CN101980715A - 皮肤血流改善剂和皮肤温度上升剂 - Google Patents

皮肤血流改善剂和皮肤温度上升剂 Download PDF

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CN101980715A
CN101980715A CN2009801112919A CN200980111291A CN101980715A CN 101980715 A CN101980715 A CN 101980715A CN 2009801112919 A CN2009801112919 A CN 2009801112919A CN 200980111291 A CN200980111291 A CN 200980111291A CN 101980715 A CN101980715 A CN 101980715A
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森圭子
勝山雅子
合津陽子
土師信一郎
城市笃
寺嶋有史
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Abstract

本发明的课题是改善皮肤血流并使皮肤温度上升，从而防止或改善肩部僵硬和/或身体发冷。作为解决本发明课题的方法是配合选自茉莉(茉莉花，jasmin sambac)的提取物、大马士革蔷薇(Rosa damascena)的水蒸气蒸馏物、3-甲基辛-4-内酯和乙酸冰片酯中的1种或2种以上作为有效成分。

Description

皮肤血流改善剂和皮肤温度上升剂
技术领域
本发明涉及使皮肤血流量增加并使皮肤温度上升的皮肤血流改善剂和皮肤温度上升剂。
背景技术
在现代社会，由于运动不足、在工作场所以固定姿势长时间工作、冷气和暖气设备完备、压力引起的自主神经失调等各种因素而导致诉说手脚发冷和/或发麻、肩部僵硬、水肿等症状的人增多。这样的症状的主要原因被认为是血液循环不良。
如果血液循环不良或障碍等导致血液循环变差，则会导致温热的血液不能充分遍布直至末梢，而且来自血液的氧和/或营养的供给阻滞，进而废物和/或水分蓄积。
此外，作为恒温动物的人具备保持稳定体温的体温调节功能，通过由位于感知环境温度变化(刺激)的脑的下丘脑部的体温调节中枢发出的指令来调节自主神经***和/或内分泌***，而使体温保持稳定，但是如果精神或身体的压力等使自主神经的平衡破坏，则变成体温调节功能不能很好地发挥作用，对于寒冷身体不能适当地应对，交感神经占优势，血管的收缩和/或肌肉的紧张持续，从而形成血液循环不良。
为了改善这样的血液循环不良引起的症状，进行了各种尝试。例如，专利文献1中记载了海索草提取物可以改善血液流动性和血流，进而使皮肤表面温度上升，改善发冷症状和/或肩部僵硬等。
此外，专利文献2中记载了包含黑醋栗浓缩物和氨基酸或有机酸的组合物可以使血管扩张而使末梢血流量增加，从而改善肩部僵硬和/或身体发冷。
此外，专利文献3中记载了春黄菊提取物的香气可以改善血流而使末梢皮肤温度上升。
然而，对于这些现有报导的化合物和/或组合物，感受性和/或嗜好性个人差异较大，还不能获得充分令人满意的效果。因此，仍然强烈需求可以更有效且普遍地改善皮肤血流并提高皮肤温度的新的物质。
专利文献1：特开2006-8575号公报
专利文献2：特开2004-262878号公报
专利文献3：特开2005-68069号公报
发明内容
本发明是鉴于上述事实而提出的，其目的在于，提供可以安全且有效地使皮肤血流量增加并可提高皮肤温度、可以有效地改善身体发冷和/或肩部僵硬等的新的物质。
本发明者发现木犀科素馨属的植物茉莉(茉莉花，jasmin sambac)的提取物、土耳其玫瑰(rose Turkish)蔷薇科的植物大马士革蔷薇(Rosadamascena)的水蒸气蒸馏物、3-甲基辛-4-内酯和乙酸冰片酯可以使皮肤血流量增加，进而使皮肤温度上升，从而完成了本发明。
本发明的皮肤血流改善剂和皮肤温度上升剂的特征在于，以选自茉莉(茉莉花，jasmin sambac)的提取物、大马士革蔷薇(Rosa damascena)的水蒸气蒸馏物、3-甲基辛-4-内酯和乙酸冰片酯中的1种或2种以上作为有效成分。本发明者证实了这些化合物均具有交感神经抑制效果，认为通过将自主神经调整成镇静而进行调节，以使副交感神经的作用与交感神经的作用相比呈相对优势，由此血管扩张且肌肉的紧张松弛而改善血流，进而通过使血液循环改善而使温热的血液遍布直至末梢，从而使皮肤温度上升。
本发明的肩部僵硬或身体发冷的预防或改善剂的特征在于，以选自茉莉(茉莉花，jasmin sambac)的提取物、大马士革蔷薇(Rosa damascena)的水蒸气蒸馏物、3-甲基辛-4-内酯和乙酸冰片酯中的1种或2种以上作为有效成分。通过改善皮肤血流进而提高皮肤温度，温热的血液遍布直至末梢，代谢增强，进而促进来自血液的氧气和/或营养的供给以及废物的***，从而可以减轻身体发冷和/或肩部僵硬的症状。
本发明的皮肤血流改善剂和皮肤温度上升剂等无副作用，且可以不依赖于个体的感受性和/或嗜好性而使末梢血流量增加并使皮肤温度上升，可以安全且有效地改善身体发冷和/或肩部僵硬等由血液循环不良引起的各种症状。
具体实施方式
本发明的皮肤血流改善剂、皮肤温度上升剂、肩部僵硬预防或改善剂、和身体发冷预防或改善剂(以下称为皮肤血流改善剂等)包含选自茉莉(茉莉花，jasmin sambac)的提取物、大马士革蔷薇(Rosa damaseena)的水蒸气蒸馏物、3-甲基辛-4-内酯和乙酸冰片酯中的1种或2种以上作为有效成分。
在本发明中“皮肤血流改善”是指使皮肤血管的血流量增加，例如，可以采用激光多普勒血流计(ADVANCE LASER FLOW-METER ALF21)等，在手指和/或脚趾等处安装探测器来测定血流量的变化而进行评价。
此外，在本发明中“皮肤温度上升”是指提高皮肤温度，例如，可以采用8ch体温记录器(日機装サ一モ(株))等，测定面颊、手指、脚趾等的皮肤温度变化而进行评价。
此外，在本发明中“预防或改善”是指防止症状的发作或者减轻或缓解症状。
茉莉(茉莉花，jasmin sambac)是木犀科素馨属的植物。茉莉的全草、叶、树皮、枝、果实或根等可以直接使用或粉碎使用，特别优选使用花。茉莉提取物，除了将提取部位直接或干燥后切断成适当大小、或粉碎加工而得的粉碎物进行提取而获得的提取物以外，还包括分离纯化而获得的更高活性的组分(成分)。对于提取，除了在室温或加热状态使提取部位浸渍在溶剂中或采用索格利特提取器等提取器具进行的溶剂提取以外，还可以使用采用水蒸气蒸馏等蒸馏法进行提取的方法、使二氧化碳变成超临界状态而进行的超临界提取法、或者进行压榨而获得提取物的压榨法等，特别可以优选使用溶剂提取而得的提取物。
作为溶剂提取中使用的提取溶剂，可以使用极性溶剂、非极性溶剂的任一种，也可以将这些提取溶剂混合使用。可列举例如，水；甲醇、乙醇、丙醇、丁醇等醇类；乙二醇、丙二醇、丁二醇等多元醇类；丙酮、甲基乙基酮等酮类；乙酸甲酯、乙酸乙酯等酯类；四氢呋喃、***等链状醚和环状醚类；聚乙二醇等聚醚类；二氯甲烷、氯仿、四氯化碳等卤代烃类；己烷、环己烷、石油醚等烃类；苯、甲苯等芳香族烃类；吡啶类；超临界二氧化碳；油脂、蜡、其它油等，这些溶剂可以单独使用或2种以上组合使用，也可以改变溶剂反复进行提取。其中，优选采用乙醇、双丙甘醇、丙二醇、丁二醇等溶剂。提取可以通过例如采用相对于1质量份植物为1～50质量份的溶剂，在3～100℃下浸渍或加热回流几小时～几周来进行。
