WO2022200887A1 - Natural multifunction coenzyme q10 liquid oral hygiene care with antimicrobial efficacy - Google Patents

Abstract

An oral care formulation contains an effective amount of COCAMIDOPROPLY BETAINE, XYLITOL, COENZYME Q10, CAMPHOR, CLOVE, PEPPERMINT, MENTHOL, and O-CYMEN-5-OL. The oral care formulation comprises a liquid toothpaste with Coenzyme Q10 as a liquid mixture to the toothpaste. The oral care formulation achieves 8-in-One "CASE-RRPP" functions, including cleansing, removing of plaque, reducing inflammation of the whole oral including gum and throat, soothing redness and pain relief, elimination of bacteria, reducing bleeding, repairing and foster recovery, being preventive of oral caries and periodontal disease, protection of oral health.

Description

NATURAL MULTIFUNCTION COENZYME Q10 LIQUID ORAL HYGIENE CARE

WITH ANTIMICROBIAL EFFICACY

BACKGROUND

[1] In light of oral diseases have affected nearly 4 billion people worldwide, people are working long hours and less rest time nowadays, the invention of this oral cleansing formulation has been targeted to achieve the ideal needs of users and for sickness people, that is to cope with the common oral problems (periodontal diseases, gum diseases, sensitive teeth, damage of oral mucosa, endostomatitis ulcers, lip sores), needs for convenient, effective distinctive result with less time consuming, and efficacy during the daily oral care routine.

[2] This successful scientific invention demonstrated a total solution for dental and oral care. The innovative oral cleansing formulation is a breakthrough from traditional toothpaste or mouthwash. It demonstrated that it is not necessary to use two products separately, that is toothpaste first and mouthwash thereafter, this unique formula can combine these two now. Furthermore, this invention would also change the perception of dental and oral care. As to maintain oral health would be associated with body health, this revolutionary invention enhances the benefits coverage from teeth to gum protection, tongue, throat, and lips in an all in one solution.

[3] Thus, this successful innovative formulation has integrated total solutions with 8-in- One benefits (“CASE-RRPP”). This is a scientifically innovative oral cleansing formulation that contributes to a multi-functional liquid toothpaste with antibacterial and restorative properties that meets global oral health needs.

[4] It is proved that it is not necessary to use chemical ingredient in order to get high efficacy of elimination of bacteria. This unique formula by using natural ingredients has been tested and proved that it can eliminate bacteria, such as Streptococcus Pneumonia, Candida Albicans, Pseudomonas Aeruginosa, Salmonella Typhimurium, and Staphylococcus Aureus, etc. Further testing will be carried out.

[5] It is proved by clinic trial that people with toothache or sensitive teeth, they can have a choice for using this oral cleansing formulation for soothing pain, or even elimination of pain after using of 3 days. Note: users who have toothache should consult dentist for further advice. This formulation is not medicine, therefore no side effect of medicine. SUMMARY

[6] The first scientific innovation is to contribute to global health needs - the world's first revolutionary 8-in-One multifunction new oral care formulation, combining the functions of liquid toothpaste and mouthwash, presented in the same liquid water-like form. [7] Traditional toothpastes come in the form of gels, gels or, creams or foams. In terms of efficacy and practicability, it far exceeds the traditional oral care, and achieves the goals of safety, super effective and high efficacy, convenience, and protection, so it is a great progress in human life.

[8] In order to reduce the risks of dental caries and effectively prevent periodontitis, dentists’ recommendation is to brush the teeth after using mouthwash for the objective to remove plaque completely. This innovative formulation has successfully combined liquid toothpaste and mouthwash into one and will simplify the cleansing steps as well as meeting the objective of removing plaque.

[9] In addition, one of the purposes of inventing the liquid toothpaste is to reduce the excessive damage to the enamel caused by the abrasive particles that may be contained in the gel toothpaste during tooth brushing.

[10] This revolutionary 8-in-One multi-functions liquid toothpaste combined with mouthwash all in one. The multi-functions bring the benefits for (1) Cleansing, remove of plaque, (2) Reduce inflammation of the whole oral including gum and throat, (3) Soothing redness and pain relief, (4) Elimination of bacteria, (5) Reduce gum bleeding, (6) Repair and foster recovery, (7) Preventive of oral caries and periodontal disease, (8) Protection of oral health.

[11] This unique formula helps reduce the spread of bacteria and fungi (refer to recognized 3rd party testing result). It can prevent plaque buildup, help improve periodontal disease and reverse periodontitis, effectively reduce inflammation and speed up the repair of gum disease.

[12] In addition, this innovative invention can also bring pain relief to people with (i) endodontic neuralgia, (ii) sensitive teeth, and (iii) periodontal disease. A person who could not undergo root canal treatment surgery for some reasons. His dentist recommended him to be tolerant for weeks. The other users with sensitive teeth and pain for years. Before those people used this innovative formulation, they were suffered by the toothache in every moments of their lifestyle - drinking, eating, brushing and sleeping. After they have used this innovative formulation for 3 days and thereafter, they have the first experience with fully pain relief.

[13] Hoping this revolutionary invention will bring hopes to people for the recovery, as well as to bring the awareness of the relationship between oral care and general health. [14] The 2nd scientific innovation is that this new oral cleansing formulation, has successfully enhanced the efficacy to "All-rounded Oral Care". The rationale of this invention is because oral health may affect the overall body health, therefore maintaining oral healthy is extremely important.

[15] This All-rounded Oral Care innovative formula ("CASE-RRPP") delivers revolutionary oral care that combines Cleansing, Anti-inflammatory, Soothing redness and pain relief, Elimination of bacteria, Relieve pain, Reduce bleeding, Preventive and Protective benefits. This is a successful scientific result and innovative formulation. It is the world's first "All-rounded Oral Care" dental and oral care formulation. It may replace the current 1 to 4 kinds of oral care products or medication. Note: this is not a medicine, and has no side effect as medicine. This innovative formulation is like a great gift to people in the world!

[16] This innovative formula effectively removes plaque, improves periodontal disease, helps reduce inflammation and accelerates repair of gum disease, and has also been proven to kill Streptococcus pneumoniae, Candida albicans, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhimurium, etc. These bacteria may cause fatal complications. This innovative formulation has the potential to help reduce the risk of bacteria/fungi, or viruses transmission via airborne or contact, and is particularly useful for reducing the chance of respiratory infections and during a pandemic.

[17] Internationally recognized test certification proves that it can quickly kill bacteria in the oral cavity in 30 seconds. (Tested by Hong Kong Standards and Testing Center Co., Ltd., report number: HC21020672, report date: 25-2-2021, use method: ASTM E2315-2016 (contact time: 30 seconds).

[18] The 3rd innovation is that this innovative oral cleansing formulation is made of natural herbal ingredients, which can effectively kill bacteria and fungal pathogens in the oral cavity. Test and verification, this oral product is safe and non-toxic.

[19] This revolutionary and innovative oral care formulation is made of natural ingredients, alcohol-free, methyl salicylate-free, fluoride-free, no lard and lard derivatives. The rationale of using natural ingredients is to reduce unnecessary sensitivity and oral tissue damages. It met the objectives of safety, all-rounded coverage, high efficacy, preventive purposes.

[20] This innovative formulation greatly enhances the flexibility of use, increases the frequency of use, expands the user group (in terms of age, religious belief, and occupational professionalism), and improves the utilization rate. (Tested by SGS in Dubai; SGS Gulf Limited (JAFZ BR.), Method used: Real-time-PCR, In-house method-FL-SOP- Tech-081 , Test report DAI 9- 10781.001 R0).

