CN107281013A - One kind removes tooth stain and suppresses bacterial plaque toothpaste - Google Patents
One kind removes tooth stain and suppresses bacterial plaque toothpaste Download PDFInfo
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- CN107281013A CN107281013A CN201710636332.2A CN201710636332A CN107281013A CN 107281013 A CN107281013 A CN 107281013A CN 201710636332 A CN201710636332 A CN 201710636332A CN 107281013 A CN107281013 A CN 107281013A
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- Prior art keywords
- cordyceps militaris
- toothpaste
- bacterial plaque
- tooth stain
- suppresses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
Tooth stain is removed the invention discloses one kind and suppresses bacterial plaque toothpaste, includes Cordyceps militaris elite, the alcohol of O cymenes 5, potassium nitrate, sodium phytate, zinc citrate and polyvinylpyrrolidone.Removal tooth stain of the present invention suppresses in bacterial plaque toothpaste containing multi-efficiency compositions such as Cordyceps militaris elite, the alcohol of O cymenes 5, potassium nitrate, sodium phytate, zinc citrate, polyvinylpyrrolidones, Cordyceps militaris elite, which coordinates, gentle non-stimulated antibacterial removes the stain factor and antimicrobial factorses, the adhesion and aggregation of oral bacteria can effectively be suppressed, dental surface color stain dirt is removed simultaneously, also has effects that to restrain Shu Min.Each functional component, which can act synergistically, in the present invention fundamentally removes the formation that tooth stain suppresses bacterial plaque, reaches nursing oral cavity, the effect of tooth-whitening.Suppress the toothpaste of bacterial plaque using removal tooth stain of the present invention for a long time, can allow outside tooth removing spots and whitening, can also the mouth disease such as pre- preventing parodontitis, gingivitis, dental calculus and dental caries.
Description
Technical field
The present invention relates to a kind of toothpaste, and in particular to one kind removes tooth stain and suppresses bacterial plaque toothpaste.
Background technology
Enhancing and the raising of quality of the life with people to the consciousness of health, the attention degree to oral care have greatly
Enhancing.Most of diseases of people are all, by the way that caused by oral cavity, it is prophylactic important step to keep oral hygiene, to keep
The key of oral hygiene is the health for keeping tooth.If tooth is unhygienic, substantial amounts of microorganism breeds wherein, corrodes tooth
Tooth, causes halitosis, gum swelling etc., and more serious odontopathy can also result in other serious systemic diseases.
Bacterial plaque is a bacteria ecological environment being present in facing or oral pocket, bacterium grows wherein, develop and
Decline, and the metabolism activity of complexity is carried out, under certain condition, bacterium and its product will be to teeth and periodontium
Produce destruction.Bacterial plaque is to stick to that dental surface is soft and the bacterial plaque of non-mineralising falls, and is not easy to discover during negligible amounts.But with
The growth of time, bacterial plaque is not removed timely, will result in the obstinate spot that can not be removed by common oral care
And spot, allow dental surface to tarnish, turn yellow obscure.Therefore, effectively remove bacterial plaque to prevent bacterial plaque expansion and
Related oral disease has very important effect.
The content of the invention
A kind of tooth stain that removes is provided and suppresses tooth bacterium it is an object of the invention to overcome the weak point of prior art presence
Dental plaque cream.
To achieve the above object, the technical scheme taken of the present invention is：One kind removes tooth stain and suppresses bacterial plaque toothpaste, comprising
Cordyceps militaris elite, O- cymene -5- alcohol, potassium nitrate, sodium phytate, zinc citrate and polyvinylpyrrolidone；The Cordyceps militaris essence
The mixture of Huawei's Cordyceps militaris extract and fruiting bodies of cordyceps militaris.
Cordyceps militaris, is the edible mushroom of food and medicament dual-purpose, Cordyceps militaris extract of the present invention, can by commercially available,
It can be the refined extract of fruiting bodies of cordyceps militaris gained after water extract-alcohol precipitation.Fruiting bodies of cordyceps militaris is by Cordyceps militaris spawn
It is inoculated on solid medium, after the regular hour cultivates, the stroma of crocus is differentiated to form from hyphostoma development
(fructification), and again gather this new fresh sporophore obtained by the processing of laggard sector-style dry grinding powder；Fructification powder passes through water extracting alcohol
After refined processing after heavy, composition the effects such as cordycepin, adenosine, cordycepic acid, polysaccharide, SOD enzymes is efficiently concentrated, especially
It is cordycepin functional component.
Fruiting bodies of cordyceps militaris in the present invention, is to be made up of materials such as moisture, ash content, protein, fat, wherein containing many
Volatile compound is planted, in the majority with aromatic aldehydes material, with certain antibacterial and anti-inflammatory effect, but aromatic volatile composition is equal
More than one hour can not be retained under 50 DEG C of extraction temperature.Therefore, the active ingredient in fruiting bodies of cordyceps militaris is difficult in essence
Remained in system heating purification process, therefore the present invention is by the addition of fruiting bodies of cordyceps militaris, can allow fruiting bodies of cordyceps militaris certainly
The entrance toothpaste system of the volatile ingredient of body completely.
Cordycepin, is first nucleosides separated from fungi antibiotics, molecular structure is 3 ,-desoxyadenossine,
Effect with broad-spectrum antiseptic, research finds that it can suppress the growth of the pathogens such as streptococcus, staphylococcus, and cordycepin
Also there is stronger antiviral activity, therefore performance natural antibacterial, anti-inflammatory, antiviral effect in formulation of tooth-paste.Due to worm
Careless element is the main antipathogenic composition in Cordyceps militaris extract, and Cordyceps militaris elite addition directly affects cordycepin in formulation of tooth-paste
In content.
The present invention uses fruiting bodies of cordyceps militaris collocation Cordyceps militaris extract, can make to contain cordycepin, cordyceps sinensis in system
Outside the multiple efficacies compositions such as acid, polysaccharide, SOD enzymes, the also volatile ingredient containing fruiting bodies of cordyceps militaris itself, so as to allow shield gum
The efficacy exertion of tooth is protected to optimal.