大马士革蔷薇(Rosa damascena)是土耳其玫瑰蔷薇科的植物。全草、花、叶、树皮、枝、果实或根等可以直接使用或粉碎使用，特别优选使用花。在本发明中“水蒸气蒸馏物”是指通过水蒸气蒸馏而获得的精油。本发明中使用的大马士革蔷薇的水蒸气蒸馏物，可以通过对将提取部位直接或干燥后切断成适当大小、或粉碎加工而得的粉碎物实施通常的水蒸气蒸馏来调制，还包括分离纯化而获得的更高活性的组分(成分)。例如，可以通过向大马士革蔷薇的花或将其干燥而得的干燥物吹入水蒸气，将挥发成分冷却并收集，将油性部分(精油)分离回收来调制。
可以将茉莉的提取物和/或大马士革蔷薇的水蒸气蒸馏物进一步分离纯化，作为分离纯化方法，可以列举例如，将提取物进行活性碳处理、液液分配、柱色谱、液相色谱、凝胶过滤、精密蒸馏等。
本发明中使用的3-甲基辛-4-内酯和乙酸冰片酯可以通过公知的合成方法来合成，或可以使用市售品。
在本发明中，茉莉的提取物、大马士革蔷薇的水蒸气蒸馏物、3-甲基辛-4-内酯和乙酸冰片酯可以1种单独使用，或者也可以2种以上组合使用。本发明的皮肤血流改善剂等只要包含上述物质作为有效成分并可以实现本发明的效果，则对其形态没有特别的限制，可以以液状、糊状、凝胶状、固体状等任意形态使用。此外，在不破坏本发明效果的范围，可以包含任意的载体、稀释剂、助剂等任意其它成分。
本发明的皮肤血流改善剂等可以用于医药品、医药部外品、化妆品、食品、饮料等任意用途。此外，由于上述有效成分可以气化而发挥效果，因此可以用于服装类和/或杂货类等。配合本发明的皮肤血流改善剂等的对象物，只要是可以以上述有效成分气化可吸入的形态配合的对象物，就可以是任何的对象物，不受剂型和/或制品形态限定。此外，根据该对象物的种类，除了上述有效成分以外，还可以包含通常该对象物中包含的任意的构成要素。还可以将其它任意的活性药剂与本发明的皮肤血流改善剂等并用。
例如，作为配合了本发明的皮肤血流改善剂等的制品形态，没有限定，可列举化妆品、医药品、医药部外品、食品、饮料等，此外，作为其剂型，可列举例如，液体制剂、粉末剂、颗粒剂、气雾剂、固体制剂、凝胶剂等。
特别是，作为一个优选方式的化妆品，没有限定，可列举例如，香水、淡香水、古龙水、面霜、乳液类、化妆水、粉底类、化妆底粉、口红、皂、香波和/或护发素类、身体香波、沐浴露、爽身粉类、浴用制剂类等。
此外，例如，芳香剂、除臭剂、香薰蜡烛、熏香、文具、钱包、手提包、鞋等任意杂货类，和/或例如内衣、西服、帽子、长筒袜、袜子等任意服装类中可以包含本发明的皮肤血流改善剂等。这些材料或制品中均可以加入本发明的皮肤血流改善剂等。
另外，虽然例示了本发明的皮肤血流改善剂等的各种使用形态，但是不限于此，只要是可以实现本发明的效果，就可以采用任意形态。
实施例
以下，通过实施例详细地说明本发明，但是本发明不限于这些实施例。茉莉的溶剂提取物和大马士革蔷薇的水蒸气蒸馏物使用由(株)ロベルテ销售的商品，3-甲基辛-4-内酯使用由曾田香料(株)销售的商品，乙酸冰片酯使用由高砂香料工业(株)销售的商品。
试验例1.对皮肤温度影响的研究
采用8ch体温记录器(日機装サ一モ(株))，测定手指的皮肤温度，调查嗅到被检物质的香气所引起的皮肤温度的变化，研究对末梢皮肤温度的影响。另外，作为对照，采用属于木犀科素馨属的素馨(jasmine)的溶剂提取物同样地进行评价。
将20几岁的女性作为被检者，采用温度为25℃且湿度为50％的恒温恒湿室进行试验。
让被检者在安乐椅上就座，保持安静30分钟，然后在两手的中指的腹侧和胸部这2处安装体温传感器，记录各部位的皮肤温度随时间的变化。由于明确了胸部的皮肤温几乎无变化，因此采用胸部的皮肤温度作为基准值，采用由指尖2处的皮肤温度的平均值减去胸部2处的皮肤温度的平均值而得到的值(T值)来评价末梢皮肤温度的变化。
测定试验，将(A)安静3分钟，(B)在鼻下粘贴无香气的棉片3分钟，(C)安静3分钟，(D)在鼻下粘贴渗入了试验样品的棉片3分钟，(E)安静3分钟，(F)在鼻下粘贴无香气棉片3分钟，(G)安静3分钟，作为1序列，在其间连续测定皮肤温度，计算T值。
将粘贴了无香气棉片的(B)与(F)时的T值作为对照，与吸入了试验样品的(D)时的T值进行比较，研究各物质对皮肤温度的影响。即，
皮肤温度变化(℃)＝T值(D)-(T值(B)与T值(F)的平均值)
图1显示结果。在嗅到茉莉提取物、大马士革蔷薇、3-甲基辛-4-内酯或乙酸冰片酯的香气的情况下，手指的皮肤温度上升，从而显示出这些物质具有皮肤温度上升作用。
此外，虽然数据没有显示，但是嗅到茉莉提取物、大马士革蔷薇、3-甲基辛-4-内酯或乙酸冰片酯的香气也可以使脚趾和面颊的皮肤温度上升。
试验例2.对皮肤血流影响的研究
采用激光多普勒血流计(ADVANCE LASER FLOW-METER ALF21)测定手指皮肤血流量，来评价茉莉提取物对皮肤血流的影响。
将男女6名作为被检者，采用调整成温度为22℃且湿度为45％的恒温恒湿室进行试验。让被检者在安乐椅上就座，保持安静30分钟，然后在右手中指的腹侧安装血流计的探测器，记录血流量随时间的变化。测定试验，将(A)安静3分钟，(B)在鼻下粘贴无香气的棉片3分钟，(C)安静3分钟，(D)在鼻下粘贴渗入了试验样品的棉片3分钟，(E)安静3分钟，(F)在鼻下粘贴无香气的棉片3分钟，(G)安静3分钟，作为1序列，在其间连续地测定血流量。
将粘贴了无香气棉片的(B)与(F)时的血流量作为对照，与吸入了试验样品的(D)时的血流量进行比较，来研究各物质对皮肤血流量的影响。即，
血流变化量(mL/min/100g)＝血流量(D)-(血流量(B)与血流量(F)的平均值)
图2显示结果。嗅到茉莉提取物的香气使皮肤血流量增加，从而显示出茉莉提取物具有皮肤血流改善作用。
试验例3.对发冷、肩部僵硬症状的效果的研究
认为发冷和/或肩部僵硬等的原因之一是血流的降低。因此，研究了茉莉提取物对发冷、肩部僵硬症状的改善效果。
将感觉身体发冷的男女4名作为被检者，采用调整成温度为22℃且湿度为45％的恒温恒湿室进行试验。让被检者在安乐椅上就座，保持安静30分钟，然后在鼻下粘贴无香的棉片，3分钟后，采用5等级对发冷和肩部僵硬的程度进行主观评价。接着，在鼻下粘贴渗入了茉莉提取物的棉片，随着3分钟自然呼吸将其吸入，然后再次采用5等级对发冷和肩部僵硬的程度进行主观评价。
图3显示结果。通过嗅到茉莉提取物的香气显示出获得确实感觉到手、脚、全身温暖的结果，肩部僵硬症状也得以改善。
以下，显示包含本发明的皮肤血流改善剂、皮肤温度上升剂、肩部僵硬防止或改善剂、或身体发冷防止或改善剂的各种组合物、杂货类、服装类等典型制品形态的应用例。另外，配合量以相对于全部制品总量的质量％表示。另外，作为本发明的皮肤血流改善剂等，茉莉的提取物、大马士革蔷薇的水蒸气蒸馏物、3-甲基辛-4-内酯或乙酸冰片酯可以单独配合或组合配合。
应用例1
化妆水
(1)甘油                                                   2.0
(2)双丙甘醇                                               2.0
