CL2008002787A1 - Compuestos derivados de piperidina, que presentan actividad moduladora sobre la actividad del receptor gpr 119; composición farmacéutica que comprende a dichos compuestos; y su uso en el tratamiento de enfermedades tales como diabetes tipo 1 y 2, hiperllpidemia, enfermedad coronaria, obesidad y disfuncion erectil. - Google Patents
Compuestos derivados de piperidina, que presentan actividad moduladora sobre la actividad del receptor gpr 119; composición farmacéutica que comprende a dichos compuestos; y su uso en el tratamiento de enfermedades tales como diabetes tipo 1 y 2, hiperllpidemia, enfermedad coronaria, obesidad y disfuncion erectil.Info
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- CL2008002787A1 CL2008002787A1 CL2008002787A CL2008002787A CL2008002787A1 CL 2008002787 A1 CL2008002787 A1 CL 2008002787A1 CL 2008002787 A CL2008002787 A CL 2008002787A CL 2008002787 A CL2008002787 A CL 2008002787A CL 2008002787 A1 CL2008002787 A1 CL 2008002787A1
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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Abstract
LA INVENCIÓN SE REFIERE A COMPUESTOS DE FORMULA GENERAL I DERIVADOS DE PIPERIDINA COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN A DICHOS COMPUESTOS Y USOS DE LOS MISMOS EN LA FABRICACIÓN DE MEDICAMENTOS PARA TRATAR O PREVENIR ENFERMEDADES O TRASTORNOS ASOCIADOS CON LA ACTIVIDAD DEL 119 TALES COMO DIABETES TIPO 1 Y 2 HIPERLIPIDEMIA ENFERMEDAD CORONARIA OBESIDAD Y DISFUNSION ERECTIL
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97406407P | 2007-09-20 | 2007-09-20 | |
US4526308P | 2008-04-15 | 2008-04-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2008002787A1 true CL2008002787A1 (es) | 2009-05-15 |
Family
ID=40039643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2008002787A CL2008002787A1 (es) | 2007-09-20 | 2008-09-17 | Compuestos derivados de piperidina, que presentan actividad moduladora sobre la actividad del receptor gpr 119; composición farmacéutica que comprende a dichos compuestos; y su uso en el tratamiento de enfermedades tales como diabetes tipo 1 y 2, hiperllpidemia, enfermedad coronaria, obesidad y disfuncion erectil. |
Country Status (22)
Country | Link |
---|---|
US (3) | US8153635B2 (es) |
EP (1) | EP2197873B1 (es) |
JP (1) | JP5465177B2 (es) |
KR (1) | KR20100055536A (es) |
CN (1) | CN101801954B (es) |
AR (1) | AR068496A1 (es) |
AU (1) | AU2008302570B2 (es) |
BR (1) | BRPI0817211A2 (es) |
CA (1) | CA2697551C (es) |
CL (1) | CL2008002787A1 (es) |
CO (1) | CO6270362A2 (es) |
CR (1) | CR11292A (es) |
EC (1) | ECSP10010042A (es) |
ES (1) | ES2499018T3 (es) |
MA (1) | MA31764B1 (es) |
MX (1) | MX2010003117A (es) |
NZ (1) | NZ583495A (es) |
PE (1) | PE20090708A1 (es) |
RU (1) | RU2443699C2 (es) |
TN (1) | TN2010000122A1 (es) |
TW (1) | TWI368618B (es) |
WO (1) | WO2009038974A1 (es) |
Families Citing this family (56)
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EA011009B1 (ru) | 2003-01-14 | 2008-12-30 | Арена Фармасьютикалз Инк. | 1,2,3-тризамещённые арильные и гетероарильные производные в качестве модуляторов метаболизма и профилактика и лечение расстройств, связанных с ним, таких как диабет и гипергликемия |
WO2009038974A1 (en) | 2007-09-20 | 2009-03-26 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
