CA2321182A1 - Derives d'acide pyrimidin-2-yloxy-carboxylique, leur production et leur utilisation comme antagonistes de l'endotheline - Google Patents

Derives d'acide pyrimidin-2-yloxy-carboxylique, leur production et leur utilisation comme antagonistes de l'endotheline Download PDF

Info

Publication number
CA2321182A1
CA2321182A1 CA002321182A CA2321182A CA2321182A1 CA 2321182 A1 CA2321182 A1 CA 2321182A1 CA 002321182 A CA002321182 A CA 002321182A CA 2321182 A CA2321182 A CA 2321182A CA 2321182 A1 CA2321182 A1 CA 2321182A1
Authority
CA
Canada
Prior art keywords
alkyl
alkoxy
halogen
phenyl
alkylthio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002321182A
Other languages
English (en)
Inventor
Wilhelm Amberg
Rolf Jansen
Andreas Kling
Dagmar Klinge
Hartmut Riechers
Stefan Hergenroder
Manfred Raschack
Liliane Unger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2321182A1 publication Critical patent/CA2321182A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

L'invention concerne des dérivés d'acide carboxylique de formule (I), dans laquelle les substituants ont les significations suivantes: R?1¿ représente tétrazole ou un groupe (1), R représente un reste OR?7¿, (2) ou (3) ou un hétéroaromatique à cinq éléments, lié par un atome d'azote, tel que pyrolyle, pyrazolyle, imidazolyle et triazolyle; R?2¿, R?3¿ représentent hydrogène, hydroxy, NH¿2?, NH(alkyle C¿1?-C¿4?), N(alkyle C¿1?-C¿4?)¿2?, halogène, alkyle C¿1?-C¿4?, alcényle C¿2?-C¿4?, alkinyle C¿2?-C¿4?, hydroxyalkyle C¿1?-C¿4?, halogénure d'alkyle C¿1?-C¿4?, alcoxy C¿1?-C¿4?, halogénure d'alcoxy C¿1?-C¿4? ou alkyle C¿1?-C¿4?-thio; X représente halogène, halogénure d'alkyle C¿1?-C¿4?, hydroxy; R?4¿ et R?5¿ représentent phényle ou naphthyle, cycloalkyle C¿3?-C¿7?, phényle ou naphthyle qui sont liés, en position ortho, par l'intermédiaire d'une liaison directe d'un groupe méthylène, éthylène, ou éthylénylène, d'un atome d'oxygène ou de soufre ou d'un groupe SO¿2?-, MH- ou N-alkyle, ou bien un hétéroaromatique à 5 ou 6 éléments; R?6¿ représente hydrogène, phényle ou naphthyle, un hétéroaromatique à 5 ou 6 éléments, alkyle C¿1?-C¿8?, alcényle C¿3?-C¿6?, alkinyle C¿3?-C¿6? ou bien cycloalkyle C¿3?-C¿8?, ces restes pouvant être chacun substitués une ou plusieurs fois, à condition que R?6¿ ne représente hydrogène que lorsque Z ne représente pas une liaison simple; Z représente soufre, oxygène ou une liaison simple. L'invention concerne également les sels physiologiquement tolérés et les formes énantiomèrement et diastéréomèrement pures de ces dérivés. Ces nouveaux composés peuvent être utilisés pour lutter contre des maladies, en particulier en tant qu'antagonistes de l'endothéline.
CA002321182A 1998-02-17 1999-02-05 Derives d'acide pyrimidin-2-yloxy-carboxylique, leur production et leur utilisation comme antagonistes de l'endotheline Abandoned CA2321182A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19806438.1 1998-02-17
DE19806438A DE19806438A1 (de) 1998-02-17 1998-02-17 Neue Carbonsäurederivate mit 5-substituiertem Pyrimidinring, ihre Herstellung und Verwendung
PCT/EP1999/000776 WO1999042453A1 (fr) 1998-02-17 1999-02-05 Derives d'acide pyrimidin-2-yloxy-carboxylique, leur production et leur utilisation comme antagonistes de l'endotheline

Publications (1)

Publication Number Publication Date
CA2321182A1 true CA2321182A1 (fr) 1999-08-26

Family

ID=7857948

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002321182A Abandoned CA2321182A1 (fr) 1998-02-17 1999-02-05 Derives d'acide pyrimidin-2-yloxy-carboxylique, leur production et leur utilisation comme antagonistes de l'endotheline

Country Status (20)

Country Link
EP (1) EP1066268A1 (fr)
JP (1) JP2002503726A (fr)
KR (1) KR20010086247A (fr)
CN (1) CN1291190A (fr)
AR (1) AR014960A1 (fr)
AU (1) AU3027199A (fr)
BG (1) BG104577A (fr)
BR (1) BR9907911A (fr)
CA (1) CA2321182A1 (fr)
DE (1) DE19806438A1 (fr)
HR (1) HRP20000602A2 (fr)
HU (1) HUP0100957A3 (fr)
IL (1) IL137038A0 (fr)
NO (1) NO20004075D0 (fr)
PL (1) PL342311A1 (fr)
SK (1) SK11512000A3 (fr)
TR (1) TR200002376T2 (fr)
TW (1) TW579376B (fr)
WO (1) WO1999042453A1 (fr)
ZA (1) ZA991214B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9174970B2 (en) 2008-01-22 2015-11-03 Dow Agrosciences Llc 5-fluoro pyrimidine derivatives

