CN105287328A - Manuka honey toothpaste for pregnant women and preparation method of toothpaste - Google Patents
Manuka honey toothpaste for pregnant women and preparation method of toothpaste Download PDFInfo
- Publication number
- CN105287328A CN105287328A CN201510613750.0A CN201510613750A CN105287328A CN 105287328 A CN105287328 A CN 105287328A CN 201510613750 A CN201510613750 A CN 201510613750A CN 105287328 A CN105287328 A CN 105287328A
- Authority
- CN
- China
- Prior art keywords
- toothpaste
- manuka honey
- anemia
- pregnant woman
- mass fraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses manuka honey toothpaste for pregnant women. The toothpaste consists of the following components in parts by mass: 20-30 parts of water, 2-4 parts of coco-glucoside, 1-3 parts of manuka honey, 0.1-0.5 parts of borneol, 0.1-0.3 parts of an echinacea purpurea extract, 0.01-0.03 parts of tea tree oil and 30-60 parts of glycine. The invention further discloses a preparation method of the manuka honey toothpaste. The toothpaste disclosed by the invention contains New Zealand manuka honey, and with UMF in the manuka honey, the toothpaste has effects of resisting bacteria, resisting inflammation and preventing decayed teeth; the natural manuka honey, as a unique biological substance, is capable of preventing and repairing periodontal diseases; and the toothpaste disclosed by the invention, with the echinacea purpurea extract, fresh ginger oil and the tea tree oil which have an effect of sterilizing, can also improve immunity.
Description
Technical field
The present invention relates to a kind of toothpaste, more precisely a kind of anemia of pregnant woman's Manuka honey toothpaste.
Background technology
Most of diseases of people are all caused by oral cavity, keep oral hygiene to be prophylactic important step, keep the key of oral hygiene to be to keep the health of tooth.If tooth is unhygienic, a large amount of microorganisms is bred wherein, and corrosion tooth, cause halitosis, swelling and aching of gum etc., more serious odontopathy also can cause other serious systemic disease.Main containing abrasivus, surfactant, wetting agent, antiseptic, antibacterial etc. in present formulation of tooth-paste, antibacterial mainly contains the materials such as antibiotic, fluoride, iodide, bromide.And antibiotic can not only kill pathogen, also can kill the normal microbial flora favourable to health, affect resistance, life-time service easily develops immunity to drugs simultaneously; Material consumption is improper is very easily detrimental to health for fluoride, iodide, bromide etc.
Anemia of pregnant woman selects the reactions such as food, inappetence, mild nausea, vomiting, dizziness, body be tired for about 6 weeks in gestation, is called morning sickness, also claims vomiting during pregnancy.Phenolics, anemia of pregnant woman vomits because of responsive, easily stimulates nauseant nerve when brushing teeth, very easily nauseating, vomiting.Cause a lot of anemia of pregnant woman to remove because of gestation reaction the process of brushing teeth from, like that only can increase the risk of periodontal, having had a strong impact on health and the mouth care of anemia of pregnant woman's tooth, is all disadvantageous to anemia of pregnant woman and fetus.
Summary of the invention
The object of this invention is to provide a kind of anemia of pregnant woman's Manuka honey toothpaste and preparation method thereof, it can solve the shortcoming that medicated toothpaste of the prior art contains the material that to be potentially dangerous to human body.
The present invention is by the following technical solutions:
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Also comprise oil of Rhizoma Zingiberis Recens, its mass fraction is 0.015-0.035 part.
Also comprise each component that mass fraction is following:
Carrageenan 0.4-0.6 part;
Xanthan gum 0.2-0.4 part.
Also comprise SIPERNAT22S, its mass fraction is 9-12 part.
Also comprise xylitol, its mass fraction is 3-6 part.
Also comprise bisabolol, its mass fraction is 0.02-0.07 part.
