CL2015002145A1 - Preparación, usos y formas sólidas de ácido obeticólico (divisional de solicitud n° 3475-2014) - Google Patents

Preparación, usos y formas sólidas de ácido obeticólico (divisional de solicitud n° 3475-2014)

Info

Publication number
CL2015002145A1
CL2015002145A1 CL2015002145A CL2015002145A CL2015002145A1 CL 2015002145 A1 CL2015002145 A1 CL 2015002145A1 CL 2015002145 A CL2015002145 A CL 2015002145A CL 2015002145 A CL2015002145 A CL 2015002145A CL 2015002145 A1 CL2015002145 A1 CL 2015002145A1
Authority
CL
Chile
Prior art keywords
preparation
divisional application
solid forms
acid
obetolic
Prior art date
Application number
CL2015002145A
Other languages
English (en)
Inventor
André Steiner
Poulsen Heidi Waenerlund
Emilie Jolibois
Melissa Rewolinski
Ralf Gross
Emma Sharp
Fiona Dubas-Fisher
Alex Eberlin
Original Assignee
Incercept Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48741553&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015002145(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incercept Pharmaceuticals Inc filed Critical Incercept Pharmaceuticals Inc
Publication of CL2015002145A1 publication Critical patent/CL2015002145A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

FORMA CRISTALINA C DEL ACIDO OBETICOLICO Y SU PROCESO DE PREPARACION, UTIL EN EL TRATAMIENTO O PREVENCION DE UNA AFECCION MEDIADA POR FXR, TAL COMO UN AENFEREMDAD CARDIOVASCULAR, HEPATOPATIA COLESTASICA, ENTRE OTROS. (DIVISIONAL 3475-14)
CL2015002145A 2012-06-19 2015-07-30 Preparación, usos y formas sólidas de ácido obeticólico (divisional de solicitud n° 3475-2014) CL2015002145A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261661531P 2012-06-19 2012-06-19

Publications (1)

Publication Number Publication Date
CL2015002145A1 true CL2015002145A1 (es) 2015-12-11

Family

ID=48741553

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2014003475A CL2014003475A1 (es) 2012-06-19 2014-12-19 Forma c cristalina de acido obeticolico; proceso de preparacion de la forma 1 de acido obeticolico a partir de la forma c cristalina; composicion farmaceutica que comprende a una forma cristalina de acido obeticolico, util para el tratamiento o prevencion de una enfermedad hepatica colestasica, hepatopatia alcoholica y enfermedades cardiovasculares tal como aterosclerosis, entre otras.
CL2015002145A CL2015002145A1 (es) 2012-06-19 2015-07-30 Preparación, usos y formas sólidas de ácido obeticólico (divisional de solicitud n° 3475-2014)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2014003475A CL2014003475A1 (es) 2012-06-19 2014-12-19 Forma c cristalina de acido obeticolico; proceso de preparacion de la forma 1 de acido obeticolico a partir de la forma c cristalina; composicion farmaceutica que comprende a una forma cristalina de acido obeticolico, util para el tratamiento o prevencion de una enfermedad hepatica colestasica, hepatopatia alcoholica y enfermedades cardiovasculares tal como aterosclerosis, entre otras.

Country Status (25)

Country Link
US (8) US9238673B2 (es)
EP (4) EP3992201A1 (es)
JP (6) JP2015521621A (es)
KR (4) KR20150022974A (es)
CN (2) CN111228278A (es)
AU (5) AU2013277429B2 (es)
BR (2) BR122016011808B1 (es)
CA (3) CA3047776C (es)
CL (2) CL2014003475A1 (es)
CO (1) CO7240414A2 (es)
DK (1) DK3336097T3 (es)
EA (2) EA201990211A1 (es)
ES (1) ES2822375T3 (es)
HK (1) HK1211296A1 (es)
IL (3) IL236231A0 (es)
IN (1) IN2014MN02561A (es)
MX (2) MX365059B (es)
NZ (3) NZ734451A (es)
PH (1) PH12014502835A1 (es)
PL (1) PL3336097T3 (es)
PT (1) PT3336097T (es)
SG (3) SG10201607230SA (es)
SI (1) SI3336097T1 (es)
TW (1) TWI673284B (es)
WO (1) WO2013192097A1 (es)

