CA2486000A1 - Utilisation de composes s'averant efficaces en tant que modulateurs selectifs des recepteurs des opiaces - Google Patents

Utilisation de composes s'averant efficaces en tant que modulateurs selectifs des recepteurs des opiaces Download PDF

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Publication number
CA2486000A1
CA2486000A1 CA002486000A CA2486000A CA2486000A1 CA 2486000 A1 CA2486000 A1 CA 2486000A1 CA 002486000 A CA002486000 A CA 002486000A CA 2486000 A CA2486000 A CA 2486000A CA 2486000 A1 CA2486000 A1 CA 2486000A1
Authority
CA
Canada
Prior art keywords
effective
compounds
opiate receptor
treatment
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002486000A
Other languages
English (en)
Inventor
Frank Weber
Jutta Jacob
Andrew Barber
Rudolf Gottschlich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tioga Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2486000A1 publication Critical patent/CA2486000A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention se rapporte à l'utilisation des composés qui s'avèrent efficaces en tant que modulateurs sélectifs des récepteurs des opiacés, destinés à la fabrication de produits pharmaceutiques permettant le diagnostic et/ou le traitement de troubles tels que les troubles de l'alimentation et les troubles digestifs, notamment les troubles de l'alimentation psychogènes. L'invention se rapporte également à la fabrication d'un produit pharmaceutique s'avérant efficace pour moduler le tonus gastro-intestinal, et à des compositions pharmaceutiques comportant un ou plusieurs desdits composés modulateurs et un ou plusieurs composés efficaces en tant que coupe-faim.
CA002486000A 2002-05-17 2003-04-28 Utilisation de composes s'averant efficaces en tant que modulateurs selectifs des recepteurs des opiaces Abandoned CA2486000A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02011047 2002-05-17
EP02011047.4 2002-05-17
PCT/EP2003/004428 WO2003097051A2 (fr) 2002-05-17 2003-04-28 Utilisation de composes s'averant efficaces en tant que modulateurs selectifs des recepteurs des opiaces

Publications (1)

Publication Number Publication Date
CA2486000A1 true CA2486000A1 (fr) 2003-11-27

Family

ID=29433078

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002486000A Abandoned CA2486000A1 (fr) 2002-05-17 2003-04-28 Utilisation de composes s'averant efficaces en tant que modulateurs selectifs des recepteurs des opiaces

Country Status (21)

Country Link
US (1) US20050176746A1 (fr)
EP (2) EP2074997A1 (fr)
JP (1) JP2005531557A (fr)
KR (1) KR101108014B1 (fr)
CN (2) CN100411618C (fr)
AR (1) AR040028A1 (fr)
AT (1) ATE429226T1 (fr)
AU (1) AU2003242527B2 (fr)
BR (1) BR0309969A (fr)
CA (1) CA2486000A1 (fr)
DE (1) DE60327315D1 (fr)
DK (1) DK1505974T3 (fr)
ES (1) ES2325782T3 (fr)
HK (1) HK1079451A1 (fr)
MX (1) MXPA04011333A (fr)
PE (1) PE20040455A1 (fr)
PL (1) PL371596A1 (fr)
RU (1) RU2336871C2 (fr)
TW (1) TWI314053B (fr)
WO (1) WO2003097051A2 (fr)
ZA (1) ZA200410160B (fr)

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EP1870096A3 (fr) * 2003-04-29 2011-04-20 Orexigen Therapeutics, Inc. Compositions pour influencer la perte de poids
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CA2630624C (fr) 2005-11-22 2013-08-06 Orexigen Therapeutics, Inc. Compositions et procedes d'augmentation de la sensibilite a l'insuline
US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
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PL2136801T3 (pl) * 2007-03-30 2013-01-31 Tioga Pharmaceuticals Inc Agoniści kappa-opioidów do leczenia zespołu jelita drażliwego w postaci zmiennej i z dominującą biegunką
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2170930B3 (fr) 2007-06-04 2013-10-02 Synergy Pharmaceuticals Inc. Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles
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US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
KR102034748B1 (ko) 2011-03-01 2019-10-21 시너지 파마슈티컬즈 인코포레이티드 구아닐레이트 사이클라제 c 작용제의 제조 방법
EA201492175A1 (ru) 2012-06-06 2015-10-30 Орексиджен Терапьютикс, Инк. Способы лечения избыточного веса и ожирения
CN104902930A (zh) 2012-08-21 2015-09-09 阿德利克斯公司 在治疗与液体潴留或盐分过载相关的疾病和胃肠道疾病中用于抑制nhe-介导的反向转运的化合物和方法
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Also Published As

Publication number Publication date
CN1655784A (zh) 2005-08-17
TWI314053B (en) 2009-09-01
AU2003242527A1 (en) 2003-12-02
JP2005531557A (ja) 2005-10-20
ZA200410160B (en) 2005-12-28
DK1505974T3 (da) 2009-08-17
ES2325782T3 (es) 2009-09-17
KR101108014B1 (ko) 2012-01-25
HK1079451A1 (en) 2006-04-07
US20050176746A1 (en) 2005-08-11
BR0309969A (pt) 2005-04-26
WO2003097051A2 (fr) 2003-11-27
AR040028A1 (es) 2005-03-09
RU2004137091A (ru) 2005-09-10
CN100411618C (zh) 2008-08-20
CN101310723A (zh) 2008-11-26
DE60327315D1 (de) 2009-06-04
EP1505974B1 (fr) 2009-04-22
KR20050010807A (ko) 2005-01-28
PE20040455A1 (es) 2004-08-07
EP1505974A2 (fr) 2005-02-16
TW200307541A (en) 2003-12-16
EP2074997A1 (fr) 2009-07-01
PL371596A1 (en) 2005-06-27
RU2336871C2 (ru) 2008-10-27
WO2003097051A3 (fr) 2004-12-09
ATE429226T1 (de) 2009-05-15
MXPA04011333A (es) 2005-02-14
AU2003242527B2 (en) 2008-10-23

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EEER Examination request
FZDE Discontinued