MXPA04010555A - Acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos y su uso como inhibidores de proteasa. - Google Patents
Acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos y su uso como inhibidores de proteasa.Info
- Publication number
- MXPA04010555A MXPA04010555A MXPA04010555A MXPA04010555A MXPA04010555A MX PA04010555 A MXPA04010555 A MX PA04010555A MX PA04010555 A MXPA04010555 A MX PA04010555A MX PA04010555 A MXPA04010555 A MX PA04010555A MX PA04010555 A MXPA04010555 A MX PA04010555A
- Authority
- MX
- Mexico
- Prior art keywords
- hydroxamic acids
- piperazinyl
- piperidinyl
- activity
- protease inhibitors
- Prior art date
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Esta invencion se refiere de manera general a inhibidores de proteinaza (tambien conocida como "proteasa"), y en particular, acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos que, Inter alia, inhiben la actividad de metaloproteinasa de matriz (tambien conocida como "metaloproteasa de matriz" o "MMP") y/o actividad de agrecanasa, dichos acidos hidroxamicos generalmente corresponden en estructura a la formula (I)(ver formula I)(en donde A1, A2 , Y, E1, E2, R3, y Rx son como se definen en esta especificacion), e incluyen ademas sales de dichos compuestos; esta invencion tambien se refiere a composiciones de dichos acidos hidroxamicos, intermedirios para las sintesis de dichos acidos hidroxamicos, metodos ara hacer dichos acidos hidroxamicos y metodos para tratar condiciones (particularmente condiciones patologicas) asociadas con actividad de MMP y/o actividad de agrecanasa.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US37559802P | 2002-04-25 | 2002-04-25 | |
US38071302P | 2002-05-15 | 2002-05-15 | |
US39202102P | 2002-06-27 | 2002-06-27 | |
PCT/US2003/013123 WO2003091247A2 (en) | 2002-04-25 | 2003-04-25 | Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
Publications (1)
Publication Number | Publication Date |
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MXPA04010555A true MXPA04010555A (es) | 2005-02-17 |
Family
ID=29273641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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MXPA04010555A MXPA04010555A (es) | 2002-04-25 | 2003-04-25 | Acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos y su uso como inhibidores de proteasa. |
Country Status (8)
Country | Link |
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US (1) | US7119203B2 (es) |
EP (1) | EP1501827A2 (es) |
JP (1) | JP2005537228A (es) |
AU (1) | AU2003221786A1 (es) |
BR (1) | BR0309671A (es) |
CA (1) | CA2483314A1 (es) |
MX (1) | MXPA04010555A (es) |
WO (1) | WO2003091247A2 (es) |
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-
2003
- 2003-04-25 CA CA002483314A patent/CA2483314A1/en not_active Abandoned
- 2003-04-25 EP EP03718529A patent/EP1501827A2/en not_active Withdrawn
- 2003-04-25 JP JP2003587805A patent/JP2005537228A/ja not_active Withdrawn
- 2003-04-25 BR BR0309671-8A patent/BR0309671A/pt not_active IP Right Cessation
- 2003-04-25 MX MXPA04010555A patent/MXPA04010555A/es unknown
- 2003-04-25 AU AU2003221786A patent/AU2003221786A1/en not_active Abandoned
- 2003-04-25 US US10/618,288 patent/US7119203B2/en not_active Expired - Fee Related
- 2003-04-25 WO PCT/US2003/013123 patent/WO2003091247A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2005537228A (ja) | 2005-12-08 |
EP1501827A2 (en) | 2005-02-02 |
US20050009838A1 (en) | 2005-01-13 |
AU2003221786A1 (en) | 2003-11-10 |
WO2003091247A3 (en) | 2004-01-15 |
US7119203B2 (en) | 2006-10-10 |
CA2483314A1 (en) | 2003-11-06 |
BR0309671A (pt) | 2005-05-03 |
WO2003091247A2 (en) | 2003-11-06 |
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