Families Citing this family (164)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072598A1 (en) 2001-03-12 2002-09-19 Roberto Pellicciari Steroids as agonists for fxr
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
NZ734451A (en) 2012-06-19 2018-12-21 Intercept Pharmaceuticals Inc Preparation, uses and solid forms of obeticholic acid
US9982008B2 (en) 2012-06-19 2018-05-29 Intercept Pharmaceuticals, Inc. Preparation and uses of obeticholic acid
CN104853758A (zh) * 2012-11-28 2015-08-19 英特赛普特医药品公司 肺部疾病的治疗
US9814733B2 (en) * 2012-12-31 2017-11-14 A,arin Pharmaceuticals Ireland Limited Compositions comprising EPA and obeticholic acid and methods of use thereof
WO2014169836A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor neuroactive steroids and methods of use thereof
PL2986624T3 (pl) 2013-04-17 2020-11-16 Sage Therapeutics, Inc. Neuroaktywne steroidy 19-NOR do stosowania w sposobach leczenia
US9725481B2 (en) 2013-04-17 2017-08-08 Sage Therapeutics, Inc. 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
US9512165B2 (en) 2013-04-17 2016-12-06 Sage Therapeutics, Inc. 19-nor C3, 3-disubstituted C21-N-pyrazolyl steroids and methods of use thereof
DK3021852T3 (da) 2013-07-19 2021-03-15 Sage Therapeutics Inc Neuroaktive steroider, sammensætninger og anvendelser deraf
CA3235088A1 (en) 2013-08-23 2015-02-26 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
EP3712254A1 (en) 2014-05-28 2020-09-23 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
DK3626725T3 (da) * 2014-05-29 2023-02-27 Bar Pharmaceuticals S R L Cholan-derivater til anvendelse ved behandlingen og/eller forebyggelsen af fxr- og tgr5/gpbar1-medierede sygdomme
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
WO2016045480A1 (zh) * 2014-09-28 2016-03-31 上海源力生物技术有限公司 一种奥贝胆酸的制备方法
SG10202009859YA (en) 2014-10-16 2020-11-27 Sage Therapeutics Inc Compositions and methods for treating cns disorders
EP3206493B1 (en) 2014-10-16 2020-05-06 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
JP6804438B2 (ja) 2014-10-17 2020-12-23 チルドレンズ ホスピタル メディカル センター 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法
AU2015343025A1 (en) 2014-11-06 2017-06-08 Enanta Pharmaceuticals, Inc. Bile acid analogs an FXR/TGR5 agonists and methods of use thereof
DK3221333T3 (da) * 2014-11-19 2019-09-30 Nzp Uk Ltd 6-alfa-alkyl-3,7-dionsteroider som mellemprodukter til fremstilling af steroide FXR-modulatorer
EP3221331B1 (en) 2014-11-19 2019-09-18 Nzp Uk Limited 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators
MX2017006567A (es) 2014-11-19 2018-01-26 Nzp Uk Ltd Esteroides 6.alfa.-alquil-6,7-diona como intermedios para la produccion de moduladores esteroides del receptor x farnesoide (fxr).
TWI686400B (zh) 2014-11-19 2020-03-01 英商Ｎｚｐ英國有限公司 化合物（二）
JP2017535570A (ja) 2014-11-26 2017-11-30 エナンタ ファーマシューティカルズ インコーポレイテッド Ｆｘｒ／ｔｇｒ５アゴニストとしての胆汁酸類似体およびその使用方法
US10208081B2 (en) 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
WO2016086115A1 (en) 2014-11-26 2016-06-02 Enanta Pharmaceuticals, Inc. Tetrazole derivatives of bile acids as fxr/tgr5 agonists and methods of use thereof
US10774108B2 (en) 2014-11-27 2020-09-15 Sage Therapeutics, Inc. Compositions and methods for treating CNS disorders
CN105777835B (zh) * 2014-12-25 2020-02-14 重庆药友制药有限责任公司 一种制备鹅去氧胆酸类似物的方法
CN105801653B (zh) * 2014-12-30 2018-04-17 苏州晶云药物科技有限公司 奥贝胆酸的晶型a及其制备方法
CN105859814A (zh) * 2015-01-23 2016-08-17 江苏奥赛康药业股份有限公司 一种奥贝胆酸化合物及其药物组合物
EP3250210B1 (en) 2015-01-26 2020-12-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
DK3253382T3 (da) 2015-02-06 2022-02-14 Intercept Pharmaceuticals Inc Farmaceutiske sammensætninger til kombinationsterapi
RU2017130466A (ru) 2015-02-11 2019-03-12 Энанта Фармасьютикалс, Инк. Аналоги желчной кислоты в качестве агонистов fxr/tgr5 и способы их применения
CN105985395A (zh) * 2015-02-13 2016-10-05 江苏奥赛康药业股份有限公司 一种奥贝胆酸化合物及含有该化合物的药物组合物
CN105985396A (zh) * 2015-02-16 2016-10-05 苏州泽璟生物制药有限公司 氘代鹅去氧胆酸衍生物以及包含该化合物的药物组合物
