CN1267121C - Eye disease treating medicine and its preparing process - Google Patents
Eye disease treating medicine and its preparing process Download PDFInfo
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- CN1267121C CN1267121C CN 200410043984 CN200410043984A CN1267121C CN 1267121 C CN1267121 C CN 1267121C CN 200410043984 CN200410043984 CN 200410043984 CN 200410043984 A CN200410043984 A CN 200410043984A CN 1267121 C CN1267121 C CN 1267121C
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Abstract
The present invention relates to an eye disease treating medicine and a preparation method thereof. A raw material formula of the medicine comprises fourteen kinds of traditional Chinese medicines comprising prepared rehmannia root and the like. The preparation method comprises the following steps: adding 8 times of water in prepared materials, decocting the prepared materials, combining decoction liquids, and filtering the obtained decoction liquids; concentrating the filter liquid into clear grease with relative density of 1.12 to 1.13 under condition that the density is measured at 80 DEG C; spray-drying the concentrated filter liquid; taking and preparing 1 portion of dry grease powder, 1 portion of dextrin, 1.2 portions of cane sugar and a proper quantity of ethanol into granules, and drying the granules into 1000g below 80 DEG C; subpackaging to obtain finished products. The present invention has the advantages of stable curative effects on various eye diseases, root cause and radical treatment and no toxic or side effects.
Description
The present invention relates to a kind of Chinese medicine for the treatment of oculopathy and preparation method thereof.
Eyes are vitals of human body, and disease of eye is commonly encountered diseases and frequently-occurring disease.Owing to continuing the myopia that eyestrain appears in the gaze distance target is exactly a kind of of oculopathy, symptoms such as often bloated, dry and astringent with eye acid, heating, headache, giddy.Because of order is the liver key, so " hepatic asthenia " by name.What be equivalent to doctor trained in Western medicine looks disease labor disease.Along with modernized development of science and technology, near-sighted number is increasing year by year, tackles myopia with glasses, becomes the method for passiveness, and adopts also respite symptom just of eye drop, is to take stopgap measures and do not effect a permanent cure.
The purpose of this invention is to provide a kind of medicine for the treatment of oculopathy and preparation method thereof, it all has stable curative effect to multiclass oculopathy, treating both the principal and secondary aspects of a disease, and without any side effects.
Of the present inventionly select medicine by following prescription:
Radix Rehmanniae Preparata 360-440g Radix Rehmanniae 360-440g Fructus Lycii 360-440g
Flos Chrysanthemi 360-440g Semen Cuscutae 270-330g Fructus Leonuri 270-330g
Semen Plantaginis 270-330g Fructus Schisandrae Chinensis 270-330g Radix Codonopsis 150.3-183.7g
Poria 270-330g Rhizoma Anemarrhenae 180-220g Radix Polygalae 180-220g
Cortex Phellodendri 119.7-146.3 Rhizoma Acori Graminei 180-220g
The method for making of treatment oculopathy medicine of the present invention is:
A, get the raw materials ready, give as one thinks fit cataclasm back standby according to composition of raw materials provided by the present invention;
B, add the water of 8 times of amounts in getting the raw materials ready, decoct, the time is 2 hours, obtain filtrate after, in getting the raw materials ready, add 7 times of water gagings again, decoct, the time is 2 hours;
C, collecting decoction filter, and concentrated filtrate to relative density is the clear paste of 1.12-1.13, and this density measurement condition is 80 ℃;
D, carry out spray drying;
E, get 1 part in dry cream powder, 1 part in dextrin, 1.2 parts of sucrose and ethanol are an amount of, make granule, make 1000g in drying below 80 ℃, and finished product is promptly made in packing.