O- cymene -5- alcohol, is a kind of bactericide of wide spectrum, with potent infiltration bactericidal action, to golden yellow grape
Also oral cavity pathogen all has good antibacterial effect for coccus, porphyromonas gingivalis, can penetrate into bacterial plaque inner sterilization,
Suitable for inflammatory patients such as gingivitis, periodontitis, commercially available prod is can select, such as Nanjing Si Baike biochemistry Industrial Co., Ltd.
Isopropyl Methylphenol etc..
Desensitization activity in potassium nitrate, the monograph of the desensitizing dental product of food and medicine Surveillance Authority of the U.S. (FDA) into
Point, the release of potassium ion can prevent the nerve endings of dentinal tubule from being activated, under enough potassium concentrations, can be with
Avoid pressure Intradental nerve from being upset, the permeability of dentine is reduced, so as to slow down the situation of dentine hypersensitivity.
Sodium phytate, the salt derivative of phytic acid has to various color stains and preferably chelates bulk effect, can be molten with spot formation
In the complex salt of water, it is easier to come off during brushing teeth and brushes, so as to effectively remove the spot on tooth, and can prevents
Only color spot is deposited and adhered on tooth surfaces again.
Zinc salt originally has a convergent characteristic, water-soluble zinc salt apply in formulation of tooth-paste there is provided zinc ion can prevent
The formation of bacterial deposition thing, reaches the effect for reducing bacterial plaque and dental calculus accumulation, the color stains such as cigarette stain deposition is also prevented simultaneously and viscous
Dental surface is attached to, so as to possess the effect of stain whitening.The zinc citrate selected in the present invention, is slightly soluble in water, can gradually release
Zinc ion is released, long term is in tissues such as gums, and when zinc citrate and other bacteriostatic active ingredients compounding uses, energy
Enough reach that more preferably suppressing bacterial plaque removes tooth stain effect.
A kind of polyvinylpyrrolidone (PVP), non-ionic macromolecule compound can be carried by chelating color stain material
Its high solubility in water, so as to effectively remove the color stain on tooth.Go stain principle because it is unique, PVP be it is a kind of not
By means of the new shield gum whitening agent of rub whitening and oxidation whitening, the stimulation to tooth is not resulted in.
Removal tooth stain of the present invention suppresses bacterial plaque toothpaste and goes the stain factor, the antiallergic factor with antibacterial using Cordyceps militaris elite
Be combined and be applied to removal tooth stain of the present invention jointly and suppress bacterial plaque toothpaste, can effectively suppress oral bacteria adhesion and
Aggregation, while removing dental surface color stain dirt, also has effects that to restrain Shu Min.Removal tooth stain of the present invention suppresses tooth bacterium
The whitening principle of dental plaque cream is different from the method for the excitant whitening using peroxide, peroxide chance water reaction decomposition, counterpart
The stimulation of chamber mucous membrane is larger, and only aqueous few matching somebody with somebody can apply peroxide ingredient just now, otherwise be failed in the short time swollen
Pipe, system can not be stablized.Conversely, of the present invention remove Cordyceps militaris elite, O- umbrellas that tooth stain suppresses to contain in bacterial plaque toothpaste
Flower hydrocarbon -5- alcohol, potassium nitrate, sodium phytate, zinc citrate and polyvinylpyrrolidone, these functional components are gently non-stimulated, can be with
Effectively suppressing bacterium prevents bacterial adhesion on tooth, and stable compatibility is more suitable for applying in formulation of tooth-paste, and these effects
Composition can synergistically to anti-plaque formation, reach oral care, the effect of tooth-whitening.
Preferably, the tooth stain that removes suppresses the preparing raw material that bacterial plaque toothpaste includes following weight percentage：Pupa worm
Careless elite 0.1~5%, O- cymene -5- alcohol 0.05~0.1%, potassium nitrate 3~10%, sodium phytate 0.2~2%, zinc citrate
0.25~2% and polyvinylpyrrolidone 0.25~2%.
Study and draw repeatedly through inventor, when the content of Cordyceps militaris elite is less than 0.1%, bacteriostasis is not notable, with
The increase of the content of Cordyceps militaris elite, bacteriostasis enhancing, but when the content of Cordyceps militaris elite is more than 5%, with pupa worm
The addition increase of careless elite, fungistatic effect increase is not notable, when the content of Cordyceps militaris elite is 0.1~5%, with preferable
Bactericidal action；When each component cooperates under the ratio, the effect of bacteriostasis and removal tooth stain is significantly increased, can be effective
Ground removes tooth stain, tooth-whitening, the generation for suppressing bacterial plaque.
It is highly preferred that the tooth stain that removes suppresses the preparing raw material that bacterial plaque toothpaste includes following weight percentage：Pupa
Lungfit 0.5~3%, O- cymene -5- alcohol 0.05~0.08%, potassium nitrate 3~5%, sodium phytate 0.2~1%, citric acid
Zinc 0.5~1.5% and polyvinylpyrrolidone 0.25~1%.
Study and draw repeatedly through inventor, when each group is divided into above-mentioned content, toothpaste of the present invention can effectively suppress
The adhesion and aggregation of oral bacteria, remove dental surface color stain dirt, and each functional component removes the formation that tooth stain suppresses bacterial plaque
Best results.
Preferably, the weight ratio of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Cordyceps militaris
Entity=80~99.9：0.01~20.
When Cordyceps militaris extract and fruiting bodies of cordyceps militaris use above-mentioned weight ratio, both can give full play to respective effect,
System is set to contain cordycepin, cordycepic acid, polysaccharide, SOD enzymes and a variety of volatile compounds, so as to reach that shield gum protects the work(of tooth
Effect.
It is highly preferred that the weight ratio of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Cordyceps militaris
Fructification=85~92：8~15.
When Cordyceps militaris extract and fruiting bodies of cordyceps militaris use above-mentioned weight ratio, the bactericidal effect that toothpaste reaches is optimal.
Preferably, the tooth stain that removes suppresses the preparing raw material of bacterial plaque toothpaste also comprising NMF, rubbing agent, thickener
And foaming agent.
Preferably, described to remove in the preparing raw material that tooth stain suppresses bacterial plaque toothpaste, the weight percent of the NMF contains
Measure as 30~50%, the weight percentage of the rubbing agent is 16~40%, the weight percentage of the thickener is 0.5
~3%, the weight percentage of the foaming agent is 1.8~3%.
