinese crude drugs soaked 1 hour; Carry out the steaming and decocting second time, the time is 40 minutes, filters, and relative density was about 1.17 when filtrating was concentrated into 80 ℃; Add ethanol, make to contain the alcohol amount and reach 70%, cold preservation 48 hours filters; Reclaim ethanol, add saccharin sodium, adjust pH to 6.0 adds the one-level clarifier again; Stir, leave standstill after 30 minutes and get supernatant, add the secondary clarifier again, stir; Add water to 1000ml, filter (400 order filter cloth), embedding, sterilization, promptly get.
Wherein, saccharin sodium is a correctives; The one-level clarifier is 101 fruit juice clarifiers of 22g; The secondary clear liquor is the chitosan of 10g.
Embodiment 2
QINGRE JIEDU KOUFUYE, process by following weight Chinese medicinal raw materials adjuvant: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g, clarifier 15g, saccharin sodium 0.8g;
The method for preparing of QINGRE JIEDU KOUFUYE: the Gypsum Fibrosum in the raw material adjuvant, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae, Radix Ophiopogonis, Flos Lonicerae and Radix Scutellariae 12 flavor Chinese crude drugs are added water temperature soaked 1 hour, decocted 1 hour, after the cold, carry out the steaming and decocting second time slightly; Time is 40 minutes, filters, and relative density was about 1.17 when filtrating was concentrated into 80 ℃, adds ethanol; Make to contain alcohol amount and reach 65%-70%, cold preservation 48 hours filters, and reclaims ethanol; Add saccharin sodium, adjust pH to 6.5 adds the one-level clarifier again, stirs; Leave standstill after 30 minutes and get supernatant, add the secondary clarifier again, stir; Add water to 1000ml, filter (400 order filter cloth), embedding, sterilization, promptly get.
Wherein, saccharin sodium is a correctives; The one-level clarifier is 101 fruit juice clarifiers of 10g; The secondary clear liquor is the chitosan of 5g.
Embodiment 3
QINGRE JIEDU KOUFUYE, process by following weight Chinese medicinal raw materials adjuvant: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g, clarifier 45g, saccharin sodium 0.8g;
The method for preparing of QINGRE JIEDU KOUFUYE: the Chinese crude drug of distinguishing the flavor of the Gypsum Fibrosum in the raw material adjuvant, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae and Radix Ophiopogonis ten is added water temperature earlier soaked 1 hour, decocted 1 hour, after waiting to seethe with excitement, cold rnning is gone into Flos Lonicerae slightly, Radix Scutellariae two flavor Chinese crude drugs soaked 1 hour; Carry out the steaming and decocting second time, the time is 40 minutes, filters, and relative density was about 1.17 when filtrating was concentrated into 80 ℃; Add ethanol, make to contain the alcohol amount and reach 25%-35%%, cold preservation 48 hours filters; Reclaim ethanol, add saccharin sodium, adjust pH to 6.0 adds the one-level clarifier again; Stir, leave standstill after 30 minutes and get supernatant, add the secondary clarifier again, stir; Add water to 1000ml, filter (400 order filter cloth), embedding, sterilization, promptly get.
Wherein, saccharin sodium is a correctives; The one-level clarifier is 101 fruit juice clarifiers of 30g; The secondary clear liquor is the chitosan of 15g.
Embodiment 4
QINGRE JIEDU KOUFUYE, process by following weight Chinese medicinal raw materials adjuvant: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g, clarifier 30g, saccharin sodium 0.8g;
The method for preparing of QINGRE JIEDU KOUFUYE: the Chinese crude drug of distinguishing the flavor of the Gypsum Fibrosum in the raw material adjuvant, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae and Radix Ophiopogonis ten is added water temperature earlier soaked 1 hour, decocted 1 hour, after waiting to seethe with excitement, cold rnning is gone into Flos Lonicerae slightly, Radix Scutellariae two flavor Chinese crude drugs soaked 1 hour; Carry out the steaming and decocting second time, the time is 40 minutes, filters, and relative density was about 1.17 when filtrating was concentrated into 80 ℃; Add ethanol, make to contain the alcohol amount and reach 40%-55%, cold preservation 48 hours filters; Reclaim ethanol, add saccharin sodium, adjust pH to 6.5 adds the one-level clarifier again; Stir, leave standstill after 30 minutes and get supernatant, add the secondary clarifier again, stir; Add water to 1000ml, filter (400 order filter cloth), embedding, sterilization, promptly get.
