UY26427A1 - Prevención de ruptura de placa por inhibidores acat - Google Patents

Prevención de ruptura de placa por inhibidores acat

Info

Publication number
UY26427A1
UY26427A1 UY26427A UY26427A UY26427A1 UY 26427 A1 UY26427 A1 UY 26427A1 UY 26427 A UY26427 A UY 26427A UY 26427 A UY26427 A UY 26427A UY 26427 A1 UY26427 A1 UY 26427A1
Authority
UY
Uruguay
Prior art keywords
rupture
prevention
plate
acat inhibitors
atherosclerotic
Prior art date
Application number
UY26427A
Other languages
English (en)
Inventor
Bocan Thomas Michael An Andrew
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of UY26427A1 publication Critical patent/UY26427A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

Esta invención es la administración de un inhibidor ACAT para prevenir la acumulación de monocito-macrófago y la expresión MMP en las lesiones ateroscleróticas. Además, esta invención se relaciona con métodos para inhibir la desestabilización y/o ruptura de placas ateroscleróticas y el tratamiento de la angina inestable.
UY26427A 1999-11-05 2000-11-03 Prevención de ruptura de placa por inhibidores acat UY26427A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16381499P 1999-11-05 1999-11-05

Publications (1)

Publication Number Publication Date
UY26427A1 true UY26427A1 (es) 2000-12-29

Family

ID=22591694

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26427A UY26427A1 (es) 1999-11-05 2000-11-03 Prevención de ruptura de placa por inhibidores acat

Country Status (19)

Country Link
EP (1) EP1229907A1 (es)
JP (1) JP2003513909A (es)
KR (1) KR20020050257A (es)
CN (1) CN1414848A (es)
AR (1) AR026354A1 (es)
AU (1) AU1210401A (es)
CA (1) CA2382676A1 (es)
CO (1) CO5270017A1 (es)
GT (1) GT200000193A (es)
HU (1) HUP0203160A3 (es)
IL (1) IL149145A0 (es)
PA (1) PA8506101A1 (es)
PE (1) PE20011027A1 (es)
PL (1) PL355148A1 (es)
SV (1) SV2001000207A (es)
TR (1) TR200201204T2 (es)
UY (1) UY26427A1 (es)
WO (1) WO2001034127A1 (es)
ZA (1) ZA200201755B (es)