Preferably, the foaming agent is at least one of amino acid surfactant and amphoteric surfactant and 12
The mixture of sodium alkyl sulfate.
It is highly preferred that the foaming agent is sodium lauroyl sarcosine, sodium lauroylmethyl taurate and cocamidopropyl propyl amide
At least one of glycine betaine and the mixture of lauryl sodium sulfate.
When foaming agent of the present invention only uses lauryl sodium sulfate, foam is few and thin, and mouthfeel of brushing teeth is slightly poor, ammonia of arranging in pairs or groups
When at least one of base acid surfaces activating agent, amphoteric surfactant, lather quickness can be accelerated, foam exquisiteness is abundant, solution
Certainly dry and astringent still sensory issues.The foaming agent is selected from commercially available prod, for example, sodium lauroyl sarcosine can select Shanghai Austria
The OLI-4208 of profit, lauroyl N-methyltaurine sodium can select the OLI-4901 of Shanghai profit difficult to understand, Cocoamidopropyl betaine
Galaxy Surfactants CAPB DC, the Lenotain C30 that Shanghai profit is contained are can select, wherein CAPB DC are specially for suitable.
Preferably, the rubbing agent be precipitated silica, superfine silicon dioxide, calcium monohydrogen phosphate and calcium carbonate at least
It is a kind of.
It is highly preferred that the rubbing agent be at least one of precipitated silica, calcium monohydrogen phosphate and calcium carbonate with it is ultra-fine
The mixture of silica, wherein, described to remove in the preparing raw material that tooth stain suppresses bacterial plaque toothpaste, the weight of superfine silicon dioxide
It is 2~6% to measure percentage composition.
Weight percentage of the superfine silicon dioxide in the preparing raw material of the toothpaste is 2~6%.When ultra-fine two
When silica consumption is less than 2%, lotion surface is more rough, and mouthfeel of brushing teeth can be poor, when superfine silicon dioxide consumption is more than 6%
When, be easily hardened under lotion high temperature water outlet, influences stability.The liquid absorption of superfine silicon dioxide is 30~44ml/20g, preferably
30~38ml/20g superfine silicon dioxide, can use commercially available prod, such as the comprehensive silica of snow company.It is heavy
The liquid absorption of shallow lake type silica is 15~25ml/20g, preferably 18~22ml/20g Precipitated silicon dioxide, can be used
Commercially available prod, such as the Zeodent115 of HUBER companies.The liquid absorption of calcium bicarbonate is 5.0~6.5ml/20g, apparent close
Spend for 0.80~1.00g/mL, preferably liquid absorption tends to maximum, while apparent density tends to minimum value, commercially available production can be used
Product, such as the toothpaste grade calcium hydrophosphate of De Bang companies.The liquid absorption of calcium carbonate be 3.8~5.0ml/20g, preferably 3.8~
4.2ml/20g calcium carbonate, can use commercially available prod, such as the calcite in powder of Man Tingfang companies.
Preferably, the thickener is at least one of sodium carboxymethylcellulose, carbomer and xanthans；The moisturizing
Agent is at least one of D-sorbite, glycerine, polyethylene glycol and propane diols.
Sodium carboxymethylcellulose can select commercially available prod, the TH10 (toothpaste level) of such as ASHLAND companies, and its substitution value is
0.75~1.02, preferably 0.95~1.02,2% solution viscosity is 600~3000mPas, preferably 1200~
2500mPas cellulose.Carbomer can select commercially available prod, such as Lubrizol companies
POLYMER (toothpaste level), adjusts pH value in 7 or so (in 6.5-7.5 interval ranges) with 25%NaOH solution, uses
Brookfield RV6 rotors survey its viscosity, 0.6% neutralization solution viscosity under 20rpm：15000~40000mPas,
It is preferred that in 20000~30000mPas.Xanthans, also known as xanthan gum, can select commercially available prod, such as CPKelco companiesXanthan Gum (oral cavity level), its 1% xanthans uses Brookfield RV6 in 1%KCl solution
Rotor surveys its viscosity under 20rpm, and viscosity is 1200~1600mPas.
The removal tooth stain of the present invention suppresses bacterial plaque toothpaste, in addition to said components are clearly required, in the lossless present invention
Effect in the range of, other adjunct ingredients can be added or used to, auxiliary material can be sweetener, pH adjusting agent, spices, coloring
Agent and fluoride etc., those skilled in the art can select conventional content according to conventional criteria.
Preferably, the tooth stain that removes suppresses the composition that bacterial plaque toothpaste also includes following mass percent：Sweetener 0.1
~2%, pH adjusting agent 0.1~3% and spices 0.1~2%.
Preferably, the sweetener is at least one of saccharin sodium, Sucralose and STEVIA REBAUDIANA；The spices is peppermint
At least one of brain, peppermint oil, spearmint oil, wintergreen, American mint, orange oil, lemon oil, fennel oil, eucalyptus oil；Institute
It is at least one in sodium hydroxide, ATSP, sodium tripolyphosphate, alkaline phosphate and sodium dihydrogen phosphate to state pH adjusting agent
Kind.
Above-mentioned removal tooth stain suppresses the preparation method of bacterial plaque toothpaste, comprises the following steps：
(1), potassium nitrate and auxiliary material are pre-dissolved；
(2), rubbing agent, thickener are premixed；
(3), the material in NMF and step (1) is added in cream tank processed；
(4) vacuum system of cream tank processed, is opened, is vacuumized, mixture, Cordyceps militaris elite, O- umbrellas obtained by step (2) are spent
Hydrocarbon -5- alcohol, potassium nitrate, sodium phytate, zinc citrate and polyvinylpyrrolidone are added, keep vacuum -0.05Mpa~-
Homogeneous is stirred between 0.085Mpa；
(5) foaming agent, is added in cream tank processed, keeps vacuum to continue stirring between -0.05Mpa~-0.085Mpa equal
Matter；
(6) it is -0.092Mpa~-0.098Mpa that, cream tank processed, which deaerates to vacuum, goes out cream, produces the removal tooth stain
Suppress bacterial plaque toothpaste.
