CA2382676A1 - Prevention de la rupture de plaques par inhibiteurs de l'acat - Google Patents

Prevention de la rupture de plaques par inhibiteurs de l'acat Download PDF

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Publication number
CA2382676A1
CA2382676A1 CA002382676A CA2382676A CA2382676A1 CA 2382676 A1 CA2382676 A1 CA 2382676A1 CA 002382676 A CA002382676 A CA 002382676A CA 2382676 A CA2382676 A CA 2382676A CA 2382676 A1 CA2382676 A1 CA 2382676A1
Authority
CA
Canada
Prior art keywords
phenyl
methylethyl
bis
sulfamic acid
phenyl ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002382676A
Other languages
English (en)
Inventor
Thomas Michael Andrew Bocan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2382676A1 publication Critical patent/CA2382676A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Cette invention est l'administration d'un inhibiteur de l'ACAT afin de prévenir l'accumulation de monocytes-macrophages et l'expression MMP dans des lésions athéroscléreuses. De plus, cette invention concerne des méthodes d'inhibition de la déstabilisation et/ou la rupture de plaques athéroscléreuses et de traitement de l'angor instable.
CA002382676A 1999-11-05 2000-10-17 Prevention de la rupture de plaques par inhibiteurs de l'acat Abandoned CA2382676A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16381499P 1999-11-05 1999-11-05
US60/163,814 1999-11-05
PCT/US2000/028705 WO2001034127A1 (fr) 1999-11-05 2000-10-17 Prevention de la rupture de plaques par inhibiteurs de l'acat

Publications (1)

Publication Number Publication Date
CA2382676A1 true CA2382676A1 (fr) 2001-05-17

Family

ID=22591694

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002382676A Abandoned CA2382676A1 (fr) 1999-11-05 2000-10-17 Prevention de la rupture de plaques par inhibiteurs de l'acat

Country Status (19)

