CL2019001115A1 - Formulación líquida de un conjugado de insulina de acción prolongada. (divisional solicitud 201500177). - Google Patents

Formulación líquida de un conjugado de insulina de acción prolongada. (divisional solicitud 201500177).

Info

Publication number
CL2019001115A1
CL2019001115A1 CL2019001115A CL2019001115A CL2019001115A1 CL 2019001115 A1 CL2019001115 A1 CL 2019001115A1 CL 2019001115 A CL2019001115 A CL 2019001115A CL 2019001115 A CL2019001115 A CL 2019001115A CL 2019001115 A1 CL2019001115 A1 CL 2019001115A1
Authority
CL
Chile
Prior art keywords
long
oxintomodulin
liquid formulation
divisional application
low density
Prior art date
Application number
CL2019001115A
Other languages
English (en)
Inventor
Sung Youb Jung
Jin-Sun Kim
Myung Hyun Jang
Sang Hyun Lee
In Young Choi
Se Chang Kwon
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49997578&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2019001115(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of CL2019001115A1 publication Critical patent/CL2019001115A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
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    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Biotechnology (AREA)

Abstract

UNA COMPOSICIÓN PARA PREVENIR O TRATAR LA HIPERLIPIDEMIA, EL HÍGADO GRASO O LA ARTERIOESCLEROSIS QUE COMPRENDE UN DERIVADO DE OXINTOMODULINA COMO INGREDIENTE ACTIVO. EL DERIVADO DE OXINTOMODULINA TIENE UNA GRAN CAPACIDAD PARA ACTIVAR EL RECEPTOR DE GLP-1 Y EL RECEPTOR DE GLUCAGON EN COMPARACIÓN CON LA OXINTOMODULINA NATIVA Y TIENE LOS EFECTOS DE REDUCIR LOS NIVELES DE COLESTEROL EN SANGRE, DE COLESTEROL DE BAJA DENSIDAD Y DE TRIGLICÉRIDOS QUE SE ELEVAN POR LAS DIETAS CON ALTO CONTENIDO EN GRASAS Y DE AUMENTAR LOS NIVELES DE COLESTEROL DE ALTA DENSIDAD Y LA RELACIÓN ENTRE EL COLESTEROL DE ALTA Y BAJA DENSIDAD. POR LO TANTO, EL DERIVADO DE OXINTOMODULINA PUEDE SER EFICAZMENTE USADO PARA EL TRATAMIENTO DE LA HIPERLIPIDEMIA Y DE LAS ENFERMEDADES RELACIONADAS.
CL2019001115A 2012-07-25 2019-04-23 Formulación líquida de un conjugado de insulina de acción prolongada. (divisional solicitud 201500177). CL2019001115A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020120081475A KR101968344B1 (ko) 2012-07-25 2012-07-25 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물

Publications (1)

Publication Number Publication Date
CL2019001115A1 true CL2019001115A1 (es) 2019-06-28

Family

ID=49997578

Family Applications (4)

Application Number Title Priority Date Filing Date
CL2015000177A CL2015000177A1 (es) 2012-07-25 2015-01-23 Composición para el tratamiento de la hiperlipidemia que comprende un derivado de oxintomodulina
CL2017002432A CL2017002432A1 (es) 2012-07-25 2017-09-27 Composición para el tratamiento de la hiperlipidemia que comprende un derivado de oxintomodulina (divisional de solicitud 0177-2015).
CL2019001115A CL2019001115A1 (es) 2012-07-25 2019-04-23 Formulación líquida de un conjugado de insulina de acción prolongada. (divisional solicitud 201500177).
CL2020002262A CL2020002262A1 (es) 2012-07-25 2020-09-01 Formulación líquida de un conjugado de insulina de acción prolongada. (divisional de solicitud 00177-2015)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CL2015000177A CL2015000177A1 (es) 2012-07-25 2015-01-23 Composición para el tratamiento de la hiperlipidemia que comprende un derivado de oxintomodulina
CL2017002432A CL2017002432A1 (es) 2012-07-25 2017-09-27 Composición para el tratamiento de la hiperlipidemia que comprende un derivado de oxintomodulina (divisional de solicitud 0177-2015).

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2020002262A CL2020002262A1 (es) 2012-07-25 2020-09-01 Formulación líquida de un conjugado de insulina de acción prolongada. (divisional de solicitud 00177-2015)

Country Status (25)

Country Link
US (3) US20150182593A1 (es)
EP (3) EP2884994B1 (es)
JP (4) JP2015524427A (es)
KR (1) KR101968344B1 (es)
CN (2) CN104507492B (es)
AR (1) AR091903A1 (es)
AU (2) AU2013293714B2 (es)
BR (2) BR122022025353B1 (es)
CA (2) CA3121985A1 (es)
CL (4) CL2015000177A1 (es)
DK (1) DK3384925T3 (es)
ES (2) ES2942187T3 (es)
HK (1) HK1206280A1 (es)
IL (2) IL236913B (es)
MX (2) MX360024B (es)
MY (2) MY171493A (es)
NZ (2) NZ705384A (es)
PE (1) PE20150633A1 (es)
PH (2) PH12015500158A1 (es)
RU (2) RU2768853C1 (es)
SG (2) SG11201500519UA (es)
TW (3) TWI780493B (es)
UA (1) UA118177C2 (es)
WO (1) WO2014017843A1 (es)
ZA (2) ZA201501238B (es)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101502299B1 (ko) 2011-06-10 2015-03-11 한미사이언스 주식회사 신규한 옥신토모듈린 유도체 및 이를 포함하는 비만 치료용 조성물
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PH12015500158B1 (en) 2015-03-16
US10493132B2 (en) 2019-12-03
TWI661837B (zh) 2019-06-11
ZA201501238B (en) 2019-12-18
CN107854691A (zh) 2018-03-30
EP2884994A4 (en) 2016-07-20
AR091903A1 (es) 2015-03-11
JP2019108394A (ja) 2019-07-04
EP3384925B1 (en) 2020-09-02
RU2015104492A (ru) 2016-09-10
US20160199451A1 (en) 2016-07-14
JP2015524427A (ja) 2015-08-24
RU2642267C2 (ru) 2018-01-24
MY171493A (en) 2019-10-15
BR122022025353B1 (pt) 2023-11-21
IL236913B (en) 2020-05-31
CA2888407C (en) 2021-08-03
CN107854691B (zh) 2021-04-09
IL274106B2 (en) 2023-08-01
ES2842881T3 (es) 2021-07-15
US20180177850A1 (en) 2018-06-28
PH12019501131A1 (en) 2020-09-14
JP2021107403A (ja) 2021-07-29
IL274106A (en) 2020-06-30
EP3384925A1 (en) 2018-10-10
JP2018090595A (ja) 2018-06-14
CL2020002262A1 (es) 2020-11-20
BR112015001596A2 (pt) 2017-08-01
KR20140018462A (ko) 2014-02-13
KR101968344B1 (ko) 2019-04-12
IL236913A0 (en) 2015-03-31
TWI780493B (zh) 2022-10-11
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PH12015500158A1 (en) 2015-03-16
AU2018203729A1 (en) 2018-06-21

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