The beneficial effects of the present invention are：Tooth stain, which is removed, the invention provides one kind suppresses bacterial plaque toothpaste, institute of the present invention
Removal tooth stain is stated to suppress to contain Cordyceps militaris elite, O- cymene -5- alcohol, potassium nitrate, sodium phytate, citric acid in bacterial plaque toothpaste
The multi-efficiency composition such as zinc, polyvinylpyrrolidone, Cordyceps militaris elite, which coordinates, gentle non-stimulated antibacterial goes the stain factor, Neng Gouyou
Effect suppresses the adhesion and aggregation of oral bacteria, while removing dental surface color stain dirt, each functional component can be synergistically from basic
It is upper to remove the formation that tooth stain suppresses bacterial plaque, also have effects that to restrain Shu Min, reach nursing oral cavity, the effect of tooth-whitening.
Suppress the toothpaste of bacterial plaque using removal tooth stain of the present invention for a long time, can allow outside tooth removing spots and whitening, can also prevent tooth
The mouth diseases such as Zhou Yan, gingivitis, dental calculus and dental caries.
Brief description of the drawings
Fig. 1 is embodiment 5 and antibacterial test comparison figure of the toothpaste described in comparative example 1~6 to staphylococcus aureus；
Fig. 2 is embodiment 5 and antibacterial test comparison figure of the toothpaste described in comparative example 1~6 to streptococcus mutans；
Fig. 3 is embodiment 5 and antibacterial test comparison figure of the toothpaste described in comparative example 1~6 to porphyromonas monococcus.
Embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Embodiment 1
It is of the present invention to remove a kind of embodiment that tooth stain suppresses bacterial plaque toothpaste, include the system of following weight percentage
Standby raw material：Cordyceps militaris elite 0.1%, O- cymene -5- alcohol 0.01%, potassium nitrate 3%, sodium phytate 0.2%, zinc citrate
0.25%th, polyvinylpyrrolidone 0.25%, NMF 50%, rubbing agent 16%, thickener 0.5%, foaming agent 1.8%, sweet tea
Taste agent 0.1%, pH adjusting agent 0.1%, the deionized water of spices 0.1% and surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight ratio for taking thing and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=99.9：0.01；The NMF
For D-sorbite；The thickener is sodium carboxymethylcellulose；The foaming agent is sodium lauroyl sarcosine and dodecyl sulphur
The mixture of sour sodium；The mixture of the rubbing agent precipitated silica and superfine silicon dioxide, superfine silicon dioxide is described
It is 2% to remove tooth stain to suppress the weight percentage in the preparing raw material of bacterial plaque toothpaste；The sweetener is saccharin sodium；It is described
Spices is menthol；The pH adjusting agent is alkaline phosphate and sodium dihydrogen phosphate.
Embodiment 2
It is of the present invention to remove a kind of embodiment that tooth stain suppresses bacterial plaque toothpaste, include the system of following weight percentage
Standby raw material：Cordyceps militaris elite 5%, O- cymene -5- alcohol 0.1%, potassium nitrate 10%, sodium phytate 2%, zinc citrate 2%, poly- second
Alkene pyrrolidone 2%, NMF 30%, rubbing agent 30%, thickener 3%, foaming agent 3%, sweetener 2%, pH adjusting agent
3%th, the deionized water of spices 2% and surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight ratio for taking thing and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=80：20；The NMF is mountain
The mixture of pears sugar alcohol and glycerine；The thickener is the mixture of sodium carboxymethylcellulose and carbomer；The foaming agent is
The mixture of sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is calcium monohydrogen phosphate and superfine silicon dioxide
Mixture, weight percentage of the superfine silicon dioxide in the removal tooth stain suppresses the preparing raw material of bacterial plaque toothpaste be
6%；The sweetener is Sucralose；The spices is spearmint oil；The pH adjusting agent is sodium hydroxide.
Embodiment 3
It is of the present invention to remove a kind of embodiment that tooth stain suppresses bacterial plaque toothpaste, include the system of following weight percentage
Standby raw material：Cordyceps militaris elite 0.5%, O- cymene -5- alcohol 0.05%, potassium nitrate 3%, sodium phytate 0.2%, zinc citrate
0.5%th, polyvinylpyrrolidone 0.25%, NMF 40%, rubbing agent 40%, thickener 0.5%, foaming agent 1.8%, sweet taste
Agent 0.1%, pH adjusting agent 0.1%, spices 0.1%, the deionized water of surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight ratio for taking thing and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=92：8；The NMF is sorb
The mixture of sugar alcohol and propane diols；The thickener is the mixture in sodium carboxymethylcellulose and xanthans；The foaming agent
For Cocoamidopropyl betaine and the mixture of lauryl sodium sulfate；The rubbing agent is calcium carbonate and superfine silicon dioxide
Mixture, weight percentage of the superfine silicon dioxide in the removal tooth stain suppresses the preparing raw material of bacterial plaque toothpaste be
4%；The sweetener is STEVIA REBAUDIANA；The spices is lemon oil；The pH adjusting agent is ATSP.