The mass fraction of each component is as follows:
A preparation method for anemia of pregnant woman's Manuka honey toothpaste, comprises the following steps:
Tea tree oil, Manuka honey, Borneolum Syntheticum and methanol mixed are evenly obtained the first solution;
Water and the first glycine are joined in container, is then heated with stirring to 90 degree, add xylitol, SIPERNAT22S, stir 30min mix homogeneously by high-speed stirring apparatus;
By xanthan gum, carrageenan and the second glycine mix homogeneously, the solution after mixing is joined in container, stirs, obtain the second solution, then add the first solution wherein, then stir until stir;
Coco-Glucoside, echinacea extract, bisabolol and oil of Rhizoma Zingiberis Recens are added wherein;
By above-mentioned solution in stirring at low speed condition, vacuum is under the condition of 0.8, is warming up to 30 degree gradually, transfer subpackage.
First solution is when mixing with the second solution, and the first solution at least fulfils 2 hours ahead of schedule.
Advantage of the present invention is: vomiting when the present invention can prevent anemia of pregnant woman from brushing teeth, at prevention and pregnancy gingivitis of releiving, periodontitis, and decayed tooth, oral ulcer, the aspects such as mouth care have significant effect, containing New Zealand's Manuka honey in toothpaste of the present invention, UMF is had in Manuka honey, there is antibacterial anti-inflammatory, the effect of caries prevention, natural Manuka honey is unique biological material, prevention and reparation periodontal, and the present invention is also containing echinacea extract, oil of Rhizoma Zingiberis Recens and tea tree oil, all there is the effect of sterilization and can immunity be improved, simultaneously because the present invention is not containing surfactant, morning sickness can be prevented, in simultaneously of the present invention, various efficacy of drugs produces synergism, thus more effectively prevent and treat gestational gingival hemorrhage, gingivitis, periodontitis, the disease such as gingival atrophy and oral ulcer, and all medical materials all antiabortive preventing or arresting vomitings of energy in the present invention, without any side effects to anemia of pregnant woman.
Detailed description of the invention
Below in conjunction with setting forth the specific embodiment of the present invention further:
Coco-Glucoside, calls as the many glycosides of cocoyl glucose; The many glycosides of cocoyl glucose; Wherein, R is cocos nucifera oil building stone.For colourless to weak yellow liquid or mastic.Very low zest is had to skin, eyes.There is excellent decontamination, foaming, steady bubble, emulsifying, dispersion, solubilising, moistening, penetrating power.Acidproof.Alkaline-resisting.Insensitive to electrolyte.The zest of other surfactants can be reduced.Without cloud point.Green surfactant.The surfactants such as alternative AEO, AES, LAS.Organic synthesis intermediate.Good with the compatibility of skin.Compare, lauryl glucoside etc., there is lower zest.
Manuka is a kind of natural tea tree, exists only in New Zealand, and is grown on remote free of contamination virgin forest more, by New Zealand aboriginal Maori is had.Manuka leaves and bark are New Zealand aboriginal Maori natural herbals for hundreds of years, can be made into Antipyretic agent, coldrex and disinfectant.In New Zealand, only about 10% Manuka honey in, active antibacterial material containing a kind of natural uniqueness---manuka factor UMF (UniqueManukaFactor), it has powerful and the antibacterial and oxidation resistance of uniqueness, have the ability to destroy antibacterial, treat body wound better, promote wound normal healing, especially in taking good care of gastrointestinal, have splendid performance, its special treatment ability even exceedes much traditional medicine.
SONGGUOJU (Echinacea) is a kind of Echinacea plant originating in North America and southern Canada, this platymiscium has 8 kinds and several mutation, 3 kinds are mainly contained: Echinacea purpurea Moench (Echinaceapurpurea at present as drug development, namely usually said Echinacea), Echinacea angustifolia (Echinaceaaugustifolia) and white Echinacea (Echinacenpallida).At present, wild amount is little, and they originate in North America, now Europe and other regionally all have introducing and planting.The ground such as China Beijing, Nanjing, Shanghai and Changsha are also introduced a fine variety and are carried out GAP kind and plant.The main chemical compositions that contains of Echinacea, Echinacea angustifolia and violet ash cone chrysanthemum can be divided into several large class: polysaccharide and glycoprotein, the caffeic acid derivative (caffeicacidderivatives) of polarity, fat-soluble alkylamide (alkamides).Every constituents that different plant contains has difference, and every compound contained by constituents is also not quite similar.Such as, the polar portion leached at ethanol mainly contains caffeic acid derivative, Echinacea angustifolia and violet ash cone chrysanthemum are mainly containing Echinacea glycoside (echinacoside), and Echinacea then mainly containing chicoric acid (cichoricacid), can be used as immunomodulator and stimulant.