Wherein, saccharin sodium is a correctives; The one-level clarifier is 101 fruit juice clarifiers of 15g; The secondary clear liquor is the chitosan of 15g.
Embodiment 5
QINGRE JIEDU KOUFUYE, process by following weight Chinese medicinal raw materials adjuvant: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g, clarifier 32g, saccharin sodium 0.8g;
The method for preparing of QINGRE JIEDU KOUFUYE: the Chinese crude drug of distinguishing the flavor of the Gypsum Fibrosum in the raw material adjuvant, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae and Radix Ophiopogonis ten is added water temperature earlier soaked 1 hour, decocted 1 hour, after waiting to seethe with excitement, cold rnning is gone into Flos Lonicerae slightly, Radix Scutellariae two flavor Chinese crude drugs soaked 1 hour; Carry out the steaming and decocting second time, the time is 40 minutes, filters, and relative density was about 1.17 when filtrating was concentrated into 80 ℃; Add ethanol, make to contain the alcohol amount and reach 65%-70%, cold preservation 48 hours filters; Reclaim ethanol, add saccharin sodium, adjust pH to 6.0 adds the one-level clarifier again; Stir, leave standstill after 30 minutes and get supernatant, stir; Add water to 1000ml, filter (400 order filter cloth), embedding, sterilization, promptly get.
Wherein, saccharin sodium is a correctives; The one-level clarifier is 101 fruit juice clarifiers of 32g.
Embodiment 6
QINGRE JIEDU KOUFUYE, process by following weight Chinese medicinal raw materials adjuvant: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g, clarifier 15g, saccharin sodium 0.8g;
The method for preparing of QINGRE JIEDU KOUFUYE: the Chinese crude drug of distinguishing the flavor of the Gypsum Fibrosum in the raw material adjuvant, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae and Radix Ophiopogonis ten is added water temperature earlier soaked 1 hour, decocted 1 hour, after waiting to seethe with excitement, cold rnning is gone into Flos Lonicerae slightly, Radix Scutellariae two flavor Chinese crude drugs soaked 1 hour; Carry out the steaming and decocting second time, the time is 40 minutes, filters, and relative density was about 1.17 when filtrating was concentrated into 80 ℃; Add ethanol, make to contain the alcohol amount and reach 20%-35%, cold preservation 48 hours filters; Reclaim ethanol, add saccharin sodium, adjust pH to 6.5 adds the one-level clarifier again; Stir, leave standstill after 30 minutes and get supernatant, add the secondary clarifier again, stir; Add water to 1000ml, filter (400 order filter cloth), embedding, sterilization, promptly get.
Wherein, saccharin sodium is a correctives; The one-level clarifier is 101 fruit juice clarifiers of 5g; The secondary clear liquor is the chitosan of 10g.
Get the sample that embodiment 1-6 makes and carry out the test of stability, the result sees the following form 1.
Can know that by last table result embodiment 1 technical scheme is best, takes into account the baicalin high-load simultaneously more than 3%, and has guaranteed the clarity and the stability of oral liquid.
Whether individual processing also has the selection of pH all can the clarity and the stability of content of baicalin, oral liquid to be exerted an influence to use, its concrete consumption and Flos Lonicerae, the Radix Scutellariae two flavor Chinese crude drugs of uniting of 101 fruit juice clarifiers and chitosan.Find equilibrium point side that preferable effect is arranged.
Claims (2)
1. QINGRE JIEDU KOUFUYE is characterized in that: processed by following weight Chinese medicinal raw materials adjuvant: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g, clarifier 32g, saccharin sodium 0.8g;
The method for preparing of QINGRE JIEDU KOUFUYE: the Chinese crude drug of distinguishing the flavor of the Gypsum Fibrosum in the raw material adjuvant, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae and Radix Ophiopogonis ten is added water temperature earlier soaked 1 hour, decocted 1 hour, after waiting to seethe with excitement, cold rnning is gone into Flos Lonicerae slightly, Radix Scutellariae two flavor Chinese crude drugs soaked 1 hour; Carry out the steaming and decocting second time, the time is 40 minutes, filters, and relative density was about 1.17 when filtrating was concentrated into 80 ℃; Add ethanol, make to contain the alcohol amount and reach 70%, cold preservation 48 hours filters; Reclaim ethanol, add saccharin sodium, adjust pH to 6.0 adds the one-level clarifier again; Stir, leave standstill after 30 minutes and get supernatant, add the secondary clarifier again, stir; Add water to 1000ml, filter (400 order filter cloth), embedding, sterilization, promptly get.
