CL2018001427A1 - Composiciones de anticuerpo injertado con citoquina y métodos para su uso en inmunorregulación. - Google Patents
Composiciones de anticuerpo injertado con citoquina y métodos para su uso en inmunorregulación.Info
- Publication number
- CL2018001427A1 CL2018001427A1 CL2018001427A CL2018001427A CL2018001427A1 CL 2018001427 A1 CL2018001427 A1 CL 2018001427A1 CL 2018001427 A CL2018001427 A CL 2018001427A CL 2018001427 A CL2018001427 A CL 2018001427A CL 2018001427 A1 CL2018001427 A1 CL 2018001427A1
- Authority
- CL
- Chile
- Prior art keywords
- cytokines
- grafted
- antibody
- proteins
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
LA PRESENTE DIVULGACIÓN PROPORCIONA PROTEÍNAS DE ANTICUERPO INJERTADAS CON CITOQUINAS QUE SE UNEN Y ESTIMULAN LA SEÑALIZACIÓN INTRACELULAR A TRAVÉS DEL RECEPTOR DE INTERLEUCINA 10. CON LA CONDICIÓN QUE LAS PROTEÍNAS DE ANTICUERPO INJERTADAS CON CITOQUINAS ENCUENTREN USO PARA MEJORAR LAS RESPUESTAS CELULARES ANTIINFLAMATORIAS Y REDUCIR LOS EFECTOS PROINFLAMATORIOS EN EL TRATAMIENTO, LA MEJORA Y LA PROFILAXIS DE LOS TRASTORNOS RELACIONADOS CON EL SISTEMA INMUNE. ADICIONALMENTE, SE PROPORCIONAN POLINUCLEÓTIDOS Y VECTORES QUE CODIFICAN PROTEÍNAS DE ANTICUERPO INJERTADAS CON CITOQUINAS Y CÉLULAS HOSPEDERAS CAPACES DE PRODUCIR PROTEÍNAS DE ANTICUERPO INJERTADAS CON CITOQUINAS, ASÍ COMO MÉTODOS DE COMBINACIÓN DE PROTEÍNAS DE ANTICUERPO INJERTADAS CON CITOQUINAS CON OTROS AGENTES TERAPÉUTICOS EN EL TRATAMIENTO DEL TRASTORNO RELACIONADO CON EL SISTEMA INMUNE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562263008P | 2015-12-04 | 2015-12-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2018001427A1 true CL2018001427A1 (es) | 2018-07-27 |
Family
ID=57543103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2018001427A CL2018001427A1 (es) | 2015-12-04 | 2018-05-28 | Composiciones de anticuerpo injertado con citoquina y métodos para su uso en inmunorregulación. |
Country Status (25)
Country | Link |
---|---|
US (3) | US10144768B2 (es) |
EP (1) | EP3383891A1 (es) |
JP (2) | JP6794448B2 (es) |
KR (2) | KR102213790B1 (es) |
CN (1) | CN108602870A (es) |
AR (1) | AR106908A1 (es) |
AU (1) | AU2016362777B2 (es) |
BR (1) | BR112018010937A2 (es) |
CA (1) | CA3006477A1 (es) |
CL (1) | CL2018001427A1 (es) |
CO (1) | CO2018005678A2 (es) |
CU (1) | CU20180047A7 (es) |
EA (1) | EA201891341A1 (es) |
EC (1) | ECSP18041733A (es) |
IL (1) | IL259529A (es) |
MA (1) | MA43372A (es) |
MX (1) | MX2018006778A (es) |
PE (1) | PE20181358A1 (es) |
PH (1) | PH12018501160A1 (es) |
RU (1) | RU2018124307A (es) |
SA (1) | SA518391711B1 (es) |
SG (1) | SG11201804259UA (es) |
TW (1) | TW201726716A (es) |
UY (1) | UY37003A (es) |
WO (1) | WO2017093947A1 (es) |
Families Citing this family (13)
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WO2018215937A1 (en) * | 2017-05-24 | 2018-11-29 | Novartis Ag | Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer |
MX2019014023A (es) * | 2017-05-24 | 2020-02-17 | Novartis Ag | Proteinas de anticuerpo injertadas con citocina y metodos de uso en el tratamiento del cancer. |
CN111107868A (zh) * | 2017-05-24 | 2020-05-05 | 诺华股份有限公司 | 抗体细胞因子移植蛋白及使用方法 |
JOP20190271A1 (ar) * | 2017-05-24 | 2019-11-21 | Novartis Ag | بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة |
CN109521192B (zh) * | 2018-11-27 | 2021-07-13 | 柏荣诊断产品(上海)有限公司 | 一种提高胶乳比浊试剂检测灵敏度的方法 |
WO2020181235A1 (en) * | 2019-03-06 | 2020-09-10 | Deka Biosciences, Inc. | Il-10 variant molecules and methods of treating inflammatory disease and oncology |
CN114206383A (zh) * | 2019-06-10 | 2022-03-18 | 武田药品工业株式会社 | 用于抗体生产的细胞培养方法和组合物 |
JP7497417B2 (ja) * | 2019-07-08 | 2024-06-10 | プロジェン・カンパニー・リミテッド | 新規il-10変異体タンパク質及びその用途 |
CN110472294B (zh) * | 2019-07-19 | 2022-09-30 | 河南科技大学 | 一种嫁接涡旋光束的掩模板的设计方法 |
JP2023534847A (ja) | 2020-07-20 | 2023-08-14 | デカ バイオサイエンシーズ, インコーポレイテッド | Il-10を含む二重サイトカイン融合タンパク質 |
EP4247857A1 (en) | 2020-11-23 | 2023-09-27 | Novartis AG | Expression technology for antibody constructs |
WO2022229854A1 (en) | 2021-04-29 | 2022-11-03 | Novartis Ag | Hypersialylating cells |
CN116063570A (zh) * | 2021-11-02 | 2023-05-05 | 广东菲鹏制药股份有限公司 | Il10单体融合蛋白及其应用 |
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AU2014225307A1 (en) | 2013-03-08 | 2015-09-24 | The Curators Of The University Of Missouri | Methods and compositions for the treatment and/or prevention of type 1 diabetes |
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MX2016010174A (es) * | 2014-02-06 | 2016-11-15 | Hoffmann La Roche | Proteinas de fusion de interleucina-10 y usos de las mismas. |
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