CN101502482A - Toothpaste containing coenzyme Q10 and preparation method thereof - Google Patents

Toothpaste containing coenzyme Q10 and preparation method thereof Download PDF

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CN101502482A
CN101502482A CNA2009100942609A CN200910094260A CN101502482A CN 101502482 A CN101502482 A CN 101502482A CN A2009100942609 A CNA2009100942609 A CN A2009100942609A CN 200910094260 A CN200910094260 A CN 200910094260A CN 101502482 A CN101502482 A CN 101502482A
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toothpaste
coenzyme
chinese herbal
herbal medicine
prescription
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CN101502482B (en
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陈林先
赵士良
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YUXI JIANKUN BIO-PHARMACEUTICAL Co Ltd
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YUXI JIANKUN BIO-PHARMACEUTICAL Co Ltd
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Abstract

The invention relates to a toothpaste containing coenzyme Q10 and a preparation method thereof, in particular to a composition of toothpastes, belonging to the field of oral healthcare products; based on weight percentage, the coenzyme Q10 in the toothpaste is 1-2% and Chinese herbal extract is 0.5-2%; the rest of accessories are conventional materials for preparing toothpastes. The formulation proportion of the components in the toothpaste is preferably as follows: 2% of coenzyme Q10 mixture, 0.7% of Chinese herbal extract, 35% of abradant, 1.5% of bonding agent, 35% of wetting agent, 0.2% of flavoring agent, 2.5% of foaming agent, 1.5% of essence and 21.6% of deionized water. The toothpaste containing coenzyme Q10 has the healthcare functions the same as the common toothpastes, such as brightening and cleaning the teeth, stopping bleeding of gums and healing oral ulcer; besides, the coenzyme Q10 and Chinese herbal extract permeate the gum cell membrane so that the gum cell obtains energy and tissue vigor is strengthened, thereby essentially conserving the gums, preventing periodontitis, gingivitis and gingival atrophy to reach the aim of strengthening the gums and fixing teeth.

Description

Contain toothpaste of coenzyme Q10 and preparation method thereof
Technical field
The present invention relates to the compositions of a kind of toothpaste that contains coenzyme Q10 and preparation method thereof, particularly toothpaste.Belong to the oral health care product field.
Background technology
Coenzyme Q10 is that human body newly becomes the indispensable material of metabolism, be present in the human body cell " mitochondrion ", it is synthetic to participate in energy ATP, have antioxidation and cell membrane repair, along with the growth at human body age, human body coenzyme Q10 synthesis capability descends after 20 years old, and concentration is lower than when a certain amount of, can cause Developmental and Metabolic Disorder, bring out tooth diseases such as periodontitis, gingivitis, gingival atrophy.
Toothpaste is one of people's articles for daily use, can cleaning oral cavity tooth and antiplaque effect with it.Toothpaste in the market is of a great variety, differs from one another, and is liked and acceptance by consumers in general with its abnormal smells from the patient and effect uniqueness.Along with people improve gradually to the understanding of health care, existing toothpaste can not satisfy the different demands of consumer far away, the most of people that particularly cause gingival hemorrhage at oral inflammation, resistance of human body is descended, easily grow other diseases, functional medical toothpaste has irreplaceable effect to improving human health.
People more and more paid attention to the health and medical function of toothpaste to various products in recent years, and people grow with each passing day to interest, the demand of toothpaste with health care usefulness.
Summary of the invention
The objective of the invention is to invent a kind of health-care toothpaste that contains coenzyme Q10, particularly a kind of health-care toothpaste that contains reduced coenzyme Q 10, it has effects such as hemostasis, analgesia, detumescence, antibacterial, antiinflammatory, antioxygen, resisting fatigue, enhancing immunity, its drug effect is wide, effective without any side effects, this health-care toothpaste can effectively be prevented and treated gingivitis, gingival hemorrhage, periodontitis, gingival swelling and pain, health care usefulness toothpaste.
The present invention also aims to adopt coenzyme Q10, particularly reduced coenzyme Q 10 and Chinese herbal medicine extract see through the gingival cell film, make gingival cell obtain energy, organizational vitality strengthens, from maintenance gingiva in essence, control periodontitis, gingivitis, gingival atrophy reach the health care purpose of being good for the gum teeth consolidating.
Zhou Yan, gingivitis, gingival atrophy reach the health care purpose of being good for the gum teeth consolidating.