ES2935476T3 (es) 2015-02-20 2023-03-07 Sage Therapeutics Inc Esteroides neuroactivos, composiciones y usos de los mismos
CN107530361A (zh) * 2015-03-09 2018-01-02 英特塞普特医药品公司 用于调节骨密度的方法
EP3277286B1 (en) 2015-03-31 2021-04-21 Enanta Pharmaceuticals, Inc. Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof
TN2017000426A1 (en) 2015-04-07 2019-04-12 Intercept Pharmaceuticals Inc Pharmaceutical compositions for combination therapy
CN105777836A (zh) * 2015-04-09 2016-07-20 厦门蔚扬药业有限公司 奥贝胆酸的多晶型物及其制备方法
WO2016168553A1 (en) * 2015-04-17 2016-10-20 Concert Pharmaceuticals, Inc. Deuterated obeticholic acid
PE20180690A1 (es) * 2015-04-27 2018-04-23 Intercept Pharmaceuticals Inc Composiciones de acido obeticolico y metodos de uso
CN106290594B (zh) * 2015-05-27 2020-07-17 中美华世通生物医药科技（武汉）有限公司 测定奥贝胆酸片溶出含量的方法
CN105294801A (zh) * 2015-07-02 2016-02-03 扬子江药业集团南京海陵药业有限公司 6-乙基鹅去氧胆酸异构体的合成及其分离测定方法
CZ2015504A3 (cs) 2015-07-16 2017-01-25 Zentiva, K.S. Krystalické formy obeticholové kyseliny
EP3124080A1 (en) * 2015-07-28 2017-02-01 Merz Pharma GmbH & Co. KGaA Semisynthetic bile acids for injection lipolysis
CN105085597B (zh) * 2015-08-28 2017-03-29 成都百裕制药股份有限公司 一种无定型奥贝胆酸的制备方法
CN106478756A (zh) * 2015-09-02 2017-03-08 中美华世通生物医药科技（武汉）有限公司 Oca-e单晶及其制备方法和用途
CN108348543A (zh) * 2015-09-21 2018-07-31 英特塞普特医药品公司 促进肝再生的方法
KR20180052756A (ko) 2015-09-24 2018-05-18 인터셉트 파마슈티컬즈, 인크. 담즙산 유도체 제조를 위한 방법 및 중간체
EA038665B1 (ru) 2015-10-07 2021-09-30 Интерсепт Фармасьютикалз, Инк. Модуляторы фарнезоидного x-рецептора
CN106589039B (zh) * 2015-10-15 2019-12-17 苏州朗科生物技术股份有限公司 一种奥贝胆酸的制备方法及相关化合物
CN106589038A (zh) * 2015-10-15 2017-04-26 重庆医药工业研究院有限责任公司 一种制备3α,7α-二羟基-6α-乙基-5β-胆烷酸的方法
CN106632564B (zh) * 2015-10-30 2021-04-13 苏州泽璟生物制药股份有限公司 奥贝胆酸盐及其无定形物和药物组合物
CN106668027A (zh) * 2015-11-05 2017-05-17 中美华世通生物医药科技（武汉）有限公司 奥贝胆酸药物组合物及其制备方法
KR20180067699A (ko) 2015-11-06 2018-06-20 인터셉트 파마슈티컬즈, 인크. 오베티콜산 및 이의 유도체의 제조 방법
CN106749466B (zh) * 2015-11-23 2019-05-21 南京济群医药科技股份有限公司 一种高纯度奥贝胆酸的制备方法
CN105315320B (zh) * 2015-11-30 2017-03-08 山东省药学科学院 一种制备奥贝胆酸的方法
CN106810586A (zh) * 2015-12-01 2017-06-09 中美华世通生物医药科技（武汉）有限公司 奥贝胆酸晶型ⅱ及其制备方法和用途
CN106810587A (zh) * 2015-12-01 2017-06-09 中美华世通生物医药科技（武汉）有限公司 制备无定型奥贝胆酸的方法
CN106822005A (zh) * 2015-12-03 2017-06-13 江苏先声药业有限公司 奥贝胆酸组合物及其制备方法
CN106854229A (zh) * 2015-12-08 2017-06-16 陈剑 一类脂肪酸盐,其制备及其在医药上的应用
CN105481925B (zh) * 2015-12-17 2018-06-22 南京济群医药科技股份有限公司 一种奥贝胆酸及其中间体的制备方法
KR20180095070A (ko) * 2015-12-22 2018-08-24 인터셉트 파마슈티컬즈, 인크. 오베티콜산의 다형성 결정질 형태들
CN105399793A (zh) * 2015-12-24 2016-03-16 北京康立生医药技术开发有限公司 一种胆烷酸的制备方法
CN106916195A (zh) * 2015-12-25 2017-07-04 中美华世通生物医药科技（武汉）有限公司 奥贝胆酸中间体的纯化方法
WO2017115324A1 (en) * 2016-01-01 2017-07-06 Lupin Limited Solid forms of obeticholic acid and processes thereof
CN105566429B (zh) * 2016-01-22 2020-12-01 南京长澳医药科技有限公司 一种奥贝胆酸1型的制备方法
CN105646633B (zh) * 2016-01-22 2020-05-26 南京长澳医药科技有限公司 一种制备奥贝胆酸1型的方法
CN105646634A (zh) * 2016-01-29 2016-06-08 中国药科大学 奥贝胆酸杂质的制备方法
WO2017133360A1 (zh) * 2016-02-02 2017-08-10 深圳市塔吉瑞生物医药有限公司 一种甾体类化合物及包含该化合物的组合物及其用途
CN113995755A (zh) * 2016-02-04 2022-02-01 辛多美制药有限公司 氘代多潘立酮组合物和用于治疗病症的方法
EP3414256B1 (en) * 2016-02-10 2022-01-19 Dr. Reddy's Laboratories Limited Purification process involving amine salt of obeticholic acid
US10364267B2 (en) 2016-02-23 2019-07-30 Enanta Pharmaceuticals, Inc. Deuterated bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
WO2017147137A1 (en) 2016-02-23 2017-08-31 Enanta Pharmaceuticals, Inc. Benzoic acid derivatives of bile acid as fxr/tgr5 agonists and methods of use thereof
US10323061B2 (en) 2016-02-23 2019-06-18 Enanta Pharmaceuticals, Inc. Heteroaryl containing bile acid analogs as FXR/TGR5 agonists and methods of use thereof
CN107126419B (zh) * 2016-02-26 2020-06-19 石药集团中诺药业（石家庄）有限公司 一种奥贝胆酸片剂及其制备方法
CN109467585A (zh) * 2016-03-11 2019-03-15 深圳市塔吉瑞生物医药有限公司 用于预防或治疗fxr-介导疾病的胆烷酸化合物
CN107188917A (zh) * 2016-03-15 2017-09-22 正大天晴药业集团股份有限公司 奥贝胆酸盐及其药物组合物
CN105541953B (zh) * 2016-03-15 2017-11-21 成都市新功生物科技有限公司 一种高纯度奥贝胆酸的重结晶纯化方法