Embodiment 4
It is of the present invention to remove a kind of embodiment that tooth stain suppresses bacterial plaque toothpaste, include the system of following weight percentage
Standby raw material：It is Cordyceps militaris elite 3%, O- cymene -5- alcohol 0.08%, potassium nitrate 5%, sodium phytate 1%, zinc citrate 1.5%, poly-
Vinylpyrrolidone 1%, NMF 45%, rubbing agent 20%, thickener 2%, foaming agent 2%, sweetener 1%, pH adjusting agent
2%th, the deionized water of spices 1% and surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight ratio for taking thing and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85：15；NMF is sorbose
The mixture of alcohol and glycerine；The thickener is carbomer；The foaming agent is sodium lauroyl sarcosine, lauroyl methyl ox sulphur
The mixture of sour sodium and lauryl sodium sulfate；The rubbing agent is the mixture of precipitated silica and superfine silicon dioxide,
Weight percentage of the superfine silicon dioxide in the removal tooth stain suppresses the preparing raw material of bacterial plaque toothpaste is 6%；It is described
Sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Embodiment 5
It is of the present invention to remove a kind of embodiment that tooth stain suppresses bacterial plaque toothpaste, include the system of following weight percentage
Standby raw material：Cordyceps militaris elite 2.5%, O- cymene -5- alcohol 0.06%, potassium nitrate 4%, sodium phytate 0.8%, zinc citrate 1%,
Polyvinylpyrrolidone 0.8%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH are adjusted
Save the deionized water of agent 2%, spices 1% and surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight ratio for taking thing and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=90：10；NMF is sorbose
The mixture of alcohol and glycerine；The thickener is carbomer；The foaming agent is sodium lauroyl sarcosine, lauroyl methyl ox sulphur
The mixture of sour sodium and lauryl sodium sulfate；The rubbing agent is the mixture of precipitated silica and superfine silicon dioxide,
Weight percentage of the superfine silicon dioxide in the removal tooth stain suppresses the preparing raw material of bacterial plaque toothpaste is 4%；It is described
Sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Embodiment 6
Of the present invention to remove a kind of embodiment that tooth stain suppresses bacterial plaque toothpaste, the present embodiment removes tooth stain and suppresses tooth bacterium
Dental plaque cream removes the difference that tooth stain suppresses the content that the difference is that only Cordyceps militaris elite of bacterial plaque toothpaste with embodiment 5,
Weight percent of the Cordyceps militaris elite of tooth stain suppression bacterial plaque toothpaste in the preparing raw material of toothpaste is removed described in the present embodiment to contain
Measure as 5%.
Embodiment 7
Of the present invention to remove a kind of embodiment that tooth stain suppresses bacterial plaque toothpaste, the present embodiment removes tooth stain and suppresses tooth bacterium
Dental plaque cream removes the difference that tooth stain suppresses the content that the difference is that only Cordyceps militaris elite of bacterial plaque toothpaste with embodiment 5,
Weight percent of the Cordyceps militaris elite of tooth stain suppression bacterial plaque toothpaste in the preparing raw material of toothpaste is removed described in the present embodiment to contain
Measure as 4%.
Embodiment 8
Of the present invention to remove a kind of embodiment that tooth stain suppresses bacterial plaque toothpaste, the present embodiment removes tooth stain and suppresses tooth bacterium
Dental plaque cream removes the difference that tooth stain suppresses the content that the difference is that only Cordyceps militaris elite of bacterial plaque toothpaste with embodiment 5,
Weight percent of the Cordyceps militaris elite of tooth stain suppression bacterial plaque toothpaste in the preparing raw material of toothpaste is removed described in the present embodiment to contain
Measure as 2%.
Embodiment 9
Of the present invention to remove a kind of embodiment that tooth stain suppresses bacterial plaque toothpaste, the present embodiment removes tooth stain and suppresses tooth bacterium
Dental plaque cream removes the difference that tooth stain suppresses the content that the difference is that only Cordyceps militaris elite of bacterial plaque toothpaste with embodiment 5,
Weight percent of the Cordyceps militaris elite of tooth stain suppression bacterial plaque toothpaste in the preparing raw material of toothpaste is removed described in the present embodiment to contain
Measure as 1%.
Embodiment 10
Of the present invention to remove a kind of embodiment that tooth stain suppresses bacterial plaque toothpaste, the present embodiment removes tooth stain and suppresses tooth bacterium
Dental plaque cream removes the difference that tooth stain suppresses the content that the difference is that only Cordyceps militaris elite of bacterial plaque toothpaste with embodiment 5,
Weight percent of the Cordyceps militaris elite of tooth stain suppression bacterial plaque toothpaste in the preparing raw material of toothpaste is removed described in the present embodiment to contain
Measure as 0.1%.
Embodiment 11
Of the present invention to remove a kind of embodiment that tooth stain suppresses bacterial plaque toothpaste, the preparation of toothpaste described in the present embodiment is former
The weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris of material and embodiment 5 than difference, the present embodiment
The weight ratio of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=99.9：
0.01。
Embodiment 12
Of the present invention to remove a kind of embodiment that tooth stain suppresses bacterial plaque toothpaste, the preparation of toothpaste described in the present embodiment is former
The weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris of material and embodiment 5 than difference, the present embodiment
The weight ratio of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=95：5.
Embodiment 13
Of the present invention to remove a kind of embodiment that tooth stain suppresses bacterial plaque toothpaste, the preparation of toothpaste described in the present embodiment is former
The weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris of material and embodiment 5 than difference, the present embodiment
The weight ratio of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=92：8.
Embodiment 14
Of the present invention to remove a kind of embodiment that tooth stain suppresses bacterial plaque toothpaste, the preparation of toothpaste described in the present embodiment is former
The weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris of material and embodiment 5 than difference, the present embodiment
The weight ratio of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85：15.
Embodiment 15
Of the present invention to remove a kind of embodiment that tooth stain suppresses bacterial plaque toothpaste, the preparation of toothpaste described in the present embodiment is former
The weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris of material and embodiment 5 than difference, the present embodiment
The weight ratio of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=80：20.
Comparative example 1
Of the present invention to remove a kind of comparative example that tooth stain suppresses bacterial plaque toothpaste, the preparation of toothpaste described in this comparative example is former
Material be with the difference of embodiment 5 be free of in the preparing raw material of toothpaste described in this comparative example Cordyceps militaris elite, O- cymenes-
Toothpaste described in 5- alcohol, sodium phytate, zinc citrate and polyvinylpyrrolidone, i.e. this comparative example includes following weight percentage
Preparing raw material：Potassium nitrate 4%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH regulations
The deionized water of agent 2%, spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, superfine silicon dioxide suppresses the preparing raw material of bacterial plaque toothpaste in the removal tooth stain
In weight percentage be 4%；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is anhydrous
Tertiary sodium phosphate.
Comparative example 2
Of the present invention to remove a kind of comparative example that tooth stain suppresses bacterial plaque toothpaste, the preparation of toothpaste described in this comparative example is former
Material be with the difference of embodiment 5 be free of in the preparing raw material of toothpaste described in this comparative example O- cymene -5- alcohol, sodium phytate,
Toothpaste includes the preparing raw material of following weight percentage described in zinc citrate and polyvinylpyrrolidone, i.e. this comparative example：Pupa
Lungfit 2.5%, potassium nitrate 4%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%,
The deionized water of pH adjusting agent 2%, spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, superfine silicon dioxide suppresses the preparing raw material of bacterial plaque toothpaste in the removal tooth stain
In weight percentage be 4%；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is anhydrous
Tertiary sodium phosphate.