The present invention contains the toothpaste of coenzyme Q10 and the purpose of preparation method is finished like this: it is characterized in that by weight percentage coenzyme Q10 is 1%-2% in the toothpaste, Chinese herbal medicine extract is 0.5%-2%, and all the other adjuvants are for making the conventional material of toothpaste.
The prescription consumption preferably, by described percentage by weight, coenzyme Q10 mixture shared ratio in toothpaste is 2%, the shared ratio of Chinese herbal medicine extract is 0.7%, and abrasive 35%, binding agent 1.5%, wetting agent 35%, correctives 0.2%, foaming agent 2.5%, essence 1.5%, deionized water are 21.6%..
Contained coenzyme Q10 is a reduced coenzyme Q 10, and wherein percent of reduced coenzyme Q 10 and oxidized coenzyme Q10 is 95-100%:0-5%, and oxidized coenzyme Q10 is 2005 editions standards of Chinese Pharmacopoeia, and reduced coenzyme Q 10 is applicant's company standard; Structural formula is:
Figure A200910094260D00061
Figure A200910094260D00062
(reduced coenzyme Q 10 structural formula) (oxidized coenzyme Q10 structural formula)
In the described Chinese herbal medicine extract, hemostasis, analgesia, detumescence class Chinese herbal medicine extract are 40%, and antibacterial, anti-inflammatory type Chinese herbal medicine extract is 30%, and antioxygen, resisting fatigue, enhancing immunity class Chinese herbal medicine extract are 30%.
Described interpolation has hemostasis, analgesia, repercussive Chinese herbal medicine extract: Folium Ginseng extracts ginsenoside (ginsenoside Rg+ginseng saponin Re 〉=2.25%), Radix Psammosilenes (45% alcohol extract 〉=40%), Rhizoma Paridis (opaque and colloid), pull out chinaroot greenbrier (60% ethanol leachable 〉=15%, the pre-saponin of potato 〉=0.04%), Radix Notoginseng total glucosides (ginsenoside Rg+ginsenoside Rb+ Panax Notoginseng saponin R, sum total 〉=5%), preferred Radix Psammosilenes, Rhizoma Paridis, Radix Notoginseng total glucosides, more preferably Radix Psammosilenes, Radix Notoginseng total glucosides in the prescription.
Described interpolation has, and Chinese herbal medicine extract antibacterial, antiinflammatory is: Taraxacum (water containing ethanol extraction extractum), terpinol (terpin tetraol 〉=3%), Herba Houttuyniae (cold-water-soluble extractum 〉=10%) fibrauretin (fibrauretin 〉=90%), preferred Taraxacum, fibrauretin, more preferably Taraxacum in the prescription.
Described interpolation has antioxygen, resisting fatigue, the Chinese herbal medicine extract of enhancing immunity is: Radix Rhodiolae (rhodioside content 〉=0.5%), Cordyceps militaris (L.) Link. (opaque), artificial fermentation Chinese caterpillar fungus extract (opaque), Semen Vignae Cylindricae bandit (volatile oil 〉=5%ml/g, Folium eucalypti globueli (Eucalyptus globulus Labill.) essence 〉=3%), Fructus Phyllanthi (cold-water-soluble extractum 〉=30%), preferred Radix Rhodiolae, Cordyceps militaris (L.) Link., Fructus Phyllanthi, more preferably artificial fermentation Chinese caterpillar fungus extract in the prescription.
The conventional adjuvant of described toothpaste is: abrasivus 15%-35%, wetting agent 15%-35%, binding agent 0.6%-2.7%; Foaming agent 0.6%-2.7%; Correctives 0.05%-0.25%; Essence 1%-2%; Deionized water 20%-25%.
Reduced coenzyme Q 10 is mixed with Chinese herbal medicine extract, add wetting agent and deionized water and stirring, make the deionized water suspension, mix with abrasivus, binding agent, foaming agent, correctives again, stir, grind and vacuum outgas, add essence at last and stir, grind and vacuum outgas, obtain lotion of toothpaste.
