CL2023002013A1 - Compuestos de isoindolinona - Google Patents

Compuestos de isoindolinona

Info

Publication number
CL2023002013A1
CL2023002013A1 CL2023002013A CL2023002013A CL2023002013A1 CL 2023002013 A1 CL2023002013 A1 CL 2023002013A1 CL 2023002013 A CL2023002013 A CL 2023002013A CL 2023002013 A CL2023002013 A CL 2023002013A CL 2023002013 A1 CL2023002013 A1 CL 2023002013A1
Authority
CL
Chile
Prior art keywords
isoindolinone compounds
compounds
stereoisomers
mammals
compound
Prior art date
Application number
CL2023002013A
Other languages
English (en)
Inventor
Fasching Bernhard
Ryckmans Thomas
Flohr Alexander
Ritzén Andreas
HARVEY Freya
MCALLISTER Laura
Original Assignee
Monte Rosa Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monte Rosa Therapeutics Inc filed Critical Monte Rosa Therapeutics Inc
Publication of CL2023002013A1 publication Critical patent/CL2023002013A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

En la presente, se describe un compuesto o estereoisómeros o sales farmacéuticamente aceptables de este de fórmula (I). Estos compuestos se usan en el tratamiento del crecimiento celular anormal en mamíferos, especialmente humanos.
CL2023002013A 2021-01-13 2023-07-11 Compuestos de isoindolinona CL2023002013A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH252021 2021-01-13
CH3862021 2021-04-14
CH6552021 2021-06-04
US202163281049P 2021-11-18 2021-11-18

Publications (1)

Publication Number Publication Date
CL2023002013A1 true CL2023002013A1 (es) 2024-01-05

Family

ID=79730447

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2023002013A CL2023002013A1 (es) 2021-01-13 2023-07-11 Compuestos de isoindolinona

Country Status (8)

Country Link
US (2) US11912682B2 (es)
EP (1) EP4277901A1 (es)
JP (1) JP2024504932A (es)
AU (1) AU2022207648A1 (es)
CA (1) CA3208313A1 (es)
CL (1) CL2023002013A1 (es)
IL (1) IL304325A (es)
WO (1) WO2022152821A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023069700A1 (en) * 2021-10-22 2023-04-27 Monte Rosa Therapeutics, Inc. Compounds that mediate protein degradation and methods of use thereof
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WO2024015855A1 (en) * 2022-07-13 2024-01-18 Monte Rosa Therapeutics, Inc. COMBINATION THERAPY COMPRISING GSPT1-DIRECTED MOLECULAR GLUE DEGRADERS AND PI3K/AKT/mTOR PATHWAY INHIBITORS
WO2024015565A1 (en) * 2022-07-14 2024-01-18 Monte Rosa Therapeutics, Inc. Methods of preparing an isoindolinone derivative and crystal forms thereof
WO2024054832A1 (en) * 2022-09-09 2024-03-14 Innovo Therapeutics, Inc. CK1α AND DUAL CK1α / GSPT1 DEGRADING COMPOUNDS

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