[21] It greatly enhances the flexibility of use, increases the frequency of use, expands the user group (in terms of age, religious belief, and occupational professionalism), and improves the utilization rate. (Tested by SGS in Dubai; SGS Gulf Limited (JAFZ BR.), Method used: Real-time-PCR, In-house method-FL-SOP-Tech-081, Test report DA19- 10781.001.R0).

[22] Traditional mouthwashes and toothpastes contain chemicals that can freshen breath and reduce plaque, but traditional toothpastes may contain excess fluoride, while traditional mouthwashes contain a lot of alcohol and other chemicals to achieve their bactericidal effects. However, these chemical ingredients may not be suitable for all users, because the high concentration of alcohol and chemicals can cause some users to feel irritated like scalding when using mouthwash. Chances of damage to the oral mucosa, prolonged use is more likely to worsen periodontal disease or ulcers in the oral cavity.

DETAILED DESCRIPTION

[23] Branch of Science Related to Invention

[24] This invention - ‘Liquid Toothpaste Coenzyme Q10’ innovative oral care formulation is in the classification of dentistry - oral care product. It is made of natural ingredients, free from alcohol, free from Methyl Salicylate, free from lard and lard derivatives. The form and efficacy of this liquid toothpaste enhance users’ experience of oral care through 8-in-One multifunctional solutions ("CASE-RRPP"), which benefits are (1) Cleansing, remove of plaque, (2) Reduce inflammation of the whole oral including gum and throat, (3) Soothing redness and pain relief, (4) Elimination of bacteria, (5) Reduce bleeding, (6) Repair and foster recovery, (7) Preventive of oral caries and periodontal disease, (8) Protection of oral health.

[25] This innovative oral care formulation belongs to the category of dental-oral care products. It is made from natural ingredients and is alcohol free, methyl salicylate free, fluoride free, lard and lard derivatives free. This liquid toothpaste combined with mouthwash in the same liquid form, integrated with a multi-functional, all-in-one clinically tested solution. Its all-in-one solution consists of 8-in-One benefits that bring Cleansing, Anti-inflammation, Soothing redness and pain relief, Eliminate bacteria, repairing,

Prevention and Protection Unique Formula (“CASE-RRPP” - Cleaning, Anti-inflammation, Soothing redness & pain relief, Eliminate bacteria, Reduce gum bleeding, Repair, Preventive & Protection). It can enhance the user's oral care experience, effectively prevent and reverse periodontal disease, reduce the risk of infection through air and saliva transmission, and improve the protection against infection for people with low immunity.

[26] FORMULA OF THIS INVENTION:

[27] In the examples below, the present disclosure provides active ingredients of aspects of the invention. In one example, embodiments of the invention provide effective amount of the active ingredients described below.

[28] The formula of the liquid toothpaste with Coenzyme Q10 is disclosed as below:

[29] This innovative oral care formulation is disclosed as below:

[30] For example, aspects of the invention may include the following: aqua 0.01%- 99%, Cocamidopropyl Betaine 0.01%-99%, Coenzyme Q10 0.01%-99%, Xylitol 0.01%-99%, Camphor 0.01%-99%, Clove 0.01%-99%, O-Cymen-5-OL 0.01%-99%, Peppermint 0.01%- 99%, Menthol 0.01%-99%, and other commonly known ingredients. In another embodiment, any of the combinations above may result in an effective amount of the active ingredients above.

[31] This innovative formula can add in some commonly known ingredients and different flavors such as apple flavor, strawberry, peach flavor, it will not affect efficacy.

[32] Innovative Natural Ingredient Formula:

[33] A clinical experiment with this liquid toothpaste was conducted (an unofficial survey for a sample size over 300 volunteers who have periodontal disease, oral cavity problems) for a period for 4 weeks to 12 months. A consistent conclusion was drawn on its effectiveness to improve healing and repairmen of periodontal tissues, gum diseases, reduce bleeding, pain relief and anti-inflammation.

[34] The 1st innovative and natural ingredient formula: Coenzyme Q10 + mixture of liquid form of oral care formulation

[35] This innovative invention is based on the successful use of Coenzyme Q10 in liquid toothpaste or mouthwash, liquid toothpaste and mouthwash, or a mixture of liquid form of oral care formulation, which coverage is well cover the whole oral cavity including tongue, throat and hidden areas. This discovery is to present coenzyme Q10 in liquid form, and it only takes 30 seconds to make it function optimally, rapidly improve vascular endothelial function, exert anti-inflammatory, hemostasis and coagulation effects, help vasoconstriction, anti -oxidation (Promote the regeneration of blood vessels and damaged tissues), repair damaged tissues, and are very effective in improving periodontal disease. [36] This discovery presents coenzyme Q10 in liquid form, and it is hoped that it can effectively bring an immediate and a kind of supplement to people who have periodontal disease and those taking statins who are deficient in coenzyme Q10. If it is compared with food intake with ingredient of coenzyme Q10, the percentage of coenzyme Q10 absorbed by the human body is only 2% to 3%, and it takes 2 to 10 hours for digestion and decomposition in the stomach.

[37] This unique formula has been clinically tested, and it showed the high efficacy with 30 seconds.

[38] Coenzyme Q10 can reach to the teeth, gums and their damaged tissues, protect the endothelial cells functions, help coagulation and hemostasis, help vasoconstriction, antioxidant (promoting blood vessels and damaged tissue regeneration), accelerate recovery of oral damaged tissue, and it’s very effective in improving periodontal disease.

[39] This scientific result CoQlO showed effectiveness in improving periodontal health, particularly restore the CoQlO deficiency for people who are associated with periodontal diseases.

[40] If coenzyme Q10 is presented in other forms, such as toothpaste, toothpaste in gel or powder form, the effect of coenzyme Q10 is very minimal, maybe less than 10%.

[41] Clinical test results indicated this innovative formulation offers:

[42] People who have with severe periodontal disease, after using this formula for the second to third time (that is, within three days), periodontal disease has been significantly controlled and improved, including anti-inflammatory, hemostasis and accelerated wound healing effects.

[43] People with oral ulcers, including the tongue, white holes in the gums, and swollen gums, this formulation can effectively control inflammation and repair.

[44] People who have thrush, it accelerates recovery in 3 days (otherwise recovery would normally take 1 to 2 weeks).

[45] Note: Coenzyme Q10 can be extracted from plants, fruits or animals. This scientific result has shown its maximize the functions and effect of Coenzyme Q10 when it is demonstrated in liquid form. This innovative oral care formulation also be presented in different forms, such as paste, gel, gel, powder, foam, etc., but the expected effect will not be as well as in liquid form.

[46] The 2nd innovative and natural ingredient formula: Coenzyme Q10 + Cocamidopropyl Betaine (CAPB) + mixture of both in liquid form of oral care formulation [47] This innovative invention is based on CoQlO + CAPB successfully used in liquid toothpaste or mouthwash, liquid toothpaste and mouthwash, or a mixture of liquid form of oral care formulation, which coverage is well cover the whole oral cavity including tongue, throat and hidden areas. It can rapidly improve endothelial cells functions within 30 seconds, exert anti-inflammatory, coagulation and hemostasis effects, significantly accelerate wound healing and repair damaged periodontal tissues, and effectively improve periodontal disease. During the cleansing process, a barrier is established to reduce the risk of infection caused by foreign substances passing through the blood of the teeth. CAPB has a strong penetration ability and high moisturizing power, combining with the formula would help maximize the benefits of the formulation, strengthens antibacterial, relieves pain and accelerate healing. CAPB plays an important role in this innovative formulation as foaming agent, it offers users soft and comfort feeling after use. Traditional toothpaste may bring users feeling try and rough on the surface of teeth after use. This innovative formulation combines Coenzyme Q10 will bring users a smooth and a protective feeling on the surface of teeth and mouth after use.