Tea tree oil is broad spectrum antimicrobial.With the Pure natural plant essential oil that the mode of distillation is extracted from the wood Myrtaceae Folium Melaleucae Leucadendrae of port, originate in Australia state.Colourless to weak yellow liquid, there is characteristic perfume and antibacterial, antiinflammatory, anthelmintic, kill effect of demodicid mite.Pollution-free, non-corrosiveness, permeability are strong.Treatment acne, acne.Its unique fragrant strongly fragrant abnormal smells from the patient contributes to refreshment.Current China, India are also at production tea tree oil, and domestic main producing region is in Guangxi.
Oil of Rhizoma Zingiberis Recens, for yellowish to yellow liquid.The quality of fresh ginger oil is more much better than Rhizoma Zingiberis oil.Density 0.877-0.888.Refractive index 1.488-1.494 (20 DEG C).Optical rotation-28 °--45 DEG C.Soap value indicative≤20.Water insoluble, glycerol and ethylene glycol, be dissolved in ethanol, ether, chloroform, mineral oil and most of animals and plants wet goods.Main constituent is zingiberene (Zingiberene), shogaol (Shogaol), zingiberol (gingerol), zingiberone (zingerone), citral, phellandrene, Borneolum Syntheticum etc.Main product is in Jamaica, West Africa, India, China and Australian.Be mainly used in preparing edible essence, various pick-me-up, soft drink and confection, also for cosmetics such as perfume.Oil of ginger except having purposes in medicinal, also propagandizing hotly, can be used as flavoring agent in cold mixing and various food; For health care, there are the effects such as appetizing, resisting cold, sterilization.Also can be used as the deodorant tune of drinks, cosmetics etc.
Embodiment 1
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 2
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 3
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 4
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 5
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 6
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 7
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 8
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 9
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 10
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 11
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 12
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 13
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 14
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 15
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 16
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 17
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 18
A kind of anemia of pregnant woman's Manuka honey toothpaste, comprises each component that mass fraction is following:
Embodiment 19
A preparation method for anemia of pregnant woman's Manuka honey toothpaste, comprises the following steps:
Tea tree oil, Manuka honey, Borneolum Syntheticum and methanol mixed are evenly obtained the first solution;
Water and the first glycine are joined in container, is then heated with stirring to 90 degree, add xylitol, SIPERNAT22S, stir 30min mix homogeneously by high-speed stirring apparatus;
By xanthan gum, carrageenan and the second glycine mix homogeneously, solution after mixing is joined in container, stir, obtain the second solution, then the first solution is added wherein, then stir until stir, 1.9% of the 98.1%, second glycine point total amount of the second glycine point total amount;
Coco-Glucoside, echinacea extract, bisabolol and oil of Rhizoma Zingiberis Recens are added wherein;
By above-mentioned solution in stirring at low speed condition, vacuum is under the condition of 0.8, is warming up to 30 degree gradually, transfer subpackage.
First solution is when mixing with the second solution, and the first solution at least fulfils 2 hours ahead of schedule.
