EP3464316A4 - Process for preparation of obeticholic acid - Google Patents

Process for preparation of obeticholic acid Download PDF

Info

Publication number
EP3464316A4
EP3464316A4 EP17805982.0A EP17805982A EP3464316A4 EP 3464316 A4 EP3464316 A4 EP 3464316A4 EP 17805982 A EP17805982 A EP 17805982A EP 3464316 A4 EP3464316 A4 EP 3464316A4
Authority
EP
European Patent Office
Prior art keywords
preparation
obeticholic acid
obeticholic
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP17805982.0A
Other languages
German (de)
French (fr)
Other versions
EP3464316A1 (en
Inventor
Vilas Hareshwar Dahanukar
Rama Mohan HINDUPUR
Rashid Abdul REHMAN KHAN
Sarishbhai Sukhlalbhai MORE
Vikas Sadashiv GAJARE
Sandip Ramdas KHOBARE
Krishna Mohan Narayana Rao THALABATHULA
Rajender DATRIKA
Sreenivasulu MADI SHETTY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Reddys Laboratories Ltd
Original Assignee
Dr Reddys Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Reddys Laboratories Ltd filed Critical Dr Reddys Laboratories Ltd
Publication of EP3464316A1 publication Critical patent/EP3464316A1/en
Publication of EP3464316A4 publication Critical patent/EP3464316A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
EP17805982.0A 2016-06-01 2017-05-31 Process for preparation of obeticholic acid Withdrawn EP3464316A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201641018884 2016-06-01
PCT/IB2017/053195 WO2017208165A1 (en) 2016-06-01 2017-05-31 Process for preparation of obeticholic acid

Publications (2)

Publication Number Publication Date
EP3464316A1 EP3464316A1 (en) 2019-04-10
EP3464316A4 true EP3464316A4 (en) 2020-02-19

Family

ID=60479201

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17805982.0A Withdrawn EP3464316A4 (en) 2016-06-01 2017-05-31 Process for preparation of obeticholic acid

Country Status (4)

Country Link
US (1) US10875887B2 (en)
EP (1) EP3464316A4 (en)
CN (1) CN109415405A (en)
WO (1) WO2017208165A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108218942A (en) * 2017-12-18 2018-06-29 南京科技职业学院 A kind of preparation method of 3-5 β of Alpha-hydroxy-7- oxos of high-purity-cholanic acid
CN110003302B (en) * 2019-04-30 2021-05-11 山东省药学科学院 Refining method of 7-ketolithocholic acid
CN112341516B (en) * 2020-11-14 2022-07-15 湖南科瑞生物制药股份有限公司 5, 6-epoxy steroid compound and preparation method and application thereof
CN114236027B (en) * 2021-12-22 2024-01-12 中山百灵生物技术股份有限公司 Detection method of (E) -6-ethylene-3 alpha-hydroxy-7-keto-5 beta-cholestane-24-acid

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140148428A1 (en) * 2012-11-28 2014-05-29 Intercept Pharmaceuticals, Inc. Treatment of Pulmonary Disease
CN105669811A (en) * 2014-11-17 2016-06-15 正大天晴药业集团股份有限公司 Novel application of 7-keto-6[beta]-alkyl cholanic acid derivative in preparation of obeticholic acid and in field of medicine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138390B2 (en) 2001-03-12 2006-11-21 Intercept Pharmaceuticals Steroids as agonists for FXR
ITMI20050912A1 (en) 2005-05-19 2006-11-20 Erregierre Spa PROCESS OF PREPARATION OF ACIDS 3-A-YA (B) -DIDROSSI-6-A (B) -ALCHIL-5B-COLANICI
DK3336097T3 (en) 2012-06-19 2020-09-28 Intercept Pharmaceuticals Inc Preparation of non-crystalline obeticholic acid
CN104876995B (en) * 2014-02-27 2016-09-07 人福医药集团股份公司 The preparation method of chenodeoxycholic acid derivatives
EP3149019B1 (en) * 2014-05-29 2019-12-04 Bar Pharmaceuticals S.r.l. Cholane derivatives for use in the treatment and/or prevention of fxr and tgr5/gpbar1 mediated diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140148428A1 (en) * 2012-11-28 2014-05-29 Intercept Pharmaceuticals, Inc. Treatment of Pulmonary Disease
CN105669811A (en) * 2014-11-17 2016-06-15 正大天晴药业集团股份有限公司 Novel application of 7-keto-6[beta]-alkyl cholanic acid derivative in preparation of obeticholic acid and in field of medicine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"PROCESS FOR PREPARATION OF OBETICHOLIC ACID", IP.COM JOURNAL, IP.COM INC., WEST HENRIETTA, NY, US, 3 June 2016 (2016-06-03), XP013171745, ISSN: 1533-0001 *
PELLICCIARI R ET AL: "6alpha-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 45, no. 17, 1 January 2002 (2002-01-01), pages 3569 - 3572, XP002287455, ISSN: 0022-2623, DOI: 10.1021/JM025529G *
See also references of WO2017208165A1 *

Also Published As

Publication number Publication date
US10875887B2 (en) 2020-12-29
US20200317715A1 (en) 2020-10-08
EP3464316A1 (en) 2019-04-10
WO2017208165A1 (en) 2017-12-07
CN109415405A (en) 2019-03-01

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