EA037330B1 (ru) * 2016-03-28 2021-03-12 Интерсепт Фармасьютикалз, Инк. Лекарственный препарат, полученный путем комбинирования агониста fxr и arb
CN107531744B (zh) * 2016-03-31 2020-03-13 江苏恒瑞医药股份有限公司 一种奥贝胆酸的新结晶形式及其制备方法
US11331273B2 (en) * 2016-03-31 2022-05-17 Intercept Pharmaceuticals, Inc. Film-coated tablet having high chemical stability of active ingredient
JPWO2017170858A1 (ja) * 2016-03-31 2019-02-14 インターセプト ファーマシューティカルズ， インコーポレイテッド 溶出性に優れた経口製剤
WO2017174515A1 (en) 2016-04-04 2017-10-12 Dipharma Francis S.R.L. Method for preparing a farnesoid x receptor agonist
EP3228306A1 (en) 2016-04-04 2017-10-11 ratiopharm GmbH Complex compound comprising obeticholic acid and cyclodextrin and pharmaceutical formulation comprising the complex compound
TW201738254A (zh) * 2016-04-19 2017-11-01 英特賽普醫藥品公司 奧貝膽酸及其衍生物之製備方法
WO2017192997A1 (en) 2016-05-05 2017-11-09 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
CN105859817A (zh) * 2016-05-09 2016-08-17 成都宇西医药技术有限公司 一种制备3α-羟基-6-乙烯基-7-酮基-5β-胆烷酸的方法
CN107400154A (zh) * 2016-05-18 2017-11-28 北京凯因科技股份有限公司 一种制备3α,7α-二-羟基-6α-乙基-5β-胆烷酸的方法
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
CN106046094A (zh) * 2016-05-30 2016-10-26 福建广生堂药业股份有限公司 一种奥贝胆酸二聚体杂质及其制备方法
CN105859818A (zh) * 2016-05-31 2016-08-17 四川瑞希康生物医药有限公司 一种奥贝胆酸α晶型及其制备方法、药物组合物和用途
EP3464316A4 (en) 2016-06-01 2020-02-19 Dr. Reddy's Laboratories Ltd. PROCESS FOR THE PREPARATION OF OBETICHOLIC ACID
CN105997909A (zh) * 2016-06-02 2016-10-12 中国药科大学 一种奥贝胆酸口崩片及其制备方法
MX2018015443A (es) 2016-06-13 2019-04-11 Gilead Sciences Inc Compuestos moduladores de fxr (nr1h4).
CA2968836A1 (en) 2016-06-13 2017-12-13 Gilead Sciences, Inc. Fxr (nr1h4) modulating compounds
CN106083971B (zh) * 2016-06-17 2017-11-14 苏州敬业医药化工有限公司 一种(E)‑3α‑羟基‑6‑亚乙基‑7‑酮‑5β‑胆烷‑24‑酸的制备方法
CZ2016385A3 (cs) 2016-06-28 2018-01-10 Zentiva, K.S. Způsoby přípravy intermediátů pro syntézu Obeticholové kyseliny
CN107540720B (zh) * 2016-06-29 2021-03-02 常州市第四制药厂有限公司 3α,7α-二羟基-6α-乙基-5β-胆烷酸晶型H及其制备方法和应用
JP7065825B2 (ja) 2016-07-11 2022-05-12 セージ セラピューティクス， インコーポレイテッド Ｃ７、ｃ１２、およびｃ１６置換神経刺激性ステロイドおよびそれらの使用方法
DK3481845T3 (da) 2016-07-11 2023-11-27 Sage Therapeutics Inc C17, c20 og c21 substituerede neuroaktive steroider og deres anvendelsesmetoder
CN107648190B (zh) * 2016-07-26 2021-04-27 海南先声药业有限公司 奥贝胆酸组合物及其制备方法
CN106279331B (zh) * 2016-07-27 2019-06-14 宋火良 胆酸类肝病治疗药物
CN107674106B (zh) * 2016-08-01 2021-06-22 华北制药集团新药研究开发有限责任公司 一种奥贝胆酸二聚体的制备方法
CN106279335A (zh) * 2016-08-12 2017-01-04 齐鲁制药有限公司 一种制备奥贝胆酸及其中间体的方法
EP3287467A1 (en) 2016-08-22 2018-02-28 ratiopharm GmbH Preparation of obeticholic acid comprising continuous flow process steps
CN107778339A (zh) * 2016-08-29 2018-03-09 鲁南制药集团股份有限公司 一种无定型奥贝胆酸的制备方法
CN115490744A (zh) * 2016-08-29 2022-12-20 山东新时代药业有限公司 一种3α-羟基-6α-乙基-7-酮-5β-胆-24-酸的制备方法
EP3293196A1 (en) 2016-09-09 2018-03-14 Hexal AG Process for purifying obeticholic acid
CN106478757B (zh) * 2016-09-27 2019-01-18 华南理工大学 一种3α,7α-二羟基-6α-乙基胆烷酸的制备方法
JP2019529481A (ja) * 2016-09-30 2019-10-17 インターセプト ファーマシューティカルズ， インコーポレイテッド 胆汁酸誘導体の結晶形態
CN107976506B (zh) * 2016-10-25 2020-05-12 成都弘达药业有限公司 一种奥贝胆酸有关物质的检测方法
US20200056157A1 (en) 2016-11-04 2020-02-20 Children's Hospital Medical Center Liver organoid disease models and methods of making and using same
MX2019006165A (es) * 2016-11-29 2019-10-14 Enanta Pharm Inc Proceso para la preparacion de derivados del acido biliar de las sulfonilureas.
KR102558606B1 (ko) 2016-12-05 2023-07-26 칠드런즈 호스피탈 메디칼 센터 결장 유사장기 및 이를 제조 및 사용하는 방법
BR112019011740A2 (pt) * 2016-12-09 2019-10-29 Cadila Healthcare Ltd composição farmacêutica e método para o tratamento de colangite biliar primária
CN108614038B (zh) * 2016-12-13 2022-05-17 亚宝药业集团股份有限公司 一种测定奥贝胆酸原料药有关物质的方法
CN106749472B (zh) * 2016-12-30 2019-02-22 江苏开元医药化工有限公司 一种3α-羟基-6α-乙基-7-酮-5β-胆烷-24-酸的制备方法
CN106645497A (zh) * 2017-01-03 2017-05-10 山东省药学科学院 一种奥贝胆酸及其制剂中有关物质的检测方法
WO2018136578A1 (en) 2017-01-18 2018-07-26 Tremco Incorporated Structural bonding composite
US10472386B2 (en) 2017-02-14 2019-11-12 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR agonists and methods of use thereof