[48] It is to be understood that CAPB may be added to subsequent formulations as well without departing from the scope and spirit of aspects of the invention.

[49] This innovative formulation has been clinically tested and this unique formula indicated that it works best in liquid form. Firstly, to use Coenzyme Q10 and CAPB in oral cavity for 30 seconds, covering throat and overall oral cavity areas and gum as well. At this time, Coenzyme Q10 can quickly reach to the periodontal and damaged tissue, and exert its’ best performance (protect endothelial cells functions, reduce or anti-inflammation, promote blood coagulation, accelerate wound healing and recovery of damaged periodontal tissue, and soothe discomfort of periodontal diseases).

[50] After 30 seconds, spit it out and brush your teeth directly with a toothbrush. This innovative formulation of Coenzyme Q10 + CAPB will generate mild foam during brushing. Furthermore, the liquid form will help bring Coenzyme Q10 to the gum tissues and periodontal areas, help endothelial cells functions effectively, rapidly heal the inflammation, help vasoconstriction and accelerate recovery of damaged tissues.

[51] For people who have periodontal disease, it significantly reduced the gingival inflammation and resulted no bleeding while brushing of teeth after using this innovative formulation. In overall, this unique formulation can quickly help improve in gingivitis and gum tissue health. [52] This innovative Coenzyme Q10 + CAPB formulation also creates a protective barrier for teeth and gums. After using this formula, a thin and smooth protective film will appear on the teeth and gums. In addition, it can quickly heal wounds, which can effectively reduce the risk of foreign infections entering the human body through the blood of the teeth or damaged tissues.

[53] This formulation can be presented in other forms, such as toothpaste, gel or powder, but the effect would be minimal, and the response effect is low; the coverage of oral cavity would be reduced and limited, and the form may potentially damage to the gums.

[54] Clinical test results indicated this innovative formulation offers:

[55] (1) User feedback from people with periodontal disease, who age are between 30 and 70. After they used this formula with Coenzyme Q10 in the first to third time after rinsing and cleaning their teeth, they had obvious experience that this formulation helps in different aspects. When brushing teeth, there is no periodontal bleeding, no swelling and no more pain on gingival. After rinse, feeling very clean and refresh, and the surface of the teeth is smooth with a thin protective layer. In overall, users feel very comfortable after use.

[56] (2) For people who have sensitive teeth, it is obvious that this liquid toothpaste containing coenzyme Q10 can best relieve the pain of red and painful teeth when he eats and brushes their teeth.

[57] (3) For people who have with oral ulcers (mucosal endostomatitis), most users use this unique natural formula for the third time, that is, within 36 hours, the initial endostomatitis can be rapidly withered and repaired.

[58] (4) For people who have oral thrush, ulcers with white holes appear on the mucous membrane of the mouth due to radiation therapy, may also grow on both sides inside of the mouth, tongue, lips, etc., with red surrounding, concave white circle in the center, and the normal recovery time is one to two weeks. When people use this formulation, the redness and swelling of the affected area are reduced, inflammation is reduced, and the tingling sensation is immediately relieved. After using this formula for 2 to 3 days, the affected area begins to shrink, it indicated that the repair and healing effect.

[59] (5) Throat inflammation, due to excessive consumption of fried and baked food, low immunity or bacterial infection. People use this unique formula after gargling and cleaning the teeth, it can quickly reduce the congestion and redness of the throat, rapidly relieve swollen throat and pain. Usage of 1 to 2 days can eliminate throat inflammation and swollen throat. [60] (6) After using this innovative formulation containing Coenzyme Q10 and CAPB, common users feel the amazing effect that it brings, such as anti-inflammatory, hemostasis, and accelerated wound healing. Coenzyme Q10 and CAPB also provide a comfortable and comfort feeling, the users would not feel grainy or toothpaste-like roughness. After using this mouthwash and liquid toothpaste, it would leave a thin protective layer on the surface of teeth, which provides users an extra protective oral care.

[61] Note: This innovative formula can also be presented in different forms, such as paste, gel, cream, powder, foam, etc.

[62] The 3rd innovative and natural ingredient formula: Camphor + O-Cymen-5- OL + Cocamidopropyl Betaine (CAPB) + mixture of liquid form of oral care formulation

[63] This innovative invention is the successfully use of Camphor + O-Cymen-5- OL + CAPB in liquid toothpaste or mouthwash, liquid toothpaste and mouthwash or a mixture of liquid form of oral care formulation, which coverage is well cover the whole oral cavity including tongue, throat and hidden areas. It help quickly relieve sore throat, gingivitis, endostomatitis and cheil sores within 30 seconds, including numbing nerve endings, antibacterial and antifungal on the mucous membranes of throat and oral cavity effectively, pain relief, redness prevention, throat congestion, swelling, and other benefits.

[64] Internationally recognized test certification proves that this unique formula can effectively kill bacteria quickly within 30 seconds, and it effectively helps to kill Pseudomonas aeruginosa.

[65] Clinical trials have shown that Camphor + O-Cymen-5-OL + CAPB in liquid form in liquid toothpaste or mouthwash can quickly eliminate oral bacteria and fungi, numb the nerve of teeth, instantly relieve pain and inflammation, and help relieve throat inflammation and pain. It offers a great relief to people who have periodontal disease, so that they no longer endure the pain of rinsing and cleaning their teeth. It does not only remove the plaque, but also quickly relieves the pain when brushing teeth. It also help control and improve the persistence of periodontal disease, or even reverse gingivitis or not getting worse.

[66] Clinical test results indicated this innovative formulation offers:

[67] For people with periodontal disease, smokers, or people with low immunity, after using this innovative formula within three days, no matter they have gum inflammation, endostomatitis, or pharyngitis, this formula can quickly relieve pain, reduce inflammation, reduce redness and pain and swelling during a short rinse. [68] Effectively fights fungi, helps to remove plaque, and help in improving periodontal disease.

[69] Users reported that this formula has a high efficacy on recovery of endostomatitis which takes about 3 to 4 days. The effect is comparable to medicine, of which normal time for healing would take 4 to 7 days.

[70] For lips ores, after using this innovative formula for 2 to 3 days, the cheil sores will quickly reduce and fade away, which is much faster than the normal recovery time of 7 to 10 days. It also reduces the tingling, redness, and unsightly feelings commonly experienced by people with cheil sores.

[71] Note: This innovative formula can also be presented in different forms, such as paste, gel, cream, powder, foam, etc.

[72] 4. The 4th innovative and natural ingredient formula: Coenzyme Q10 + Camphor + O-Cymen-5-OL + Cocamidopropyl Betaine (CAPB) + mixture of liquid form of oral care formulation

[73] This innovative invention is successfully used CoQlO + Camphor + O- Cymen-5-OL + CAPB in liquid toothpaste or mouthwash, liquid toothpaste and mouthwash, or a mixture of liquid form of oral care formulation, which coverage is well cover the whole oral cavity including tongue, throat and hidden areas. Within 30 seconds, it can quickly help reduce inflammation, relieve pain, prevent redness, swelling and bleeding in the inflamed area, antibacterial and antifungal on the mucous membranes of the throat and oral cavity, and can significantly accelerate wound healing and repair periodontal tissue, effectively prevent periodontal disease and bad breath (halitosis), and is particularly effective in relieving the discomfort of periodontal disease.

[74] This innovative invention first brings anti-inflammatory and bactericidal effects and analgesic feeling to users by using the mouthwash for 30 seconds, soothing and pain relief will be effect. Follow by brushing of teeth, it produces mild and smooth foam, it will effectively remove plaque, and build a thin antibacterial protective layer on the surface of teeth. This formula can help maintain oral health and effectively control periodontal disease.