Embodiment 20
Echinacea extract in the present invention prepares by the following method:
Fresh SONGGUOJU leaf pretreatment: fresh for 500g SONGGUOJU after 19 hours, is ground into 300 object powder, cold preservation under-20 DEG C of conditions in 60 DEG C of dryings, for subsequent use;
B. supercritical CO
2extraction:
200g step a gained powder is loaded in extraction kettle, extraction temperature 38 DEG C, extracting pressure 40MPa, CO
2flow velocity 35kg/h; The pressure of flash trapping stage still is 11MPa, and temperature is 32 DEG C, and the second-order separation still pressure is 7MPa, and temperature is 45 DEG C, collects product, for subsequent use;
C. intensified by ultrasonic wave lixiviate: get 100g step b products therefrom, add 300g ethanol, temperature is 40 DEG C, and ultrasonic power is 230w, ultrasonic lixiviate 20min; Lixiviating solution 0 DEG C, with the centrifugation 15min of 5000r/min; Then sediment fraction adds 200g ethyl acetate, repeats said extracted step; Merge gained supernatant, for subsequent use;
D. concentrated supernatant: by step c gained supernatant at 55 DEG C, obtain pasty masses through reduction vaporization and vacuum drying under 0.01MPa, for subsequent use;
E. obtained active component: by steps d gained paste W extractum: the distilled water of W distilled water=1:10 dissolves, after using the concentrated hydrochloric acid adjust ph 7 of 30%-36.5% again, upper AB-8 macroporous adsorbent resin, carry out eluting with the flow velocity water of 1.0ml/min, 80% ethanol successively, collect ethanol elution, decompression recycling ethanol, extract with isoamyl alcohol again, reclaim under reduced pressure isoamyl alcohol, finally obtaining content is that Echinacea total phenol content is greater than 3.5%, and the content of chicoric acid is greater than 3.8%.
Embodiment 21
1, name of product: experimental products: the product of embodiment 3; Reference substance: LIUBIZHI YAGAO;
2, test method: adopt double blinding, random experiment design, with 70 subjects, age 20-38 year, wherein primipara 52 example, multipara 18 example, experimenter uses all teeth of the full mouth of 12 time-of-week before and after 2 kinds of toothpaste separately to adopt the method for Oral epidemiological investigation to check, every tooth 2 sites (cheek side near in, central authorities, far away in 3 sites and tongue side central authorities) gingival index (GI), visit examine after have hemorrhage site to account for the situation of change of the percent (BOP%) in the total site of full mouth.
3, using method:
Dosage: experimental group, matched group experimenter brush teeth 2 times sooner or later every day, each use 2 grams, toothpaste.
The course for the treatment of: 12 weeks.
4, observation item and index:
Gingival index (GI)
1: NIP;
2: mild inflammation, gingiva color and luster and quality slightly change;
3: moderate inflammation, gingiva light, red, swollen, hypertrophy;
4) hyperphlogosis, visits after examining and has hemorrhage site to account for the percent in the total site of full mouth
5, untoward reaction
Observe with or without allergy, irritative response after using toothpaste, feel sick and other untoward reaction.
The degree of mouthfeel, sense of taste, tolerance.
6, toothpaste uses front and back clinical indexes to check by same position doctor.
7, statistical method
The gingival index of two groups of experimenters, BOP% Indexes Comparison, when meeting (contrast-test)/contrast >=15%, produce
Product have and alleviate periodontal disease, improve gingival hemorrhage effect.
8, result:
Test period is in June, 2014 in JIUYUE ,-2014, has 70 experimenters and completes omnidistance observation.
8.1, two groups of experimenters use the situation of change of periodontal index before and after toothpaste
Table 1 liang group experimenter uses the comparison of GI before and after toothpaste
| Product | GI baseline value | After 4 weeks | After 12 weeks |
| Containing Chinese medicine composition toothpaste | 1.57 | 1.18 | 0.98 |
| Not containing Chinese medicine composition toothpaste | 1.47 | 1.35 | 1.21 |
Table 2 liang group experimenter uses the comparison of BOP% before and after toothpaste
| Product | BOP% baseline value | After 4 weeks | After 12 weeks |
| Containing Chinese medicine composition toothpaste | 7.56％ | 2.54％ | 0.91％ |
| Not containing Chinese medicine composition toothpaste | 4.74％ | 2.45％ | 1.25％ |
Embodiment 22
1, name of product: experimental products: the product of embodiment 18; Reference substance: LIUBIZHI YAGAO;
2, test method: adopt double blinding, random experiment design, with 70 subjects, age 20-38 year, wherein primipara 52 example, multipara 18 example, experimenter uses all teeth of the full mouth of 12 time-of-week before and after 2 kinds of toothpaste separately to adopt the method for Oral epidemiological investigation to check, every tooth 2 sites (cheek side near in, central authorities, far away in 3 sites and tongue side central authorities) gingival index (GI), visit examine after have hemorrhage site to account for the situation of change of the percent (BOP%) in the total site of full mouth.
