CN102552670B

CN102552670B - Preparation method for oral liquid capable of clearing heat and removing toxicity

Info

Publication number: CN102552670B
Application number: CN2010106054079A
Authority: CN
Inventors: 邹武斌
Original assignee: Jiangxi Jimin Kexin Group Co Ltd; Jiangxi Jimin Kexin Pharmaceutical Co Ltd
Current assignee: Jiangxi Jimin Kexin Group Co Ltd; Jiangxi Jimin Kexin Pharmaceutical Co Ltd
Priority date: 2010-12-27
Filing date: 2010-12-27
Publication date: 2013-11-20
Anticipated expiration: 2030-12-27
Also published as: CN102552670A

Abstract

The invention discloses a preparation method for oral liquid capable of clearing heat and removing toxicity, which comprises the following steps: according to a prescription dose specified by the pharmacopeia, taking 12 medicines of gypsum, honeysuckle, radix scrophulariae, dried rehmannia root, fructus forsythia, jasmine, Chinese violet, scutellaria baicalensis, radix gentianae, isatis root, rhizoma anemarrhenae and radix ophiopogonis; firstly extracting the honeysuckle by ethanol, filtering, and concentrating filtrate; decocting filter residue and other 11 medicines with water for two times; combining, filtering and concentrating decoction; adding the ethanol to ensure that the ethanol content is 65%; refrigerating for 48h; filtering, and concentrating; adding activated carbon and sodium benzoate; stirring to dissolve the activated carbon and the sodium benzoate; adding crane sugar, heating and cooling; adding the honeysuckle to extract the concentrated solution; stirring to dissolve the honeysuckle; adding water to the specified volume; and evenly mixing to obtain the oral liquid.

Description

A kind of preparation method of QINGRE JIEDU KOUFUYE

Technical field

The present invention relates to a kind of Chinese medicinal preparation method, be specifically related to a kind of preparation method of QINGRE JIEDU KOUFUYE, belong to field of traditional Chinese medicine pharmacy.

Background technology

QINGRE JIEDU KOUFUYE be by medical materials such as Flos Lonicerae, Radix Scutellariaes through extracting to such an extent that prepare burden after clear paste and make, have effects for removing toxic heat, for diseases such as the flushed complexion of generating heat due to hyperactivity of toxic heat, irritated thirsty, laryngopharynx swelling and pain, influenza, upper respiratory tract infection are shown in above-mentioned disease person.Existing QINGRE JIEDU KOUFUYE preparation method: except Flos Lonicerae, Radix Scutellariae, the ten flavor medical materials such as all the other Gypsum Fibrosum first add water temperature and soaked 1 hour, then decoct secondary (after seething with excitement, slightly cold rnning Flos Lonicerae and Radix Scutellariae), 1 hour for the first time, 40 minutes for the second time, filter, merging filtrate, filtrate is concentrated into relative density and is about 1.17(80 ℃), obtain clear paste, add ethanol, make to contain the alcohol amount and reach 65% ~ 70%, cold preservation 48 hours, filter, reclaim ethanol, add 0.5% active carbon, heated 30 minutes, filter, add water to recipe quantity, filter fill, sterilizing, obtain.Method exists the interior Main Ingredients and Appearance chlorogenic acid extraction of Flos Lonicerae not exclusively now, thereby affects the treatment, and has waste medical material problem.

Summary of the invention

The object of the present invention is to provide a kind of effective extraction ratio that can improve the interior chlorogenic acid of Flos Lonicerae in QINGRE JIEDU KOUFUYE, thereby improve the effect of QINGRE JIEDU KOUFUYE, reduce the waste of Chinese crude drug.Preparation technology of the present invention is convenient and practical, and is easy to control product quality, and the present invention realizes by following structure.

Preparation method of the present invention is:

QINGRE JIEDU KOUFUYE, it is write out a prescription by weight:

80 parts of 107 parts of Radix Rehmanniae of 134 portions of Radix Scrophulariaes of 670 portions of Flos Loniceraes of Gypsum Fibrosum

67 parts of 67 parts of Radix Scutellariaes of 67 parts of Herba Gueldenstaedtiaes of 67 portions of Fructus Gardeniaes of Fructus Forsythiae

54 parts of 67 parts of Rhizoma Anemarrhenaes of 67 parts of Radix Isatidis of Radix Gentianae 54 parts of Radix Ophiopogonis

Step 1, get Flos Lonicerae 50-95% alcohol reflux 2 times in recipe quantity, and each 1 hour, filter, reclaim ethanol, Flos Lonicerae slag and concentrated solution are standby;

Step 2, get and Gypsum Fibrosum, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae, Radix Ophiopogonis in prescription add water temperature and soaked 1 hour, after being heated to boiling, add the Radix Scutellariae of Flos Lonicerae slag and recipe quantity, decoct twice, 1 hour for the first time, the 2nd time 40 minutes, filter, merge and filter, mention liquid concentrated, be about 1.17 to relative density, add ethanol, make to contain the alcohol amount and reach 65% ~ 70%, cold preservation 48 hours, filter, reclaim ethanol, being concentrated into relative density is 1.25, add 0.5% active carbon, heated 30 minutes; Add appropriate sodium benzoate in mentioning liquid, be stirred to dissolve, continuous add the appropriate amount of auxiliary materials post-heating and boil, filter, let cool;

Step 3, the liquid of mentioning of getting in step 2 adds the Flos Lonicerae in step 1 to extract concentrated solution, stirs and makes its dissolving, adds water to recipe quantity, mixes, and obtains.

