CN102048688B - 以胆固醇复合物为中间载体的紫杉醇亚微乳 - Google Patents

以胆固醇复合物为中间载体的紫杉醇亚微乳 Download PDF

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Publication number: CN102048688B
Authority: CN; China
Prior art keywords: paclitaxel; submicron emulsion; agent; paclitaxel submicron; emulsion agent
Prior art date: 2009-10-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

CN200910236959.4A

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English (en)

Chinese (zh)

Other versions

CN102048688A (zh

Inventor

刘玉玲

夏学军

郭瑞芳

汪仁芸

王洪亮

金笃嘉

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Beijing wuhebao Pharmaceutical Co.,Ltd.

Original Assignee

Institute of Materia Medica of CAMS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-10-29

Filing date

2009-10-29

Publication date

2014-03-05

2009-10-29 Priority to CN200910236959.4A priority Critical patent/CN102048688B/zh

2009-10-29 Application filed by Institute of Materia Medica of CAMS filed Critical Institute of Materia Medica of CAMS

2010-10-28 Priority to KR1020167031342A priority patent/KR20160137646A/ko

2010-10-28 Priority to JP2012535617A priority patent/JP2013509361A/ja

2010-10-28 Priority to EP10826102.5A priority patent/EP2494957A4/en

2010-10-28 Priority to CN201410053531.7A priority patent/CN104224711B/zh

2010-10-28 Priority to CN201080059672.XA priority patent/CN102686217B/zh

2010-10-28 Priority to AU2010312021A priority patent/AU2010312021B2/en

2010-10-28 Priority to KR1020127013916A priority patent/KR20120091257A/ko

2010-10-28 Priority to BR112012010148-0A priority patent/BR112012010148A2/pt

2010-10-28 Priority to US13/505,168 priority patent/US20120308616A1/en

2010-10-28 Priority to KR1020147006983A priority patent/KR20140041952A/ko

2010-10-28 Priority to CA2779166A priority patent/CA2779166C/en

2010-10-28 Priority to PCT/CN2010/078209 priority patent/WO2011050739A1/zh

2011-05-11 Publication of CN102048688A publication Critical patent/CN102048688A/zh

2013-03-11 Priority to HK13103019.6A priority patent/HK1175707A1/xx

2014-03-05 Application granted granted Critical

2014-03-05 Publication of CN102048688B publication Critical patent/CN102048688B/zh

2014-04-22 Priority to JP2014088189A priority patent/JP2014133764A/ja

2016-08-02 Priority to AU2016210620A priority patent/AU2016210620A1/en

Status Active legal-status Critical Current

2029-10-29 Anticipated expiration legal-status Critical

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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dispersion Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Dermatology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

CN200910236959.4A 2009-10-29 2009-10-29 以胆固醇复合物为中间载体的紫杉醇亚微乳 Active CN102048688B (zh)

Priority Applications (16)

Application Number	Priority Date	Filing Date	Title
CN200910236959.4A CN102048688B (zh)	2009-10-29	2009-10-29	以胆固醇复合物为中间载体的紫杉醇亚微乳
KR1020147006983A KR20140041952A (ko)	2009-10-29	2010-10-28	스테로이드 복합체를 중간 담체로서 이용한 파클리탁셀의 서브마이크론 에멀젼
EP10826102.5A EP2494957A4 (en)	2009-10-29	2010-10-28	SUBMICRIC EMULSION OF PACLITAXEL WITH A STEROID COMPLEX AS INTERMEDIATE CARRIER
CN201410053531.7A CN104224711B (zh)	2009-10-29	2010-10-28	以类固醇复合物为中间载体的紫杉醇亚微乳
CN201080059672.XA CN102686217B (zh)	2009-10-29	2010-10-28	以类固醇复合物为中间载体的紫杉醇亚微乳
AU2010312021A AU2010312021B2 (en)	2009-10-29	2010-10-28	A submicron emulsion of paclitaxel using steroid complex as intermediate carrier
KR1020127013916A KR20120091257A (ko)	2009-10-29	2010-10-28	스테로이드 복합체를 중간 담체로서 이용한 파클리탁셀의 서브마이크론 에멀젼
BR112012010148-0A BR112012010148A2 (pt)	2009-10-29	2010-10-28	emulsão submicrometrica de paclitaxel com o uso de complexo de esteoride como carreador intermediario
KR1020167031342A KR20160137646A (ko)	2009-10-29	2010-10-28	스테로이드 복합체를 중간 담체로서 이용한 파클리탁셀의 서브마이크론 에멀젼
JP2012535617A JP2013509361A (ja)	2009-10-29	2010-10-28	ステロイド化合物を中間担体としてタクソールサブマイクロエマルション
CA2779166A CA2779166C (en)	2009-10-29	2010-10-28	Submicro emulsion of paclitaxel using steroid complex as intermediate carrier
PCT/CN2010/078209 WO2011050739A1 (zh)	2009-10-29	2010-10-28	以类固醇复合物为中间载体的紫杉醇亚微乳
US13/505,168 US20120308616A1 (en)	2009-10-29	2010-10-28	Submicro emulsion of paclitaxel using steroid complex as intermediate carrier
HK13103019.6A HK1175707A1 (en)	2009-10-29	2013-03-11	Submicro emulsion of paclitaxel using steroid complex as intermediate carrier
JP2014088189A JP2014133764A (ja)	2009-10-29	2014-04-22	ステロイド化合物を中間担体としたタクソールサブマイクロエマルション
AU2016210620A AU2016210620A1 (en)	2009-10-29	2016-08-02	A submicron emulsion of paclitaxel using steroid complex as intermediate carrier