Chinese medicine thinks that watching for a long time is worked with one's mind and overtaxed one's nerves, and decreases blood consumption gas, loss of nutrient of eyes, and overworked eyes, the high consumption of Liver and kidney essence and blood can not be moistened and be supported the order key, and its pathogenesis is a deficiency of YIN-blood, and vital essence is lost empty, so oculopathy is main relevant with liver, the heart, kidney.Effect of the present invention is by the kidney invigorating nourishing the liver, and beneficial intensive culture blood makes asthenopia, blurring of vision due to the asthenia of essence and blood, photophobia sheds tears, two dry and astringent, the discomfort of swelling and pain obtains curing.The present invention is a monarch drug with Radix Rehmanniae Preparata, Radix Rehmanniae, and the Radix Rehmanniae Preparata sweet and slightly bitter taste is warm in nature, can enriching kidney essence, and tonifying liver benefit blood.The Radix Rehmanniae sweet in the mouth is cool in nature, and kind energy YIN nourishing is product on the YIN nourishing blood.With Fructus Lycii, Flos Chrysanthemi is ministerial drug, and the Fructus Lycii sweet in the mouth is flat, energy nourishing kidney tonifying liver, replenishing vital essence to improve eyesight.Flos Chrysanthemi sweet in the mouth bitterness is flat, can clearing away heat to improve acuity of vision.Fructus Leonuri, Semen Cuscutae, Fructus Schisandrae Chinensis, Semen Plantaginis are adjuvant drug, Fructus Leonuri energy replenishing vital essence to improve eyesight, and Semen Cuscutae can make eye bright in invigorating the liver and kidney, the clearing away heat to improve acuity of vision of Semen Plantaginis energy, Fructus Schisandrae Chinensis energy tonifying the kidney to consolidate the essence, smart sufficient then bright ending.Help again in the side with Radix Codonopsis, Poria, replenishing QI to invigorate the spleen, enriching spleen-QI is precise and tiny to change, and promptly mends the day after tomorrow to support congenital meaning.Rhizoma Acori Graminei, Radix Polygalae, happy Fructus Alpiniae Oxyphyllae, normal hearing and eyesight.The Rhizoma Anemarrhenae, Cortex Phellodendri nourishing YIN to lower pathogenic fire, with control the deficiency of YIN given birth within heat.Make the present invention play nourishing the kidney and liver, nourishing YIN to lower pathogenic fire, the effect that beneficial essence is enriched blood, made eye bright.The present invention has done acute toxicity testing and long term toxicity test according to country about the specification requirement of toxicological study, proves avirulence.Through stability test, prove the medicine stable performance.In December, 1995 to one in February, 996, in Heilongjiang Province Academy of Traditional Chinese Medicine Pharmaceutical Manufacturing Plant, Heilongjiang Provincial Hospital, the Second Academy of Heilongjiang University of Chinese Medicine carry out 400 routine clinical observations, male's 192 examples wherein, women's 208 examples.Include all dialectical caused by liver and kidney deficiency type regulating liver-QI blood deficiency type that belongs to the nearly timid disease far away of energy of the traditional Chinese medical science of case of experiment in, promptly be equivalent to the myopia of modern medicine.Wherein age-based distribution situation: 10-12 year 79 examples are organized in 300 examples in treatment, 13-15 year 130 examples, 16-18 year 91 examples; 10-12 year 30 examples in matched group 100 examples, 13-15 year 46 examples, 16-18 year 24 examples; By course of disease distribution situation: 99 examples in 1 year, 1-2 104 examples, 97 examples more than 2 years are organized in 300 examples in treatment; 34 examples in 1 year in matched group 100 examples, 1-2 36 examples, 30 examples more than 2 years; Press vision weight distribution situation: 140 of 560 mild or moderates of treatment group, 282 of moderates, 138 of severes; 53 of matched group mild or moderates, 89 of moderates, 48 of severes.Oral manufactured goods of the present invention are organized in treatment, and each 1 bag, every day 3 times, warm boiled water, matched group are taken the Chinese patent medicine QIJU DIHUANG WAN, every day 3 times, 10-14 year 5 of each clothes; 15-18 year 8 of each clothes, warm water delivery service.Around be the course of treatment.Treatment group and matched group adopt the method for random packet contrast.No significant difference aspect sex, age, the course of disease, vision weight distribution situation has comparability.All case serves as the detection index with distant vision improvement situation, a dry and astringent improvement situation, dizzy tinnitus improvement situation, the sour improvement situation soreness of the waist and knees improvement situation that expands of eyeball, blurred vision improvement situation, asthenopia and improving situation all.。Through clinical verification statistics, the present invention is definite to the curative effect of caused by liver and kidney deficiency regulating liver-QI blood deficiency type that can nearly timid disease far away, and its effective percentage is 90.2%.Carry out the detection of blood, routine urinalysis and liver function, kidney merit before and after the treatment, all no abnormal variation.Observe case and during medication, all do not find any toxic and side effects.
Below in conjunction with embodiment the present invention is further described:
Get the raw materials ready by following prescription:
Radix Rehmanniae Preparata 400g Radix Rehmanniae 400g Fructus Lycii 400g Flos Chrysanthemi 400g
Semen Cuscutae 300g Fructus Leonuri 300g Semen Plantaginis 300g Fructus Schisandrae Chinensis 300g
Radix Codonopsis 167g Poria 300g Rhizoma Anemarrhenae 200g Radix Polygalae 200g
Cortex Phellodendri 133g Rhizoma Acori Graminei 200g
The method for making of this medicine is:
A, get the raw materials ready, give as one thinks fit cataclasm back standby according to composition of raw materials provided by the present invention;
B, add the water of 8 times of amounts in getting the raw materials ready, decoct, the time is 2 hours, obtain filtrate after, in getting the raw materials ready, add 7 times of water gagings again, decoct, the time is 2 hours;
C, collecting decoction filter, and concentrated filtrate to relative density is the clear paste of 1.12-1.13, and this density measurement condition is 80 ℃;
D, carry out spray drying;
E, get 1 part in dry cream powder, 1 part in dextrin, 1.2 parts of sucrose and ethanol are an amount of, make granule, make 1000g in drying below 80 ℃, and finished product is promptly made in packing.
