CN101254263A - Compound Japanese polygala oral liquid and method of preparing the same - Google Patents
Compound Japanese polygala oral liquid and method of preparing the same Download PDFInfo
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- CN101254263A CN101254263A CNA2007100354275A CN200710035427A CN101254263A CN 101254263 A CN101254263 A CN 101254263A CN A2007100354275 A CNA2007100354275 A CN A2007100354275A CN 200710035427 A CN200710035427 A CN 200710035427A CN 101254263 A CN101254263 A CN 101254263A
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- japanese polygala
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Abstract
The invention discloses compound Japanese milkwort herb oral liquor and a preparation method thereof. The invention takes Japanese milkwort herb, indigowoad leaf, wild chrysanthemum, Japanese climbing fern spore, spreading hedyotis herb and Philippine violet herb as raw materials, which are merged, decocted and filtrated according to the different characteristics of each herbal medicine, the filtrate is condensed to a clear paste with a certain density, the water is added for reasonable preparation according to the proportion and still placement, after that, the filtration, the filling and the sterilization are carried out for preparation. The formula and the production method of the invention are unique, and the oral liquor has exact efficacy, no toxicity or side effects, convenient administration, cheap price and significant treatment effect through the clinical application.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of upper respiratory tract infection, particularly relating to a kind of is the Chinese medicine compound oral liquid that raw material is made with the vegetable Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Background technology
The compound Japanese polygala granule is concealed in the 14th in Drug Standard of Ministry of Public Health of the Peoples Republic of China Chinese traditional patent formulation preparation and version " Chinese pharmacopoeia in 2005.Compound japanese polygala chewing gum and production technology thereof are open on Chinese patent March 8 nineteen ninety-five, publication number CN1099650A, and the particulate function of compound Japanese polygala is the sore-throat relieving heat clearing away, removing obstruction for relieving pain, expelling phlegm for arresting cough is used for acute and chronic pharyngitis or other upper respiratory tract infection.Compound japanese polygala chewing gum is the oral cavity with new novel form, and this medicine is refrigerant good to eat, and is rapid-action, and the oral cavity partial therapeutical effect is good.In addition, also has the record of compound Japanese polygala buccal tablet in " modern traditional Chinese patent medicine ".The composition of above-mentioned several medicines is a primary raw material with 6 flavor medicines such as Herba Polygalae Japonicae, Folium Isatidis, Flos Chrysanthemi Indici all, but the dispersion of its medicine is relatively poor, difficult the absorption.
Summary of the invention
Purpose of the present invention, be on the basis of existing compound recipe, in conjunction with the complete multi-form oral liquid of a kind of and former dosage form of modern production technology invention, by changing dosage form, provide a kind of taking convenience, big, the safe and effective new Chinese medicine of dispersion, to adapt to clinical different patients' needs.
Another object of the present invention provides the preparation method of this compound Japanese polygala oral liquid.
Solution of the present invention is based on motherland's medical science to pharyngolaryngitis and pathogenetic understanding of upper respiratory tract infection and Therapeutic Principle, achieve with reference to modern pharmacological research, protect the storehouse from motherland's medicine, filter out expelling phlegm for arresting cough, heat-clearing and toxic substances removing, removing heat from blood detumescence, relieving sore throat and pain, by the theory of Chinese medical science prescription, skim the cream off milk, its performance is enhanced metabolism, increase biologos, the effect of development takes place in treatment, minimizing, alleviation pharyngolaryngitis and upper respiratory tract infection pathological changes.