The abrasivus that toothpaste adds is: calcium carbonate, calcium hydrogen phosphate, silicon dioxide, aluminium hydroxide, Alumina hydrate, thermoplastic resin, preferred silicon dioxide, aluminium hydroxide, more preferably calcium hydrogen phosphate in the prescription;
The wetting agent that toothpaste adds is: sorbitol, glycerol, propylene glycol, xylitol, Polyethylene Glycol (400-600), preferably glycerine, xylitol, Polyethylene Glycol, more preferably xylitol in the prescription;
The binding agent that toothpaste adds is: extra large bath acid sodium, carboxymethyl cellulose, xanthan gum, hydroxyethyl-cellulose, guar gum, carrageenan, preferred extra large bath acid sodium, carboxymethyl cellulose, hydroxyethyl-cellulose, more preferably carboxymethyl cellulose in the prescription;
The correctives that toothpaste adds is: sucrose, glucide, cyclamate, dipeptide sodium, preferably sucrose, glucide, more preferably cyclamate in the prescription;
The essence that toothpaste adds is: peppermint, lemon sesame oil, Oleum Menthae Rotundifoliae, orange oil, citrus seed oil, winter wood oil, Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, Borneolum Syntheticum, preferred peppermint, lemon sesame oil, Oleum Menthae Rotundifoliae, Borneolum Syntheticum, more preferably Oleum Menthae Rotundifoliae, peppermint in the prescription;
The foaming agent that toothpaste adds is: sodium lauryl sulphate, N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, phenolic group sodium glutamate, preferred N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, more preferably sodium lauryl sulphate in the prescription;
The present invention contains the toothpaste of coenzyme Q10, and general toothpaste brilliant white cleans the teeth except that having, the gingiva hemostasis, oral ulcer healing health care, also have coenzyme Q10 and Chinese herbal medicine extract and see through the gingival cell film, make gingival cell obtain energy, organizational vitality strengthens, from maintenance gingiva in essence, control periodontitis, gingivitis, gingival atrophy, thus reach the purpose of being good for the gum teeth consolidating.
The specific embodiment:
The coenzyme Q10 that has gross weight 1%-2% in the toothpaste of the present invention; The Chinese herbal medicine extract that also adds effects such as 0.5%-1% hemostasis, antiinflammatory, analgesia; Other component also has abrasivus 30%-35%; Wetting agent 30%-35%; Binding agent 0.6%-2.7%; Foaming agent 0.6%-2.7%; Correctives 0.05%-0.25%; Essence 1%-2%; Deionized water is 20%-25%.
Figure A200910094260D00081
Figure A200910094260D00082
(reduced coenzyme Q 10 structural formula) (oxidized coenzyme Q10 structural formula)
Preparation method is: with reduced form or oxidized coenzyme Q10 and Chinese herbal medicine extract with effects such as hemostasis, antiinflammatory, analgesia, antibacterial, antioxidation, resisting fatigue, adding wetting agent or deionized water and stirring are made the deionized water suspension and are mixed with abrasivus, binding agent, foaming agent, correctives, stir, grind and vacuum outgas, add essence at last and stir, grind and vacuum outgas, obtain lotion of toothpaste.
Embodiment 1: take by weighing reduced coenzyme Q 10 200g, Chinese herbal medicine extract arasaponin 28g, Taraxacum extractum 21g, Fructus Phyllanthi extractum 21g, add glycerol 3500g, add deionized water 2160ml again and stir into suspension, add calcium hydrogen phosphate 3500g, carboxymethyl cellulose 150g, sodium lauryl sulphate 250g, cyclamate 20g stirring, grinding, vacuum outgas, add Oleum Menthae Rotundifoliae 150g agitation grinding, vacuum outgas at last, get the coenzyme Q10 lotion of toothpaste, by aseptic canning, pack 100, every 100g.
Embodiment 2: take by weighing reduced coenzyme Q 10 240g, Chinese herbal medicine extract Radix Psammosilenes 33.6g, terpin tetraol 25.2g, artificial fermentation Chinese caterpillar fungus extract 25.2g, adding Polyethylene Glycol (400) 4200g, add deionized water 2592ml again and stir into suspension, add calcium carbonate 4200g, hydroxyethyl-cellulose 180g, sodium lauryl sulphate 300g, glucide 24g stirring, grinding, vacuum outgas, add peppermint 180g agitation grinding, vacuum outgas at last, get the coenzyme Q10 lotion of toothpaste, pass through aseptic canning, pack 100, every 120g.