Country Link
EP (1) EP1229907A1 (fr)
JP (1) JP2003513909A (fr)
KR (1) KR20020050257A (fr)
CN (1) CN1414848A (fr)
AR (1) AR026354A1 (fr)
AU (1) AU1210401A (fr)
CA (1) CA2382676A1 (fr)
CO (1) CO5270017A1 (fr)
GT (1) GT200000193A (fr)
HU (1) HUP0203160A3 (fr)
IL (1) IL149145A0 (fr)
PA (1) PA8506101A1 (fr)
PE (1) PE20011027A1 (fr)
PL (1) PL355148A1 (fr)
SV (1) SV2001000207A (fr)
TR (1) TR200201204T2 (fr)
UY (1) UY26427A1 (fr)
WO (1) WO2001034127A1 (fr)
ZA (1) ZA200201755B (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004267972B2 (en) 2003-08-29 2010-07-08 Kowa Co., Ltd. Method of stabilizing lipid-rich plaque and method of preventing rupture thereof
PL1755642T3 (pl) * 2004-04-15 2010-06-30 Athera Biotechnologies Ab Aneksyna V do zapobiegania pękaniu blaszek miażdżycowych
RU2576316C2 (ru) 2010-11-03 2016-02-27 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Пестицидная композиция, способ контроля вредителей, способ контроля эндопаразитов, эктопаразитов или обоих и способ усиления жизнестойкости растений
KR102006039B1 (ko) 2011-10-26 2019-07-31 다우 아그로사이언시즈 엘엘씨 살충 조성물 및 그와 관련된 방법
US9282739B2 (en) 2012-04-27 2016-03-15 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
RU2623233C2 (ru) 2012-04-27 2017-06-23 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Пестицидные композиции и относящиеся к ним способы
US9708288B2 (en) 2012-04-27 2017-07-18 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
KR20160072155A (ko) 2013-10-17 2016-06-22 다우 아그로사이언시즈 엘엘씨 살충성 화합물의 제조 방법
CN105636445B (zh) 2013-10-17 2018-12-07 美国陶氏益农公司 制备杀虫化合物的方法
CA2925914A1 (fr) 2013-10-17 2015-04-23 Dow Agrosciences Llc Procedes de preparation de composes pesticides
MX2016004948A (es) 2013-10-17 2016-06-28 Dow Agrosciences Llc Procesos para la preparacion de un compuesto pesticida.
MX2016004946A (es) 2013-10-17 2016-06-28 Dow Agrosciences Llc Procesos para la preparacion de compuestos plaguicidas.
JP2016536295A (ja) 2013-10-17 2016-11-24 ダウ アグロサイエンシィズ エルエルシー 有害生物防除性化合物の製造方法
CN105636441B (zh) 2013-10-17 2018-06-15 美国陶氏益农公司 制备杀虫化合物的方法
AR098105A1 (es) 2013-10-22 2016-05-04 Dow Agrosciences Llc Composiciones plaguicidas y métodos relacionados
US9155304B2 (en) 2013-10-22 2015-10-13 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
TWI651049B (zh) 2013-10-22 2019-02-21 陶氏農業科學公司 殺蟲組成物及相關方法
MX2016005319A (es) 2013-10-22 2016-08-12 Dow Agrosciences Llc Composiciones pesticidas y metodos relacionados.
US9788546B2 (en) 2013-10-22 2017-10-17 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
AR098092A1 (es) 2013-10-22 2016-05-04 Dow Agrosciences Llc Composiciones plaguicidas sinérgicas y los métodos relacionados
RU2656888C2 (ru) 2013-10-22 2018-06-07 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Пестицидные композиции и связанные с ними способы
AU2014340407B2 (en) 2013-10-22 2017-05-04 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
NZ720113A (en) 2013-10-22 2017-06-30 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
AR098091A1 (es) 2013-10-22 2016-05-04 Dow Agrosciences Llc Composiciones pesticidas sinérgicas y métodos relacionados
RU2656391C2 (ru) 2013-10-22 2018-06-05 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Пестицидные композиции и связанные с ними способы
JP2016535022A (ja) 2013-10-22 2016-11-10 ダウ アグロサイエンシィズ エルエルシー 農薬組成物および関連する方法
CN105828611A (zh) 2013-10-22 2016-08-03 美国陶氏益农公司 协同杀虫组合物和相关方法
JP2016538265A (ja) 2013-10-22 2016-12-08 ダウ アグロサイエンシィズ エルエルシー 相乗的有害生物防除組成物および関連する方法
CA2927206A1 (fr) 2013-10-22 2015-04-30 Dow Agrosciences Llc Compositions pesticides synergiques et procedes associes
KR20160074621A (ko) 2013-10-22 2016-06-28 다우 아그로사이언시즈 엘엘씨 상승작용적 살충 조성물 및 관련 방법
MX2016005308A (es) 2013-10-22 2016-08-08 Dow Agrosciences Llc Composiciones pesticidas sinergicas y metodos relacionados.
CA2954345A1 (fr) 2014-07-31 2016-02-04 Dow Agrosciences Llc Procede pour la preparation de 3-(3-chloro-1h-pyrazol-1-yl) pyridine
EP3186229A4 (fr) 2014-07-31 2018-01-10 Dow AgroSciences LLC Procédé pour la préparation de 3-(3-méthyl-phényl-1h-pyrazol-1-yl)pyridine
US9249122B1 (en) 2014-07-31 2016-02-02 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine
WO2016028328A1 (fr) 2014-08-19 2016-02-25 Dow Agrosciences Llc Procédé de préparation de 3-(3-chloro-1h-pyrazol-1-yl)pyridine
AR098113A1 (es) 2014-09-12 2016-05-04 Dow Agrosciences Llc Proceso para la preparación de 3-(3-cloro-1h-pirazol-1-il)piridina
US10377781B2 (en) * 2014-10-21 2019-08-13 Council Of Scientific & Industrial Research Alkylidene phosphonate esters as p-glycoprotein inducers
US20190275012A9 (en) * 2016-07-29 2019-09-12 Lupin Limited Substituted thiazolo-pyridine compounds as malt1 inhibitors
US11065216B2 (en) 2016-11-16 2021-07-20 Purdue Research Foundation Compositions and methods for regulating body weight and metabolic syndromes
US10233155B2 (en) 2016-12-29 2019-03-19 Dow Agrosciences Llc Processes for the preparation of pesticide compounds
WO2018125815A1 (fr) 2016-12-29 2018-07-05 Dow Agrosciences Llc Procédés de préparation de composés pesticides
SG11202003662XA (en) 2017-10-27 2020-05-28 Bayer Ag Novel pyrazolo-pyrrolo-pyrimidine-dione derivatives as p2x3 inhibitors
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100193743B1 (ko) * 1990-10-30 1999-06-15 로즈 암스트롱, 크리스틴 에이. 트러트웨인 옥시술포닐 카르바메이트
IL109431A (en) * 1993-05-14 2001-01-11 Warner Lambert Co Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds
IT1270976B (it) * 1993-08-06 1997-05-26 Pierrel Spa Composti inibitpri di acil enzima-a-colesterolo-o-acil transferasi ad attivita' terapeutica, loro uso e composizioni farmaceutiche che li contengono
SK12598A3 (en) * 1995-08-04 1999-02-11 Warner Lambert Co Use of sulfamic acid derivatives, acyl sulfonamides or sulfonyl carbamates for the manufacture of a medicament for lowering lipoprotein levels
WO1997016184A1 (fr) * 1995-11-02 1997-05-09 Warner-Lambert Company Procede et composition pharmaceutique visant a reguler la concentration lipidique
OA11584A (en) * 1998-07-21 2004-07-20 Warner Lambert Co Coadministration of ACAT and MMP inhibitors for the treatment of atherosclerotic lesions.

Also Published As

Publication number Publication date
PE20011027A1 (es) 2001-10-16
PA8506101A1 (es) 2002-10-28
HUP0203160A3 (en) 2006-02-28
AR026354A1 (es) 2003-02-05
WO2001034127A1 (fr) 2001-05-17
SV2001000207A (es) 2001-10-16
KR20020050257A (ko) 2002-06-26
EP1229907A1 (fr) 2002-08-14
IL149145A0 (en) 2002-11-10
HUP0203160A2 (hu) 2003-01-28
UY26427A1 (es) 2000-12-29
AU1210401A (en) 2001-06-06
JP2003513909A (ja) 2003-04-15
TR200201204T2 (tr) 2002-08-21
CN1414848A (zh) 2003-04-30
CO5270017A1 (es) 2003-04-30
ZA200201755B (en) 2003-08-27
GT200000193A (es) 2002-04-27
PL355148A1 (en) 2004-04-05

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Legal Events

Date Code Title Description
FZDE Discontinued