(3)PEG-60氢化蓖麻籽油                                     0.3
(4)三甲基甘氨酸                                           0.1
(5)防腐剂                                                 适量
(6)螯合剂                                                 适量
(7)染料                                                   适量
(8)皮肤血流改善剂(茉莉(茉莉花，jasmin sambac)的提取物)    0.05
(9)纯化水                                                 残余
应用例2
化妆水
(1)乙醇                                                   30.0
(2)丁二醇                                                 4.0
(3)甘油                                                   2.0
(4)癸基十四烷基聚氧乙烯(24)聚氧丙烯(13)聚醚               0.3
(5)辛基甲氧基肉桂酸酯                                     0.1
(6)薄荷脑                                                 0.2
(7)生育酚乙酸酯                                           0.1
(8)螯合剂                                                 适量
(9)染料                                                   适量
(10)皮肤血流改善剂(乙酸冰片酯)                            0.01
(11)纯化水                                                残余
应用例3
乳液
(1)硬脂酸                              2.0
(2)鲸蜡醇                              1.5
(3)凡士林                              4.0
(4)角鲨烷                              5.0
(5)三(2-乙基己酸)甘油酯                2.0
(6)失水山梨醇单油酸酯                  2.0
(7)双丙甘醇                            5.0
(8)PEG1500                             0.3
(9)三乙醇胺                            0.1
(10)防腐剂                             适量
(11)皮肤血流改善剂(3-甲基辛-4-内酯)    0.2
(12)纯化水                             残余
应用例4
乳液
(1)乙醇                                10.0
(2)环状聚二甲基硅氧烷                  0.1
(3)丁二醇                              5.0
(4)聚二甲基硅氧烷                      3.0
(5)Glycene                             0.1
(6)薄荷脑                              1.0
(7)三甲基硅烷氧基硅酸                  0.1
(8)咖啡因                              1.0
(9)三甲基甘氨酸                        1.0
(10)黄原胶                             0.001
(11)羟乙基纤维素                       0.1
(12)大豆发酵提取物                     1.0
(13)月桂基甜菜碱                       0.5
(14)卡波姆                       0.2
(15)螯合剂                       适量
(16)对羟基苯甲酸酯               适量
(17)苯甲酸                       适量
(18)皮肤温度上升剂(乙酸冰片酯)   0.1
(19)氧化铁                       适量
(20)氢氧化钾                     0.05
(21)甘草酸二钙                   0.01
(22)盐酸吡哆醇                   0.01
(23)抗坏血酸葡糖苷               0.01
(24)熊果苷                       3.0
(25)虎耳草提取液                 0.1
(26)水                           残余
应用例5
乳液
(1)丁二醇                        4.0
(2)丙二醇                        4.0
(3)卡波姆                        0.2
(4)氢氧化钾                      0.2
(5)山萮酸                        0.5
(6)硬脂酸                        0.5
(7)异硬脂酸                      0.5
(8)硬脂酸甘油酯                  1.0
(9)异硬脂酸甘油酯                1.0
(10)山萮醇                       0.5
(11)角鲨烷                       5.0
(12)三辛酸甘油酯                 3.0
(13)苯基聚三甲基硅氧烷                        2.0
(14)鲨肝醇                                    0.5
(15)甘草酸二钙                                0.01
(16)防腐剂                                    适量
(17)螯合剂                                    适量
(18)颜料                                      适量
(19)皮肤温度上升剂                            0.1
(大马士革蔷薇(Rosa damascena)的水蒸气蒸馏物)
