CL2011000663A1 - Compuestos derivados de n-heterociclil-2-sulfonil acetamida, moduladores del receptor cb2, utiles para el tratamiento del dolor, enfermedad pulmonar, reumatica, autoinmune, entre otras. - Google Patents

Compuestos derivados de n-heterociclil-2-sulfonil acetamida, moduladores del receptor cb2, utiles para el tratamiento del dolor, enfermedad pulmonar, reumatica, autoinmune, entre otras.

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Publication number
CL2011000663A1
CL2011000663A1 CL2011000663A CL2011000663A CL2011000663A1 CL 2011000663 A1 CL2011000663 A1 CL 2011000663A1 CL 2011000663 A CL2011000663 A CL 2011000663A CL 2011000663 A CL2011000663 A CL 2011000663A CL 2011000663 A1 CL2011000663 A1 CL 2011000663A1
Authority
CL
Chile
Prior art keywords
rheumatic
heterocyclyl
pain
pulmonary
useful
Prior art date
Application number
CL2011000663A
Other languages
English (en)
Inventor
Eugene Richard Hickey
Doris Riether
Alessandra Bartolozzi
Lifem Wu
Renee Zindell
Stephen Peter East
Monika Ermann
Original Assignee
Boehringer Ingelheim Intrnational Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Boehringer Ingelheim Intrnational Gmbh filed Critical Boehringer Ingelheim Intrnational Gmbh
Publication of CL2011000663A1 publication Critical patent/CL2011000663A1/es

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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

Compuestos derivados de n-heterociclil-2-sulfonil acetamida, moduladores de CB2; composición farmacéutica; y su uso para tratar el dolor, enfermedad pulmonar, reumática, autoinmune, alérgica, vascular, gastrointestinal, renal, dermatológica, entre otras.
CL2011000663A 2008-09-25 2011-03-25 Compuestos derivados de n-heterociclil-2-sulfonil acetamida, moduladores del receptor cb2, utiles para el tratamiento del dolor, enfermedad pulmonar, reumatica, autoinmune, entre otras. CL2011000663A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10007708P 2008-09-25 2008-09-25

Publications (1)

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CL2011000663A1 true CL2011000663A1 (es) 2011-07-29

Family

ID=41698020

Family Applications (2)

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CL2011000662A CL2011000662A1 (es) 2008-09-25 2011-03-25 Compuestos derivados de n-heteroaril-sulfonil-amida, moduladores selectivos del receptor cb2; composicion farmaceutica; y uso para el tratamiento del dolor, enfermedad pulmonar,enfermedad autoinmune, enfermedad neurologica, entre otras.
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Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5448164B2 (ja) * 2006-07-28 2014-03-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を変調する化合物
US7928123B2 (en) 2006-09-25 2011-04-19 Boehringer Ingelheim International Gmbh Compounds which modulate the CB2 receptor
WO2008048914A1 (en) * 2006-10-17 2008-04-24 Boehringer Ingelheim International Gmbh Polycyclic compounds which modulate the cb2 receptor
US8173638B2 (en) 2006-11-21 2012-05-08 Boehringer Ingelheim International Gmbh Compounds which modulate the CB2 receptor
JP2011500820A (ja) * 2007-10-25 2011-01-06 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を制御するジアゼパン化合物
WO2009061652A1 (en) * 2007-11-07 2009-05-14 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
WO2009105509A1 (en) 2008-02-21 2009-08-27 Boehringer Ingelheim International Gmbh Amine and ether compounds which modulate the cb2 receptor
JP5749162B2 (ja) 2008-07-10 2015-07-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節するスルホン化合物
AP2011005674A0 (en) * 2008-09-25 2011-04-30 Boehringer Ingelheim Int Sulfonyl compounds which selectively modulate the CB2 receptor.
WO2010077836A2 (en) 2009-01-05 2010-07-08 Boehringer Ingelheim International Gmbh Pyrrolidine compounds which modulate the cb2 receptor
US8889670B2 (en) 2009-02-18 2014-11-18 Boehringer Ingelheim International Gmbh Heterocyclic compounds which modulate the CB2 receptor
US8299103B2 (en) * 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
WO2010147791A1 (en) 2009-06-16 2010-12-23 Boehringer Ingelheim International Gmbh Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor
WO2011037795A1 (en) * 2009-09-22 2011-03-31 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the cb2 receptor
CN102933579B (zh) 2009-12-17 2015-07-15 贝林格尔.英格海姆国际有限公司 新的ccr2受体拮抗剂及其用途
EP2523936A1 (en) * 2010-01-15 2012-11-21 Boehringer Ingelheim International GmbH Compounds which modulate the cb2 receptor
US8329735B2 (en) 2010-03-05 2012-12-11 Boehringer Ingelheim International Gmbh Tetrazole compounds which selectively modulate the CB2 receptor
EP2595959B1 (en) 2010-07-22 2015-11-04 Boehringer Ingelheim International GmbH Sulfonyl compounds which modulate the cb2 receptor
US20140113898A1 (en) * 2010-11-08 2014-04-24 Zalicus Pharmaceuticals Ltd. Bisarylsulfone and dialkylarylsulfone compounds as calcium channel blockers
EA027780B1 (ru) * 2012-12-07 2017-08-31 Ф.Хоффманн-Ля Рош Аг Пиридин-2-амиды, пригодные в качестве агонистов каннабиноидного рецептора 2
EP2803668A1 (en) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
CA2990460C (en) 2015-07-02 2023-10-17 Centrexion Therapeutics Corporation (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4-yl)methanone citrate
US11161852B1 (en) 2020-05-08 2021-11-02 Halia Therapeutics, Inc. Inhibitors of NEK7 kinase
KR102584607B1 (ko) * 2023-01-19 2023-10-04 아주대학교산학협력단 1h-피라졸-3-아마이드계 화합물 유도체를 포함하는 염증성 피부질환 예방 또는 치료용 조성물