[75] It has been proved by clinical experiments that most of the users use this innovative natural formula on the second to third day from the onset, the endostomatitis symptom can be quickly withered and recovered. [76] Internationally recognized test certification proves that this unique formula can effectively kill bacteria quickly within 30 seconds, it can help kill Pseudomonas aeruginosa, Staphylococcus aureus, etc.

[77] Using this unique natural formula, it helps reduce the risk of potential infection of bacteria through tooth blood.

[78] Note: This innovative formula can also be presented in different forms, such as paste, gel, cream, powder, foam, etc.

[79] Clinical test results indicated this innovative formulation offers:

[80] The mouthwash and liquid oral hygiene care or dentifrice with this unique formula can effectively control and improve periodontal problems within three days after use, including analgesic, anti-inflammatory, bactericidal and restorative effects.

[81] People who have chemotherapy, have a lower immune system than the normal healthy person. In average, endostomatitis symptoms will occur in every two months. Be extra careful when eating and avoid eating hot and spicy food. In a similar situation, the normal recovery time is 7 to 10 days. If alcohol -based mouthwash is used, the average recovery time could be reduced to 4 or 5 days.

[82] Feedback from users is that after using this innovative formula for 2 to 3 days, they feel that it helps quickly relieve pain, high efficacy on anti-inflammatory and bactericidal effect, reduce the redness and swelling of the affected area.

[83] Using this formula of mouthwash is unlike the common ordinary alcohol- based mouthwash, which would lead to irritated feeling, and it will leave an unspoken chemical taste in the mouth after use. However, after using this formula in the third day, the endostomatitis has subsided in several places, no pain and feel good, the effect is remarkable.

[84] 5. The 5th innovative and natural ingredient formula: Clove + O-Cymen- 5-OL + Cocamidopropyl Betaine (CAPB) + mixture of liquid form of oral care formulation

[85] This innovative invention is Clove + O-Cymen-5-OL + CAPB successfully used in liquid toothpaste or mouthwash, liquid toothpaste and mouthwash, or a mixture of liquid form of oral care formulation, which coverage is well cover the whole oral cavity including tongue, throat and hidden areas. It can quickly help gingival anesthesia, analgesia, antipyretic, antibacterial and antifungal on the mucous membranes of the throat and oral cavity, pain relief and anti-inflammatory effects within 30 seconds. When oral bacteria grow or become infected, toxins are produced, and this unique herbal formula is effective in its antifungal properties. [86] Internationally recognized test certification proves that this unique formula can effectively kill 99.9999% of Candida albicans within 30 seconds.

[87] This formula effectively reduces the potential risks of being infected with fungus via contact.

[88] Clinical test results indicated this innovative formulation offers:

[89] The mouthwash and liquid oral hygiene care or dentifrice with this unique formula can effectively control and improve periodontal problems within three days after use, including analgesic, anti-inflammatory, bactericidal and restorative effects.

[90] For people with sensitive teeth, this unique formula can effectively relieve the redness of their teeth. After using this formulation for 3 days, the past experience of pain have been eliminated while eating or drinking.

[91] For people who have oral ulcers (Candida endostomatitis), after using this unique natural formula for the third time, the endostomatitis symptom can be rapidly withered and repaired within 36 hours.

[92] Note: This innovative formula can also be presented in different forms, such as paste, gel, cream, powder, foam, etc.

[93] 6. The 6th innovative and natural ingredient formula: Coenzyme Q10 + Camphor + Clove + O-Cymen-5-OL + Cocamidopropyl Betaine (CAPB) + mixture of liquid form of oral care formulation

[94] This innovative invention successfully use Coenzyme Q10 + Camphor +

Clove + O-Cymen-5-OL + Cocamidopropyl Betaine (CAPB) in liquid toothpaste or mouthwash, liquid toothpaste and mouthwash or a mixture of liquid form of oral care formulation, which coverage is well cover the whole oral cavity including tongue, throat and hidden areas.

[95] Clinical trials have proven that this unique formula Coenzyme Q10 +

Camphor + Clove + O-Cymen-5-OL + CAPB is presented in liquid form, which coverage is well cover the whole oral cavity including tongue, throat and hidden areas. It can rapidly kill bacteria and fungi on the mucous membranes of the throat and in oral cavity within 30 seconds, numb the nerve of teeth and pain relief. In addition, it can help gums, tongue and throat anti-inflammatory and analgesic, help prevent redness, swelling and bleeding, significantly accelerate wound healing and repair periodontal tissue, prevent periodontal disease and halitosis (bad breath), and is particularly effective in relieving the discomfort of periodontal disease, and also has helps improve or control periodontal disease. [96] Internationally recognized test certification proves that this unique formula can effectively kill bacteria, fungi, such as Pseudomonas aeruginosa, Candida albicans, etc. up to 99.999% within 30 seconds.

[97] Clinical test results indicated this innovative formulation offers:

[98] For people who have oral ulcers (Candida endostomatitis, herpetic endostomatitis), after using this unique natural formula for the third time, it provides immediate relieves, reduces inflammation and relieves the endostomatitis symptom within 36 hours. Rapid withering and repairing effect.

[99] Effectively soothing redness and pain relief, which effect is comparable to the effect of medicine (note: this formulation is produced from natural ingredients, it not a medicine).

[100] Note: This innovative formula can also be presented in different forms, such as paste, gel, cream, powder, foam, etc.

[101] 7. The 7th innovative and natural ingredient formula: Coenzyme Q10 + Camphor + Clove + O-Cymen-5-OL + Peppermint + Cocamidopropyl Betaine (CAPB) + mixture of liquid form of oral care formulation

[102] This innovative invention successfully use Coenzyme Q10 (Coenzyme Q10) + Camphor + Clove + O-Cymen-5-OL + Peppermint + Cocamidopropyl Betaine (CAPB) in liquid toothpaste or mouthwash, liquid toothpaste and mouthwash, or a mixture of liquid form of oral care formulation, which coverage is well cover the whole oral cavity including tongue, throat and hidden areas.

[103] Clinical trials have proven that this unique formula of Coenzyme Q10 + Camphor + Clove + Peppermint + O-Cymen-5-OL + CAPB is presented as a liquid form, presented in liquid form, which coverage is well cover the whole oral cavity including tongue, throat and hidden areas. It can quickly relieve gingival pain within 30 seconds, quickly kill bacteria and fungi on the mucous membranes of the throat and in oral cavity, reduce the growth of oral bacteria, eliminate bad breath, effectively reduce the possibility of tooth decay, help the gums, tongue and throat anti-inflammatory and analgesic, prevent redness, swelling and bleeding from inflammation. In addition, it accelerates wound healing and repair periodontal tissue, and prevent periodontal disease. Its reduce of inflammation and pain relieve effect is comparable to the effect of medicine. It offers refresh, moisturizing and comfortable feeling after use. [104] Internationally recognized test certification proves the high efficacy of this unique formula can help eliminate bacteria and fungi within 30 seconds, such as Streptococcus pneumonia, Candida albicans, Pseudomonas aeruginosa, etc.

[105] Note: This innovative formula can also be presented in different forms, such as paste, gel, cream, powder, foam, etc.

[106] 8. The 8th innovative and natural ingredient formula: Coenzyme Q10 + Camphor + Clove + O-Cymen-5-OL + Peppermint + Xylitol + Cocamidopropyl Betaine (CAPB) + mixture of liquid form of oral care formulation

[107] This innovative invention successfully use Coenzyme Q10 + Camphor +

Clove + O-Cymen-5-OL + Peppermint + Xylitol + Cocamidopropyl Betaine (CAPB) in liquid toothpaste or mouthwash, liquid toothpaste and mouthwash, or a mixture of liquid form of oral care formulation, which coverage is well cover the whole oral cavity including tongue, throat and hidden areas.