Embodiment 3: take by weighing reduced coenzyme Q 10 120g, Chinese herbal medicine extract Rhizoma Paridis 16.8g, fibrauretin 12.6g, Radix Rhodiolae 12.6g, add sorbitol (400) 2100g, add deionized water 1296ml again and stir into suspension, add silicon dioxide 2100g, hydroxyethyl-cellulose 90g, sodium lauryl sulphate 150g, glucide 12g stirring, grinding, vacuum outgas, add lemon sesame oil 90g agitation grinding, vacuum outgas at last, get the coenzyme Q10 lotion of toothpaste, by aseptic canning, pack 100, every 60g.

Claims (10)

1, a kind of toothpaste that contains coenzyme Q10 is characterized in that by weight percentage, and coenzyme Q10 is 1%-2% in the toothpaste, and Chinese herbal medicine extract is 0.5%-2%, and all the other adjuvants are for making the conventional material of toothpaste.
2, the health-care toothpaste that contains coenzyme Q10 according to claim 1, it is characterized in that: described prescription consumption preferably, by weight percentage, coenzyme Q10 mixture shared ratio in toothpaste is 2%, the shared ratio of Chinese herbal medicine extract is 0.7%, and abrasive 35%, binding agent 1.5%, wetting agent 35%, correctives 0.2%, foaming agent 2.5%, essence 1.5%, deionized water are 21.6%.
3, the toothpaste that contains coenzyme Q10 according to claim 1 and 2, it is characterized in that contained coenzyme Q10 is a reduced coenzyme Q 10, wherein percent of reduced coenzyme Q 10 and oxidized coenzyme Q10 is 95-100%:0-5%, oxidized coenzyme Q10 is 2005 editions standards of Chinese Pharmacopoeia, and reduced coenzyme Q 10 is applicant's company standard; Structural formula is:
Figure A200910094260C00021
(reduced coenzyme Q 10 structural formula) (oxidized coenzyme Q10 structural formula)
4, the toothpaste that contains coenzyme Q10 according to claim 1 and 2, it is characterized in that in the described Chinese herbal medicine extract, hemostasis, analgesia, detumescence class Chinese herbal medicine extract are 40%, antibacterial, anti-inflammatory type Chinese herbal medicine extract is 30%, and antioxygen, resisting fatigue, enhancing immunity class Chinese herbal medicine extract are 30%.
5, the toothpaste that contains coenzyme Q10 according to claim 4, it is characterized in that described interpolation has hemostasis, analgesia, the repercussive Chinese herbal medicine extract is: Folium Ginseng extracts ginsenoside (ginsenoside Rg+ginseng saponin Re 〉=2.25%), Radix Psammosilenes (45% alcohol extract 〉=40%), Rhizoma Paridis (opaque and colloid), pull out chinaroot greenbrier (60% ethanol leachable 〉=15%, the pre-saponin of potato 〉=0.04%), Radix Notoginseng total glucosides (ginsenoside Rg+ginsenoside Rb+ Panax Notoginseng saponin R, sum total 〉=5%), preferred Radix Psammosilenes in the prescription, Rhizoma Paridis, Radix Notoginseng total glucosides, more preferably Radix Psammosilenes, Radix Notoginseng total glucosides.
6, the toothpaste that contains coenzyme Q10 according to claim 4, it is characterized in that described interpolation has Chinese herbal medicine extract antibacterial, antiinflammatory and is: Taraxacum (water containing ethanol extraction extractum), terpinol (terpin tetraol 〉=3%), Herba Houttuyniae (cold-water-soluble extractum 〉=10%) fibrauretin (fibrauretin 〉=90%), preferred Taraxacum, fibrauretin, more preferably Taraxacum in the prescription.
7, the toothpaste that contains coenzyme Q10 according to claim 4, it is characterized in that: described interpolation has antioxygen, resisting fatigue, the Chinese herbal medicine extract of enhancing immunity is: Radix Rhodiolae (rhodioside content 〉=0.5%), Cordyceps militaris (L.) Link. (opaque), artificial fermentation Chinese caterpillar fungus extract (opaque), Semen Vignae Cylindricae bandit (volatile oil 〉=5%ml/g, Folium eucalypti globueli (Eucalyptus globulus Labill.) essence 〉=3%), Fructus Phyllanthi (cold-water-soluble extractum 〉=30%), preferred Radix Rhodiolae, Cordyceps militaris (L.) Link., Fructus Phyllanthi, more preferably artificial fermentation Chinese caterpillar fungus extract in the prescription.