(20)皮肤温度上升剂                            0.05
(茉莉(茉莉花，jasmin sambac)的提取物)
(21)纯化水                                    残余
应用例6
乳液
(1)甘油                                       3.0
(2)木糖醇                                     2.0
(3)卡波姆                                     0.1
(4)氢氧化钾                                   0.1
(5)异硬脂酸甘油酯                             1.0
(6)硬脂酸甘油酯                               0.5
(7)山嵛醇                                     1.0
(8)鲨肝醇                                     1.0
(9)氢化棕榈油                                 2.0
(10)凡士林                                    1.0
(11)角鲨烷                                    5.0
(12)辛酸赤藓醇酯                              3.0
(13)环状聚二甲基硅氧烷                        1.0
(14)防腐剂                                    适量
(15)螯合剂                                        适量
(16)皮肤血流改善剂                                0.2
(大马士革蔷薇(Rosa damaseena)的水蒸气蒸馏物)
(17)纯化水                                        残余
(18)凝血酸                                        1.0
(19)泛醇***                                      0.5
(20)烟酰胺                                        0.1
(21)海藻糖                                        0.1
(22)迷迭香提取物                                  0.1
(23)维生素A                                       0.1
(24)抗坏血酸糖苷                                  0.001
(25)树莓提取液                                    1.0
(26)黄芩提取液                                    0.001
(27)黄柏提取液                                    0.01
应用例7
乳液
(1)乙醇                                           2.0
(2)环状聚二甲基硅氧烷                             10.0
(3)甘油                                           5.0
(4)二丁二醇                                       1.0
(5)聚二甲基硅氧烷                                 1.0
(6)玉米淀粉                                       4.0
(7)矿物油                                         2.0
(8)三甲基硅烷氧基硅酸                             5.0
(9)聚乙二醇                                       3.0
(10)乳酸薄荷酯                                    0.1
(11)PEG-60氢化蓖麻油                              1.0
                            3.0
(12)氨基丙基聚二甲基硅氧烷           1.0
(13)黄原胶                           0.01
(14)生育酚乙酸酯                     0.01
(15)咖啡因                           0.1
(16)透明质酸钠                       0.1
(17)大豆发酵提取物                   0.01
(18)金缕梅提取物                     0.01
(19)鱼腥草提取物                     0.01
(20)卡波姆                           0.3
(21)丙烯酸-甲基丙烯酸烷基酯共聚物    0.2
(22)EDTA                             适量
(23)防腐剂                           适量
(24)皮肤温度上升剂(乙酸冰片酯)       0.3
(25)颜料                             适量
(26)氢氧化钾                         0.15
(27)氨基甲基丙醇                     0.05
(28)水                               残余
应用例8
乳液
(1)乙醇                              15.0
(2)环状聚二甲基硅氧烷                6.0
(3)丁二醇                            0.5
(4)聚二甲基硅氧烷                    1.0
(5)甘油                              1.0
(6)聚乙二醇                          1.0
(7)乳酸薄荷酯                        1.0
(8)薄荷脑                            0.1
   
(9)三甲基硅烷氧基硅酸                      1.0
(10)咖啡因                                 0.5
(11)三亚甲基甘氨酸(trimethyleneglycine)    0.1
(12)黄原胶                                 0.1