Family Cites Families (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3117128A (en) 1964-01-07 Certificate of correction
US3116284A (en) * 1963-12-31 Chs chj
CH312963A (de) 1953-03-10 1956-03-15 Sandoz Ag Verfahren zur Herstellung von Azofarbstoffen
GB853799A (en) 1957-11-21 1960-11-09 Pfizer & Co C Diquaternary compounds and process of preparing same
GB884258A (en) 1958-11-06 1961-12-13 Ciba Ltd A new quinone derivative
GB1237126A (en) 1968-04-10 1971-06-30 Agfa Gevaert Nv 3-acyl-amino-pyrazolin-5-ones
US3577462A (en) 1968-08-08 1971-05-04 American Home Prod N-arylalkyl-beta-hydroxy-beta-phenyl-ethylamines and the salts thereof
US3966809A (en) 1973-11-19 1976-06-29 Stauffer Chemical Company Insect repellent compounds
US4257954A (en) * 1978-08-08 1981-03-24 Sterling Drug Inc. Novel compounds, processes and marking systems
US4535087A (en) 1982-11-19 1985-08-13 Chevron Research Company N-Substituted phenoxyacetamide fungicides
US4672065A (en) 1982-11-19 1987-06-09 Chevron Research Company N-substituted phenoxyacetamide fungicides
US4859707A (en) * 1983-08-23 1989-08-22 Key Pharmaceuticals, Inc. Sulfur-substituted phenylacetamides
JPS6127955A (ja) 1984-07-18 1986-02-07 Hokko Chem Ind Co Ltd アリ−ルスルホニル脂肪酸アミド誘導体、その製造法および除草剤
JPS6127905U (ja) 1984-07-25 1986-02-19 本田技研工業株式会社 Ｏｈｃ型内燃機関
JPS61126071A (ja) 1984-11-22 1986-06-13 Hokko Chem Ind Co Ltd 農園芸用殺菌剤
DE3600950A1 (de) 1986-01-15 1987-07-16 Bayer Ag 5-acylamido-1-aryl-pyrazole
EP0507863A4 (en) * 1989-12-28 1993-07-07 Virginia Commonwealth University Sigma receptor ligands and the use thereof
KR0169501B1 (ko) 1990-11-26 1999-03-20 우에하라 아키라 아닐리드 유도체
US5362878A (en) 1991-03-21 1994-11-08 Pfizer Inc. Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
CA2077252C (en) 1992-08-31 2001-04-10 Khashayar Karimian Methods of making ureas and guanidines, and intermediates therefor
IL107120A (en) 1992-09-29 1997-09-30 Boehringer Ingelheim Int Atomising nozzle and filter and spray generating device
US5256658A (en) * 1993-01-15 1993-10-26 Ortho Pharmaceutical Corporation Angiotensin II inhibitors
US5428037A (en) 1993-04-09 1995-06-27 Syntex Pharmaceuticals, Ltd. Heterocyclic derivatives in the treatment of Ischaemia and related diseases
DE4319039A1 (de) 1993-06-08 1994-12-15 Bayer Ag Substituierte (2-Oxo-1-benzimidazolinyl)-piperidine, Verfahren zu ihrer Herstellung und Verwendung als anti-retrovirale Mittel
EP0710654A4 (en) 1993-07-23 1996-08-28 Green Cross Corp TRIAZOLE DERIVATIVE AND ITS PHARMACEUTICAL USE
US5583147A (en) 1994-03-23 1996-12-10 The Dupont Merck Pharmaceutical Company Amides for the treatment of atherosclerosis
WO1996026925A1 (fr) 1995-03-01 1996-09-06 Banyu Pharmaceutical Co., Ltd. Derives de l'arylthioacetamide
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
DE19536903C2 (de) 1995-10-04 1998-09-10 Boehringer Ingelheim Int Vorrichtung zum Haltern eines fluidischen Bauteils
DE19545226C1 (de) * 1995-12-05 1997-06-19 Boehringer Ingelheim Int Sperrspannwerk für einen federbetätigten Abtrieb
JP2000511903A (ja) 1996-06-07 2000-09-12 メルク エンド カンパニー インコーポレーテッド 糖尿病および肥満の治療のための選択性β▲下３▼作動薬としてのオキサジアゾール・ベンゼンスルホンアミド
US5808453A (en) 1996-08-21 1998-09-15 Siliconix Incorporated Synchronous current sharing pulse width modulator
EP0931077B1 (en) 1996-09-13 2005-04-27 Schering Corporation Substituted benzocycloheptapyridine useful as inhibitors of farnesyl-protein transferase
CN1158254C (zh) 1996-09-27 2004-07-21 法玛西雅厄普约翰美国公司 作为基质金属蛋白酶抑制剂的β-磺酰基异羟肟酸