CN106892954B (zh) * 2017-02-23 2019-04-30 广州隽沐生物科技有限公司 奥贝胆酸的制备工艺
KR20190122813A (ko) * 2017-03-08 2019-10-30 인터셉트 파마슈티컬즈, 인크. 오베티콜산의 결정질 형태
JP6906626B2 (ja) 2017-03-28 2021-07-21 ギリアード サイエンシーズ， インコーポレイテッド 肝疾患を処置するための治療的組み合わせ
CN108659086A (zh) * 2017-03-29 2018-10-16 杭州源昶医药科技有限公司 一种奥贝胆酸的合成方法
US10676500B2 (en) 2017-04-07 2020-06-09 Enanta Pharmaceuticals, Inc. Process for preparation of sulfonyl carbamate bile acid derivatives
CN106986910A (zh) * 2017-04-19 2017-07-28 成都百特万合医药科技有限公司 奥贝胆酸中间体的制备方法
WO2018194426A1 (ko) * 2017-04-20 2018-10-25 대웅바이오 주식회사 연속흐름반응을 이용한 담즙산 유도체의 제조 방법
WO2018211413A1 (en) * 2017-05-15 2018-11-22 Dr. Reddy’S Laboratories Limited Solid forms of obeticholic acid and process for preparation
CZ2017298A3 (cs) 2017-05-26 2018-12-05 Zentiva, K.S. Amorfní formy obeticholové kyseliny
CN107286160A (zh) * 2017-06-05 2017-10-24 毛佳婧 一种抗肝炎药物的哌啶并吡啶并吡唑‑锌配合物的制备方法
US11364226B2 (en) 2017-06-30 2022-06-21 Cinrx Pharma, Llc Deuterated domperidone compositions, methods, and preparation
CN109280071A (zh) * 2017-07-19 2019-01-29 东莞东阳光药物研发有限公司 奥贝胆酸的晶型及其制备方法
WO2019023103A1 (en) 2017-07-24 2019-01-31 Intercept Pharmaceuticals, Inc. BILIARY ACID DERIVATIVES WITH ISOTOPIC MARKING
KR102388809B1 (ko) 2017-08-03 2022-04-21 (주)메디톡스 담즙산류를 제조하기 위한 방법
CN107383139A (zh) * 2017-08-09 2017-11-24 杭州和泽医药科技有限公司 一种3α‑羟基‑7‑氧代‑5β‑胆烷酸新衍生物制备奥贝胆酸的方法
CN109485687A (zh) * 2017-09-12 2019-03-19 成都弘达药业有限公司 奥贝胆酸的晶型j及其制备方法
US10611793B1 (en) 2017-11-27 2020-04-07 Teva Czech Industries S.R.O. Solid state forms of obeticholic acid salts
WO2019106043A1 (en) 2017-11-29 2019-06-06 Hexal Ag Pharmaceutical composition comprising obeticholic acid
US20200291059A1 (en) * 2017-12-08 2020-09-17 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
US11434256B2 (en) 2018-01-25 2022-09-06 Msn Laboratories Private Limited, R&D Center Process for the preparation of 3α,7α-dihydroxy-6α-ethyl-5β-cholan-24-oic acid
CN108440629A (zh) * 2018-03-16 2018-08-24 丽珠集团新北江制药股份有限公司 一种制备奥贝胆酸中间体及奥贝胆酸的方法
WO2019197962A1 (en) * 2018-04-09 2019-10-17 Biophore India Pharmaceuticals Pvt. Ltd Crystalline forms of (3α, 5β, 6α, 7α)-6-ethyl-3, 7-dihydroxycholan-24-oic acid (obeticholic acid) and processes thereof
CN110655550A (zh) * 2018-06-29 2020-01-07 江苏海悦康医药科技有限公司 (E)-3α-羟基-6-亚乙基-7-氧代-5β-胆甾烷-24-酸的制备方法
CN108794558B (zh) * 2018-07-03 2020-05-22 丽珠集团新北江制药股份有限公司 一种反应条件温和的奥贝胆酸制备方法
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
WO2020039449A1 (en) * 2018-08-24 2020-02-27 Solara Active Pharma Sciences Limited An improved process for the preparation of obeticholic acid and intermediates used in the process thereof
JP2022506782A (ja) * 2018-11-08 2022-01-17 インターセプト ファーマシューティカルズ， インコーポレイテッド オベチコール酸の使用方法
CN109535217B (zh) * 2018-11-13 2020-04-14 丽珠集团新北江制药股份有限公司 一种奥贝胆酸的精制方法
BR112021011762A2 (pt) 2019-01-15 2021-11-03 Gilead Sciences Inc Compostos para modulação de fxr (nr1h4)
AU2020225225B2 (en) 2019-02-19 2022-12-22 Gilead Sciences, Inc. Solid forms of FXR agonists
US20220226350A1 (en) 2019-05-30 2022-07-21 Intercept Pharmaceuticals, Inc. Pharmaceutical compositions comprising a fxr agonist and a fibrate for use in the treatment of cholestatic liver disease
US11643434B2 (en) 2019-05-31 2023-05-09 Sage Therapeutics, Inc. Neuroactive steroids and compositions thereof
WO2021029656A1 (ko) * 2019-08-14 2021-02-18 주식회사 바이오톡스텍 하이드로퀴논 유도체, 및 오베티콜릭산을 포함하는 비알콜성 지방간염의 예방 또는 치료용 약학조성물
CN112824425B (zh) * 2019-11-21 2023-10-03 成都西岭源药业有限公司 一种6-位烯基取代胆酸化合物及其制备方法和应用
WO2021231539A1 (en) * 2020-05-13 2021-11-18 Children's Hospital Medical Center Alleviation of liver injury by activating the signaling pathway mediated by farnesoid x receptor
WO2022051321A1 (en) 2020-09-03 2022-03-10 Coherus Biosciences, Inc. Fixed dose combinations of chs-131 and a fxr agonist
KR102526452B1 (ko) * 2020-10-28 2023-04-27 (주)델로 관절 구조를 포함하는 토이 로봇
CN114644670A (zh) * 2020-12-17 2022-06-21 四川弘远药业有限公司 奥贝胆酸和对氨基苯甲酸的共晶及其制备方法
CN114236027B (zh) * 2021-12-22 2024-01-12 中山百灵生物技术股份有限公司 一种(E)-6-亚乙基-3α-羟基-7-酮基-5β-胆甾烷-24-酸的检测方法