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CN200910236959.4A CN102048688B (zh)	2009-10-29	2009-10-29	以胆固醇复合物为中间载体的紫杉醇亚微乳

Publications (2)

Publication Number	Publication Date
CN102048688A CN102048688A (zh)	2011-05-11
CN102048688B true CN102048688B (zh)	2014-03-05

Family

ID=43921351

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
CN200910236959.4A Active CN102048688B (zh)	2009-10-29	2009-10-29	以胆固醇复合物为中间载体的紫杉醇亚微乳
CN201080059672.XA Active CN102686217B (zh)	2009-10-29	2010-10-28	以类固醇复合物为中间载体的紫杉醇亚微乳
CN201410053531.7A Active CN104224711B (zh)	2009-10-29	2010-10-28	以类固醇复合物为中间载体的紫杉醇亚微乳

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
CN201080059672.XA Active CN102686217B (zh)	2009-10-29	2010-10-28	以类固醇复合物为中间载体的紫杉醇亚微乳
CN201410053531.7A Active CN104224711B (zh)	2009-10-29	2010-10-28	以类固醇复合物为中间载体的紫杉醇亚微乳

Country Status (10)

Country	Link
US (1)	US20120308616A1 (ko)
EP (1)	EP2494957A4 (ko)
JP (2)	JP2013509361A (ko)
KR (3)	KR20120091257A (ko)
CN (3)	CN102048688B (ko)
AU (2)	AU2010312021B2 (ko)
BR (1)	BR112012010148A2 (ko)
CA (1)	CA2779166C (ko)
HK (1)	HK1175707A1 (ko)
WO (1)	WO2011050739A1 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102048688B (zh) *	2009-10-29	2014-03-05	中国医学科学院药物研究所	以胆固醇复合物为中间载体的紫杉醇亚微乳
KR101404948B1 (ko) *	2012-08-23	2014-06-10	부경대학교 산학협력단	나비쿨라 인서타로부터 분리된 스티그마스테롤 및 5 베타-히드록시시토스타놀을 함유하는 간암의 예방 또는 치료용 조성물
EP3043781A1 (en) *	2013-09-13	2016-07-20	Arbor Therapeutics, LLC	Nanoparticulate compositions for targeted delivery of lipophilic drugs and acid labile, lipophilic prodrugs of cancer chemotherapeutics and their preparation
ITMI20131927A1 (it)	2013-11-20	2015-05-21	Cosmo Technologies Ltd	Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection. emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica
ITMI20131924A1 (it) *	2013-11-20	2015-05-21	Cosmo Technologies Ltd	Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica
AU2016204933B2 (en) *	2015-07-14	2020-02-27	Best Pet Rx Ip, Inc.	Poloxamer-based intralesional injections for the delivery of chemotherapeutic agents
CN107668720A (zh) *	2017-09-28	2018-02-09	山西琪尔康翅果生物制品有限公司	一种具有缓解体力疲劳的翅果油亚微乳及其制备方法
CN109908366B (zh) *	2019-03-20	2022-03-25	佛山科学技术学院	改性壳聚糖载体与药物的包合物及其制备方法
CN115252551A (zh) *	2022-08-18	2022-11-01	南昌大学	一种紫杉醇注射用微乳、冻干粉及其制备方法

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US5616330A (en) *	1994-07-19	1997-04-01	Hemagen/Pfc	Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same
CN1676125A (zh) *	2004-03-31	2005-10-05	张昊	含有紫杉碱类或难溶药物的纳米级乳剂
WO2005118612A1 (en) *	2004-06-04	2005-12-15	Sonus Pharmaceuticals, Inc.	Cholesterol/bile acid/bile acid derivative-modified therapeutic anti-cancer drugs
CN1743337B (zh) *	2004-09-03	2012-06-13	上海复旦张江生物医药股份有限公司	一种紫杉醇衍生物及其药物组合物
US8557861B2 (en) *	2004-09-28	2013-10-15	Mast Therapeutics, Inc.	Low oil emulsion compositions for delivering taxoids and other insoluble drugs
CN101011355B (zh) *	2006-02-01	2013-01-02	陈献	经维生素e琥珀酸酯稳定的医药组合物、其制备及用途
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CN102048725B (zh) *	2009-10-29	2014-07-16	中国医学科学院药物研究所	紫杉醇胆固醇复合物
CN102048688B (zh) *	2009-10-29	2014-03-05	中国医学科学院药物研究所	以胆固醇复合物为中间载体的紫杉醇亚微乳