US5968929A (en) 1996-10-30 1999-10-19 Schering Corporation Piperazino derivatives as neurokinin antagonists
US6048900A (en) * 1998-02-13 2000-04-11 Bayer Corporation Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists
DK0966436T3 (da) * 1997-02-21 2003-03-31 Bayer Ag Arylsulfonamider og analoger deraf og anvendelse deraf til behandling af neurodegenerative lidelser
SK115899A3 (en) 1997-02-27 2000-05-16 American Cyanamid Co N-hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
US5958940A (en) 1997-09-11 1999-09-28 Schering Corporation Tricyclic compounds useful as inhibitors of farnesyl-protein transferase
TR200001391T2 (tr) * 1997-11-21 2000-11-21 Pharmacia & Upjohn Company Matris metaloproteinaz önleyicileri olarak beta-sülfonil hidroksamik asitlerin alfa-hidroksi, -amino ve halo türevleri.
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
US6359009B1 (en) * 1998-04-08 2002-03-19 Basf Aktiengesellschaft Substituted anilide insecticidal agents
GB9810671D0 (en) * 1998-05-18 1998-07-15 Pfizer Ltd Anti-pruritic agents
AU772373B2 (en) 1998-08-07 2004-04-22 Laboratoires Serono Sa FSH mimetics for the treatment of infertility
IL145508A0 (en) * 1999-03-26 2002-06-30 Euro Celtique Sa Aryl substituted pyrazole, imidazole, oxazole, thiazole and pyrrole derivatives and pharmaceutical compositions containing the same
DE19929076A1 (de) * 1999-06-25 2000-12-28 Aventis Pharma Gmbh Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
US6355653B1 (en) 1999-09-06 2002-03-12 Hoffmann-La Roche Inc. Amino-triazolopyridine derivatives
EP1224173B1 (en) 1999-10-18 2005-10-12 The University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
AR035912A1 (es) 2000-03-02 2004-07-28 Aventis Cropscience Sa Compuestos de 4-tiometilpirazol, composicion plaguicida, metodo para el control de plagas en un lugar, semillas tratadas o recubiertas,uso de estos compuestos o composiciones para el control de plagas, uso de estos compuestos para preparar un medicamento veterinario, y,proceso para la preparacion de
MXPA03005648A (es) * 2000-12-22 2003-10-06 Astrazeneca Ab Derivados de carbazol y su uso, como ligandos de receptor del neuropeptido y5.
US20020099035A1 (en) 2001-01-24 2002-07-25 Sandanayaka Vincent P. Method for preparing alpha-sulfonyl hydroxamic acid derivatives
US7067539B2 (en) 2001-02-08 2006-06-27 Schering Corporation Cannabinoid receptor ligands
US7507767B2 (en) 2001-02-08 2009-03-24 Schering Corporation Cannabinoid receptor ligands
WO2002088089A1 (fr) 2001-04-19 2002-11-07 Banyu Pharmaceutical Co., Ltd. Derives de spiropiperidine, antagonistes du recepteur de nociceptine les contenant en tant qu'ingredient actif et compositions medicinales
DE10129899A1 (de) 2001-06-21 2003-01-09 Basf Coatings Ag Physikalisch, thermisch oder thermisch und mit aktinischer Strahlung härtbarer wäßriger Beschichtungsstoff und seine Verwendung
CN1564809A (zh) * 2001-10-04 2005-01-12 诺瓦提斯公司 有机化合物
ATE455104T1 (de) * 2001-11-01 2010-01-15 Icagen Inc Pyrazolamide zur anwendung in der behandlung von schmerz
JP2003155285A (ja) 2001-11-19 2003-05-27 Toray Ind Inc 環状含窒素誘導体
AU2002351748B2 (en) 2001-12-21 2009-07-09 Novo Nordisk A/S Amide derivatives as GK activators
JP2005533809A (ja) 2002-06-19 2005-11-10 シェーリング　コーポレイション カンナビノイドレセプタアゴニスト
US20040132726A1 (en) 2002-08-09 2004-07-08 Astrazeneca Ab And Nps Pharmaceuticals, Inc. New compounds
US7074809B2 (en) 2002-08-09 2006-07-11 Astrazeneca Ab Compounds