(13)羟乙基纤维素                           0.1
(14)大豆发酵提取物                         0.01
(15)生育酚乙酸酯                           0.05
(16)月桂基甜菜碱                           0.01
(17)褐藻提取物                             0.01
(18)鱼腥草提取物                           0.01
(19)红藻提取物                             0.01
(20)绿藻提取物                             0.01
(21)纤维素末                               1.0
(22)异硬脂酸PEG-60甘油酯                   1.0
(23)异硬脂酸                               1.0
(24)卡波姆                                 0.1
(25)丙烯酸-甲基丙烯酸烷基酯聚合物          0.1
(26)EDTA                                   0.1
(27)偏磷酸钠                               0.1
(28)苯氧基乙醇                             0.2
(29)对羟基苯甲酸酯                         0.2
(30)皮肤温度上升剂(3-甲基辛-4-内酯)        0.20
(31)皮肤温度上升剂(乙酸冰片酯)             0.15
(32)氧化铁(红)                             0.02
(33)薄荷基甘油基醚                         0.01
(33)水                                     残余
应用例9
面霜
(1)甘油                                       10.0
(2)丁二醇                                     5.0
(3)卡波姆                                     0.1
(4)氢氧化钾                                   0.2
(5)硬脂酸                                     2.0
(6)硬脂酸甘油酯                               2.0
(7)异硬脂酸甘油酯                             2.0
(8)凡士林                                     5.0
(9)防腐剂                                     适量
(10)抗氧化剂                                  适量
(11)皮肤血流改善剂                            0.3
(大马士革蔷薇(Rosa damascena)的水蒸气蒸馏物)
(12)纯化水                                    残余
(13)螯合剂                                    适量
(14)颜料                                      适量
(15)硬脂醇                                    2.0
(16)山嵛醇                                    2.0
(17)氢化棕榈油                                2.0
(18)角鲨烷                                    10.0
(19)4-甲氧基水杨酸钾                          3.0
应用例10
面霜
(1)甘油                                       3.0
(2)双丙甘醇                                   7.0
(3)聚乙二醇                                   3.0
(4)硬脂酸甘油酯                               3.0
(5)异硬脂酸甘油酯                                          2.0
(6)硬脂醇                                                  2.0
(7)山嵛醇                                                  2.0
(8)液体石蜡                                                7.0
(9)环状聚二甲基硅氧烷                                      3.0
(10)聚二甲基硅氧烷                                         1.0
(11)辛基甲氧基肉桂酸酯                                     0.1
(12)透明质酸钠                                             0.05
(13)防腐剂                                                 适量
(14)抗氧化剂                                               适量
(15)皮肤血流改善剂(茉莉(茉莉花，jasmin sambac)的提取物)    0.3
(16)皮肤血流改善剂(3-甲基辛-4-内酯)                        0.1
(17)纯化水                                                 残余
(18)螯合剂                                                 适量
(19)颜料                                                   适量
应用例11
凝胶
(1)乙醇                                                    10.0
(2)甘油                                                    5.0
(3)丁二醇                                                  5.0
(4)卡波姆                                                  0.5
(5)氨基甲基丙醇                                            0.3