3, using method:
Dosage: experimental group, matched group experimenter brush teeth 2 times sooner or later every day, each use 2 grams, toothpaste.
The course for the treatment of: 12 weeks.
4, observation item and index:
Gingival index (GI)
1: NIP;
2: mild inflammation, gingiva color and luster and quality slightly change;
3: moderate inflammation, gingiva light, red, swollen, hypertrophy;
4) hyperphlogosis, visits after examining and has hemorrhage site to account for the percent in the total site of full mouth
5, untoward reaction
Observe with or without allergy, irritative response after using toothpaste, feel sick and other untoward reaction.
The degree of mouthfeel, sense of taste, tolerance.
6, toothpaste uses front and back clinical indexes to check by same position doctor.
7, statistical method
The gingival index of two groups of experimenters, BOP% Indexes Comparison, when meeting (contrast-test)/contrast >=15%, produce
Product have and alleviate periodontal disease, improve gingival hemorrhage effect.
8, result:
Test period is in June, 2014 in JIUYUE ,-2014, has 70 experimenters and completes omnidistance observation.
8.1, two groups of experimenters use the situation of change of periodontal index before and after toothpaste
Table 3 liang group experimenter uses the comparison of GI before and after toothpaste
| Product | GI baseline value | After 4 weeks | After 12 weeks |
| Containing Chinese medicine composition toothpaste | 1.78 | 1.23 | 0.95 |
| Not containing Chinese medicine composition toothpaste | 1.47 | 1.35 | 1.21 |
Table 4 liang group experimenter uses the comparison of BOP% before and after toothpaste
| Product | BOP% baseline value | After 4 weeks | After 12 weeks |
| Containing Chinese medicine composition toothpaste | 8.54％ | 3.23％ | 0.85％ |
| Not containing Chinese medicine composition toothpaste | 4.74％ | 2.45％ | 1.25％ |
From the data of above-mentioned table 3 and table 4, tested by double blind random, use two kinds of toothpaste all to have no adverse reaction.
Use comparatively to use containing Chinese medicine composition toothpaste and do not improve significantly containing the BOP% of Chinese medicine composition toothpaste group experimenter and the hemorrhage index of periodontal disease, prompting has containing Chinese medicine composition toothpaste and significantly improves gingival hemorrhage effect.
Anemia of pregnant woman is at phenolics, and anemia of pregnant woman vomits because of responsive, easily stimulates nauseant nerve when brushing teeth, very easily nauseating, vomiting.Cause a lot of anemia of pregnant woman to remove because of gestation reaction the process of brushing teeth from, like that only can increase the risk of periodontal, having had a strong impact on health and the mouth care of anemia of pregnant woman's tooth, is all disadvantageous to anemia of pregnant woman and fetus.The present invention, owing to adding Coco-Glucoside, has excellent decontamination, foaming, steady bubble, emulsifying, dispersion, solubilising, moistening, penetrating power.For green surfactant, there is lower zest, therefore better can alleviate the morning sickness phenomenon of anemia of pregnant woman.Simultaneously, add Manuka honey, echinacea extract, tea tree oil and glycine, due to synergism between various component, can effectively prevent and treat pregnancy gingivitis, gestational epulis, periodontitis, gingival atrophy, oral ulcer, halitosis and dental caries etc.
Containing New Zealand's Manuka honey in toothpaste of the present invention, UMF is had in Manuka honey, there is antibacterial anti-inflammatory, the effect of caries prevention, natural Manuka honey is unique biological material, prevention and reparation periodontal, and the present invention is also containing echinacea extract, oil of Rhizoma Zingiberis Recens and tea tree oil, all has the effect of sterilization and can improve immunity.Raw material of the present invention is natural material, and therapeutic effect is good.Anemia of pregnant woman's special-purpose medicaments toothpaste of the present invention has pain easing and hemostasis, detumescence, the effects such as anti-inflammation, can be used for vomiting when effectively preventing anemia of pregnant woman from brushing teeth, and effectively prevent and treat pregnancy gingivitis, gestational epulis, periodontitis, gingival atrophy, oral ulcer, halitosis and dental caries etc.After using one week, above-mentioned symptom obviously improves, and pregnancy and puerperium uses, without any side effects, and can be used for keeping oral cavity cleaning, pre-preventing tooth diseases occurs, and impels dental health.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. anemia of pregnant woman's Manuka honey toothpaste, is characterized in that, comprises each component that mass fraction is following:
2. anemia of pregnant woman's Manuka honey toothpaste according to claim 1, is characterized in that, the mass fraction of each component is:
3. anemia of pregnant woman's Manuka honey toothpaste according to claim 1 and 2, is characterized in that, also comprise oil of Rhizoma Zingiberis Recens, and its mass fraction is 0.015-0.035 part.
