CL2008001634A1 - Anticuerpo de la region regulatoria negativa anti-notch1 aislado; polinucleotido que lo codifica; vector y celula huesped; metodo de produccion; composicion que lo comprende; y su uso para preparar un medicamento para tratar un trastorno asociado con un aumento en la señalizacion o expresion de notch1 en un individuo. - Google Patents

Anticuerpo de la region regulatoria negativa anti-notch1 aislado; polinucleotido que lo codifica; vector y celula huesped; metodo de produccion; composicion que lo comprende; y su uso para preparar un medicamento para tratar un trastorno asociado con un aumento en la señalizacion o expresion de notch1 en un individuo.

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Publication number
CL2008001634A1
CL2008001634A1 CL2008001634A CL2008001634A CL2008001634A1 CL 2008001634 A1 CL2008001634 A1 CL 2008001634A1 CL 2008001634 A CL2008001634 A CL 2008001634A CL 2008001634 A CL2008001634 A CL 2008001634A CL 2008001634 A1 CL2008001634 A1 CL 2008001634A1
Authority
CL
Chile
Prior art keywords
notch1
antibody
vector
hvr
polynucleotide
Prior art date
Application number
CL2008001634A
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English (en)
Inventor
Yan Wu
Christian W Siebel
Original Assignee
Genentech Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39735560&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008001634(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CL2008001634A1 publication Critical patent/CL2008001634A1/es

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Abstract

UN ANTICUERPO DE LA REGIÓN REGULATORIA NEGATIVA (NRR) ANTI-NOTCHL AISLADO, SE UNE A UN NOTCH1 NRR CON UNA KD DE 1 X 10-7 O MAYOR, DONDE DICHO ANTICUERPO, CUANDO SE UNE A DICHO NOTCHL NRR, DISMINUYE LA SEÑALIZACIÓN DE NOTCH1, Y DONDE EL ANTICUERPO COMPRENDE HVR•L1, HVR•L2, HVR•L3, HVR•HL. HVR•H2 Y HVR•H3, DONDE CADA UNO, EN ORDEN, COMPRENDE: (I) SEA ID NO: 7, 8, 9, 1, 2, 6; (II)SEO ID NO: 7, 8, LA, 1, 3, 6; (III) SEA ID NO: 7, 8,11,1,4,6; O (IV) SEA ID NO: 7, 8, 12, 1, 5, 6. UN POLINUCLEÓTIDO QUE LO CODIFICA. UN VECTOR QUE COMPRENDE DICHO POLINUCLEÓTIDO. UNA CÉLULA HUÉSPED QUE COMPRENDE DICHO VECTOR. UN MÉTODO PARA PREPARAR UN ANTICUERPO ANTI-NOTCH1 NRR, DONDE DICHO MÉTODO COMPRENDE (A) EXPRESAR DICHO VECTOR EN UNA CÉLULA HUÉSPED ADECUADA Y (B) RECUPERAR EL ANTICUERPO. UNA COMPOSICIÓN QUE COMPRENDE UN ANTICUERPO ANTI-NOTCH1 NRR. USO DE UNA CANTIDAD EFECTIVA DE UN ANTICUERPO ANTI-NOTCH1 NRR, PARA PREPARAR UN MEDICAMENTO ÚTIL PARA TRATAR TRASTORNOS ASOCIADOS CON AUMENTO DE LA SEÑALIZACIÓN O EXPRESIÓN DE NOTCH1 O CON UNA MUTACIÓN EN UNA SECUENCIA DE AMINOÁCIDOS DE NOTCH1 EN UN INDIVIDUO, PARA TRATAR CÁNCER, UN TUMOR Y/O UN TRASTORNO PROLIFERATIVO CELULAR EN UN INDIVIDUO, ENTRE OTROS.
CL2008001634A 2007-06-04 2008-06-04 Anticuerpo de la region regulatoria negativa anti-notch1 aislado; polinucleotido que lo codifica; vector y celula huesped; metodo de produccion; composicion que lo comprende; y su uso para preparar un medicamento para tratar un trastorno asociado con un aumento en la señalizacion o expresion de notch1 en un individuo. CL2008001634A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93307207P 2007-06-04 2007-06-04
US99464607P 2007-09-20 2007-09-20

Publications (1)

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CL2008001634A1 true CL2008001634A1 (es) 2009-05-22

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CL2008001634A CL2008001634A1 (es) 2007-06-04 2008-06-04 Anticuerpo de la region regulatoria negativa anti-notch1 aislado; polinucleotido que lo codifica; vector y celula huesped; metodo de produccion; composicion que lo comprende; y su uso para preparar un medicamento para tratar un trastorno asociado con un aumento en la señalizacion o expresion de notch1 en un individuo.

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US (5) US8846871B2 (es)
EP (1) EP2152748B1 (es)
JP (4) JP5623272B2 (es)
KR (2) KR20100021581A (es)
CN (1) CN101796074B (es)
AR (1) AR066846A1 (es)
BR (1) BRPI0811382A2 (es)
CA (1) CA2687866C (es)
CL (1) CL2008001634A1 (es)
CO (1) CO6150200A2 (es)
CR (2) CR11139A (es)
CY (1) CY1114690T1 (es)
DK (1) DK2152748T3 (es)
EC (1) ECSP099785A (es)
ES (1) ES2432798T3 (es)
HK (1) HK1141040A1 (es)
HR (1) HRP20131107T1 (es)
IL (3) IL202183A0 (es)
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NZ (1) NZ581303A (es)
PE (1) PE20090321A1 (es)
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PL (1) PL2152748T3 (es)
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RU (1) RU2476443C2 (es)
SI (1) SI2152748T1 (es)
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WO (1) WO2008150525A1 (es)

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PL2032166T3 (pl) 2006-06-13 2013-09-30 Oncomed Pharm Inc Kompozycje i sposoby diagnozowania i leczenia nowotworów
US7994285B2 (en) 2006-10-19 2011-08-09 Genentech, Inc. Anti-Notch3 antibodies
WO2008136848A2 (en) 2006-10-19 2008-11-13 Genentech Inc. Novel anti-notch3 antibodies and their use in the detection and diagnosis of disease
CL2007003661A1 (es) 2006-12-18 2008-07-18 Genentech Inc Regiones de cadena pesada variable y liviana variable; acidos nucleicos que las codifican; metodo de produccion; anticuerpos anti-notch3 que las comprenden; y uso de los anticuerpos para tratar enfermedades relacionadas con el receptor notch3.
JP5618544B2 (ja) 2007-01-24 2014-11-05 オンコメッドファーマシューティカルズ インコーポレイテッド 癌の診断および処置のための組成物および方法
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
CN104402998A (zh) 2008-07-08 2015-03-11 昂考梅德药品有限公司 分离的抗体
CA2736429A1 (en) 2008-10-01 2010-04-08 Genentech, Inc. Anti-notch2 antibodies and methods of use
CA2765989C (en) * 2009-06-18 2016-11-29 Pfizer Inc. Anti notch-1 antibodies
US20120129189A1 (en) * 2009-07-17 2012-05-24 Chulan Kwon Methods of Controlling Cell Proliferation
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