Can promote the dissolving and the absorption of medicine after the effect of the particle size influences lixiviate of medical material, medicine are pulverized, help the stripping of active ingredient, so that we give medicine as one thinks fit before extraction is cataclasm.
The active ingredient of medicine of the present invention is mainly water-soluble components, the present invention adopts orthogonal experiment to select decocting time, decoct three factors such as number of times and decoction water consumption, select to add the water of 8 times of amounts at last in getting the raw materials ready, decoct, the time is 2 hours, after obtaining filtrate, add 7 times of water gagings again in getting the raw materials ready, decoct, the time is 2 hours; The aqueous extract yield is the highest.It is the most complete that active ingredient is extracted.
Drying means of the present invention adopts spray drying, and it is a wink-dry, is specially adapted to heat sensitive material, good product quality, and quality index such as the fineness degree of product and water content can be controlled and regulate to easily dissolving as required, and can change the dissolution rate of the kind preparation of difference.
The present invention makes granule, be because granule is a kind of form of Chinese drug that grows up in conjunction with the characteristics of decoction, medicated wine, syrup, it has kept decoction to absorb fast, produce effects characteristics rapidly, the interim decoction before having overcome decoction and taking put for a long time and easily mouldly lost rotten characteristics, and can cover the bitterness of medicine, the Chinese crude drug of this kind all divides through extracting refining, volume-diminished, transportation, taking convenience, the comfortable product of flavor, the patient is glad to take.
Claims (2)
1, a kind of medicine for the treatment of oculopathy, it is characterized in that: the raw material of this medicine is:
Radix Rehmanniae Preparata 360-440g Radix Rehmanniae 360-440g Fructus Lycii 360-440g
Flos Chrysanthemi 360-440g Semen Cuscutae 270-330g Fructus Leonuri 270-330g
Semen Plantaginis 270-330g Fructus Schisandrae Chinensis 270-330g Radix Codonopsis 150.3-183.7g
Poria 270-330g Rhizoma Anemarrhenae 180-220g Radix Polygalae 180-220g
Cortex Phellodendri 119.7-146.3 Rhizoma Acori Graminei 180-220g.
2, according to a kind of preparation method for the treatment of the oculopathy medicine that claim 1 provided, it is characterized in that:
A, get the raw materials ready, give as one thinks fit cataclasm back standby according to the composition of raw materials that claim 1 provided;
B, add the water of 8 times of amounts in getting the raw materials ready, decoct, the time is 2 hours, obtain filtrate after, in getting the raw materials ready, add 7 times of water gagings again, decoct, the time is 2 hours;
C, merging filtrate filter, and concentrated filtrate to relative density is the clear paste of 1.12-1.13, and this density measurement condition is 80 ℃;
D, carry out spray drying;
E, get 1 part in dry cream powder, 1 part in dextrin, 1.2 parts of sucrose and ethanol are an amount of, make granule, make 1000g in drying below 80 ℃, and finished product is promptly made in packing.
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CN 200410043984 CN1267121C (en) | 2004-10-27 | 2004-10-27 | Eye disease treating medicine and its preparing process |
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CN 200410043984 CN1267121C (en) | 2004-10-27 | 2004-10-27 | Eye disease treating medicine and its preparing process |
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CN1634272A CN1634272A (en) | 2005-07-06 |
CN1267121C true CN1267121C (en) | 2006-08-02 |
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Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104096153A (en) * | 2014-08-04 | 2014-10-15 | 毕宏生 | Pharmaceutical composition containing multiple plant active ingredients and preparation method and application thereof |
CN104887928A (en) * | 2015-06-29 | 2015-09-09 | 关则钦 | Traditional Chinese medicine preparation with vision fatigue relieving function and method for manufacturing traditional Chinese medicine preparation |
CN105311383B (en) * | 2015-07-06 | 2019-11-08 | 厦门医学院 | A kind of health-care Chinese medicinal composition and preparation method thereof of prevention and improvement visual fatigue |
CN105878627A (en) * | 2016-06-03 | 2016-08-24 | 马小英 | Traditional Chinese medicine formula for treating myopic disease |
CN111035748A (en) * | 2020-01-10 | 2020-04-21 | 徐力 | Traditional Chinese medicine composition for improving myopia, external application preparation for improving myopia and eye patch for improving myopia |
CN117771322A (en) * | 2024-02-26 | 2024-03-29 | 云南红青夫生物科技股份有限公司 | Astaxanthin capsule for relieving visual fatigue |
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