[108] Clinical trials have proven that this unique formula with Coenzyme Q10 + Camphor + Clove + O-Cymen-5-OL + Peppermint + Xylitol + CAPB can quickly kill bacteria and fungi on the mucous membranes of the throat and in oral cavity within 30 seconds, reduce the growth of oral bacteria, eliminate bad breath, help the gums, tongue, and throat to reduce inflammation and pain, prevent redness, swelling and bleeding in the inflamed area, and can significantly accelerate wound healing and repair periodontal tissue, preventing periodontal disease. In addition, it helps maintain a neutral pH in the oral cavity, helps prevent bacteria from adhering to the teeth, reduce the amount of bacteria in the mouth, and prevent tooth decay. Its reduce of inflammation and pain relieve benefit is comparable to the effect of medicine. It offers refresh, moisturizing and comfortable feeling after use.

[109] Note: This innovative formula can also be presented in different forms, such as paste, gel, gel, powder, foam, etc.

[110] 9. The 9th innovative and natural ingredient formula: Coenzyme Q10 + Camphor + Clove + O-Cymen-5-OL + Peppermint + Xylitol + Menthol + Cocamidopropyl Betaine (CAPB) + mixture of liquid form of oral care formulation.

[111] This innovative invention successfully use Coenzyme Q10 + Camphor +

Clove + O-Cymen-5-OL + Peppermint + Xylitol + Menthol + Cocamidopropyl Betaine (CAPB) in liquid toothpaste or mouthwash, liquid toothpaste and mouthwash, or a mixture of liquid form of oral care formulation, which coverage is well cover the whole oral cavity including tongue, throat and hidden areas. [112] Clinical trials have shown that this innovative invention is formulated with Coenzyme Q10 + Camphor + Clove + O-Cymen-5-OL + Peppermint + Xylitol + Peppermint + CAPB in liquid form, which coverage is well cover the whole oral cavity including tongue, throat and hidden areas. This invention will help maintain your oral health. This scientific result has the following benefits:

[113] This innovative formulation provides “All-round Dental and Oral Care ” which combined mouthwash and liquid toothpaste into the same form in liquid. Its’ benefits coverage areas include teeth, gum, and extends to tongue, throat, and lips all-in-one solution; each of these effect is distinctive.

[114] This innovative formulation provides 8-in-One “multi-functions” and benefits to maintain oral health, which unique formula is “CASE-RRPP”: (i) Cleansing, remove of plaque, (ii) Reduce inflammation of the whole oral including gum and throat, (iii) Soothing redness and pain relief, (iv) Elimination of bacteria, (v) Reduce gum bleeding, (vi) Repair and foster recovery, (vii) Preventive of oral caries and periodontal disease, (vi) Protection of oral health.

[115] Rapidly eliminate pathogens, such as kill bacteria and fungi on the mucous membranes of the throat and in oral cavity within 30 seconds.

[116] It can quickly exert analgesic, anti-inflammatory, antioxidant and coagulation effects. Soothing gum inflammation, soreness, tissue repair and healing effectively.

[117] It can effectively remove dental plaque and reduce the accumulation of dental plaque, effectively prevent periodontitis and help reverse periodontal disease.

[118] It can effectively relieve root canal inflammation; the effect is comparable to the effect of medicine. (Clinical trial, usage of 2 to 4 days of this formulation will eliminate the pain; average 3 days)

[119] It can effectively help people with sensitive teeth. (Clinical trial, usage of this formulation within 2 to 4 days, it helps eliminate the feeling of tooth numbness; average 3 days. Elderly users have been using this innovative formulation for 6 to 12 months are without the feeling of tooth numbness and pain anymore.)

[120] Helps maintain a neutral pH in the oral cavity, quickly resist and eliminate common oral bacteria, and reduce the formation of plaque.

[121] Reduce the opportunity of tooth decay and gum disease.

[122] Effectively prevent periodontal disease, effectively reduce the growth of bacteria in the mouth, and eliminate bad breath.

[123] Effectively relieve pharyngitis (throat inflammation) and relieve pain. [124] Effectively relieve endostomatitis ulcers and lip sores, reduce redness and swelling, and have a significant effect on promoting the healing of infected areas.

[125] Proved by internationally recognized testing, this unique formula can eliminate Streptococcus pneumoniae, Candida albicans, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhimurium, etc. within 30 seconds.

[126] This unique formula may reduce the risk of respiratory tract infections due to airborne viral or bacterial transmission and is especially useful during pandemic.

[127] This formula contains alcohol-free, methyl salicylate-free, fluorine-free, and is formulated with natural ingredients, which is mild in nature and strengthens the protective barrier of the oral mucosa. Suitable for a wide range of people, especially for people who has low immunity.

[128] It offers cool, deeply clean, moisturizing and reliable feeling after use.

[129] This innovative formulation is suitable for vegetarians. It is free of lard and lard derivatives (tested by SGS in Dubai; SGS Gulf Limited (JAFZ BR.)), Method: Real- time-PCR, In-house method-FL-SOP - Tech-081, Test Report DA19-10781.001.R0. )

[130] Clinical test results indicated this innovative formulation offers breakthrough effects:

[131] People who have root canal inflammation. The level of painful impacts the daily lifestyle and emotion while eating, brushing, touching or sleeping. After usage of the innovative formulation, pain is relieved in 2 to 4 days, and eliminate of pain thereafter when keep using this formulation.

[132] People who have periodontal diseases, the inflammation and swelling of the gums can be quickly reduced and relieved.

[133] People who have periodontal diseases, it reduces bleeding while brushing teeth, and bleeding situation is ceased thereafter.

[134] People who have sensitive teeth, tooth numbness and pain will relieve after usage of 3 days of this formulation. Past experience was painful when eating cold and hot drink or food. (Users have participated in clinical testing for 12 months.)

[135] People have oral endostomatitis after radiation therapy. Oral endostomatitis occurs every six to eight weeks, and normal recovery period took 7-10 days. After the users use this formulation, immediately feel cooling sensation, soothing redness, reduce inflammation, and relieve pain. The ulcer site has begun to wither and heal, after 2 - 3 days after using this formula. [136] The recovery speed of cheil sore is very fast, average recovery in 2 to 3 days after using this innovative formulation. The cheil sore will quickly heal and recover. It can cool and dissipate heat, reducing the tingling feeling of inflammation of cheil sores. (The normal recovery period is 7 to 10 days with intake of medicines in spray or cream.)

[137] No oral decay is diagnosed by a dentist 12 months after using this innovative formulation.

[138] Note: This innovative formula can also be presented in different forms, such as paste, gel, gel, powder, foam, etc.

[139] PRODUCTION METHOD :

1) Dissolve. 2) Mixture of all ingredients. 3) Sanitize packaging bottles. 4) Vacuum packaging

[140] One embodiment

1. Simply Demand for Change: -

[141] Pursue a Simple and Convenient Lifestyle, Natural Ingredients, Free from chemicals

[142] Traditional toothpaste comes in the form of paste or gel, which is actually convenient to use, but it has only one main function - cleaning teeth, that does not sufficiently able to eliminate bacteria and remove plaque.