EP2146210A1 (en) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY |
KR20100137561A (ko) * | 2008-04-07 | 2010-12-30 | 아이알엠 엘엘씨 | Gpr119 활성의 조절제로서의 화합물 및 조성물 |
WO2010006191A1 (en) * | 2008-07-11 | 2010-01-14 | Irm Llc | 4-phenoxymethylpiperidines as modulators of gpr119 activity |
CN102803255A (zh) * | 2009-06-18 | 2012-11-28 | 卡迪拉保健有限公司 | 新的gpr119激动剂 |
TW201113269A (en) | 2009-06-24 | 2011-04-16 | Boehringer Ingelheim Int | New compounds, pharmaceutical composition and methods relating thereto |
US8293729B2 (en) | 2009-06-24 | 2012-10-23 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical composition and methods relating thereto |
AR077638A1 (es) * | 2009-07-15 | 2011-09-14 | Lilly Co Eli | Compuesto de (metanosulfonil -piperidin )-( alcoxi-aril) -tetrahidro- piridina , composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para el tratamiento de diabetes u obesidad |
US8552022B2 (en) | 2009-08-13 | 2013-10-08 | Merck Sharp & Dohme Corp. | Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment |
WO2011030139A1 (en) | 2009-09-11 | 2011-03-17 | Astrazeneca Ab | 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators |
EP2486033A1 (en) * | 2009-10-09 | 2012-08-15 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
US8912206B2 (en) | 2009-11-23 | 2014-12-16 | Merck Sharp & Dohme Corp. | Pyrimidine ether derivatives and methods of use thereof |
CN103221391B (zh) | 2010-01-27 | 2018-07-06 | 艾尼纳制药公司 | (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法 |
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WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
US20130109703A1 (en) | 2010-03-18 | 2013-05-02 | Boehringer Ingelheim International Gmbh | Combination of a GPR119 Agonist and the DPP-IV Inhibitor Linagliptin for Use in the Treatment of Diabetes and Related Conditions |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
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EP2720544B1 (en) | 2011-06-16 | 2016-12-21 | Merck Sharp & Dohme Corp. | Substituted cyclopropyl compounds, compositions containing such compounds, and methods of treatment |
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RU2443699C2 (ru) | 2012-02-27 |
CA2697551C (en) | 2013-03-12 |
KR20100055536A (ko) | 2010-05-26 |
ECSP10010042A (es) | 2010-04-30 |
CO6270362A2 (es) | 2011-04-20 |
JP2010540441A (ja) | 2010-12-24 |
ES2499018T3 (es) | 2014-09-26 |
US20090270409A1 (en) | 2009-10-29 |
TN2010000122A1 (en) | 2011-09-26 |
EP2197873A1 (en) | 2010-06-23 |
NZ583495A (en) | 2011-11-25 |
CN101801954A (zh) | 2010-08-11 |
WO2009038974A1 (en) | 2009-03-26 |
AR068496A1 (es) | 2009-11-18 |
MA31764B1 (fr) | 2010-10-01 |
US20110224185A1 (en) | 2011-09-15 |
MX2010003117A (es) | 2010-04-01 |
AU2008302570A1 (en) | 2009-03-26 |
PE20090708A1 (es) | 2009-07-15 |
TW200914448A (en) | 2009-04-01 |
CN101801954B (zh) | 2013-10-09 |
BRPI0817211A2 (pt) | 2017-05-16 |
JP5465177B2 (ja) | 2014-04-09 |
US20120196844A1 (en) | 2012-08-02 |
US8153635B2 (en) | 2012-04-10 |
RU2010115260A (ru) | 2011-10-27 |
CA2697551A1 (en) | 2009-03-26 |
AU2008302570B2 (en) | 2012-05-31 |
US8258156B2 (en) | 2012-09-04 |
TWI368618B (en) | 2012-07-21 |
EP2197873B1 (en) | 2014-07-16 |
CR11292A (es) | 2010-03-22 |
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