4. anemia of pregnant woman's Manuka honey toothpaste according to claim 3, is characterized in that, also comprises each component that mass fraction is following:
Carrageenan 0.4-0.6 part;
Xanthan gum 0.2-0.4 part.
5. anemia of pregnant woman's Manuka honey toothpaste according to claim 4, is characterized in that, also comprise SIPERNAT22S, and its mass fraction is 9-12 part.
6. anemia of pregnant woman's Manuka honey toothpaste according to claim 5, is characterized in that, also comprise xylitol, and its mass fraction is 3-6 part.
7. anemia of pregnant woman's Manuka honey toothpaste according to claim 6, is characterized in that, also comprise bisabolol, and its mass fraction is 0.02-0.07 part.
8. anemia of pregnant woman's Manuka honey toothpaste according to claim 7, it is characterized in that, the mass fraction of each component is as follows:
9. a preparation method for anemia of pregnant woman's Manuka honey toothpaste, is characterized in that, comprises the following steps:
Tea tree oil, Manuka honey and Borneolum Syntheticum mix homogeneously are obtained the first solution;
Water and the first glycine are joined in container, is then heated with stirring to 90 degree, add xylitol, SIPERNAT22S, stir 30min mix homogeneously by high-speed stirring apparatus;
By xanthan gum, carrageenan and the second glycine mix homogeneously, the solution after mixing is joined in container, stirs, obtain the second solution, then add the first solution wherein, then stir until stir;
Coco-Glucoside, echinacea extract, bisabolol and oil of Rhizoma Zingiberis Recens are added in above-mentioned mixed solution;
By above-mentioned solution in stirring at low speed condition, vacuum is under the condition of 0.8, is warming up to 30 degree gradually, transfer subpackage.
10. the preparation method of anemia of pregnant woman's Manuka honey toothpaste according to claim 8, is characterized in that, the first solution is when mixing with the second solution, and the first solution at least fulfils 2 hours ahead of schedule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510613750.0A CN105287328A (en) | 2015-09-23 | 2015-09-23 | Manuka honey toothpaste for pregnant women and preparation method of toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510613750.0A CN105287328A (en) | 2015-09-23 | 2015-09-23 | Manuka honey toothpaste for pregnant women and preparation method of toothpaste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105287328A true CN105287328A (en) | 2016-02-03 |
Family
ID=55185627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510613750.0A Pending CN105287328A (en) | 2015-09-23 | 2015-09-23 | Manuka honey toothpaste for pregnant women and preparation method of toothpaste |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105287328A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109987A (en) * | 2016-06-29 | 2016-11-16 | 何勤 | A kind of repair liquid after operation on oral cavity |
| CN112641711A (en) * | 2020-12-29 | 2021-04-13 | 深圳爱尔创口腔技术有限公司 | Manuka honey mouthwash and preparation method thereof |
| CN113208799A (en) * | 2021-06-07 | 2021-08-06 | 经鸿纬健康科技发展(上海)有限公司 | A polyurethane condom containing flavonoid antibacterial active factor |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101692997A (en) * | 2009-09-30 | 2010-04-14 | 广东名臣有限公司 | Toothpaste containing trace active mineral substances |
| JP2013184971A (en) * | 2012-03-06 | 2013-09-19 | Cyclochem-Bio Co Ltd | Oral cavity care product blended with cyclodextrin |
-
2015
- 2015-09-23 CN CN201510613750.0A patent/CN105287328A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101692997A (en) * | 2009-09-30 | 2010-04-14 | 广东名臣有限公司 | Toothpaste containing trace active mineral substances |
| JP2013184971A (en) * | 2012-03-06 | 2013-09-19 | Cyclochem-Bio Co Ltd | Oral cavity care product blended with cyclodextrin |