2009
- 2009-10-29 CN CN200910236959.4A patent/CN102048688B/zh active Active
2010
- 2010-10-28 US US13/505,168 patent/US20120308616A1/en not_active Abandoned
- 2010-10-28 CN CN201080059672.XA patent/CN102686217B/zh active Active
- 2010-10-28 EP EP10826102.5A patent/EP2494957A4/en not_active Ceased
- 2010-10-28 KR KR1020127013916A patent/KR20120091257A/ko not_active Application Discontinuation
- 2010-10-28 WO PCT/CN2010/078209 patent/WO2011050739A1/zh active Application Filing
- 2010-10-28 AU AU2010312021A patent/AU2010312021B2/en not_active Ceased
- 2010-10-28 KR KR1020167031342A patent/KR20160137646A/ko not_active Application Discontinuation
- 2010-10-28 CN CN201410053531.7A patent/CN104224711B/zh active Active
- 2010-10-28 BR BR112012010148-0A patent/BR112012010148A2/pt not_active IP Right Cessation
- 2010-10-28 JP JP2012535617A patent/JP2013509361A/ja active Pending
- 2010-10-28 CA CA2779166A patent/CA2779166C/en not_active Expired - Fee Related
- 2010-10-28 KR KR1020147006983A patent/KR20140041952A/ko active Application Filing
2013
- 2013-03-11 HK HK13103019.6A patent/HK1175707A1/xx not_active IP Right Cessation
2014
- 2014-04-22 JP JP2014088189A patent/JP2014133764A/ja active Pending
2016
- 2016-08-02 AU AU2016210620A patent/AU2016210620A1/en not_active Abandoned

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CN101396346A (zh) *	2007-09-26	2009-04-01	中国医学科学院药物研究所	紫杉醇脂质复合物

Also Published As

Publication number	Publication date
HK1175707A1 (en)	2013-07-12
US20120308616A1 (en)	2012-12-06
CA2779166C (en)	2015-05-05
CN102048688A (zh)	2011-05-11
EP2494957A1 (en)	2012-09-05
CN104224711A (zh)	2014-12-24
WO2011050739A1 (zh)	2011-05-05
CN102686217A (zh)	2012-09-19
CN102686217B (zh)	2015-02-18
AU2016210620A1 (en)	2016-08-18
KR20120091257A (ko)	2012-08-17
CN104224711B (zh)	2017-04-26
AU2010312021B2 (en)	2016-08-18
KR20140041952A (ko)	2014-04-04
KR20160137646A (ko)	2016-11-30
JP2014133764A (ja)	2014-07-24
BR112012010148A2 (pt)	2018-03-20
EP2494957A4 (en)	2014-04-16
AU2010312021A1 (en)	2012-06-21
JP2013509361A (ja)	2013-03-14
CA2779166A1 (en)	2011-05-05

Legal Events

Date	Code	Title	Description
2011-05-11	C06	Publication
2011-05-11	PB01	Publication
2012-11-28	C10	Entry into substantive examination
2012-11-28	SE01	Entry into force of request for substantive examination
2014-03-05	GR01	Patent grant
2014-03-05	GR01	Patent grant
2016-11-09	C41	Transfer of patent application or patent right or utility model
2016-11-09	TR01	Transfer of patent right	Effective date of registration: 20161019 Address after: 102600 Zhongguancun Daxing District science and Technology Park Daxing biomedical industry base, Fu Fu Street, No. 30 Patentee after: Beijing Wehand-Bio Pharmaceutical Co., Ltd. Address before: 100050 Beijing city Xuanwu District Xiannongtan Street No. 1 Patentee before: Institute of Materia Medica of Chinese Academy of Medical Sciences
2021-05-28	CP03	Change of name, title or address	Address after: 102600 30 Tianfu street, Daxing biomedical industry base, Zhongguancun Science and Technology Park, Daxing District, Beijing Patentee after: Beijing wuhebao Pharmaceutical Co.,Ltd. Address before: 102600 No.30 Tianfu street, Daxing biomedical industry base, Zhongguancun Science and Technology Park, Daxing District, Beijing Patentee before: BEIJING WEHAND-BIO PHARMACEUTICAL Co.,Ltd.
2021-05-28	CP03	Change of name, title or address

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