UY27939A1 (es) 2002-08-21 2004-03-31 Glaxo Group Ltd Compuestos
US7319110B2 (en) 2002-09-19 2008-01-15 Solvay Pharmaceuticals B.V. 1H-1,2,4-triazole-3-carboxamide derivatives having cannabinoid-CB1 receptor agonistic, partial agonistic, inverse agonistic or antagonistic activity
GB0222495D0 (en) 2002-09-27 2002-11-06 Glaxo Group Ltd Compounds
AU2003284165B2 (en) 2002-10-30 2008-12-11 Merck Sharp & Dohme Corp. Piperidinyl-alpha-aminoamide modulators of chemokine receptor activity
US7642277B2 (en) 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
SE0300010D0 (sv) 2003-01-07 2003-01-07 Astrazeneca Ab Novel Compounds
US7718692B2 (en) 2004-02-13 2010-05-18 Carson John R Hetero-substituted acetanilide derivatives as analgesic agents
US7449464B2 (en) 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
SE0301372D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab Novel compounds
JP2006525990A (ja) 2003-05-12 2006-11-16 ファイザー・プロダクツ・インク 神経変性障害の処置のためのイソオキサゾール化合物およびイソチアゾール化合物
JP2004337701A (ja) * 2003-05-14 2004-12-02 Seiko Epson Corp 液滴吐出方法、及び液滴吐出装置
US20070105914A1 (en) 2003-09-18 2007-05-10 Armstrong Helen M Substituted sulfonamides
WO2005030127A2 (en) * 2003-09-23 2005-04-07 Merck & Co., Inc. Novel crystalline form of a phosphoric acid salt of a dipeptidyl peptidase-iv inhibitor
AU2004283313A1 (en) 2003-10-24 2005-05-06 Exelixis, Inc. TAO kinase modulators and methods of use
US7820673B2 (en) 2003-12-17 2010-10-26 Takeda Pharmaceutical Company Limited Urea derivative, process for producing the same, and use
WO2005077345A1 (en) 2004-02-03 2005-08-25 Astrazeneca Ab Compounds for the treatment of gastro-esophageal reflux disease
WO2005077373A2 (en) 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)
WO2005077368A2 (en) 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)
US7585881B2 (en) * 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
FR2866885B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique
JP2007526324A (ja) 2004-03-02 2007-09-13 スミスクライン・ビーチャム・コーポレイション Ａｋｔ活性のある阻害剤
WO2005121758A1 (en) * 2004-06-03 2005-12-22 Ciphergen Biosystems, Inc. Biomarkers for peripheral artery disease
US20050288338A1 (en) 2004-06-24 2005-12-29 Wenqing Yao Amido compounds and their use as pharmaceuticals
FR2872813B1 (fr) 2004-07-09 2007-01-19 Sanofi Synthelabo Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
MX2007003161A (es) 2004-09-16 2007-05-16 Astellas Pharma Inc Derivado de triazol o una sal del mismo.
WO2006044645A2 (en) * 2004-10-13 2006-04-27 Adolor Corporation Sulfamoyl benzamides and methods of their use
CN102633730A (zh) 2004-12-03 2012-08-15 先灵公司 作为cb1拮抗剂的取代哌嗪
AU2006203845A1 (en) * 2005-01-10 2006-07-13 Alexandros Makriyannis Novel heteropyrrole analogs acting on cannabiniod receptors
US20090043129A1 (en) 2005-01-25 2009-02-12 Antonella Brizzi Potent and selective ligands of cannabinoid receptors
GB0504753D0 (en) 2005-03-08 2005-04-13 Astrazeneca Ab Chemical compounds
GB0506133D0 (en) 2005-03-24 2005-05-04 Sterix Ltd Compound
FR2885364B1 (fr) 2005-05-03 2007-06-29 Sanofi Aventis Sa Derives d'alkyl-, alkenyl-et alkynylcarbamates, leur preparation et leur application en therapeutique
WO2007020502A2 (en) 2005-08-16 2007-02-22 Pharmacia & Upjohn Company Llc Cannabinoid receptor ligands and uses thereof
WO2007054770A2 (en) 2005-11-08 2007-05-18 Pfizer Limited Pyrazole derivatives and their medical use