8, the toothpaste that contains coenzyme Q10 according to claim 1 and 2 is characterized in that the conventional adjuvant of described toothpaste is: abrasivus 15%-35%, wetting agent 15%-35%, binding agent 0.6%-2.7%; Foaming agent 0.6%-2.7%; Correctives 0.05%-0.25%; Essence 1%-2%; Deionized water 20%-25%.
9, the preparation method that contains coenzyme Q10 toothpaste according to claim 1 and 2, it is characterized in that: reduced coenzyme Q 10 is mixed with Chinese herbal medicine extract, add wetting agent and deionized water and stirring, make the deionized water suspension, mix with abrasivus, binding agent, foaming agent, correctives again, stir, grind and vacuum outgas, add essence at last and stir, grind and vacuum outgas, obtain lotion of toothpaste.
10, the preparation method that contains coenzyme Q10 toothpaste according to claim 9, it is characterized in that the abrasivus that toothpaste adds is: calcium carbonate, calcium hydrogen phosphate, silicon dioxide, aluminium hydroxide, Alumina hydrate, thermoplastic resin, preferred silicon dioxide, aluminium hydroxide, more preferably calcium hydrogen phosphate in the prescription;
The wetting agent that toothpaste adds is: sorbitol, glycerol, propylene glycol, xylitol, Polyethylene Glycol (400-600), preferably glycerine, xylitol, Polyethylene Glycol, more preferably xylitol in the prescription;
The binding agent that toothpaste adds is: extra large bath acid sodium, carboxymethyl cellulose, xanthan gum, hydroxyethyl-cellulose, guar gum, carrageenan, preferred extra large bath acid sodium, carboxymethyl cellulose, hydroxyethyl-cellulose, more preferably carboxymethyl cellulose in the prescription;
The correctives that toothpaste adds is: sucrose, glucide, cyclamate, dipeptide sodium, preferably sucrose, glucide, more preferably cyclamate in the prescription;
The essence that toothpaste adds is: peppermint, lemon sesame oil, Oleum Menthae Rotundifoliae, orange oil, citrus seed oil, winter wood oil, Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, Borneolum Syntheticum, preferred peppermint, lemon sesame oil, Oleum Menthae Rotundifoliae, Borneolum Syntheticum, more preferably Oleum Menthae Rotundifoliae, peppermint in the prescription;
The foaming agent that toothpaste adds is: sodium lauryl sulphate, N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, phenolic group sodium glutamate; preferred N one sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, more preferably sodium lauryl sulphate in the prescription.
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CN102144958A (en) * 2011-04-14 2011-08-10 云南文山七丹药业股份有限公司 Notoginsenoside-containing medicinal toothpaste and preparation method thereof
WO2012001337A1 (en) * 2010-07-01 2012-01-05 Robert Peter Taylor Composition for dental health
CN102552082A (en) * 2011-09-24 2012-07-11 云南龙润药业有限公司 Toothpaste containing Phyllanthus emblica extracts
CN102961320A (en) * 2012-11-20 2013-03-13 张伟 Toothpaste containing extractive of Chinese caterpillar fungus and machining method thereof
CN104306207A (en) * 2014-09-26 2015-01-28 江苏奇力康皮肤药业有限公司 Herbal tooth-protecting toothpaste and preparation method thereof
CN104337753A (en) * 2014-11-23 2015-02-11 沈阳源康医疗器械有限公司 Face cream containing cordyceps militaris and preparation method thereof
CN104522646A (en) * 2014-12-18 2015-04-22 无限极(中国)有限公司 Composition with functions of enhancing immunity and relieving physical fatigue and application thereof
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CN105534786A (en) * 2015-12-25 2016-05-04 名臣健康用品股份有限公司 Special care toothpaste for middle aged and elderly people
CN105920202A (en) * 2016-03-26 2016-09-07 广东润和生物科技有限公司 Coenzyme Q10 gum for protecting teeth, strengthening brain and removing odor
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WO2012001337A1 (en) * 2010-07-01 2012-01-05 Robert Peter Taylor Composition for dental health