2. QINGRE JIEDU KOUFUYE is characterized in that: processed by following weight Chinese medicinal raw materials adjuvant: Gypsum Fibrosum 670g, Flos Lonicerae 134g, Radix Scrophulariae 107g, Radix Rehmanniae 80g, Fructus Forsythiae 67g, Fructus Gardeniae 67g, Herba Gueldenstaedtiae 67g, Radix Scutellariae 67g, Radix Gentianae 67g, Radix Isatidis 67g, Rhizoma Anemarrhenae 54g, Radix Ophiopogonis 54g, clarifier 32g, saccharin sodium 0.8g;
The method for preparing of QINGRE JIEDU KOUFUYE: the Chinese crude drug of distinguishing the flavor of the Gypsum Fibrosum in the raw material adjuvant, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae and Radix Ophiopogonis ten is added water temperature earlier soaked 1 hour, decocted 1 hour, after waiting to seethe with excitement, cold rnning is gone into Flos Lonicerae slightly, Radix Scutellariae two flavor Chinese crude drugs soaked 1 hour; Carry out the steaming and decocting second time, the time is 40 minutes, filters, and relative density was about 1.17 when filtrating was concentrated into 80 ℃; Add ethanol, make to contain the alcohol amount and reach 70%, cold preservation 48 hours filters; Reclaim ethanol, add saccharin sodium, adjust pH to 6.0 adds the one-level clarifier again; Stir, leave standstill after 30 minutes and get supernatant, add the secondary clarifier again, stir; Add water to 1000ml, filter (400 order filter cloth), embedding, sterilization, promptly get;
Wherein, saccharin sodium is a correctives; The one-level clarifier is 101 fruit juice clarifiers of 22g; The secondary clear liquor is the chitosan of 10g.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201110292558 CN102319354B (en) | 2011-09-30 | 2011-09-30 | Heat clearing and detoxication oral liquid, and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201110292558 CN102319354B (en) | 2011-09-30 | 2011-09-30 | Heat clearing and detoxication oral liquid, and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102319354A true CN102319354A (en) | 2012-01-18 |
CN102319354B CN102319354B (en) | 2013-04-03 |
Family
ID=45447279
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 201110292558 Active CN102319354B (en) | 2011-09-30 | 2011-09-30 | Heat clearing and detoxication oral liquid, and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102319354B (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104922442A (en) * | 2015-06-30 | 2015-09-23 | 贵州黄平靓鸥桑综合开发有限公司 | Traditional Chinese medicine for treating fever |
CN105726929A (en) * | 2014-12-10 | 2016-07-06 | 瑞普(天津)生物药业有限公司 | Preparation method of heat clearing and detoxifying soluble powder |
CN106938001A (en) * | 2017-04-07 | 2017-07-11 | 四川好医生药业集团有限公司 | Heat-clearing and detoxicating oral liquid and its preparation technology |
CN116870094A (en) * | 2023-06-26 | 2023-10-13 | 江西和盈药业有限公司 | Preparation method of oral liquid for clearing heat and detoxicating |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101628077A (en) * | 2009-08-20 | 2010-01-20 | 河南太龙药业股份有限公司 | Preparation method of concentrated type heat-clearing and detoxicating oral liquid |
-
2011
- 2011-09-30 CN CN 201110292558 patent/CN102319354B/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101628077A (en) * | 2009-08-20 | 2010-01-20 | 河南太龙药业股份有限公司 | Preparation method of concentrated type heat-clearing and detoxicating oral liquid |
Non-Patent Citations (2)
Title |
---|
周进东等: "吸附澄清剂在纯化中药制剂中的应用", 《时珍国医国药》, no. 08, 30 August 2001 (2001-08-30) * |
国家药典委员会编: "《中华人民共和国药典 2005年版 一部》", 1 January 2005, article "清热解毒口服液", pages: 619 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105726929A (en) * | 2014-12-10 | 2016-07-06 | 瑞普(天津)生物药业有限公司 | Preparation method of heat clearing and detoxifying soluble powder |
CN104922442A (en) * | 2015-06-30 | 2015-09-23 | 贵州黄平靓鸥桑综合开发有限公司 | Traditional Chinese medicine for treating fever |
