CH625803A5 - Process for the preparation of thienamycin and its isomers deacetyl-890 A1 and 890 A3 - Google Patents

Process for the preparation of thienamycin and its isomers deacetyl-890 A1 and 890 A3 Download PDF

Info

Publication number
CH625803A5
CH625803A5 CH1459976A CH1459976A CH625803A5 CH 625803 A5 CH625803 A5 CH 625803A5 CH 1459976 A CH1459976 A CH 1459976A CH 1459976 A CH1459976 A CH 1459976A CH 625803 A5 CH625803 A5 CH 625803A5
Authority
CH
Switzerland
Prior art keywords
amidohydrolase
acetylthienamycin
solution
antibiotics
antibiotic
Prior art date
Application number
CH1459976A
Other languages
German (de)
English (en)
Inventor
Jean Kahan-Sawyer
Frederick Marvin Kahan
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH625803A5 publication Critical patent/CH625803A5/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CH1459976A 1975-11-24 1976-11-19 Process for the preparation of thienamycin and its isomers deacetyl-890 A1 and 890 A3 CH625803A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63456075A 1975-11-24 1975-11-24

Publications (1)

Publication Number Publication Date
CH625803A5 true CH625803A5 (en) 1981-10-15

Family

ID=24544292

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1459976A CH625803A5 (en) 1975-11-24 1976-11-19 Process for the preparation of thienamycin and its isomers deacetyl-890 A1 and 890 A3

Country Status (16)

Country Link
JP (1) JPS5265295A (es)
AR (1) AR224224A1 (es)
AU (1) AU510252B2 (es)
BE (1) BE848349A (es)
CH (1) CH625803A5 (es)
DE (1) DE2652678A1 (es)
DK (1) DK497476A (es)
ES (1) ES453508A1 (es)
FR (1) FR2351979A1 (es)
GB (1) GB1561108A (es)
GR (1) GR61407B (es)
HU (1) HU175266B (es)
NL (1) NL7612932A (es)
PT (1) PT65845B (es)
SE (1) SE7612295L (es)
ZA (1) ZA766986B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7800979L (sv) * 1977-02-11 1978-08-12 Merck & Co Inc Antibiotikum
SE7800978L (sv) * 1977-02-11 1978-08-12 Merck & Co Inc Antibiotikum
US4162193A (en) * 1977-08-19 1979-07-24 Merck & Co., Inc. Enzymatic cleavage of N-acyl-thienamycins
PH16708A (en) 1978-07-24 1984-01-20 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates
DE2965923D1 (en) * 1979-08-28 1983-08-25 Merck & Co Inc Process for purifying thienamycin
DE3146190A1 (de) * 1981-11-21 1983-06-16 Hoechst Ag, 6230 Frankfurt Isolierung von chemisch instabilen antibiotika aus fermentationsloesungen
WO2017132321A1 (en) * 2016-01-29 2017-08-03 The Johns Hopkins University Novel inhibitors of bacterial growth

Also Published As

Publication number Publication date
NL7612932A (nl) 1977-05-26
FR2351979B1 (es) 1982-08-13
AU510252B2 (en) 1980-06-19
DE2652678A1 (de) 1977-06-02
HU175266B (hu) 1980-06-28
GR61407B (en) 1978-11-11
ES453508A1 (es) 1978-03-01
PT65845A (en) 1976-12-01
PT65845B (en) 1978-10-10
GB1561108A (en) 1980-02-13
AU1964576A (en) 1978-05-25
JPS5265295A (en) 1977-05-30
DK497476A (da) 1977-05-25
BE848349A (fr) 1977-05-16
FR2351979A1 (fr) 1977-12-16
ZA766986B (en) 1978-06-28
AR224224A1 (es) 1981-11-13
SE7612295L (sv) 1977-05-25

Similar Documents

Publication Publication Date Title
DE2552638C3 (de) Thienamycin, Verfahren zu seiner Herstellung und Thienamycin enthaltende Arzneimittel
DE2634499A1 (de) Neue tylosinderivate und verfahren zu ihrer herstellung
DE2718782C2 (es)
US4162323A (en) Antibiotic N-acetyl-dehydro-thienamycin
DE2843702C2 (de) Neue antibiotische Substanz und ihre Herstellung durch Züchtung eines Streptomyces
DE2537902A1 (de) Neue rifamycine
CH625803A5 (en) Process for the preparation of thienamycin and its isomers deacetyl-890 A1 and 890 A3
CH627494A5 (de) Verfahren zur herstellung eines neuen antibioticums.
DE2652677C2 (de) Antibiotica 890A↓1↓ und 890A↓3↓, Verfahren zu ihrer Herstellung und diese Antibiotika enthaltende antibakterielle Mittel
US4282322A (en) Process for enzymatic deacylation of antibiotics
CH637960A5 (en) The antibiotic deacetyl 890A10
CH626628A5 (en) Process for the preparation of an antibiotic
DE2805724A1 (de) Das antibiotikum desacetyl-dihydro 890a tief 9
CA1046965A (en) Naphthyridinomycin antibiotics from streptomyces
DE3132786C2 (de) Antibiotikum SF-2103A, Verfahren zu dessen Herstellung und antibiotisches Mittel, welches das Antibiotikum enthält
DE2224640A1 (de) Verbessertes Fermentationsverfahren
DE2509653C2 (de) Gegen Kokzidien wirksame Substanz und deren Herstellung durch Kultur eines Streptomyces
FR2464265A1 (fr) Nouvelle substance antibiotique a base de dihydro-3,4 hydroxy-4(hydroxy-3 pyridyl-2)-5 methyl-4 2h-pyrrolecarboxamide-2, utile notamment comme medicament et procede de sa preparation utilisant une nouvelle souche de micro-organisme
US4264734A (en) Process for producing antibiotic desacetyl 890A10
CH630118A5 (en) Process for the preparation of the antibiotic N-acetylthienamycin
JPS5811199B2 (ja) 30 504rp オヨビ ソノ シオノセイゾウホウホウ
CH636127A5 (en) Process for the preparation of the novel antibiotic MSD890A9
CH634104A5 (en) Process for the preparation of the novel antibiotic MSD 890A10
DE2012695A1 (de) Verfahren zur Herstellung von antibiotisch aktiven Substanzen in Gärmaischen
DE2102718A1 (de) Neues Antibiotikum und Verfahren zu dessen Herstellung

Legal Events

Date Code Title Description
PL Patent ceased