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072695A (en) * 1972-09-21 1978-02-07 Intellectual Property Development Corporation 3α,7α-Dihydroxy-cholanic acid derivatives
IT1137459B (it) * 1981-04-14 1986-09-10 Erregierre Spa Prodesso per la preparazione di acido ursodeossicolico ad alta purezza
EP0101554B1 (en) 1982-07-29 1986-10-15 Lehner A.G. New derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same
IT1206112B (it) 1983-04-29 1989-04-14 Lehner Ag Nuovi derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.
IT1212835B (it) 1983-08-18 1989-11-30 Lehner Ag Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.
US4892868A (en) 1984-08-17 1990-01-09 Gipharmex, S.P.A. Derivatives of biliary acids, process for the production thereof and corresponding pharmaceutical compositions
IT1196377B (it) 1984-12-21 1988-11-16 Lehner Ag Derivati di acidi biliari,procedimento per la loro preparazione e relative composizioni farmaceutiche
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
IT1223313B (it) 1987-10-20 1990-09-19 Gipharmex Spa Derivati di acidi biliari loro preparazione e composizioni farmaceutiche che li contengono
JPH0320265A (ja) * 1989-02-10 1991-01-29 Meiji Seika Kaisha Ltd アミノチアゾール酢酸誘導体並びにその製造法
US5175320A (en) 1989-04-17 1992-12-29 Giuliani S.P.A. Fluorinated bile acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
IT1229570B (it) 1989-04-17 1991-09-04 Giuliani Spa Derivati fluorurati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono.
ES2074113T3 (es) 1989-12-13 1995-09-01 Mitsubishi Chem Corp Nuevos derivados de acido pirazolil acrilico, utiles como fungicidas sistemicos para la proteccion de plantas y materiales.
AU1856997A (en) 1996-02-02 1997-08-22 Merck & Co., Inc. Method for raising hdl cholesterol levels
GB9604242D0 (en) 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
GB9606805D0 (en) 1996-03-30 1996-06-05 Glaxo Wellcome Inc Medicaments
CA2260044A1 (en) 1996-07-12 1998-01-22 Stephen Alistair Smith Novel treatment of leptine resistance
JP3600713B2 (ja) 1997-08-06 2004-12-15 東京応化工業株式会社 ポジ型ホトレジスト組成物
US6008237A (en) 1997-12-19 1999-12-28 Merck & Co., Inc. Arylthiazolidinedione derivatives
AU759255B2 (en) 1998-01-29 2003-04-10 Amgen, Inc. PPAR-gamma modulators
JP3146187B2 (ja) * 1998-06-26 2001-03-12 高砂香料工業株式会社 ジホスフィンオキシドの新規な製造方法
EP1137940A4 (en) 1998-10-23 2004-06-02 Glaxo Group Ltd METHOD FOR IDENTIFYING LIGANDS OF NUCLEAR RECEPTORS
US6639078B1 (en) 1998-12-23 2003-10-28 Smithkline Beecham Corporation Assays for ligands for nuclear receptors
AU2409600A (en) 1999-01-07 2000-07-24 Tularik Inc. Fxr receptor-mediated modulation of cholesterol metabolism
WO2000057915A1 (en) 1999-03-26 2000-10-05 City Of Hope Method of affecting cholesterol catabolism using nuclear bile acid receptor
EP1473042B1 (en) 1999-03-26 2006-06-21 City of Hope Screening for FXR receptor modulators
US20020132223A1 (en) 1999-03-26 2002-09-19 City Of Hope Methods for modulating activity of the FXR nuclear receptor
US6906057B1 (en) 1999-06-11 2005-06-14 Allergan, Inc. Methods for modulating FXR receptor activity
EP1185277B1 (en) 1999-06-11 2005-10-26 Allergan, Inc. Use of FXR synthetic ligands for the treatment of diseseas linked to cholesterol imbalance and colon cancer
US6559188B1 (en) 1999-09-17 2003-05-06 Novartis Ag Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
WO2001030343A1 (en) 1999-10-22 2001-05-03 Merck & Co., Inc. Pharmaceuticals for treating obesity
US6627636B2 (en) 2000-06-15 2003-09-30 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
AU2001288623A1 (en) 2000-09-05 2002-03-22 Tularik, Inc. Fxr modulators
US20020119958A1 (en) 2001-02-13 2002-08-29 Shinichiro Tojo Therapeutic agent for hyperlipidemia
WO2002072598A1 (en) * 2001-03-12 2002-09-19 Roberto Pellicciari Steroids as agonists for fxr
EP1378749A4 (en) 2001-04-12 2005-05-11 Takeda Pharmaceutical SCREENING METHOD