Comparative example 3
Of the present invention to remove a kind of comparative example that tooth stain suppresses bacterial plaque toothpaste, the preparation of toothpaste described in this comparative example is former
Expect that the difference with embodiment 5 is, is free of Cordyceps militaris elite, sodium phytate, lemon in the preparing raw material of toothpaste described in this comparative example
Toothpaste described in lemon acid zinc and polyvinylpyrrolidone, i.e. this comparative example includes the preparing raw material of following weight percentage：O- umbrellas
Flower hydrocarbon -5- alcohol 0.06%, potassium nitrate 4%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener
1%th, the deionized water of pH adjusting agent 2%, spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, superfine silicon dioxide suppresses the preparing raw material of bacterial plaque toothpaste in the removal tooth stain
In weight percentage be 4%；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is anhydrous
Tertiary sodium phosphate.
Comparative example 4
Of the present invention to remove a kind of comparative example that tooth stain suppresses bacterial plaque toothpaste, the preparation of toothpaste described in this comparative example is former
Material be with the difference of embodiment 5 be free of in the preparing raw material of toothpaste described in this comparative example Cordyceps militaris elite, O- cymenes-
Preparation of the toothpaste described in 5- alcohol, zinc citrate and polyvinylpyrrolidone, i.e. this comparative example comprising following weight percentage is former
Material：Potassium nitrate 4%, sodium phytate 0.8%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%,
The deionized water of pH adjusting agent 2%, spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, superfine silicon dioxide suppresses the preparing raw material of bacterial plaque toothpaste in the removal tooth stain
In weight percentage be 4%；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is anhydrous
Tertiary sodium phosphate.
Comparative example 5
Of the present invention to remove a kind of comparative example that tooth stain suppresses bacterial plaque toothpaste, the preparation of toothpaste described in this comparative example is former
Material be with the difference of embodiment 5 be free of in the preparing raw material of toothpaste described in this comparative example Cordyceps militaris elite, O- cymenes-
Toothpaste includes the preparing raw material of following weight percentage described in 5- alcohol, sodium phytate and polyvinylpyrrolidone, i.e. this comparative example：
Potassium nitrate 4%, zinc citrate 1%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH
The deionized water of conditioning agent 2%, spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, superfine silicon dioxide suppresses the preparing raw material of bacterial plaque toothpaste in the removal tooth stain
In weight percentage be 4%；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is anhydrous
Tertiary sodium phosphate.
Comparative example 6
Of the present invention to remove a kind of comparative example that tooth stain suppresses bacterial plaque toothpaste, the preparation of toothpaste described in this comparative example is former
Material be with the difference of embodiment 5 be free of in the preparing raw material of toothpaste described in this comparative example Cordyceps militaris elite, O- cymenes-
Toothpaste includes the preparing raw material of following weight percentage described in 5- alcohol, sodium phytate and zinc citrate, i.e. this comparative example：Potassium nitrate
4%th, polyvinylpyrrolidone 0.8%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%,
The deionized water of pH adjusting agent 2%, spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, superfine silicon dioxide suppresses the preparing raw material of bacterial plaque toothpaste in the removal tooth stain
In weight percentage be 4%；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is anhydrous
Tertiary sodium phosphate.
Comparative example 7
Of the present invention to remove a kind of comparative example that tooth stain suppresses bacterial plaque toothpaste, the preparation of toothpaste described in this comparative example is former
Material be with the difference of embodiment 5 be free of in the preparing raw material of toothpaste described in this comparative example Cordyceps militaris elite, O- cymenes-
Toothpaste described in 5- alcohol, polyvinylpyrrolidone, potassium nitrate, sodium phytate and zinc citrate, i.e. this comparative example includes following weight hundred
Divide the preparing raw material of content：NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH adjusting agent
2%th, the deionized water of spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, superfine silicon dioxide suppresses the preparing raw material of bacterial plaque toothpaste in the removal tooth stain
In weight percentage be 4%；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is anhydrous
Tertiary sodium phosphate.
Comparative example 8
Of the present invention to remove a kind of embodiment that tooth stain suppresses bacterial plaque toothpaste, the present embodiment removes tooth stain and suppresses tooth bacterium
Dental plaque cream removes the difference that tooth stain suppresses the content that the difference is that only Cordyceps militaris elite of bacterial plaque toothpaste with embodiment 5,
Weight percent of the Cordyceps militaris elite of tooth stain suppression bacterial plaque toothpaste in the preparing raw material of toothpaste is removed described in the present embodiment to contain
Measure as 6%.
Comparative example 9
Of the present invention to remove a kind of comparative example that tooth stain suppresses bacterial plaque toothpaste, the preparation of toothpaste described in this comparative example is former
The weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris of material and embodiment 5 than difference, this comparative example
The weight ratio of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=100:0.
Comparative example 10
Of the present invention to remove a kind of comparative example that tooth stain suppresses bacterial plaque toothpaste, the preparation of toothpaste described in this comparative example is former
The weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris of material and embodiment 5 than difference, this comparative example
The weight ratio of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=75:25.
Embodiment 16
Tooth stain will be removed described in embodiment 1~15 and suppresses bacterial plaque toothpaste with toothpaste described in comparative example 1~10 for oral cavity
Interior common several bacteriums carry out antibacterial test.
Antibacterial method of testing：According to《Disinfection technology standard》2.1.8. anti-(suppression) test method, passes through third party's machine
Structure is tested.
The preparation of bacteria inhibition tablet：In the sterilized petri dishes of cleaning, a diameter of 5mm is made, thickness is no more than the suppression of 4mm disks (block)
Microbial inoculum original cream piece, one group of every 4 (blocks).
The preparation of negative control piece：Take standby after sterile dry filter paper piece, every dropwise addition sterile distilled water.
The inoculation of test organisms：It is 5 × 10 that concentration is dipped with sterile cotton swab5Cfu/ml~5 × 106Cfu/ml test organisms hangs
Liquid, nutrient agar planar surface uniformly smear 3 times, often smear 1 time, flat board should rotate 60 °, finally by cotton swab around
Plate edge is smeared one week, is covered plate, is put drying at room temperature 5min.