(6)PEG-60氢化蓖麻油                                        0.3
(7)薄荷脑                                                  0.02
(8)防腐剂                                                  适量
(9)螯合剂                                                  适量
(10)皮肤温度上升剂                                         0.05
(大马士革蔷薇(Rosa damascena)的水蒸气蒸馏物)
(11)皮肤温度上升剂(乙酸冰片酯)                            0.1
(12)纯化水                                                残余
应用例12
气雾剂
(1)甘油                                                   2.0
(2)双丙甘醇                                               2.0
(3)PEG-60氢化蓖麻油                                       0.3
(4)HPPCD                                                  1.0
(5)防腐剂                                                 适量
(6)螯合剂                                                 适量
(7)染料                                                   适量
(8)皮肤血流改善剂(茉莉(茉莉花，jasmin sambac)的提取物)    0.2
(9)纯化水                                                 适量
(10)LPG                                                   残余
应用例13
气雾剂
(1)乙醇                                                   15.0
(2)丁二醇                                                 2.0
(3)甘油                                                   1.0
(4)癸基十四烷基聚氧乙烯(24)聚氧丙烯(13)聚醚               0.1
(5)银负载沸石                                             1.0
(6)螯合剂                                                 适量
(7)染料                                                   适量
(8)皮肤血流改善剂(乙酸冰片酯)                             0.15
(9)纯化水                                                 残余
(10)LPG                                                    40.0
应用例14
气雾剂
(1)乙醇                                                    60.0
(2)乳酸薄荷酯                                              0.1
(3)乳酸钠                                                  0.1
(4)生育酚乙酸酯                                            0.01
(5)乳酸                                                    0.01
(6)咖啡因                                                  0.01
(7)茴香提取物                                              1.0
(8)金缕梅提取物                                            1.0
(9)鱼腥草提取物                                            1.0
(10)双丙甘醇                                               1.0
(11)氮气                                                   0.9
(12)聚氧乙烯聚氧丙烯癸基十四烷基醚                         1.0
(13)丁二醇                                                 2.0
(14)生育酚                                                 0.05
(15)皮肤温度上升剂(茉莉(茉莉花，jasmin sambac)的提取物)    0.05
(16)皮肤温度上升剂                                         0.05
(大马士革蔷薇(Rosa damascena)的水蒸气蒸馏物)
(17)PEG-60氢化蓖麻油                                       0.1
(18)水                                                     残余
应用例15
香波
(1)月桂基聚氧乙烯(3)硫酸酯钠盐(30％水溶液)                 30.0
(2)月桂醇硫酸酯钠盐(30％水溶液)                            10.0
(3)椰子油脂肪酸二乙醇酰胺                  4.0
(4)甘油                                    1.0
(5)防腐剂                                  适量
(6)皮肤血流改善剂(乙酸冰片酯)              0.5
(7)色素                                    适量
(8)金属离子封锁剂、pH调节剂                适量
(9)纯化水                                  残余
应用例16
护发素      