[143] In fact, most people only brush their teeth with toothpaste morning and night, not everyone would use flosses and mouthwash. Oral diseases have affected nearly 4 billion people worldwide. There may be many reasons for not using mouthwash. For example, people live in a fast pace environment, work in long hours and in-balance lifestyle. They would rather take 5 minutes for sleeping, rather than opt for using mouthwash. Another reason could be people do not like the strong chemical smelling of mouthwash, which has burning feeling from its alcohol ingredient. Other reasons could be mouthwash is not recommended to use frequently or longer than 30 seconds, otherwise it may cause damage to the oral mucosa and so on.

[144] This innovative invention can completely solve the various difficulties that exist today:

[145] This innovative invention is the first successful liquid toothpaste in the world, which is presented in the form of liquid and combined with mouthwash.

[146] Experiments have shown that liquid toothpaste has broad applications and is more convenient than traditional toothpaste. It can also effectively help people who don't floss remove dirt and plaque. (Note: This liquid formulation could not completely replace the benefits of flossing.) Traditional toothpaste may contain particles, which may damage the surface of enamel and calculus resulting possible capture of plaque. This innovative formulation provides gentle foam without any particles, leaving your teeth feeling smooth and protective layer after use.

[147] This invention is a revolutionary dental and oral care formulation. This All- rounded Dental and Oral Care revolutionary formula ("CASE-RRPP") provides 8-in-One benefits. It provides (i) Cleansing, remove of plaque, (ii) Reduce inflammation of the whole oral including gum and throat, (iii) Soothing redness and pain relief, (iv) Elimination of bacteria, (v) Reduce gum bleeding, (vi) Repair and foster recovery, (vi) Preventive of oral caries and periodontal disease, (vii) Protection of oral health.

[148] (3) This invention combined mouthwash and liquid toothpaste in the same form of liquid, it provides convenience to some users who have wounds or post oral surgery, or wear braces, as they may not be inconvenient to use toothpaste to brush their teeth. In addition, this formulation uses natural ingredients, alcohol-free, it reduces the irritation for those users.

[149] (4) The revolutionary formulation allows people with a busy life to enjoy oral hygiene and hygiene protection at the same time.

[150] (5) This formulation uses a unique natural herbal formula, which is alcohol-free and chemical -free, which can achieve bactericidal effect without damaging the oral mucosa.

[151] (6) No alcohol, no burning sensation. Unique natural herbal formula can also help wound healing.

[152] (7) Innovative oral care can achieve simplicity, convenience, effectiveness, and convenience in lifestyle. It also helps reduce the occurrence of periodontal problems.

[153] (8) This oral care formulation provides a mild and gentle foam, it does not contain any particles that may damage tooth enamel, users will feel smooth and protected tooth surface after using this liquid toothpaste.

[154] This oral care formulation has been tested by The Hong Kong Standards and Testing Centre Ltd, report number HC21020672, report date: 25-2-2021, method used:

ASTM E2315-2016 (contact time: 30 seconds and 1 minute) Antibacterial efficacy against:

(1) Streptococcus pneumoniae: 99.9998% (30 seconds)

(2) Candida albicans: 99.9999% (30 seconds)

(3) Pseudomonas aeruginosa: 99.9999% (30 seconds)

(4) Salmonella typhimurium: 99.1121% (30 seconds), 99.6449% (1 minute) (5) Staphylococcus aureus: 68.4211% (30 seconds), 72.3077% (1 minute)

[155] 2. ASPECTS OF EMBODIMENTS OF THE INVENTION

[156] 2.1) The characteristics and purposes of this oral care formulation invention are mainly to alleviate the existing oral problems, innovate, strive for improvement, and invent an oral care product that is safe and harmless to human beings. Details are described as follows:

(1) The purpose of invention was to study the problem of oral diseases, which have affected nearly 4 billion people worldwide.

(2) Attempt to find solutions to complement the needs and deficiencies between dental patients and dentists. It is not possible for the user to see the dentist every day for areas such as anti-inflammatory, analgesic, reduce redness and help to suppress bleeding, speed up repair of gum damage and help healing of wound due to radiation therapy, post oral surgery, etc.

(3) The goal is to develop a "multi-functions " and "All-in-one" mouthwash and tooth cleaning oral care to help contribute to human health. Research results showed 8-in-One "multi-functional" and "All-rounded oral care" mouthwash and liquid toothpaste were successfully produced.

(4) Effectively relieve and resolve the pain and toothache due to different reasons.

(5) Breakthrough the tradition form and procedures, bring convenience to people current living habits, and provide an effective solution to oral problems.

(6) This innovative invention provides simple and ease of use all-in-one oral care in daily routine, reduce plaque buildup and cope with oral diseases.

(7) Use natural herbal ingredients as targeted to invent oral products that are harmless and beneficial to the human body.

(8) Help remove plaque, kill viruses and bacteria with high efficacy. Its unique formula can effectively prevent periodontal problems.

(9) This formulation also helps protect the oral health and overall for special group of people. For example, dental patients who are waiting for dentist surgery, people who have sensitive teeth, oral ulcers, those people who have low immunity people, healthcare professional who have higher risks of being infected.

(10) Alcohol-free, reducing irritation and damage to the oral mucosa and gums.

(11) Effectively reduce the formation and accumulation of plaque, prevent periodontitis, and relieve periodontal disease. (12) Helps reduce inflammation (including sore throat), and speed up the repair of gum problems.

(13) Effectively reduce the chance of tooth decay and gum disease.

(14) High-efficacy in antibacterial, fight against the growth of bacteria.

(15) Possibly reduce the risk of bacterial infection via air-born transmission or human contact.

(16) Provide prevention and protection measures.

(17) Simple and convenient to use.

(18) Widely accepted by people of different age groups and religious groups.

(19) Clinical trials, more than 90% of users are satisfied and effective.

(20) Internationally tested and certified to effectively eliminate oral bacteria and fungi.

(21) Achieve the invention goals for safety, simplicity, effectiveness, prevention and protection.

[157] The above details are the goals for the scientific invention and this oral care formulation has successfully achieved the goals and exceeds the original expected result.

[158] 2.2) According to the American Oral Health Association, 77% of American adults over the age of 30 are suffered from periodontitis, and there is an urgent need to make oral health a routine part of clinical practice.

[159] 2.3) Human infection of viruses or fungi through different routes of transmission: Viruses or fungi may be detected in the oral cavity of cancer patients, HIV patients; through human-to-human contact by health care personnel; in men and women with vaginal yeast infection People may be infected after having sex. Common areas of the body where Candida albicans is infected include the skin, genitals, throat, mouth, and blood. This formulation can solve this problem, and its unique formula has been tested for its high efficacy against viruses and fungus:

[160] Tested by The Hong Kong Standards and Testing Centre Ltd, report number HC21020672, report date: 25-2-2021, method used: ASTM E2315-2016 (contact time: 30 seconds and 1 minute) Antibacterial efficacy against:

[161] (5) Streptococcus pneumoniae: 99.9998% (30 seconds)

[162] (6) Candida albicans: 99.9999% (30 seconds)

[163] (7) Pseudomonas aeruginosa: 99.9999 % (30 seconds)

[164] (8) Salmonella typhimurium: 99.1121% (30 seconds), 99.6449% (1 minute)

[165] (5) Staphylococcus aureus: 68.4211% (30 seconds), 72.3077% (1 minute) [166] 3. GLOBAL AWARENESS FOR ORAL CARE IN RELATION TO

WHOLE BODY HEALTH

[167] 3.1 Streptococcus Pneumoniae Infection

[168] Streptococcus pneumoniae resides asymptomatically in healthy carriers typically colonizing the respiratory tract, sinuses, and nasal cavity. However, in susceptible individuals with weaker immune systems, such as the elderly and young children, the bacterium may become pathogenic and spread to other locations to cause disease. It spreads by direct person-to-person contact via

[169] respiratory droplets and by auto inoculation in persons carrying the bacteria in their upper respiratory tracts. Streptococcus pneumoniae is the main cause of community acquired pneumonia and meningitis in children and the elderly. These invasive pneumococcal diseases include bronchitis, rhinitis, acute sinusitis, otitis media, conjunctivitis, meningitis, sepsis, osteomyelitis, septic arthritis, endocarditis, peritonitis, pericarditis, cellulitis, and brain abscess.