Medicine of the present invention is made (consumption is a weight portion) by following component:
1.9 parts～2.5 parts of 0.8 part～1.2 portions Folium Isatidiss of Herba Polygalae Japonicae
1.3 parts～2.0 parts of 1.0 parts～1.6 parts Spora Lygodii of Flos Chrysanthemi Indici
1.0 parts～1.6 parts of 1.4 parts～2.1 parts Herba Violaes of Herba Hedyotidis Diffusae
The formula optimization weight proportion scope of preparation medicine of the present invention is:
2.2 parts～2.4 parts of 0.9 part～1.1 portions Folium Isatidiss of Herba Polygalae Japonicae
1.5 parts～1.8 parts of 1.2 parts～1.4 parts Spora Lygodii of Flos Chrysanthemi Indici
1.2 parts～1.4 parts of 1.5 parts～1.9 parts Herba Violaes of Herba Hedyotidis Diffusae
The optimum weight ratio range of medicine of the present invention is:
1.3 parts of 2.3 parts of Flos Chrysanthemi Indicis of 1 portion of Folium Isatidis of Herba Polygalae Japonicae
1.3 parts of 1.7 parts of Herba Violaes of 1.7 parts of Herba Hedyotidis Diffusaes of Spora Lygodii
Above-mentioned each component is made medicine production method of the present invention is:
(1) decoct to extract: get Herba Polygalae Japonicae, Folium Isatidis, Flos Chrysanthemi Indici, Spora Lygodii, Herba Hedyotidis Diffusae, Herba Violae and add 8～10 times of water gagings and extract secondaries, each 1.5 hours, filter with 200 mesh sieves, collecting decoction, standby.
(2) concentrate, leave standstill: get the extractum that above-mentioned filtrate decompression (imitates negative pressure 0.05MP, and two imitate the about 0.07MP of negative pressure) is concentrated into relative density 1.08～1.10 (60 ℃), left standstill 36 hours, filter filtrate for later use.
(3) prepare burden, leave standstill: get above-mentioned filtrate and add an amount of correctives, antiseptic, add water to total amount, left standstill 24 hours, filter.
(4) packing: get above-mentioned filtrate and be distributed into every 10ml.
(5) sterilization: get the oral liquid that branch installs and put in the autoclave cabinet, pressure sterilizing (107 ℃～121 ℃) 20-40 minute promptly.
In the such scheme, the Folium Isatidis hardship is let out hot loosing, and trembles with fear and can win heat.Go into liver, the heart, stomach warp, heat-clearing and toxic substances removing, cooling blood for hemostasis, relieving sore throat and pain is product on the heat-clearing and toxic substances removing, so be monarch drug; Herba Polygalae Japonicae is arduous, and flavor is flat.Removing toxic substances and promoting subsidence of swelling, expelling phlegm for arresting cough, blood-promoting and mind-easing, kind cough with copious phlegm, the laryngopharynx swelling and pain controlled; Herba Hedyotidis Diffusae is bitter sweet cold in nature, goes into the heart, liver, spleen three warps, and specially in heat-clearing and toxic substances removing, dampness removing is apt to control lung-heat cough with asthma, tonsillitis, pharyngolaryngitis, and two medicines are assisted the monarch drug Folium Isatidis, strengthen the power of heat-clearing and toxic substances removing, are to be ministerial drug, playing the only expectorant effect of eliminating the phlegm simultaneously; Flos Chrysanthemi Indici bitter in the mouth suffering, lung is gone in the gas cold, Liver Channel, heat-clearing and toxic substances removing, the dried liver of dispelling wind is usually used in treating anemopyretic cold, laryngopharynx swelling and pain; Herba Violae bitter in the mouth suffering, cold in nature, go into the heart, liver two warps, removing pathogenic heat from blood and toxic substance from the body, the heat that stagnates in the blood that looses, swollen poison, the eliminating stagnation parasite killing treated of treatment pain is longer than in the desilting detumescence; Above-mentioned two medicine heat clearing away and non-impairment of YIN, eliminating evil and just do not hinder, be for adjuvant drug also; Spora Lygodii is sweet light, and is cold, goes into small intestinal, urinary bladder channel, and heat-clearing and toxic substances removing, relieving stranguria by diuresis have and draw the descending merit of heat, make scorchingly hot heresy, and that lets out has a road, as messenger drug.
Full side's Six-element medicine, parum drug and centralize the power is played relieving sore-throat by clearing away heat altogether, removing obstruction for relieving pain, the merit of expelling phlegm for arresting cough.Be used for the treatment of the acute pharyngitis of wind-heat syndrome, acute episode of chronic pharyngitis and other upper respiratory tract infection of expectorant heat syndrome, logos interlocks, the medicine card is suitable mutually.