CN106938001A (en) * | 2017-04-07 | 2017-07-11 | 四川好医生药业集团有限公司 | Heat-clearing and detoxicating oral liquid and its preparation technology |
CN116870094A (en) * | 2023-06-26 | 2023-10-13 | 江西和盈药业有限公司 | Preparation method of oral liquid for clearing heat and detoxicating |
CN116870094B (en) * | 2023-06-26 | 2024-05-14 | 江西和盈药业有限公司 | Preparation method of oral liquid for clearing heat and detoxicating |
Also Published As
Publication number | Publication date |
---|---|
CN102319354B (en) | 2013-04-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103893252A (en) | Composition capable of clearing heat from throat and relieving sore throat and preparation method and application thereof | |
CN102319354B (en) | Heat clearing and detoxication oral liquid, and preparation method thereof | |
CN102552670B (en) | Preparation method for oral liquid capable of clearing heat and removing toxicity | |
CN210250587U (en) | Veterinary shuanghuanglian oral liquid production device | |
CN100506261C (en) | Process for preparing concentration type heat clearing and detoxifying oral liquid | |
CN101041001A (en) | Medicine for treating cough and asthma and removing phlegm and the method for preparing the oral liquid thereof | |
CN101095793A (en) | Chinese traditional medicine preparations liuweidihuang wine having functions of reinforcing body fluid and nourishing the blood and the kidney | |
CN101254263A (en) | Compound Japanese polygala oral liquid and method of preparing the same | |
CN102258719A (en) | Preparation method of traditional Chinese medicinal oral liquid preparation for treating children's cold | |
CN102784215B (en) | Snow pear cough-relieving syrup and preparation method | |
CN101683429A (en) | Animal Chinese medicine granular formulation for preventing and treating infectious bursal disease of fowl and preparation method thereof | |
CN104800504A (en) | Traditional Chinese medicine preparation for treating nephritis and preparation method | |
CN1267121C (en) | Eye disease treating medicine and its preparing process | |
CN102552861A (en) | Ginseng Sini granules and preparing method thereof | |
CN1283391A (en) | Extracted liquor for disinfection | |
CN102028789A (en) | Accumulation removing plaster for children | |
CN102120000B (en) | Composition of effective parts of traditional Chinese medicine preparation for resisting Coxsackie virus B and preparation method thereof | |
CN102077894A (en) | Chewing gum for preventing and treating cold diseases | |
CN102293883B (en) | Chinese medicinal composition for treating child acute upper respiratory tract infection, and preparation method and application thereof | |
CN102225103A (en) | Formulation and production process of traditional Chinese medicinal injection solution for controlling Newcastle disease | |
CN104523962A (en) | Radix morindae officinalis health maintenance traditional Chinese medicine wine and preparation method | |
CN1314434C (en) | Heat-clearing and detoxic medicine and its preparation method | |
CN103656137A (en) | Traditional Chinese medicine composition for dispelling wind, relieving heat, stopping cough and resolving phlegm and preparation method thereof | |
CN105560425A (en) | Preparation method of collateral-dredging oral liquid | |
CN1927376A (en) | Small thorowax droplet and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee |
Owner name: CHINA RESOURCES SANJIU (NANCHANG) PHARMACEUTICAL C Free format text: FORMER NAME: JIANGXI SANJIU PHARMACEUTICAL INDUSTRY CO., LTD. |
|
CP03 | Change of name, title or address |
Address after: 330012, Dongsheng Road, Chang Dong Industrial Zone, Jiangxi, Nanchang, 398 Patentee after: Huarun 39 (Nanchang) Pharmaceutical Co., Ltd. Address before: 330012 No. two, No. 16, Chang Dong Road, Chang Dong Industrial Zone, Jiangxi, Nanchang Patentee before: Jiangxi Sanjiu Pharmaceutical Co., Ltd. |