[170] According to the World Health Organization (WHO), Streptococcus pneumoniae infection is the leading cause of total deaths among vaccine-preventable diseases.

[171] It has been tested and proven that this innovative oral care formulation can eliminate 99.9998% of Streptococcus pneumoniae within 30 seconds, it may help reduce the risks of being infected via airborne transmission or contact.

[172] 3.2 Oral Candidiasis Detected in Oral:

[173] 3.2.1 Oral candidiasis, also known as oral thrush, is candidiasis that occurs in the mouth. That is, oral candidiasis is a mycosis (yeast/fungal infection) of Candida species on the mucous membranes of the mouth. Candida albicans is the most commonly implicated organism in this condition. Candida albicans is carried in the mouths of about 50% of the world's population as a normal component of the oral micro biota. Acute pseudomembranous candidiasis is a classic form of oral candidiasis, commonly referred to as thrush.

[174] It has been tested and proven that this innovative oral care formulation can effectively eliminate bacteria and fungus in 30 seconds (Candida albicans, and Pseudomonas aeruginosa at 99.9999%).

[175] 3.2.2 Erythematous (atrophic) candidiasis is when the condition appears as a red, raw-looking lesion. Some sources consider denture-related stomatitis, angular stomatitis, median rhomboid glossitis, and antibiotic-induced stomatitis as subtypes of erythematous candidiasis, since these lesions are commonly erythematous/atrophic. It has been tested and proven that this oral care formulation can effectively eliminate bacteria and fungus in 30 seconds (Candida albicans at 99.9999%).

[176] 3.2.3 Some sources state that erythematous candidiasis accounts for 60% of oral candidiasis cases. Where it is associated with inhalation steroids (often used for treatment of asthma), erythematous candidiasis commonly appears on the palate or the dorsum of the tongue. On the tongue, there is loss of the lingual papillae (depopulation), leaving a smooth area. This innovative oral care formulation can solve this problem as its unique formula has been tested and proven of its high efficacy in killing virus and fungus (Candida albicans).

[177] 3.3 Side Effect from Long Term Medicine:

[178] Acute erythematous candidiasis usually occurs on the dorsum of the tongue in persons taking long term corticosteroids or antibiotics, but occasionally it can occur after only a few days of using a topical antibiotic. This is usually termed "antibiotic sore mouth", "antibiotic sore tongue", or "antibiotic-induced stomatitis" because it is commonly painful as well as red. Chronic erythematous candidiasis is more usually associated with denture wearing (see denture-related stomatitis).

[179] This formulation can solve this problem as its unique formula has been tested and proven of its high efficacy in killing virus and fungus (Candida albicans), also its unique formula offers healing and reduce inflammation from gum diseases.

[180] This innovative oral care formulation can help can solve the abovementioned problems as its unique formula has been tested and proven of its high efficacy in eliminate bacteria and fungus. Using this liquid toothpaste, it may accelerate the repair and speedy recovery in 1 - 3 days (or 2 days in average), which offers faster recovery by 3 times than common treatment.

[181] 3.5 Pseudomonas aeruginosa

[182] Pseudomonas aeruginosa is an immunocompromised opportunistic pathogen that typically affects the lungs and urinary tract, or causes wounds and other blood infections such as sepsis. Pseudomonas aeruginosa can also cause pneumonia. Pseudomonas aeruginosa is one of the bacteria that needs to be isolated in many studies of respiratory-related pneumonia. About 10% of nosocomial infections are caused by Pseudomonas aeruginosa. The lungs patients with cystic fibrosis are the first group to be infected with Pseudomonas aeruginosa. It is also one of the bacteria that causes dermatitis. Pseudomonas aeruginosa can damage human nasal ciliary function and destroy pyocyanin (pyocyanin) of respiratory epithelium, which is one of the pro-inflammatory factors. Pseudomonas aeruginosa is an opportunistic infection. The pathogen does not cause disease when parasitizing a healthy host with normal immune function, but invades the host when the host is immunocompromised.

[183] This innovative formulation has been tested and certified by an internationally recognized test and can effectively eliminate Pseudomonas aeruginosa by 99.9999% within 30 seconds.

[184] 4. NEEDS FOR TRANSFORMATION

[185] This formulation of mouthwash and liquid toothpaste is presented in is a liquid, clear water, all-in-one (“CASE-RRPP”) formula.

[186] This innovative formulation can help people with periodontitis, periodontal disease, sensitive teeth, or people with dentures and braces to clean their teeth easily and painlessly. It also helps prevent and enhance protective oral care products that help reduce the spread of viruses and bacteria. It's made from natural ingredients, it is alcohol-free, it's free of methyl salicylate, and its mild formula allows users to use it regularly.

[187] It is "multi-functional" and "all-in-one" benefits that offer people who are in need. Mouthwash can be used alone for gargling and disinfection, or in combination with liquid toothpaste. It provides the option to people who may want to use it after lunch, after smoking or before any face-to-face appointment. It applies to the occupational needs of patients, healthcare professionals, and certain individuals. Suitable for all ages (10+) for regular use. Easy to use and highly provides oral health and protection.

[188] This Superior Liquid Toothpaste Coenzyme Q10 is in liquid form, clear like water, it integrates with mouthwash carrying multifunction (“CASE-RRPP”). It helps people wearing denture and braces to cleansing teeth and easily. It helps reduce transmission of virus and bacteria. It is made by natural ingredients, free from alcohol, free from Methyl Salicylate, its’ mild formula enables users use it frequently.

[189] Its multifunction offer to people who have the need, can be used for single purpose for mouthwash and disinfection, or to combined with cleansing. Suitable for patients, healthcare people, and some people occupational needs.

[190] Suitable for frequent usage by all ages of people (age above 10). Convenient to use, highly offer oral health and protection.

[191] This inventive oral care formulation, exerts its antibacterial effect against bacteria and fungi, helps reduce the possibility of virus and bacterial transmission, and provides comprehensive oral protection. [192] It is high Efficacy: antimicrobial effectiveness against bacteria and fungus, help reduce the probability of virus and bacteria transmission, and offers overall oral cavity protection.

[193] This formulation has been tested by The Hong Kong Standards and Testing Center Ltd, Report No. HC21020672, Report date: 25-2-2021.

[194] Method used: ASTM E2315-2016 (contact time: 30 seconds and 1 minute) for antimicrobial effectiveness against: i) Streptococcus pneumoniae: 99.9998% (30 seconds) ii) Candida albicans: 99.9999% (30 seconds) iii) Pseudomonas aeruginosa: 99.9999% (30 seconds)

[195] iv) Salmonella typhimurium: 99.1121% (30 seconds), 99.6449% (1 minute)

[196] v) Staphylococcus aureus: 68.4211% (30 seconds), 72.3077% (1 minute)

[197] 5. REVOLUTIONARY DESIGN AND BREAKTHROUGH EFFECTS

[198] 5.1 This is a revolutionary oral care invention. It successfully covers the entire oral cavity with pure water-like liquid toothpaste, which can fully penetrate between the teeth and difficult-to-reach niche areas, offer all round and comprehensive oral and gum protection. It can solve gum problems such as dental plaque, tooth decay and periodontal disease, which is resulted by deficient daily oral due from traditional approach. It’s particularly helpful for people who have braces, and to those people who have periodontal disease or people who habitually do oral cleaning deficiently, etc.