CA2632030A1 (en) 2005-12-15 2007-06-21 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
CA2635997A1 (en) 2006-01-11 2007-07-19 Astrazeneca Ab Morpholino pyrimidine derivatives and their use in therapy
WO2007101270A1 (en) 2006-03-02 2007-09-07 Incyte Corporation MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
WO2007102059A1 (en) 2006-03-06 2007-09-13 Pfizer Japan Inc. Sulfonyl benzimidazole derivatives
EP2007707A1 (en) 2006-04-07 2008-12-31 Boehringer Ingelheim International GmbH Compounds which modulate the cb2 receptor
BRPI0712720A2 (pt) * 2006-05-31 2012-11-20 Abbott Lab compostos tiazàis como ligantes do receptor canabinàide e usos dos mesmos
JP5448164B2 (ja) * 2006-07-28 2014-03-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を変調する化合物
MX2009002046A (es) 2006-08-24 2009-03-06 Astrazeneca Ab Derivados de morfolino pirimidina utiles en el tratamiento de trastornos proliferativos.
US7928123B2 (en) * 2006-09-25 2011-04-19 Boehringer Ingelheim International Gmbh Compounds which modulate the CB2 receptor
WO2008048914A1 (en) 2006-10-17 2008-04-24 Boehringer Ingelheim International Gmbh Polycyclic compounds which modulate the cb2 receptor
US8173638B2 (en) 2006-11-21 2012-05-08 Boehringer Ingelheim International Gmbh Compounds which modulate the CB2 receptor
WO2008098025A1 (en) 2007-02-08 2008-08-14 Boehringer Ingelheim International Gmbh Arylsulfonamide compounds which modulate the cb2 receptor
JP5491871B2 (ja) 2007-02-28 2014-05-14 アドビナス セラピュティックス プライベート リミテッド グルコキナーゼ活性化因子としての２，２，２−三置換アセトアミド誘導体、その方法及び薬学的応用
CN101646679A (zh) 2007-03-29 2010-02-10 弗·哈夫曼-拉罗切有限公司 杂环抗病毒化合物
JP2011500820A (ja) * 2007-10-25 2011-01-06 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を制御するジアゼパン化合物
WO2009061652A1 (en) 2007-11-07 2009-05-14 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
CN101896471A (zh) 2007-12-17 2010-11-24 詹森药业有限公司 氟代烷基取代的苯并咪唑***素激动剂
JP2011507910A (ja) * 2007-12-21 2011-03-10 ユニバーシティー オブ ロチェスター 真核生物の寿命を変更するための方法
WO2009105509A1 (en) 2008-02-21 2009-08-27 Boehringer Ingelheim International Gmbh Amine and ether compounds which modulate the cb2 receptor
US20120015988A1 (en) 2008-05-13 2012-01-19 Boehringer Ingelheim International Gmbh Sulfone Compounds Which Modulate The CB2 Receptor
JP5749162B2 (ja) 2008-07-10 2015-07-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節するスルホン化合物
AP2011005674A0 (en) * 2008-09-25 2011-04-30 Boehringer Ingelheim Int Sulfonyl compounds which selectively modulate the CB2 receptor.
WO2010077836A2 (en) 2009-01-05 2010-07-08 Boehringer Ingelheim International Gmbh Pyrrolidine compounds which modulate the cb2 receptor
US8889670B2 (en) 2009-02-18 2014-11-18 Boehringer Ingelheim International Gmbh Heterocyclic compounds which modulate the CB2 receptor
US8299103B2 (en) * 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
WO2010147791A1 (en) 2009-06-16 2010-12-23 Boehringer Ingelheim International Gmbh Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor
WO2011037795A1 (en) 2009-09-22 2011-03-31 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the cb2 receptor
EP2523936A1 (en) 2010-01-15 2012-11-21 Boehringer Ingelheim International GmbH Compounds which modulate the cb2 receptor
US8329735B2 (en) 2010-03-05 2012-12-11 Boehringer Ingelheim International Gmbh Tetrazole compounds which selectively modulate the CB2 receptor
EP2595959B1 (en) 2010-07-22 2015-11-04 Boehringer Ingelheim International GmbH Sulfonyl compounds which modulate the cb2 receptor