Non-Patent Citations (5)
| Title |
|---|
| ESPERANZA: ""Manuka Health, Manuka & Propolis Toothpaste With Manuka Oil, 3.53oz(100g)"", 《获取网址：HTTP://WWW.COSDNA.COM/CHS/COSMETIC_4598167557.HTML》 * |
| 刘德军: "《现代中药化妆品制作工艺及配方》", 31 May 2009, 化学工业出版社 * |
| 埃米尔: "《家庭诊疗全书》", 28 February 2010, 中央编译出版社 * |
| 李江平: ""生姜提取物在牙膏中的应用"", 《牙膏工业》 * |
| 陈三斌: "《300种实用化工产品配方与制造》", 30 June 2006, 金盾出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109987A (en) * | 2016-06-29 | 2016-11-16 | 何勤 | A kind of repair liquid after operation on oral cavity |
| CN112641711A (en) * | 2020-12-29 | 2021-04-13 | 深圳爱尔创口腔技术有限公司 | Manuka honey mouthwash and preparation method thereof |
| CN113208799A (en) * | 2021-06-07 | 2021-08-06 | 经鸿纬健康科技发展(上海)有限公司 | A polyurethane condom containing flavonoid antibacterial active factor |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104887581B (en) | A kind of oral care composition and preparation method thereof | |
| CN105770191B (en) | With the composition and its preparation method and application for reducing Periodontal Pathogens active function | |
| TW201141496A (en) | Oral compositions containing a combination of natural extracts and related methods | |
| CN105055230A (en) | Multifunctional Chinese medicinal toothpaste composition, toothpaste prepared from composition and preparation method of toothpaste | |
| CN101933977B (en) | Traditional Chinese medicine composition against tooth sensitivity, toothpaste and preparation method thereof | |
| CN103520049B (en) | Compound Chinese medicine extract is preparing the application in oral cavity nursing health products | |
| CN102397176A (en) | Traditional Chinese herbal gargle liquid and preparation method thereof | |
| CN104013547A (en) | Toothpaste for stopping bleeding, brightening and refreshing breath and preparation method thereof | |
| CN105596253A (en) | Edible toothpaste which is prepared from olive extracts and does not contain fluorine and preparation method thereof | |
| CN105997615A (en) | Natural and edible children's mouthwash and preparation method thereof | |
| CN108938501A (en) | Chinese medicine composition and oral care product applied to oral care product | |
| CN106535911A (en) | Oral composition for preventing and treating periodontitis, comprising mulberry root bark extract and winged spindle extract as active ingredients | |
| Charantimath et al. | Herbal therapy in dentistry: a review | |
| CN105287328A (en) | Manuka honey toothpaste for pregnant women and preparation method of toothpaste | |
| CN108078871B (en) | A kind of mouthwash of the rare saponin(e containing Radix Notoginseng and preparation method thereof | |
| CN104721114A (en) | Borneol, beewax and gel type toothpaste and preparation method thereof | |
| CN101007088A (en) | A traditional Chinese medicine composition for treating periodontal diseases and its preparation method | |
| CN103599182A (en) | Traditional Chinese medicine composition and preparation method thereof, and oral cavity cleaning and nursing product and preparation method thereof | |
| KR20200118322A (en) | Cleanser for women and methods for manufacturing the same | |
| CN104983612A (en) | Plant tooth health care product and preparing method thereof | |
| CN113520957A (en) | Chinese herbal medicine toothpaste formula for gingivitis and gingival atrophy and preparation method thereof | |
| CN110013452A (en) | Permanent tooth shield gum is cured the Chinese medicine compound prescription toothpaste and preparation method thereof of ulcer and dark hair | |
| CN104622708A (en) | Application of geniposide in preparation of oral care health products | |
| CN105726402B (en) | Dracaena boisiana extract is preparing the application in oral care product | |
| CN108354872A (en) | A kind of Chinese medicinal toothpaste and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160203 |