(1)硅油                                    3.0
(2)液体石蜡                                1.0
(3)鲸蜡醇                                  1.5
(4)硬脂醇                                  1.0
(5)硬脂基三甲基氯化铵                      0.7
(6)甘油                                    3.0
(7)皮肤温度上升剂                          0.5
(大马士革蔷薇(Rosa damaseena)的水蒸气蒸馏物)
(8)色素、防腐剂                            适量
(9)纯化水                                  残余
应用例17
身体香波
(1)月桂酸                                  2.5
(2)肉豆蔻酸                                5.0
(3)棕榈酸                                  2.5
(4)油酸                                    2.5
(5)椰油酸二乙醇酰胺                        1.0
(6)甘油                                                  20.0
(7)氢氧化钾                                              3.6
(8)染料                                                  适量
(9)皮肤血流改善剂                                        0.5
(大马士革蔷薇(Rosa damascena)的水蒸气蒸馏物)
(10)金属离子封锁剂                                       适量
(11)纯化水                                               残余
应用例18
香水
(1)乙醇                                                  75.0
(2)纯化水                                                残余
(3)双丙甘醇                                              5.0
(4)皮肤温度上升剂(3-甲基辛-4-内酯)                       10.0
(5)抗氧化剂                                              8.0
(6)色素                                                  适量
(7)紫外线吸收剂                                          适量
此处，“香水”是指，在醇(例如乙醇)或醇水溶液中溶解精油而得的溶液。香水含有1％～99％质量％的精油。水与醇的配合比为50∶50～0∶100的范围。香水可以含有增溶剂、软化剂、保湿剂、增稠剂、抑菌剂、或其它通常化妆品中使用的材料。
应用例19
家居香氛
(1)乙醇                                                   80.0
(2)纯化水                                                 残余
(3)抗氧化剂                                               5.0
(4)皮肤血流改善剂(茉莉(茉莉花，jasmin sambac)的提取物)    2.0
(5)皮肤血流改善剂(3-甲基辛-4-内酯)              1.0
(6)3-甲基-3甲氧基丁醇                           5.0
(7)二亚苄基山梨糖醇                             5.0
应用例20
熏香
(1)红楠粉                                       75.5
(2)苯甲酸钠                                     15.5
(3)皮肤血流改善剂(乙酸冰片酯)                   5.0
(4)桉树油                                       1.0
(5)茴香油                                       1.0
(6)纯化水                                       残余
应用例21
浴用制剂
(1)硫酸钠                                       45.0
(2)碳酸氢钠                                     45.0
(3)海索草油                                     9.0
(4)皮肤温度上升剂                               1.0
(大马士革蔷薇(Rosa damaseena)的水蒸气蒸馏物)
应用例22
按摩用凝胶
(1)赤藓糖醇                                     2.0
(2)咖啡因                                       5.0
(3)黄柏提取物                                   3.0
(4)甘油                                         50.0
(5)羧基乙烯基聚合物                             0.4
(6)聚乙二醇400                                              30.0
(7)乙二胺四乙酸三钠                                         0.1
(8)聚氧乙烯(10)-甲基聚硅氧烷共聚物                          2.0
(9)角鲨烷                                                   1.0
(10)氢氧化钾                                                0.15
(11)皮肤血流改善剂(茉莉(茉莉花，jasmin sambac)的提取物)     0.3
(12)皮肤血流改善剂                                          0.2
(大马士革蔷薇(Rosa damaseena)的水蒸气蒸馏物)
(13)皮肤血流改善剂(3-甲基辛-4-内酯)                         0.5