Preparation method of the present invention, preparation method with respect to existing QINGRE JIEDU KOUFUYE, increased the step of first using the ethanol extraction Flos Lonicerae, this improvement, produced beyond thought effect: with high performance liquid chromatogram, surveying the content of product Content of Chlorogenic Acid, is 1.5 times of the Content of Chlorogenic Acid in Qingrejiedu Oral Liquid content that makes of prior art with the content of the prepared Content of Chlorogenic Acid in Qingrejiedu Oral Liquid of the present invention.Namely the extraction ratio of Content of Chlorogenic Acid in Qingrejiedu Oral Liquid is 1.5 times of existing technology of preparing.

The specific embodiment

Embodiment mono-:

Prescription: Gypsum Fibrosum 670g Flos Lonicerae 134g Radix Scrophulariae 107g Radix Rehmanniae 80g

Fructus Forsythiae 67g Fructus Gardeniae 67g Herba Gueldenstaedtiae 67g Radix Scutellariae 67g

Radix Gentianae 67g Radix Isatidis 67g Rhizoma Anemarrhenae 54g 54g Radix Ophiopogonis

Method for making:

(1) extracting honeysuckle 134 g, with 70% ethanol 1200ml reflux, extract, 2 times, each 1 hour, filter, filtrate recycling ethanol is to relative density 1.30, and Flos Lonicerae slag and concentrated solution are standby;

(2) get Gypsum Fibrosum, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae, Radix Ophiopogonis and add water temperature and soaked 1 hour, be heated to add Flos Lonicerae slag and Radix Scutellariae decoction twice, 1 hour for the first time after boiling, the 2nd time 40 minutes, filter merging filtrate, heating is concentrated into relative density and is about 1.17, adds ethanol, makes to contain the alcohol amount and reaches 65% ~ 70%, cold preservation 48 hours, filter, reclaim ethanol, being concentrated into relative density is 1.25, add the 5g active carbon, heated 30 minutes;

(3) add the 0.3g sodium benzoate in decocting liquid, be stirred to dissolve, continuous add 300ml simple syrup post-heating and boil, filter, let cool;

(4) the continuous Flos Lonicerae ethanol extraction concentrated solution that adds, stir and make its dissolving, adds water to 1000ml, mixes, and obtains.

Embodiment bis-:

Method for making:

(1) extracting honeysuckle 134 g, with 50% ethanol 1200ml reflux, extract, 2 times, each 1 hour, filter, filtrate recycling ethanol is to relative density 1.25, and Flos Lonicerae slag and concentrated solution are standby;

(2) adding Gypsum Fibrosum, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae, Radix Ophiopogonis water temperature soaked 1 hour, be heated to add Flos Lonicerae slag and Radix Scutellariae to decoct twice after boiling, 1 hour for the first time, the 2nd time 40 minutes, filter, merging filtrate, heating is concentrated into relative density and is about 1.17, adds ethanol, makes to contain the alcohol amount and reaches 65% ~ 70%, cold preservation 48 hours, filter, reclaim ethanol, being concentrated into relative density is 1.25, add 0.6g steviosin, 5g active carbon, heated 30 minutes;

(3) add the 0.3g sodium benzoate in decocting liquid, be stirred to dissolve, heated and boiled, filter, and lets cool;

Claims

1. the preparation method of a QINGRE JIEDU KOUFUYE, is characterized in that, by following composition, is processed into:

Gypsum Fibrosum 670g Flos Lonicerae 134g Radix Scrophulariae 107g Radix Rehmanniae 80g

Method for making:

(1) extracting honeysuckle 134g, with 70% ethanol 1200ml reflux, extract, 2 times, each 1 hour, filter, filtrate recycling ethanol is to relative density 1.30, and Flos Lonicerae slag and concentrated solution are standby;

(2) get Gypsum Fibrosum, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae, Radix Ophiopogonis and add water temperature and soaked 1 hour, be heated to add Flos Lonicerae slag and Radix Scutellariae decoction twice, the 1 time 1 hour after boiling, the 2nd time 40 minutes, filter merging filtrate, it is 1.17 that heating is concentrated into relative density, adds ethanol, makes to contain the alcohol amount and reaches 65%-70%, cold preservation 48 hours, filter, reclaim ethanol, be concentrated into relative density 1.25, add the 5g active carbon, heated 30 minutes;