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IL210853A0 (en) 2011-04-28
CN102164917A (zh) 2011-08-24
US8372874B2 (en) 2013-02-12
UY32139A (es) 2010-04-30
JP5453437B2 (ja) 2014-03-26
BRPI0919172A2 (pt) 2015-12-15
WO2010036631A2 (en) 2010-04-01
AP2011005674A0 (en) 2011-04-30
AR073688A1 (es) 2010-11-24
PE20110397A1 (es) 2011-07-01
US20110312932A1 (en) 2011-12-22
CL2011000662A1 (es) 2011-09-02
TW201018677A (en) 2010-05-16
AU2009296837A1 (en) 2010-04-01
EP2342199B1 (en) 2014-02-26
IL210433A0 (en) 2011-03-31
US20100081644A1 (en) 2010-04-01
EP2342199A2 (en) 2011-07-13
WO2010036630A3 (en) 2010-05-20
NZ591111A (en) 2013-08-30
TW201016690A (en) 2010-05-01
JP4928650B2 (ja) 2012-05-09
CO6361912A2 (es) 2012-01-20
CA2737645A1 (en) 2010-04-01
ZA201100483B (en) 2011-10-26
JP2012503662A (ja) 2012-02-09
CN102164916A (zh) 2011-08-24
EP2342200A2 (en) 2011-07-13
WO2010036630A2 (en) 2010-04-01
KR20110063485A (ko) 2011-06-10
EP2342200B1 (en) 2013-01-23
US8362039B2 (en) 2013-01-29

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