An important feature of the present invention is that crude drug is vegetable drug and processes in the medicament, according to heavy metal inspection technique second method of Chinese Pharmacopoeia version in 2000 this product has been carried out the heavy metal inspection; get standard lead solution 1ml and compare; testing result need testing solution color all is shallower than the standard lead solution, sees Table 1.
Heavy metal check result in table 1 test sample
According to an arsenic salt of Chinese Pharmacopoeia version in 2000 inspection technique first method this product is carried out the inspection of arsenic salt, get standard arsenic solution 2ml and compare, testing result need testing solution arsenic speckle color all is shallower than standard arsenic speckle color, sees
Table 2.
Arsenic salt check result in table 2 test sample
Therefore, this preparation not column weight metal and arsenic salt two item inspections in process of production.
The present invention uses the result to show, following advantage is arranged:
(1) to select the homologous natural edible-plant medicine of medicated diet for use be raw material in the present invention, and each component meets the pharmaceutical control law regulation.Utilize the comprehensive function treatment pharyngolaryngitis and the upper respiratory tract infection of every plant amedica, the compound Japanese polygala oral liquid sugar-free, nontoxic to human body, unrestricted to many old peoples and the sugared patient's medication of taboo.
(2) through hplc determination, amount of water is 8～10 times of amounts of medical material weight, and it is higher to decoct back extraction yield, has stablized the active ingredient and the pharmacological function of compound recipe Semen Benincasae taboo oral medicine liquid.
(3) filtrate decompression is concentrated is the clear paste of 1.24～1.28 (70 ℃) to density mutually, reduces to and is concentrated to the clear paste that relative density is 1.08～1.10 (60 ℃), has simplified production technology, has reduced production cost.
(4) oral liquid dispersion of the present invention is better, absorbs easily.
The specific embodiment
Embodiment
Take by weighing raw material by following proportioning:
Herba Polygalae Japonicae 300kg, Folium Isatidis 700kg, Flos Chrysanthemi Indici 400kg, Spora Lygodii 500kg, Herba Hedyotidis Diffusae 500kg, Herba Violae 400kg.
Production method is as follows:
Get Herba Polygalae Japonicae, Folium Isatidis, Flos Chrysanthemi Indici, Spora Lygodii, Herba Hedyotidis Diffusae, Herba Violae earlier and add 9 times of water gagings, decoct secondary, decocted 1.5 hours at every turn, cross 200 mesh sieves, collecting decoction filters, and filtrate is concentrated into the clear paste that limit density is 1.09 (60 ℃), left standstill 36 hours, and filtered filtrate for later use.
Above-mentioned extractum is added correctives aspartame 2kg, citric acid 4kg, preservative sodium benzoate 5kg, ethyl hydroxybenzoate be 1 objective, add purified water 324L reaches 1000L to messenger drug filter total amount, left standstill after shaking up 36 hours, filtration, fill, pressure sterilizing adopt fill to be incubated 10 minutes 121 ℃ times fortunately, reduce to 115 ℃ of insulations 10 minutes then, be cooled to 107 ℃ again and kept 10 minutes.
Detect qualified after, can obtain compound Japanese polygala oral liquid up to standard.
Claims (4)
1. compound Japanese polygala oral liquid is characterized in that the medicinal liquid of being made by the following weight proportion raw material:
1.9 parts～2.5 parts of 0.8 part～1.2 portions Folium Isatidiss of Herba Polygalae Japonicae
1.3 parts～2.0 parts of 1.0 parts～1.6 parts Spora Lygodii of Flos Chrysanthemi Indici
1.0 parts～1.6 parts of 1.4 parts～2.1 parts Herba Violaes of Herba Hedyotidis Diffusae.
2. compound Japanese polygala oral liquid according to claim 1, wherein the weight proportion of each raw material is:
2.2 parts～2.4 parts of 0.9 part～1.1 portions Folium Isatidiss of Herba Polygalae Japonicae
1.5 parts～1.8 parts of 1.2 parts～1.4 parts Spora Lygodii of Flos Chrysanthemi Indici
1.2 parts～1.4 parts of 1.5 parts～1.9 parts Herba Violaes of Herba Hedyotidis Diffusae.