EP1423113A4 (en) 2001-08-13 2007-04-18 Phenex Pharmaceuticals Ag NR1H4 NUCLEAR RECEPTOR BINDING COMPOUNDS
US20070010562A1 (en) 2001-08-13 2007-01-11 Ulrike Bauer Nr1h4 nuclear receptor binding compounds
EP1285914B1 (en) 2001-08-13 2007-12-19 PheneX Pharmaceuticals AG Nr1h4 nuclear receptor binding compounds
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
CN1612866A (zh) 2001-11-14 2005-05-04 特瓦制药工业有限公司 无定形和结晶形的氯沙坦钾及其制备方法
US20030144360A1 (en) 2001-11-19 2003-07-31 Allergan Sales, Inc. Composition and method for modulating BAR/FXR receptor activity
AU2003225903A1 (en) 2002-03-21 2003-10-08 Curagen Corporation Methods of using farnesoid x receptor (fxr) agonists
EP1494533A2 (en) 2002-04-12 2005-01-12 The University of Chicago Farnesoid x-activated receptor agonists
US6987121B2 (en) 2002-04-25 2006-01-17 Smithkline Beecham Corporation Compositions and methods for hepatoprotection and treatment of cholestasis
ITMI20021532A1 (it) 2002-07-12 2004-01-12 Roberto Pellicciari Composti chimici
US7319109B2 (en) 2002-11-22 2008-01-15 Smith Kline Beecham Corporation Farnesoid X receptor agonists
WO2005032549A1 (en) 2003-09-26 2005-04-14 Smithkline Beecham Corporation Compositions and methods for treatment of fibrosis
EP1568706A1 (en) * 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
AR048918A1 (es) * 2004-03-11 2006-06-14 Fresenius Kabi De Gmbh Conjugados de almidon de hidroxietilo y eritropoyetina
PT1734970E (pt) 2004-03-12 2015-03-11 Intercept Pharmaceuticals Inc Tratamento de fibrose utilizando ligandos de rfx
WO2006020680A2 (en) * 2004-08-10 2006-02-23 Exelixis, Inc. Heterocyclic compounds as pharmaceutical agents
US20060252670A1 (en) * 2004-10-14 2006-11-09 Intercept Pharmaceuticals Inc. Method of reducing drug-induced adverse side effects in a patient
EP2527355B1 (en) * 2005-04-25 2019-02-20 Enterin, Inc. Polymorphic and amorphous salt forms of squalamine dilactate
ITMI20050912A1 (it) 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
JP2007077123A (ja) 2005-09-16 2007-03-29 Shiono Chemical Co Ltd 非晶質セフジニル、その製造方法およびこれを含有する経口投与用医薬組成物
ES2523591T3 (es) 2006-06-27 2014-11-27 Intercept Pharmaceuticals Inc. Derivados de ácidos biliares como ligandos de FXR para la prevención o el tratamiento de enfermedades o estados mediados por FXR
EP1894924A1 (en) * 2006-08-29 2008-03-05 Phenex Pharmaceuticals AG Heterocyclic FXR binding compounds
CL2007003035A1 (es) * 2006-10-24 2008-05-16 Smithkline Beechman Corp Compuestos derivados de isoxazol sustituidos, agonistas de receptores farnesoid x; procedimiento de preparacion; composicion farmaceutica que lo comprende; y uso del compuesto en el tratamiento de la obesidad, diabetes mellitus, fibrosis en organos,
EP1947108A1 (en) 2007-01-19 2008-07-23 Intercept Pharmaceuticals, Inc. TGR5 modulators and methods of use thereof
ES2438271T3 (es) 2007-01-19 2014-01-16 Intercept Pharmaceuticals, Inc. Ácidos biliares 23-sustituidos como moduladores de TGR5 y métodos de uso de los mismos
US8338628B2 (en) 2007-08-28 2012-12-25 City Of Hope Method of synthesizing alkylated bile acid derivatives
US7825258B2 (en) * 2007-11-15 2010-11-02 Hoffmann-La Roche Inc. Methyl-benzimidazole derivatives
AU2009276507B2 (en) 2008-07-30 2015-11-19 Intercept Pharmaceuticals, Inc. TGR5 modulators and methods of use thereof
WO2010039529A2 (en) * 2008-09-23 2010-04-08 Resolvyx Pharmaceuticals, Inc. Compositions and methods for the treament of inflammatory disease
EP2698375B1 (en) 2008-11-19 2018-02-21 Intercept Pharmaceuticals, Inc. TGR5 modulators and method of use thereof
BR112012004284B8 (pt) 2009-08-25 2021-05-25 Ahab Sheps Jonathan ácidos biliares poli-hidroxilados para tratamento de transtornos biliares
CN102121547B (zh) * 2010-12-23 2013-01-16 拉卡萨安吉拉股份有限公司 用于管道接头的衬套和采用该衬套的管道接头
CN102372757B (zh) * 2011-10-31 2013-01-16 安徽科宝生物工程有限公司 酯化法制备猪胆汁中鹅去氧胆酸的方法
NZ734451A (en) 2012-06-19 2018-12-21 Intercept Pharmaceuticals Inc Preparation, uses and solid forms of obeticholic acid

