CL2012002318A1 - Compuestos derivados de tieno [2,3-d]pirimidina, inhibidores de quinasa mnk1 y mnk2; composición farmaceutica; que los comprende; y su uso en el tratamiento de enfermedades metabolicas, hematopoyeticas, neurodegenerativas, renales, inflamatorias y cancer. - Google Patents
Compuestos derivados de tieno [2,3-d]pirimidina, inhibidores de quinasa mnk1 y mnk2; composición farmaceutica; que los comprende; y su uso en el tratamiento de enfermedades metabolicas, hematopoyeticas, neurodegenerativas, renales, inflamatorias y cancer.Info
- Publication number
- CL2012002318A1 CL2012002318A1 CL2012002318A CL2012002318A CL2012002318A1 CL 2012002318 A1 CL2012002318 A1 CL 2012002318A1 CL 2012002318 A CL2012002318 A CL 2012002318A CL 2012002318 A CL2012002318 A CL 2012002318A CL 2012002318 A1 CL2012002318 A1 CL 2012002318A1
- Authority
- CL
- Chile
- Prior art keywords
- mnk1
- pharmaceutical composition
- metabolic
- neurodegenerative
- hematopoietic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
Compuestos derivados de tienopirimidinas-heterocicloalquilo, inhibidores de Mnk1 o Mnk2; una sal de dicho compuesto; composición farmaceutica; y su uso para preparar un medicamento útil para la profilaxis o la terapia de enfermedades metabólicas, trastornos hematopoyéticos, enfermedades neurodegenerativas entre otras.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10154925 | 2010-02-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2012002318A1 true CL2012002318A1 (es) | 2012-11-23 |
Family
ID=43902874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2012002318A CL2012002318A1 (es) | 2010-02-26 | 2012-08-21 | Compuestos derivados de tieno [2,3-d]pirimidina, inhibidores de quinasa mnk1 y mnk2; composición farmaceutica; que los comprende; y su uso en el tratamiento de enfermedades metabolicas, hematopoyeticas, neurodegenerativas, renales, inflamatorias y cancer. |
Country Status (15)
Country | Link |
---|---|
US (1) | US8648068B2 (es) |
EP (1) | EP2539346B1 (es) |
JP (1) | JP5639197B2 (es) |
KR (1) | KR20120130052A (es) |
CN (1) | CN102869669A (es) |
AR (1) | AR080327A1 (es) |
AU (1) | AU2011219761A1 (es) |
BR (1) | BR112012021264A2 (es) |
CA (1) | CA2791105A1 (es) |
CL (1) | CL2012002318A1 (es) |
EA (1) | EA201201193A1 (es) |
MX (1) | MX2012009409A (es) |
TW (1) | TW201141482A (es) |
UY (1) | UY33241A (es) |
WO (1) | WO2011104337A1 (es) |
Families Citing this family (31)
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US20100143341A1 (en) * | 2005-06-22 | 2010-06-10 | Develogen Aktiengesellschaft | Thienopyrimidines for pharmaceutical compositions |
KR20090047391A (ko) | 2006-04-07 | 2009-05-12 | 데벨로겐 악틴게젤샤프트 | 약제학적 조성물을 위한 Mnk1/Mnk2 억제 활성을 갖는티에노피리미딘 |
EP1889847A1 (en) | 2006-07-10 | 2008-02-20 | DeveloGen Aktiengesellschaft | Pyrrolopyrimidines for pharmaceutical compositions |
UY32072A (es) | 2008-08-26 | 2010-03-26 | Boehringer Ingelheim Int | Tienopirimidinas para composiciones farmacéuticas |
WO2011105590A1 (ja) | 2010-02-26 | 2011-09-01 | 日本たばこ産業株式会社 | 1,3,4,8-テトラヒドロ-2H-ピリド[1,2-a]ピラジン誘導体及びそのHIVインテグラーゼ阻害剤としての利用 |
UY33245A (es) * | 2010-02-26 | 2011-09-30 | Boehringer Ingelheim Int | Tienopirimidinas que contienen un grupo alquilo sustituido para composiciones farmacéuticas |
AR080326A1 (es) * | 2010-02-26 | 2012-03-28 | Boehringer Ingelheim Int | Tienipirimidinas que contienen cicloalquilo para composiciones farmaceuticas |
UY33241A (es) | 2010-02-26 | 2011-09-30 | Boehringer Ingelheim Int | ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?. |
US10280168B2 (en) | 2012-03-30 | 2019-05-07 | Agency For Science, Technology And Research | Bicyclic heteroaryl derivatives as MNK1 and MNK2 modulators and uses thereof |
GB201205669D0 (en) | 2012-03-30 | 2012-05-16 | Agency Science Tech & Res | Bicyclic heterocyclic derivatives as mnk2 and mnk2 modulators and uses thereof |
CA2873975A1 (en) | 2012-05-21 | 2013-11-28 | Bayer Pharma Aktiengesellschaft | Thienopyrimidines |
CN104470931B (zh) | 2012-05-21 | 2016-10-26 | 拜耳医药股份有限公司 | 取代的苯并噻吩并嘧啶 |