3. compound Japanese polygala oral liquid according to claim 1, wherein the weight proportion of each raw material is:
1.3 parts of 2.3 parts of Flos Chrysanthemi Indicis of 1 portion of Folium Isatidis of Herba Polygalae Japonicae
1.3 parts of 1.7 parts of Herba Violaes of 1.7 parts of Herba Hedyotidis Diffusaes of Spora Lygodii.
4. the method for preparing the described compound Japanese polygala oral liquid of claim 1 is characterized in that this method may further comprise the steps composition:
(a) decoct to extract: get Herba Polygalae Japonicae, Folium Isatidis, Flos Chrysanthemi Indici, Spora Lygodii, Herba Hedyotidis Diffusae, Herba Violae and add 8～10 times of water gagings and extract secondaries, each 1.5 hours, filter with 200 mesh sieves, collecting decoction, standby;
(b) concentrate, leave standstill: get the extractum that above-mentioned filtrate decompression (imitates negative pressure 0.05MP, and two imitate the about 0.07MP of negative pressure) is concentrated into relative density 1.08～1.10 (60 ℃), left standstill 36 hours, filter filtrate for later use;
(c) prepare burden, leave standstill: get above-mentioned filtrate and add an amount of correctives, antiseptic, add water to total amount, left standstill 24 hours, filter;
(d) packing: get above-mentioned filtrate and be distributed into every 10ml;
(e) sterilization: get the oral liquid that branch installs and put in the autoclave cabinet, pressure sterilizing (107 ℃～121 ℃) 20-40 minute promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100354275A CN101254263A (en) | 2007-07-20 | 2007-07-20 | Compound Japanese polygala oral liquid and method of preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100354275A CN101254263A (en) | 2007-07-20 | 2007-07-20 | Compound Japanese polygala oral liquid and method of preparing the same |
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| CN101254263A true CN101254263A (en) | 2008-09-03 |
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| CNA2007100354275A Pending CN101254263A (en) | 2007-07-20 | 2007-07-20 | Compound Japanese polygala oral liquid and method of preparing the same |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751295A (en) * | 2014-02-24 | 2014-04-30 | 万小耀 | Externally-applied medical composition for treating swelling as well as externally-applied medicinal oil for treating swelling and preparation method of medicinal oil |
| CN105213638A (en) * | 2015-11-19 | 2016-01-06 | 哈尔滨圣吉药业股份有限公司 | A kind of compound Japanese polygala dispersible tablet and preparation method thereof |
| CN106074884A (en) * | 2016-06-22 | 2016-11-09 | 南京华宽信息咨询中心 | Compound Japanese polygala granule and preparation method thereof |
| CN110772581A (en) * | 2019-12-24 | 2020-02-11 | 哈尔滨圣吉药业股份有限公司 | Compound polygala japonica dispersible tablets |
| CN113413427A (en) * | 2020-12-03 | 2021-09-21 | 江中药业股份有限公司 | Compound Japanese polygala buccal tablet and preparation method thereof |
-
2007
- 2007-07-20 CN CNA2007100354275A patent/CN101254263A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751295A (en) * | 2014-02-24 | 2014-04-30 | 万小耀 | Externally-applied medical composition for treating swelling as well as externally-applied medicinal oil for treating swelling and preparation method of medicinal oil |
| CN105213638A (en) * | 2015-11-19 | 2016-01-06 | 哈尔滨圣吉药业股份有限公司 | A kind of compound Japanese polygala dispersible tablet and preparation method thereof |
| CN106074884A (en) * | 2016-06-22 | 2016-11-09 | 南京华宽信息咨询中心 | Compound Japanese polygala granule and preparation method thereof |
| CN110772581A (en) * | 2019-12-24 | 2020-02-11 | 哈尔滨圣吉药业股份有限公司 | Compound polygala japonica dispersible tablets |
| CN113413427A (en) * | 2020-12-03 | 2021-09-21 | 江中药业股份有限公司 | Compound Japanese polygala buccal tablet and preparation method thereof |
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Open date: 20080903 |