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RU2358734C2 (ru) 2003-08-29 2009-06-20 Кова Ко., Лтд. Способ стабилизации бляшки с высоким содержанием липидов и способ профилактики ее разрушения
JP2007532617A (ja) * 2004-04-15 2007-11-15 アテラ バイオテクノロジーズ エービー アテローム血栓症およびプラーク破壊を予防するためのアネキシンｖ
NZ608903A (en) 2010-11-03 2014-06-27 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
AU2012329045A1 (en) 2011-10-26 2014-04-17 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
US9708288B2 (en) 2012-04-27 2017-07-18 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
US9282739B2 (en) 2012-04-27 2016-03-15 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
US20130291227A1 (en) 2012-04-27 2013-10-31 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
CA2925873A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
MX2016004942A (es) 2013-10-17 2016-06-28 Dow Agrosciences Llc Procesos para la preparacion de compuestos plaguicidas.
US9029554B1 (en) 2013-10-17 2015-05-12 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
BR112016007518A2 (pt) 2013-10-17 2017-08-01 Dow Agrosciences Llc processos para a preparação de compostos pesticidas
JP6487426B2 (ja) 2013-10-17 2019-03-20 ダウ アグロサイエンシィズ エルエルシー 有害生物防除化合物の調製法
CN105636442B (zh) 2013-10-17 2018-04-27 美国陶氏益农公司 制备杀虫化合物的方法
EP3057428A4 (en) 2013-10-17 2017-05-17 Dow AgroSciences LLC Processes for the preparation of pesticidal compounds
CN105792652A (zh) 2013-10-22 2016-07-20 美国陶氏益农公司 协同杀虫组合物和相关方法
US9295260B2 (en) 2013-10-22 2016-03-29 Dow Agrosciences Llc Pesticidal compositions and related methods
TW201517797A (zh) 2013-10-22 2015-05-16 Dow Agrosciences Llc 協同性殺蟲組成物及相關方法（十一）
US9474276B2 (en) 2013-10-22 2016-10-25 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
US9801383B2 (en) 2013-10-22 2017-10-31 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
WO2015061140A1 (en) 2013-10-22 2015-04-30 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
JP2016535739A (ja) 2013-10-22 2016-11-17 ダウ アグロサイエンシィズ エルエルシー 農薬組成物および関連する方法
MX2016005317A (es) 2013-10-22 2016-08-12 Dow Agrosciences Llc Composiciones pesticidas y metodos relacionados.
RU2016119368A (ru) 2013-10-22 2017-11-28 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Синергетические пестицидные композиции и связанные с ними способы
NZ719754A (en) 2013-10-22 2017-06-30 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
AR098096A1 (es) 2013-10-22 2016-05-04 Dow Agrosciences Llc Composiciones plaguicidas sinérgicas y métodos relacionados
JP2016535024A (ja) 2013-10-22 2016-11-10 ダウ アグロサイエンシィズ エルエルシー 相乗的有害生物防除組成物および関連する方法
NZ719688A (en) 2013-10-22 2017-06-30 Dow Agrosciences Llc Pesticidal compositions and related methods
KR20160074582A (ko) 2013-10-22 2016-06-28 다우 아그로사이언시즈 엘엘씨 상승작용적 살충 조성물 및 관련 방법
WO2015061163A1 (en) 2013-10-22 2015-04-30 Dow Agrosciences Llc Pesticidal compositions and related methods
JP2016538266A (ja) 2013-10-22 2016-12-08 ダウ アグロサイエンシィズ エルエルシー 相乗的有害生物防除組成物および関連する方法
MX2016005323A (es) 2013-10-22 2016-08-12 Dow Agrosciences Llc Composiciones pesticidas y metodos relacionados.
KR20170038785A (ko) 2014-07-31 2017-04-07 다우 아그로사이언시즈 엘엘씨 3-(3-클로로-1h-피라졸-1-일)피리딘의 제조 방법
BR112017000565A2 (pt) 2014-07-31 2017-11-07 Dow Agrosciences Llc processo para a preparação de 3-(3-cloro-1h-pirazol-1-il)piridina
JP2017523168A (ja) 2014-07-31 2017-08-17 ダウ アグロサイエンシィズ エルエルシー ３−（３−クロロ−１ｈ−ピラゾール−１−イル）ピリジンの製造方法
WO2016028328A1 (en) 2014-08-19 2016-02-25 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
US9085552B1 (en) 2014-09-12 2015-07-21 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine
EP3209671B8 (en) * 2014-10-21 2019-07-31 Council of Scientific and Industrial Research Alkylidene phosphonate esters as p-glycoprotein inducers
PE20190656A1 (es) * 2016-07-29 2019-05-08 Lupin Ltd Compuestos de tiazolo-piridina sustituida como inhibidores de malt1
WO2018093966A1 (en) 2016-11-16 2018-05-24 Purdue Research Foundation Compositions and methods for regulating body weight and metabolic syndromes
US10233155B2 (en) 2016-12-29 2019-03-19 Dow Agrosciences Llc Processes for the preparation of pesticide compounds
CN110139853B (zh) 2016-12-29 2023-06-16 美国陶氏益农公司 用于制备杀有害生物化合物的方法
AU2018354777A1 (en) 2017-10-27 2020-04-16 Bayer Aktiengesellschaft Novel Pyrazolo-pyrrolo-pyrimidine-dione derivatives as P2X3 inhibitors
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU654688B2 (en) * 1990-10-30 1994-11-17 Warner-Lambert Company Oxysulfonyl carbamates
IL109431A (en) * 1993-05-14 2001-01-11 Warner Lambert Co Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds
IT1270976B (it) * 1993-08-06 1997-05-26 Pierrel Spa Composti inibitpri di acil enzima-a-colesterolo-o-acil transferasi ad attivita' terapeutica, loro uso e composizioni farmaceutiche che li contengono
JPH11510184A (ja) * 1995-08-04 1999-09-07 ワーナー−ランバート・コンパニー リポ蛋白レベルを低下させるための医薬の製造用スルファミン酸誘導体、アシルスルホンアミドまたはスルホニルカルバメートの使用
CN1217656C (zh) * 1995-11-02 2005-09-07 沃尼尔·朗伯公司 用于调节脂浓度的方法和药物组合物
IL140982A0 (en) * 1998-07-21 2002-02-10 Warner Lambert Co Coadministration of acat and mmp inhibitors for the treatment of atherosclerotic lesions

Also Published As

Publication number Publication date
KR20020050257A (ko) 2002-06-26
PA8506101A1 (es) 2002-10-28
ZA200201755B (en) 2003-08-27
PL355148A1 (en) 2004-04-05
GT200000193A (es) 2002-04-27
WO2001034127A1 (en) 2001-05-17
AR026354A1 (es) 2003-02-05
CO5270017A1 (es) 2003-04-30
HUP0203160A2 (hu) 2003-01-28
AU1210401A (en) 2001-06-06
IL149145A0 (en) 2002-11-10
HUP0203160A3 (en) 2006-02-28
CA2382676A1 (en) 2001-05-17
SV2001000207A (es) 2001-10-16
PE20011027A1 (es) 2001-10-16
CN1414848A (zh) 2003-04-30
TR200201204T2 (tr) 2002-08-21
JP2003513909A (ja) 2003-04-15
EP1229907A1 (en) 2002-08-14

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Legal Events

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Effective date: 20120529