应用例23
按摩霜
(1)固体石蜡                                                 5.0
(2)蜂蜡                                                     10.0
(3)凡士林                                                   15.0
(4)液体石蜡                                                 41.0
(5)1.3-丁二醇                                               4.0
(6)单硬脂酸甘油酯                                           2.0
(7)POE(20)失水山梨醇单月桂酸酯                              2.0
(8)硼砂                                                     0.2
(9)咖啡因                                                   2.0
(10)防腐剂                                                  适量
(11)抗氧化剂                                                适量
(12)皮肤血流改善剂(乙酸冰片酯)                              1.0
(13)纯化水                                                  残余
应用例24
芳香性纤维
向铜铵纤维素溶液(纤维素浓度为10重量％，铵浓度为7重量％，铜浓度为3.6重量％)中以相对于纤维素重量为0.1～20重量％的范围内添加内包了本发明的皮肤血流改善剂(大马士革蔷薇(Rosa damaseena)的水蒸气蒸馏物)的微胶囊(粒径为50μm以下，微胶囊中精油所占的比例为50重量％)，混合，然后根据通常的湿式纺纱方法进行纺纱，经过精炼工序、干燥工序，从而获得了芳香性纤维。
应用例25
颗粒
(1)三氯蔗糖                                    0.1
(2)皮肤温度上升剂                              0.1
(大马士革蔷薇(Rosa damaseena)的水蒸气蒸馏物)
(3)香料                                        5.0
(4)赋形剂(Ceolus)                              10.0
(5)麦芽糖醇                                    残余
应用例26
片剂(咀嚼型)
(1)肌醇                                        11.0
(2)麦芽糖醇                                    21.0
(3)蔗糖                                        0.5
(4)鲑鱼鱼白提取物(DNA Na)                      0.1
(5)酵母提取物                                  0.1
(6)皮肤血流改善剂(3-甲基辛-4-内酯)             0.1
(7)香料                                        5.0
(8)赋形剂                                      残余
应用例27
片剂
(1)润滑剂(蔗糖脂肪酸酯等)                             1.0
(2)***树胶水溶液(5％)                              2.0
(3)酸味剂                                             1.0
(4)着色剂                                             适量
(5)皮肤温度上升剂(茉莉(茉莉花，jasmin sambac)的提取物)0.1
(6)糖质(糖粉或山梨糖醇等)                             残余
应用例28
糖果
(1)砂糖                                               50.0
(2)麦芽糖浆                                           47.95
(3)有机酸                                             2.0
(4)皮肤温度上升剂(乙酸冰片酯)                         0.05
应用例29
口香糖
(1)砂糖                                               43.0
(2)胶基                                               30.95
(3)葡萄糖                                             10.0
(4)麦芽糖浆                                           16.0
(5)皮肤血流改善剂                                     0.02
(大马士革蔷薇(Rosa damascena)的水蒸气蒸馏物)
(6)皮肤血流改善剂(3-甲基辛-4-内酯)                    0.03
这些应用例的各种组合物、杂货类、服装类等，通过在各种制品形态的典型使用方式中的使用试验可知，可以改善肩部僵硬并改善身体发冷。
附图说明
图1是显示对皮肤温度的影响的图。
图2是显示对皮肤血流的影响的图。
图3是显示对发冷、肩部僵硬症状的影响的图。

Claims (4)

1.一种皮肤血流改善剂，以选自茉莉(jasmin sambac)的提取物、大马士革蔷薇(Rosa damascena)的水蒸气蒸馏物、3-甲基辛-4-内酯和乙酸冰片酯中的1种或2种以上作为有效成分。
2.一种皮肤温度上升剂，以选自茉莉(jasmin sambac)的提取物、大马士革蔷薇(Rosa damascena)的水蒸气蒸馏物、3-甲基辛-4-内酯和乙酸冰片酯中的1种或2种以上作为有效成分。
3.一种肩部僵硬预防或改善剂，以选自茉莉(jasmin sambac)的提取物、大马士革蔷薇(Rosa damascena)的水蒸气蒸馏物、3-甲基辛-4-内酯和乙酸冰片酯中的1种或2种以上作为有效成分。
4.一种身体发冷预防或改善剂，以选自茉莉(jasmin sambac)的提取物、大马士革蔷薇(Rosa damascena)的水蒸气蒸馏物、3-甲基辛-4-内酯和乙酸冰片酯中的1种或2种以上作为有效成分。
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