CN101014594A - 哌啶衍生物作为肾素抑制剂 - Google Patents
哌啶衍生物作为肾素抑制剂 Download PDFInfo
- Publication number
- CN101014594A CN101014594A CNA2005800227495A CN200580022749A CN101014594A CN 101014594 A CN101014594 A CN 101014594A CN A2005800227495 A CNA2005800227495 A CN A2005800227495A CN 200580022749 A CN200580022749 A CN 200580022749A CN 101014594 A CN101014594 A CN 101014594A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- base
- alkoxyl group
- group
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1158/04 | 2004-07-09 | ||
CH11582004 | 2004-07-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN101014594A true CN101014594A (zh) | 2007-08-08 |
Family
ID=35448323
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2005800227495A Pending CN101014594A (zh) | 2004-07-09 | 2005-07-11 | 哌啶衍生物作为肾素抑制剂 |
Country Status (15)
Country | Link |
---|---|
US (1) | US20080076766A1 (ja) |
EP (1) | EP1776359B1 (ja) |
JP (1) | JP4842262B2 (ja) |
CN (1) | CN101014594A (ja) |
AR (1) | AR053406A1 (ja) |
AT (1) | ATE521607T1 (ja) |
BR (1) | BRPI0513199A (ja) |
CA (1) | CA2570920A1 (ja) |
ES (1) | ES2372502T3 (ja) |
HK (1) | HK1104037A1 (ja) |
IL (1) | IL180242A0 (ja) |
PL (1) | PL1776359T3 (ja) |
PT (1) | PT1776359E (ja) |
TW (1) | TW200613274A (ja) |
WO (1) | WO2006005741A2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102015682B (zh) * | 2008-05-05 | 2014-07-16 | 埃科特莱茵药品有限公司 | 作为肾素抑制剂的3,4-取代的哌啶衍生物 |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE462703T1 (de) | 2004-08-25 | 2010-04-15 | Actelion Pharmaceuticals Ltd | Bicyclononen-derivate als renin-inhibitoren |
GB0428526D0 (en) | 2004-12-30 | 2005-02-09 | Novartis Ag | Organic compounds |
EP1707202A1 (de) * | 2005-03-31 | 2006-10-04 | Speedel Experimenta AG | Organische Verbindungen |
AR053836A1 (es) * | 2005-03-31 | 2007-05-23 | Speedel Experimenta Ag | Piperdinas 3,4,5-sustituidas |
TW200722424A (en) | 2005-03-31 | 2007-06-16 | Speedel Experimenta Ag | Substituted piperidines |
GB0508992D0 (en) * | 2005-05-03 | 2005-06-08 | Novartis Ag | Organic compounds |
GB0510810D0 (en) * | 2005-05-26 | 2005-06-29 | Novartis Ag | Organic compounds |
KR100963455B1 (ko) | 2005-05-27 | 2010-06-18 | 액테리온 파마슈티칼 리미티드 | 신규한 피페리딘 카르복실산 아미드 유도체 |
GB0514203D0 (en) | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
US8129411B2 (en) | 2005-12-30 | 2012-03-06 | Novartis Ag | Organic compounds |
EP1816122A3 (en) * | 2006-01-19 | 2007-09-19 | Speedel Experimenta AG | 3,4,5-substituted piperidines as therapeutic compounds |
TW200804359A (en) * | 2006-01-19 | 2008-01-16 | Speedel Experimenta Ag | Substituted 4-phenylpiperidines |
TW200821303A (en) * | 2006-08-08 | 2008-05-16 | Speedel Experimenta Ag | Organic compounds |
EP1908761A1 (en) * | 2006-10-04 | 2008-04-09 | Speedel Experimenta AG | Organic compounds |
EP1911758A1 (en) * | 2006-10-04 | 2008-04-16 | Speedel Experimenta AG | Phenyl piperidine derivatives for use as renin inhibitors |
WO2008074450A2 (en) * | 2006-12-20 | 2008-06-26 | Nicox S.A. | Non-peptidic renin inhibitors nitroderivatives |
TWI452044B (zh) * | 2007-06-15 | 2014-09-11 | Mitsubishi Tanabe Pharma Corp | 嗎啉衍生物 |
BRPI0813900A2 (pt) | 2007-06-25 | 2014-12-30 | Novartis Ag | Derivados de n5-(2-etoxietil)-n3-(2-piridinil)-3,5-piperidinodicarboxa mida para uso como inibidores de renina |
TW200922596A (en) * | 2007-10-25 | 2009-06-01 | Speedel Experimenta Ag | 4,4-disubstituted piperidines |
TW200932241A (en) * | 2007-12-05 | 2009-08-01 | Speedel Experimenta Ag | Organic compounds |
AU2009211377A1 (en) * | 2008-02-08 | 2009-08-13 | Novartis Ag | Substituted piperidines as renin inhibitors |
EA201001239A1 (ru) * | 2008-02-08 | 2011-04-29 | Новартис Аг | Замещённые пиперидины в качестве ингибиторов ренина |