[199] 5.2 This is a revolutionary design, firstly take the liquid toothpaste for mouth wash, then brush teeth and protect gum health. Particularly helpful for consumers who do not habitually use dental floss, and result in plaque or tartar formation. (Note: This product cannot completely replace the effect of dental floss)

[200] 5.3 The unique formula is designed to combine the single purpose of traditional toothpaste and mouthwash. Users feel clean, cool, comfortable and moisturizing after use.

[201] 5.4 The newly designed liquid toothpaste has a breakthrough effect. The unique formula offers disinfection, cleansing and anti-inflammatory effect, reduces the formation of plaque, and relieve gum problems, refers to "CASE-RRPP" unique formula. This formulation has been proven to have antimicrobial effects, such as Streptococcus pneumoniae, Candida albicans, Pseudomonas aeruginosa, Salmonella typhimurium, and Staphylococcus aureus (tested by The Hong Kong Standards and Testing Center Ltd, Report No. HC21020672, Report date: 25-2-2021, Method used: ASTME2315-2016 (contact time: 30 seconds and 1 minute).

[202] 5.5 Using natural herbal ingredients, gentle in nature, do not damage the tooth enamel. Does not contain alcohol and protects the oral mucosa. Does not contain Methyl Salicylate, avoid excessive external use and poisoning. Coenzyme Q10 helps reduce inflammation and repair.

[203] gum tissue. In addition to effective disinfection and comprehensive oral protection (including the throat, tongue and oral cavity areas), it accelerates a repair effect on common gum damage.

[204] 6. INNOVATIVE NATURAL INGREDIENT FORMULA AND

RECOMMEND TO USE

[205] More and more people who are suffering from periodontitis are increasing. Understanding majority people habitually focus on daily oral cleansing purely by traditional toothpaste, they aspire for a good oral care but without a good and convenient oral care solution.

[206] This innovative oral care formulation is designed for multifunction. It aims to breakthrough traditional toothpaste with single function. It combined the traditional products of mouthwash and liquid toothpaste into one product to meet the "CASE-RRPP” objectives. It is made of natural ingredients, alcohol-free, Methyl Salicylate-free, and not consists of lard and lard derivatives.

[207] As traditional toothpaste or mouthwash contains alcohol and chemical, the frequency of use and length of usage (gargling) are limited. This innovative formulation is designed with innovative natural ingredients, which are favorable to people to use as daily oral care, and when there is a need such as people in healthcare or other occupational professions to reduce the probability of infection via transmission of virus or bacteria. It can be single used as mouthwash before and after patient care. ‘ Superior and innovative Liquid Toothpaste Coenzyme Q10’ has been tested and proven to have a high efficacy in antimicrobial effectiveness, such as Streptococcus pneumoniae, Candida albicans, Pseudomonas aeruginosa, Salmonella typhimurium, and Staphylococcus aureus.

Claims

CLAIMS:

1. An oral care formulation comprising: an effective amount of Coenzyme Q10 in liquid form.

2. An oral care formulation comprising: an effective amount of Coenzyme Q10 in liquid form; and an effective amount of Cocamidoproply Betaine in liquid form.

3. An oral care formulation comprising: an effective amount of Camphor in liquid form; an effective amount of O-Cymen-5-OL in liquid form; and an effective amount of Cocamidoproply Betaine in liquid form.

4. An oral care formulation comprising: an effective amount of Coenzyme Q10 in liquid form; an effective amount of Camphor in liquid form; an effective amount of O-Cymen-5-OL in liquid form; and an effective amount of Cocamidoproply Betaine in liquid form.

5. An oral care formulation comprising: an effective amount of Clove in liquid form; an effective amount of O-Cymen-5-OL in liquid form; and an effective amount of Cocamidoproply Betaine in liquid form.

6. An oral care formulation comprising: an effective amount of Coenzyme Q10 in liquid form; an effective amount of Camphor in liquid form; an effective amount of Clove in liquid form; an effective amount of O-Cymen-5-OL in liquid form; and an effective amount of Cocamidoproply Betaine in liquid form.

7. An oral care formulation comprising: an effective amount of Coenzyme Q10 in liquid form; an effective amount of Camphor in liquid form; an effective amount of Clove in liquid form; an effective amount of Peppermint in liquid form; an effective amount of O-Cymen-5-OL in liquid form; and an effective amount of Cocamidoproply Betaine in liquid form.

8. An oral care formulation comprising: an effective amount of Coenzyme Q10 in liquid form; an effective amount of Camphor in liquid form; an effective amount of Clove in liquid form; an effective amount of Peppermint in liquid form; an effective amount of Xylitol in liquid form; an effective amount of Cocamidoproply Betaine in liquid form; and an effective amount of O-Cymen-5-OL in liquid form.

9. An oral care formulation comprising: an effective amount of Coenzyme Q10 in liquid form; an effective amount of Camphor in liquid form; an effective amount of Clove in liquid form; an effective amount of Peppermint in liquid form; an effective amount of Xylitol in liquid form; an effective amount of Menthol in liquid form; an effective amount of Cocamidoproply Betaine in liquid form; and an effective amount of O-Cymen-5-OL in liquid form.

10. An oral care formulation comprising: an effective amount of Coenzyme Q10; and an effective amount of Cocamidoproply Betaine; wherein the formulation is mixed in a form of liquid, paste, gel, cream, powder, or foam.

11. An oral care formulation comprising: an effective amount of Camphor; an effective amount of O-Cymen-5-OL; and an effective amount of Cocamidoproply Betaine; wherein the formulation is mixed in a form of liquid, paste, gel, cream, powder, or foam.

12. An oral care formulation comprising: an effective amount of Coenzyme Q10; an effective amount of Camphor; an effective amount of O-Cymen-5-OL; and an effective amount of Cocamidoproply Betaine; wherein the formulation is mixed in a form of liquid, paste, gel, cream, powder, or foam.

13. An oral care formulation comprising: an effective amount of Clove; an effective amount of O-Cymen-5-OL; and an effective amount of Cocamidoproply Betaine; wherein the formulation is mixed in a form of liquid, paste, gel, cream, powder, or foam.

14. An oral care formulation comprising: an effective amount of Coenzyme Q10; an effective amount of Camphor; an effective amount of Clove; an effective amount of O-Cymen-5-OL; and an effective amount of Cocamidoproply Betaine; wherein the formulation is mixed in a form of liquid, paste, gel, cream, powder, or foam.

15. An oral care formulation comprising: an effective amount of Coenzyme Q10; an effective amount of Camphor; an effective amount of Clove; an effective amount of Peppermint; an effective amount of O-Cymen-5-OL; and an effective amount of Cocamidoproply Betaine; wherein the formulation is mixed in a form of liquid, paste, gel, cream, powder, or foam.

16. An oral care formulation comprising: an effective amount of Coenzyme Q10; an effective amount of Camphor; an effective amount of Clove; an effective amount of Peppermint; an effective amount of Xylitol; an effective amount of Cocamidoproply Betaine; and an effective amount of O-Cymen-5-OL; wherein the formulation is mixed in a form of liquid, paste, gel, cream, powder, or foam.

17. An oral care formulation comprising: an effective amount of Coenzyme Q10; an effective amount of Camphor; an effective amount of Clove; an effective amount of Peppermint; an effective amount of Xylitol; an effective amount of Menthol; an effective amount of Cocamidoproply Betaine; and an effective amount of O-Cymen-5-OL; wherein the formulation is mixed in a form of liquid, paste, gel, cream, powder, or foam.