KR20150034209A (ko) | 2012-06-26 | 2015-04-02 | 델 마 파마슈티컬스 인코포레이티드 | 디안하이드로갈락티톨, 디아세틸디안하이드로갈락티톨, 디브로모둘시톨, 또는 그의 유사체 또는 유도체를 이용하여 유전학적 다형성이 있는 환자에 있어서 티로신-키나아제-억제제 내성 악성종양, ahi1 조절곤란 또는 돌연변이를 치료하는 방법 |
TW201412740A (zh) | 2012-09-20 | 2014-04-01 | Bayer Pharma AG | 經取代之吡咯并嘧啶胺基苯并噻唑酮 |
WO2014118226A1 (en) | 2013-02-01 | 2014-08-07 | Bayer Pharma Aktiengesellschaft | Substituted pyrazolopyrimidinylamino-indazoles |
JP2016514087A (ja) | 2013-02-01 | 2016-05-19 | バイエル・ファルマ・アクティエンゲゼルシャフト | 置換チエノピリミジンおよびその薬学的使用 |
EP2964656A1 (en) | 2013-03-06 | 2016-01-13 | Bayer Pharma Aktiengesellschaft | Substituted thiazolopyrimidines |
EP2983674A4 (en) | 2013-04-08 | 2017-05-10 | Dennis M. Brown | Therapeutic benefit of suboptimally administered chemical compounds |
CN103356624B (zh) * | 2013-08-02 | 2014-12-31 | 上海市第十人民医院 | 一种嘧啶类化合物在制备抗真菌药物中的应用 |
CN103417545B (zh) * | 2013-08-02 | 2014-12-31 | 上海市第十人民医院 | 一种吡唑并嘧啶类化合物在制备抗烟曲霉菌感染性疾病药物中的应用 |
CN103356627B (zh) * | 2013-08-02 | 2014-10-29 | 上海市第十人民医院 | 一种药物在光滑假丝酵母菌感染性疾病应用 |
CN103356625B (zh) * | 2013-08-02 | 2014-10-29 | 上海市第十人民医院 | 嗓唑并嘧啶类在***滑假丝酵母菌感染性疾病应用 |
CN103356626B (zh) * | 2013-08-02 | 2015-01-07 | 上海市第十人民医院 | 吡唑并嘧啶类化合物在制备抗红色毛癣菌感染疾病药物中的应用 |
CN103356628B (zh) * | 2013-08-02 | 2014-10-29 | 上海市第十人民医院 | 嗓唑并嘧啶类化合物在制药中的应用 |
US9512084B2 (en) * | 2013-11-29 | 2016-12-06 | Novartis Ag | Amino pyrimidine derivatives |
AU2014359456B2 (en) * | 2013-12-04 | 2019-01-24 | Evotec International Gmbh | Sulfoximine substituted quinazolines for pharmaceutical compositions |
WO2015091156A1 (en) * | 2013-12-17 | 2015-06-25 | Boehringer Ingelheim International Gmbh | Sulfoximine substituted pyrrolotriazines for pharmaceutical compositions |
AU2015257917C1 (en) * | 2014-05-07 | 2019-03-14 | Evotec International Gmbh | Sulfoximine substituted quinazolines for pharmaceutical compositions |
GB201520500D0 (en) * | 2015-11-20 | 2016-01-06 | Medical Res Council Technology | Compounds |
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WO2019023651A2 (en) * | 2017-07-28 | 2019-01-31 | Massachusetts Institute Of Technology | MODULATORS OF THE SMALL MOLECULE ANDROGEN RECEPTOR |
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2011
- 2011-02-24 UY UY0001033241A patent/UY33241A/es not_active Application Discontinuation
- 2011-02-25 AR ARP110100601A patent/AR080327A1/es unknown
- 2011-02-25 KR KR1020127022310A patent/KR20120130052A/ko not_active Application Discontinuation
- 2011-02-25 AU AU2011219761A patent/AU2011219761A1/en not_active Abandoned
- 2011-02-25 WO PCT/EP2011/052810 patent/WO2011104337A1/en active Application Filing
- 2011-02-25 JP JP2012554347A patent/JP5639197B2/ja active Active
- 2011-02-25 CN CN2011800209929A patent/CN102869669A/zh active Pending
- 2011-02-25 MX MX2012009409A patent/MX2012009409A/es not_active Application Discontinuation
- 2011-02-25 US US13/034,913 patent/US8648068B2/en active Active
- 2011-02-25 BR BR112012021264A patent/BR112012021264A2/pt not_active Application Discontinuation
- 2011-02-25 CA CA2791105A patent/CA2791105A1/en not_active Abandoned
- 2011-02-25 EP EP11707387.4A patent/EP2539346B1/en active Active
- 2011-02-25 TW TW100106540A patent/TW201141482A/zh unknown
- 2011-02-25 EA EA201201193A patent/EA201201193A1/ru unknown
-
2012
- 2012-08-21 CL CL2012002318A patent/CL2012002318A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AR080327A1 (es) | 2012-03-28 |
BR112012021264A2 (pt) | 2016-05-17 |
WO2011104337A1 (en) | 2011-09-01 |
TW201141482A (en) | 2011-12-01 |
CA2791105A1 (en) | 2011-09-01 |
EA201201193A1 (ru) | 2013-04-30 |
UY33241A (es) | 2011-09-30 |
EP2539346B1 (en) | 2014-04-16 |
JP2013520472A (ja) | 2013-06-06 |
MX2012009409A (es) | 2012-09-07 |
EP2539346A1 (en) | 2013-01-02 |
JP5639197B2 (ja) | 2014-12-10 |
CN102869669A (zh) | 2013-01-09 |
US20110212102A1 (en) | 2011-09-01 |
KR20120130052A (ko) | 2012-11-28 |
US8648068B2 (en) | 2014-02-11 |
AU2011219761A1 (en) | 2012-08-16 |
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