Also Published As

Publication number Publication date
JP6978544B2 (ja) 2021-12-08
US9238673B2 (en) 2016-01-19
IN2014MN02561A (es) 2015-09-04
CA3047776C (en) 2022-10-18
MX2014016062A (es) 2015-07-17
KR20160143894A (ko) 2016-12-14
EA032347B1 (ru) 2019-05-31
TW201410699A (zh) 2014-03-16
CA3028207A1 (en) 2013-12-27
KR101881245B1 (ko) 2018-07-23
US20190153020A1 (en) 2019-05-23
KR20150022974A (ko) 2015-03-04
ES2822375T3 (es) 2021-04-30
MX365059B (es) 2019-05-22
MX2019005819A (es) 2019-10-21
CN111228278A (zh) 2020-06-05
US20160215014A1 (en) 2016-07-28
EP3789394A1 (en) 2021-03-10
EP3336097A1 (en) 2018-06-20
HK1211296A1 (en) 2016-05-20
AU2017204057B2 (en) 2018-11-01
US9732116B2 (en) 2017-08-15
US20210395293A1 (en) 2021-12-23
JP2016074724A (ja) 2016-05-12
JP6527077B2 (ja) 2019-06-05
EP2861613A1 (en) 2015-04-22
JP2015521621A (ja) 2015-07-30
PL3336097T3 (pl) 2021-05-31
SI3336097T1 (sl) 2021-07-30
US20170226149A1 (en) 2017-08-10
IL257841A (en) 2018-04-30
PT3336097T (pt) 2020-10-29
EA201990211A1 (ru) 2019-06-28
US20130345188A1 (en) 2013-12-26
SG10201607230SA (en) 2016-10-28
US20160176913A1 (en) 2016-06-23
BR122016011808A2 (pt) 2018-12-11
SG10201610434YA (en) 2017-02-27
AU2020202405A1 (en) 2020-04-30
PH12014502835A1 (en) 2015-02-02
SG11201408501UA (en) 2015-01-29
US20160074419A1 (en) 2016-03-17
EA201590040A1 (ru) 2015-05-29
US10047117B2 (en) 2018-08-14
JP2020125317A (ja) 2020-08-20
JP2017075169A (ja) 2017-04-20
CA2877122A1 (en) 2013-12-27
AU2016200832B2 (en) 2017-05-18
AU2018241172A1 (en) 2018-11-01
TWI673284B (zh) 2019-10-01
AU2017204057A1 (en) 2017-07-06
CN104781272A (zh) 2015-07-15
CO7240414A2 (es) 2015-04-17
JP2018172438A (ja) 2018-11-08
CL2014003475A1 (es) 2015-08-07
AU2013277429A1 (en) 2015-01-22
CA3047776A1 (en) 2013-12-27
BR122016011808B1 (pt) 2021-09-21
KR20190121871A (ko) 2019-10-28
JP6877389B2 (ja) 2021-05-26
NZ719360A (en) 2017-08-25
KR20180083966A (ko) 2018-07-23
NZ703072A (en) 2016-06-24
AU2018241172B2 (en) 2020-03-05
DK3336097T3 (da) 2020-09-28
EP3992201A1 (en) 2022-05-04
CA2877122C (en) 2020-04-28
US10174073B2 (en) 2019-01-08
WO2013192097A1 (en) 2013-12-27
AU2013277429B2 (en) 2016-01-14
BR112014031828A2 (pt) 2021-07-06
EP3336097B1 (en) 2020-08-19
BR112014031828B1 (pt) 2021-12-21
IL261372A (en) 2018-10-31
US20230340010A1 (en) 2023-10-26
US10155787B2 (en) 2018-12-18
AU2016200832A1 (en) 2016-02-25
IL236231A0 (en) 2015-02-01
NZ734451A (en) 2018-12-21
JP2018184443A (ja) 2018-11-22

Similar Documents

Publication Publication Date Title
CL2015002145A1 (es) Preparación, usos y formas sólidas de ácido obeticólico (divisional de solicitud n° 3475-2014)
CL2014003643A1 (es) Compuesto derivado de éster del ácido 2-aminonicotínico y bactericida que contiene el mismo como ingrediente activo.
PH12015501703A1 (en) Trifluormethyl-substituted ring-fused pyrimidines and use thereof
MX2015009037A (es) Enjuague nasal con miel.
UY34750A (es) ?compuestos para el tratamiento del hiv, composiciones,métodos de preparación, intermediarios y métodos terapéuticos?.
MY164356A (en) Substituted 5-fluoro-1h-pyrazolopyridines and their use
UY34651A (es) ?formas de dosificación de liberación inmediata resistentes a la manipulación, procesos para prepararlas, métodos y usos de las mismas?..
NZ704662A (en) Crystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid
DOP2016000253A (es) Nuevos compuestos
AR091465A1 (es) Una composicion farmaceutica que contiene acido nicotinico y/o nicotinamida y/o triptofano para influenciar positivamente la microbiota intestinal
DK3045456T3 (da) Bicyklisk substituerede uraciler og anvendelse heraf
AR093986A1 (es) Cuerpos de carbono ferromagneticos y proceso de produccion
CL2015001610A1 (es) Compuestos derivados de pirimido-[4,5-b]-quinolina-4,5(3h,10h)-dionas para utilizarse como un medicamento para el tratamiento de una enfermedad causada por una mutacion sin sentido; composicion y combinacion farmaceutica que los comprende.
CO6731092A2 (es) Nueva forma de administración de inhibidor de encefalinasa
CL2014002165A1 (es) Composiciones similares a azeótropos de z-1,1,1,4,4,4-hexafluoro-2-buteno y e-1,1,1,4,4,4-hexafluoro-2-buteno; proceso; y composicion formadora de espuma.
MX2014010433A (es) Nueva forma cristalina de sulfato de sitagliptina.
PH12016500054A1 (en) Substituted pyrazolo-pyridinamines
IN2013CH04023A (es)
CL2016002879A1 (es) Composiciones farmacéuticas para tratar enfermedades infecciosas
PH12016501814A1 (en) Inhibitors of the wnt signalling pathways
CL2016001130A1 (es) Composiciones sólidas de triglicéridos y usos de estas
CR20120166A (es) Composiciones y productos antimicrobianos
CR20150545A (es) Agentes quelantes de precursores de producto final de glicación avanzada (age)
CL2015000354A1 (es) Compuestos derivados de piridina; proceso de preparacion; composicion farmaceutica; y uso en el tratamiento o profilaxis de la diabetes, aterosclerosis, entre otras.
MX2014008985A (es) Composicion farmaceutica de naproxeno sodico, paracetamol y pamabrom, para el tratamiento de molestias relacionadas con la dismenorrea y/o sindrome premestrual.