Bacteriostatic agent print is placed with：Experiment is placed with 1 microbiological contamination flat board every time, and each flat board is placed with the examination of 4 same test groups
Test print, 1 negative control piece, totally 5.It is placed with aseptic nipper coupongs in planar surface.Between each print center apart
More than 25mm, the periphery with flat board is at a distance of more than 15mm.After being placed with,
With the light pressure-like piece of aseptic nipper, it is set to be close to planar surface.Plate is covered, 37 DEG C of incubators are put, culture 16h~
18h observes result.With the direct of vernier caliper measurement antibacterial ring size and record, experiment is repeated 3 times.
The bacterial strain of this test has selected common oral cavity pathogen：Staphylococcus aureus, streptococcus mutans and gum
Porphyrin monococcus.
Antibacterial test evaluation standard：Inhibition zone diameter is more than 7mm person, has been judged to bacteriostasis；Inhibition zone diameter be less than or
Equal to 7mm person, no bacteriostasis is judged to.The antibacterial test result of toothpaste is shown in Table 1 described in embodiment 1~10 and comparative example 1~7,
Embodiment 5 and the antibacterial test comparison of toothpaste described in comparative example 1~7 are shown in accompanying drawing 1~3, embodiment 5,11~15 and comparative example 8,9
The antibacterial test result of the toothpaste is shown in Table 2.
The antibacterial test result of toothpaste described in the embodiment 1~10 of table 1 and comparative example 1~7
As it can be seen from table 1 tooth stain is removed described in embodiment 1~10 suppresses the fungistatic effect of bacterial plaque toothpaste better than contrast
The fungistatic effect of toothpaste described in example 1~8, embodiment 5 can with the fungistatic effect contrast of comparative example 1~7 especially from accompanying drawing 1~3
To draw, the fungistatic effect of embodiment 5, which is more than, is free of Cordyceps militaris elite, O- cymene -5- alcohol, potassium nitrate, sodium phytate, citric acid
Zinc and polyvinylpyrrolidone only add Cordyceps militaris elite, O- cymene -5- alcohol, potassium nitrate, sodium phytate, zinc citrate and gathered
Vinylpyrrolidone one or more therein, illustrate Cordyceps militaris elite, O- cymene -5- alcohol, potassium nitrate, sodium phytate, lemon
Sour zinc and polyvinylpyrrolidone are compounded in certain proportion can play the bactericidal effect of Synergistic.From implementation
The fungistatic effect comparative example of example 5~10 and comparative example 8 can be drawn, with the increase of the addition of Cordyceps militaris elite, antibacterial effect
Fruit increases, but comparative example 8 is compared with Example 6, and addition adds 1%, but fungistatic effect increase is not obvious.
The embodiment 5,11~15 of table 2 and the antibacterial test result of toothpaste described in comparative example 7,8
From table 2 it can be seen that in the case where Cordyceps militaris elite content is certain, with the increasing of fruiting bodies of cordyceps militaris content
Greatly, the fungistatic effect of made toothpaste is in the trend for first increasing and reducing afterwards, and real in Cordyceps militaris extract and Cordyceps militaris
The weight ratio of body is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85~92：Effect reaches most preferably when 8~15.
Embodiment 17
Toothpaste described in suppressing bacterial plaque toothpaste and comparative example 7 to removal tooth stain described in the embodiment of the present invention 4 is purged color
The clinical test of spot, specific testing program is as follows：
It is classified and is scored using Lobene color spots index, the size and color spot degree at 0~3 grade of evaluation color spot position,
Such as table 3：
The grading system standard of table 3
Check labial surface of the tooth position for the lip, lingual surface and premanillary teeth of mandibular anterior teeth.Each facing is divided into two score areas：Tooth
Gum area and Ya Ti areas.The average color spot score mean of each subject is size score mean and degree score mean.Area meter
Point mean is the inspection facing of the color spot size score sum of each facing divided by total facing number, the i.e. score of color spot size/total
Count, degree score mean is：Color spot degree score/total inspection facing number.The inspection of whole color spots is completed by an examiner,
Examiner does not know the toothpaste species that testee uses, examiner's error is measured before checking, the Kappa values of examiner are
0.85, reliability is high.
Test group toothpaste is the toothpaste of embodiment 4, and contrast groups toothpaste is the toothpaste of comparative example 8, it is desirable to which experimenter brushes daily
Twice, brushed teeth tooth 2min, and clinical examination was carried out in baseline, 4 weeks and 8 weeks.
Aspiration experimenter one has 122, has been fully completed test in 8 weeks, test group 62, man 30, female 32；Contrast
Group 60, man 31, female 29, average age is 35 years old.Volunteer the knot of Lobene color spot indexes when experimenter's baseline is checked
Fruit is shown in Table 4, statistically indifference (P ＞ 0.5) between two groups of detection display.
The result of Lobene color spot indexes when the aspiration experimenter baseline of table 4 is checked
| Index for examination | Toothpaste | Tested number | Lobene color spot indexes |
| Color spot size | Embodiment 4 | 62 | 1.87±0.32 |
| Color spot degree | Embodiment 4 | 62 | 1.60±0.21 |
| Color spot size | Comparative example 7 | 60 | 1.71±0.29 |
| Color spot degree | Comparative example 7 | 60 | 1.52±0.15 |
Aspiration the 4th week of experimenter and the 8th weekly check the results are shown in Table 5, through statistical analysis, embodiment 4 and the phase of comparative example 7
Than there is significant significant difference (P ＜ 0.5).
Table 5 volunteers experimenter in the 4th weekly check result and the Lobene color spot index inspection results of the 8th week
It is can be seen that from table 4 and table 5 after using toothpaste described in embodiment 4 and comparative example 74 weeks and 8 weeks, with comparative example 7
Compare, can effectively treat removal using the use that tooth stain suppression bacterial plaque toothpaste is removed described in embodiment 4 and suppress tooth bacterium
The generation of spot.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected
The limitation of scope is protected, although being explained in detail with reference to preferred embodiment to the present invention, one of ordinary skill in the art should
Understand, technical scheme can be modified or equivalent substitution, without departing from the essence of technical solution of the present invention
And scope.