CN102144958A (en) * 2011-04-14 2011-08-10 云南文山七丹药业股份有限公司 Notoginsenoside-containing medicinal toothpaste and preparation method thereof
CN102144958B (en) * 2011-04-14 2012-11-21 云南文山七丹药业股份有限公司 Notoginsenoside-containing medicinal toothpaste and preparation method thereof
CN102552082A (en) * 2011-09-24 2012-07-11 云南龙润药业有限公司 Toothpaste containing Phyllanthus emblica extracts
CN102961320A (en) * 2012-11-20 2013-03-13 张伟 Toothpaste containing extractive of Chinese caterpillar fungus and machining method thereof
CN102961320B (en) * 2012-11-20 2014-06-04 张伟 Toothpaste containing extractive of Chinese caterpillar fungus and machining method thereof
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WO2015122531A1 (en) * 2014-02-17 2015-08-20 株式会社カネカ Composition comprising reduced coenzyme q10
CN104306207A (en) * 2014-09-26 2015-01-28 江苏奇力康皮肤药业有限公司 Herbal tooth-protecting toothpaste and preparation method thereof
CN104337753A (en) * 2014-11-23 2015-02-11 沈阳源康医疗器械有限公司 Face cream containing cordyceps militaris and preparation method thereof
CN104522646A (en) * 2014-12-18 2015-04-22 无限极(中国)有限公司 Composition with functions of enhancing immunity and relieving physical fatigue and application thereof
CN104523562A (en) * 2015-01-09 2015-04-22 俄热 Tibetan worm grass, fritillaria and saffron crocus toothpaste
CN104666621A (en) * 2015-02-03 2015-06-03 湖南炎帝生物工程有限公司 Traditional Chinese medicine composition playing roles of stopping bleeding, diminishing inflammations and preventing bacteria and toothpaste containing same
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CN106137787A (en) * 2015-04-10 2016-11-23 伊比西(北京)植物药物技术有限公司 Emulsification composition of reduced coenzyme Q 10 and preparation method thereof
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CN104958210A (en) * 2015-06-26 2015-10-07 江苏奇力康皮肤药业有限公司 Heat-removing fire-purging toothpaste and preparing method thereof
CN105012173A (en) * 2015-07-09 2015-11-04 常州艾瑞特电子有限公司 Toothpaste for preventing and treating oral ulcer and preparation method thereof
CN105534786A (en) * 2015-12-25 2016-05-04 名臣健康用品股份有限公司 Special care toothpaste for middle aged and elderly people
CN105920202A (en) * 2016-03-26 2016-09-07 广东润和生物科技有限公司 Coenzyme Q10 gum for protecting teeth, strengthening brain and removing odor
CN105963217A (en) * 2016-07-09 2016-09-28 青岛大学 Preparation method of toothpaste composition with caries prevention effect
CN107468553A (en) * 2017-07-28 2017-12-15 鹰仕达(中国)有限公司 A kind of anti-caries toothpaste
CN107485584A (en) * 2017-07-28 2017-12-19 鹰仕达(中国)有限公司 A kind of oral care composition
CN107362112A (en) * 2017-07-28 2017-11-21 鹰仕达(中国)有限公司 One kind shield gum healing toothpaste
CN107281013A (en) * 2017-07-28 2017-10-24 鹰仕达(中国)有限公司 One kind removes tooth stain and suppresses bacterial plaque toothpaste
CN107468553B (en) * 2017-07-28 2020-08-07 健天然(中国)有限公司 Dental caries prevention toothpaste
CN107281013B (en) * 2017-07-28 2020-08-25 健天然(中国)有限公司 Toothpaste for removing tooth stain and inhibiting dental plaque
CN107362112B (en) * 2017-07-28 2020-08-25 健天然(中国)有限公司 Gum-protecting and healing toothpaste
CN108245439A (en) * 2017-09-01 2018-07-06 好维股份有限公司 Composition comprising silica and Co-Q10
CN108245440A (en) * 2018-02-09 2018-07-06 彭芬芳 A kind of soft round rubbing agent Co-Q10 composite fragrant toothpaste of true qualities
CN108938473A (en) * 2018-09-19 2018-12-07 上海纯元萃生物科技有限公司 A kind of herbaceous toothpaste and its preparation method and application for preventing and treating oral inflammation
CN112691058A (en) * 2020-12-31 2021-04-23 玉溪健坤生物药业有限公司 Reduced vitamin K-containing food2Toothpaste and preparation method thereof
WO2022200887A1 (en) * 2021-03-25 2022-09-29 Kwok Wannarat Natural multifunction coenzyme q10 liquid oral hygiene care with antimicrobial efficacy

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