WO2009106599A2 (en) * | 2008-02-29 | 2009-09-03 | Novartis Ag | Substituted piperidines as therapeutic compounds |
WO2009127251A1 (en) * | 2008-04-16 | 2009-10-22 | Novartis Ag | Combinations comprising a renin inhibitor |
GEP20135957B (en) | 2008-06-19 | 2013-11-11 | Takeda Pharmaceuticals Co | Heterocyclic compound and usage thereof |
EP2163245A1 (en) | 2008-09-10 | 2010-03-17 | Novartis Ag | Renin inhibitors for the treatment of psoriasis |
US8592454B2 (en) | 2008-09-19 | 2013-11-26 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound and use of same |
US20120035214A1 (en) * | 2009-04-03 | 2012-02-09 | Merck Canada Inc. | Renin inhibitors |
US8563035B2 (en) | 2010-05-05 | 2013-10-22 | Sanovel Ilac Sanayi Ve Ticaret Anomin Sirketi | Oral tablet compositions of dexlansoprazole |
EP2384745A3 (en) * | 2010-05-05 | 2012-01-18 | Sanovel Ilac Sanayi ve Ticaret A.S. | Modified release pharmaceutical compositions of dexlansoprazole |
EP2384746A3 (en) | 2010-05-05 | 2012-03-07 | Sanovel Ilac Sanayi ve Ticaret A.S. | Dual release oral tablet compositions of dexlansoprazole |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997009311A1 (de) * | 1995-09-07 | 1997-03-13 | F. Hoffmann-La Roche Ag | Neue 4-(oxyalkoxyphenyl)-3-oxy-piperidine zur behandlung von herz- und niereninsuffizienz |
US6376672B1 (en) * | 1999-04-27 | 2002-04-23 | Hoffmann-La Roche Inc. | Naphthalenylmethoxypiperidines as renin inhibitors |
US6197959B1 (en) * | 1999-04-27 | 2001-03-06 | Hoffmann-La Roche Inc. | Piperidine derivatives |
AU2002256418A1 (en) * | 2001-04-27 | 2002-11-11 | Vertex Pharmaceuticals Incorporated | Inhibitors of bace |
US20040204455A1 (en) * | 2003-04-10 | 2004-10-14 | Cody Wayne Livingston | Piperidine derivative rennin inhibitors |
-
2005
- 2005-07-08 TW TW094123146A patent/TW200613274A/zh unknown
- 2005-07-08 AR ARP050102851A patent/AR053406A1/es not_active Application Discontinuation
- 2005-07-11 AT AT05761185T patent/ATE521607T1/de active
- 2005-07-11 ES ES05761185T patent/ES2372502T3/es active Active
- 2005-07-11 BR BRPI0513199-5A patent/BRPI0513199A/pt not_active IP Right Cessation
- 2005-07-11 JP JP2007519812A patent/JP4842262B2/ja not_active Expired - Fee Related
- 2005-07-11 CA CA002570920A patent/CA2570920A1/en not_active Abandoned
- 2005-07-11 PL PL05761185T patent/PL1776359T3/pl unknown
- 2005-07-11 US US11/631,777 patent/US20080076766A1/en not_active Abandoned
- 2005-07-11 WO PCT/EP2005/053306 patent/WO2006005741A2/en not_active Application Discontinuation
- 2005-07-11 PT PT05761185T patent/PT1776359E/pt unknown
- 2005-07-11 CN CNA2005800227495A patent/CN101014594A/zh active Pending
- 2005-07-11 EP EP05761185A patent/EP1776359B1/en not_active Not-in-force
-
2006
- 2006-12-21 IL IL180242A patent/IL180242A0/en unknown
-
2007
- 2007-08-14 HK HK07108836.4A patent/HK1104037A1/xx not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102015682B (zh) * | 2008-05-05 | 2014-07-16 | 埃科特莱茵药品有限公司 | 作为肾素抑制剂的3,4-取代的哌啶衍生物 |
Also Published As
Publication number | Publication date |
---|---|
AR053406A1 (es) | 2007-05-09 |
EP1776359A2 (en) | 2007-04-25 |
ATE521607T1 (de) | 2011-09-15 |
CA2570920A1 (en) | 2006-01-19 |
JP4842262B2 (ja) | 2011-12-21 |
PT1776359E (pt) | 2011-12-15 |
ES2372502T3 (es) | 2012-01-20 |
WO2006005741A3 (en) | 2006-07-06 |
IL180242A0 (en) | 2007-07-04 |
BRPI0513199A (pt) | 2008-04-29 |
PL1776359T3 (pl) | 2012-01-31 |
US20080076766A1 (en) | 2008-03-27 |
HK1104037A1 (en) | 2008-01-04 |
TW200613274A (en) | 2006-05-01 |
EP1776359B1 (en) | 2011-08-24 |
JP2008505871A (ja) | 2008-02-28 |
WO2006005741A2 (en) | 2006-01-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C12 | Rejection of a patent application after its publication | ||
RJ01 | Rejection of invention patent application after publication |
Open date: 20070808 |