Claims (10)
1. one kind, which removes tooth stain, suppresses bacterial plaque toothpaste, it is characterised in that include Cordyceps militaris elite, O- cymene -5- alcohol, nitric acid
Potassium, sodium phytate, zinc citrate and polyvinylpyrrolidone；The Cordyceps militaris elite is Cordyceps militaris extract and fruiting bodies of cordyceps militaris
Mixture.
2. removing tooth stain as claimed in claim 1 suppresses bacterial plaque toothpaste, it is characterised in that the removal tooth stain suppresses bacterial plaque
Toothpaste includes the preparing raw material of following weight percentage：Cordyceps militaris elite 0.1~5%, O- cymene -5- alcohol 0.01~
0.1%th, potassium nitrate 3~10%, sodium phytate 0.2~2%, zinc citrate 0.25~2% and polyvinylpyrrolidone 0.25~
2%.
3. removing tooth stain as claimed in claim 1 suppresses bacterial plaque toothpaste, it is characterised in that the removal tooth stain suppresses bacterial plaque
Toothpaste includes the preparing raw material of following weight percentage：Cordyceps militaris elite 0.5~3%, O- cymene -5- alcohol 0.05~
0.08%th, potassium nitrate 3~5%, sodium phytate 0.2~1%, zinc citrate 0.5~1.5% and polyvinylpyrrolidone 0.25~
1%.
4. removing tooth stain as claimed in claim 1 suppresses bacterial plaque toothpaste, it is characterised in that the Cordyceps militaris extract and pupa worm
The weight ratio of grass seed entity is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=80~99.9：0.01~20；Preferably, the pupa
The weight ratio of Cordyceps and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85~92：8~15.
5. removing tooth stain as claimed in claim 1 suppresses bacterial plaque toothpaste, it is characterised in that the removal tooth stain suppresses bacterial plaque
The preparing raw material of toothpaste also includes NMF, rubbing agent, thickener and foaming agent.
6. removing tooth stain as claimed in claim 4 suppresses bacterial plaque toothpaste, it is characterised in that the removal tooth stain suppresses bacterial plaque
In the preparing raw material of toothpaste, the weight percentage of the NMF is 30~50%, the weight percentage of the rubbing agent
For 16~40%, the weight percentage of the thickener is 0.5~3%, the weight percentage of the foaming agent for 1.8~
3%.
7. removing tooth stain as claimed in claim 5 suppresses bacterial plaque toothpaste, it is characterised in that the foaming agent is amino acid surface
At least one of activating agent and amphoteric surfactant and the mixture of lauryl sodium sulfate.
8. removing tooth stain as claimed in claim 5 suppresses bacterial plaque toothpaste, it is characterised in that the foaming agent is lauroyl flesh ammonia
At least one of sour sodium, sodium lauroylmethyl taurate and Cocoamidopropyl betaine and the mixing of lauryl sodium sulfate
Thing.
9. removing tooth stain as claimed in claim 5 suppresses bacterial plaque toothpaste, it is characterised in that the rubbing agent is precipitated silica
At least one of silicon, superfine silicon dioxide, calcium monohydrogen phosphate and calcium carbonate；Preferably, the rubbing agent be precipitated silica,
The mixture of at least one of calcium monohydrogen phosphate and calcium carbonate and superfine silicon dioxide, wherein, the removal tooth stain suppresses tooth bacterium
In the preparing raw material of dental plaque cream, the weight percentage of superfine silicon dioxide is 2~6%.
10. removing tooth stain as claimed in claim 5 suppresses bacterial plaque toothpaste, it is characterised in that thickener is carboxymethyl cellulose
At least one of sodium, carbomer and xanthans；The NMF is in D-sorbite, glycerine, polyethylene glycol and propane diols
It is at least one.
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| CN108670881A (en) * | 2018-08-16 | 2018-10-19 | 苏州清馨健康科技有限公司 | Whitening maintenance toothpaste |
| CN109568189A (en) * | 2018-12-27 | 2019-04-05 | 温州市森马网络技术有限公司 | One kind is antibacterial to remove stain nanometer toothpaste and preparation method thereof |
| CN110755309A (en) * | 2019-11-08 | 2020-02-07 | 苏州克劳丽化妆品有限公司 | Cordyceps militaris essence particles, cordyceps militaris toothpaste and preparation methods of cordyceps militaris essence particles and cordyceps militaris toothpaste |
| CN112315827A (en) * | 2020-09-25 | 2021-02-05 | 好维股份有限公司 | Oral care composition and application |
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| CN115025022A (en) * | 2022-07-13 | 2022-09-09 | 博雅(广州)生物科技研究院有限公司 | Efficient antibacterial toothpaste and preparation method thereof |
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| CN110755309A (en) * | 2019-11-08 | 2020-02-07 | 苏州克劳丽化妆品有限公司 | Cordyceps militaris essence particles, cordyceps militaris toothpaste and preparation methods of cordyceps militaris essence particles and cordyceps militaris toothpaste |
| CN112315827A (en) * | 2020-09-25 | 2021-02-05 | 好维股份有限公司 | Oral care composition and application |
| CN112315827B (en) * | 2020-09-25 | 2023-02-28 | 好维股份有限公司 | Oral care composition and application |
| CN114259424A (en) * | 2021-12-24 | 2022-04-01 | 福建爱洁丽日化有限公司 | Anhydrous antibacterial toothpaste containing peach carin and cymene and preparation method thereof |
| CN114795993A (en) * | 2022-02-25 | 2022-07-29 | 上海弗艾柏生物科技有限公司 | Antibacterial and antiseptic composition for pet oral cleaning product and application thereof |
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| CN115025022A (en) * | 2022-07-13 | 2022-09-09 | 博雅(广州)生物科技研究院有限公司 | Efficient antibacterial toothpaste and preparation method thereof |
| CN115025022B (en) * | 2022-07-13 | 2023-09-05 | 湖南互美电子商务有限公司 | Antibacterial toothpaste and preparation method thereof |
| CN115813799A (en) * | 2022-12-09 | 2023-03-21 | 云南白药集团健康产品有限公司 | Whitening and tooth-protecting composition and application thereof in oral care products |
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