BR112016013347A8 - anticorpo monoclonal humano neutralizante anti-il-33,composição farmacêutica,inibidor da expressão de citocinas,epitopo,molécula de ácido nucleico,vetor,célula hospedeira,método de produção e uso dos mesmos. - Google Patents

anticorpo monoclonal humano neutralizante anti-il-33,composição farmacêutica,inibidor da expressão de citocinas,epitopo,molécula de ácido nucleico,vetor,célula hospedeira,método de produção e uso dos mesmos. Download PDF

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BR112016013347A8
BR112016013347A8 BR112016013347A BR112016013347A BR112016013347A8 BR 112016013347 A8 BR112016013347 A8 BR 112016013347A8 BR 112016013347 A BR112016013347 A BR 112016013347A BR 112016013347 A BR112016013347 A BR 112016013347A BR 112016013347 A8 BR112016013347 A8 BR 112016013347A8
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amino acid
acid sequences
neutralizing human
monoclonal antibody
human monoclonal
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BR112016013347A
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BR112016013347B1 (pt
BR112016013347A2 (pt
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Ochi Hiroshi
Yoshikawa Tsutomo
Fujino Yasuhiro
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Mitsubishi Tanabe Pharma Corp
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Publication of BR112016013347B1 publication Critical patent/BR112016013347B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P27/16—Otologicals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

a presente invenção refere-se a um anticorpo tendo efeito antagonista contra il-33, especialmente um anticorpo monoclonal humano neutralizante anti-il-33 isolado, em que as sequências de aminoácidos das regiões de arcabouço (framework) são sequências de aminoácidos que provêm de uma linhagem germinativa ou são uma combinação de sequências de aminoácidos destas, ou um fragmento destas. os epitopos para uma pluralidade de anticorpos monoclonais anti-il-33 foram identificados, anticorpos monoclonais humanos neutralizantes anti-il-33 foram obtidos, e as regiões determinantes de complementaridade que alcançam alta afinidade de ligação a il-33 foram especificadas introduzindo mutações nas regiões determinantes de complementaridade. as regiões determinantes de complementaridade identificadas foram utilizadas para produzir um anticorpo monoclonal humano neutralizante anti-il-33 com regiões framework compreendendo sequências de aminoácidos que são sequências de aminoácidos de uma linhagem germinativa ou uma combinação de sequências de aminoácidos destas.
BR112016013347-1A 2013-12-26 2014-12-26 Anticorpo monoclonal humano neutralizante anti-il-33, composição farmacêutica, inibidor da expressão de citocinas, molécula de ácido nucleico, vetor, célula bacteriana transgênica, método de produção e uso dos mesmos BR112016013347B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2013-270551 2013-12-26
JP2013270551 2013-12-26
JP2014-078223 2014-04-04
JP2014078223 2014-04-04
PCT/JP2014/084695 WO2015099175A1 (ja) 2013-12-26 2014-12-26 ヒト抗ｉｌ－３３中和モノクローナル抗体

Publications (3)

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BR112016013347A2 BR112016013347A2 (pt) 2017-09-26
BR112016013347A8 true BR112016013347A8 (pt) 2018-04-17
BR112016013347B1 BR112016013347B1 (pt) 2023-12-12

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BR112016013347-1A BR112016013347B1 (pt) 2013-12-26 2014-12-26 Anticorpo monoclonal humano neutralizante anti-il-33, composição farmacêutica, inibidor da expressão de citocinas, molécula de ácido nucleico, vetor, célula bacteriana transgênica, método de produção e uso dos mesmos

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US (4) US9758578B2 (pt)
EP (2) EP4223874A3 (pt)
JP (5) JP6159419B2 (pt)
KR (1) KR102400060B1 (pt)
CN (2) CN112079923A (pt)
AU (1) AU2014370883B2 (pt)
BR (1) BR112016013347B1 (pt)
CA (2) CA3190793A1 (pt)
DK (1) DK3088517T3 (pt)
ES (1) ES2963673T3 (pt)
FI (1) FI3088517T3 (pt)
HU (1) HUE064292T2 (pt)
MX (1) MX2016008472A (pt)
PH (1) PH12016501212B1 (pt)
PL (1) PL3088517T3 (pt)
PT (1) PT3088517T (pt)
RU (1) RU2709722C1 (pt)
TW (1) TWI563003B (pt)
WO (1) WO2015099175A1 (pt)

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US11725049B2 (en) 2023-08-15
CA3190793A1 (en) 2015-07-02
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