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19924892A1 (de) * 1999-06-01 2000-12-07 Basf Ag Neue Carbonsäurederivate mit arylsubstituierten Stickstoffheterocyclen, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten
EP2183223A2 (fr) * 2007-07-31 2010-05-12 Gilead Colorado, Inc. Métabolites et dérivés d'ambrisentan
CN104521977A (zh) * 2008-08-01 2015-04-22 陶氏益农公司 5-氟胞嘧啶作为杀真菌剂的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4411225A1 (de) * 1994-03-31 1995-10-05 Basf Ag Verwendung von Carbonsäurederivaten als Arzneimittel
DE19533023B4 (de) * 1994-10-14 2007-05-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
DE19614534A1 (de) * 1996-04-12 1997-10-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
DE19614533A1 (de) * 1996-04-12 1997-10-16 Basf Ag Neue alpha-Hydroxysäurederivate, ihre Herstellung und Verwendung
BR9714047A (pt) * 1996-12-18 2000-05-09 Basf Ag Derivados de ácido carboxìlico, uso dos mesmos, combinação destes com um ou mais compostos ativos, preparação de drogas para a administração oral e parenteral, e, antagonista de receptor de endotelina
DE19726146A1 (de) * 1997-06-19 1998-12-24 Basf Ag Neue ß-Amino und ß-Azidopcarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten
TR200001182T2 (tr) * 1997-10-31 2000-11-21 Basf Aktiengesellschaft Yeni karbonik asit türevleri, üretimleri ve kullanımları.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9174970B2 (en) 2008-01-22 2015-11-03 Dow Agrosciences Llc 5-fluoro pyrimidine derivatives
US9204653B2 (en) 2008-01-22 2015-12-08 Dow Agrosciences Llc 5-fluoro pyrimidine derivatives

Also Published As

Publication number Publication date
IL137038A0 (en) 2001-06-14
BR9907911A (pt) 2000-10-24
WO1999042453A1 (fr) 1999-08-26
DE19806438A1 (de) 1999-08-19
HUP0100957A3 (en) 2002-03-28
JP2002503726A (ja) 2002-02-05
NO20004075L (no) 2000-08-15
HRP20000602A2 (en) 2001-06-30
TR200002376T2 (tr) 2000-12-21
TW579376B (en) 2004-03-11
PL342311A1 (en) 2001-06-04
KR20010086247A (ko) 2001-09-10
SK11512000A3 (sk) 2001-04-09
ZA991214B (en) 2000-08-16
NO20004075D0 (no) 2000-08-15
CN1291190A (zh) 2001-04-11
AR014960A1 (es) 2001-04-11
AU3027199A (en) 1999-09-06
HUP0100957A2 (hu) 2002-02-28
BG104577A (bg) 2001-03-30
EP1066268A1 (fr) 2001-01-10

Similar Documents

Publication Publication Date Title
HRP980560A2 (en) New carboxylic acid derivatives, carrying amido side-chains, their production and use as endothelin receptor antagonists
KR20000057642A (ko) 헤테로시클릭 카르복실산 유도체, 그의 제제 및 엔도텔린 수용체길항제로서의 용도
CA2321182A1 (fr) Derives d'acide pyrimidin-2-yloxy-carboxylique, leur production et leur utilisation comme antagonistes de l'endotheline
CA2294050A1 (fr) Nouveaux derives d'acide .beta.-amino et .beta.-azido carboxylique, leur preparation et leur utilisation comme antagonistes du recepteur de l'endotheline
KR20010023615A (ko) 신규 카르복실산 유도체, 그 제조 및 혼합 ｅｔａ/ｅｔｂ엔도텔린 수용체 길항제로서의 용도
MXPA02000616A (es) Derivados de acidos carboxilicos, novedosos, con anillo pirimidina sustituido en las posiciones 5, 6, su preparacion y uso como antagonistas de los receptores para endotelina.
CA2375666A1 (fr) Nouveaux derives d'acide carboxylique comprenant des heterocycles d'azote substitues par aryle, leur preparation et leur utilisation comme antagonistes du recepteur d'entholine
KR20010032083A (ko) 헤테로사이클로 치환된 신규한 α-히드록시카르복실산유도체, 그의 제법 및 엔도셀린 수용체 길항제로서의 용도
CA2340167A1 (fr) Nouveaux derives de l'acide carbonique porteurs de chaines laterales cetone, leur fabrication et leur utilisation comme antagonistes des recepteurs de l'endotheline
HRP20000650A2 (en) Novel unsymmetrically substituted carboxylic acid derivatives, method for producing them, and their use as mixed et<->a<p>/et<->b<p> receptor antafonists
MXPA00001479A (en) Novel carboxylic acid derivatives, their production and their use as mixed eta
MXPA00006463A (en) 5-substituted pyrimidine-2-yloxy carboxylic acid derivatives, the production of the same and their utilization as endothelin antagonists
CZ2001437A3 (cs) Deriváty kyseliny karboxylové a jejich použití
CZ20002963A3 (cs) Nové deriváty karboxylové kyseliny, obsahující 5- substituovaný pyrimidinový kruh, jejich příprava a použiti
CZ61999A3 (cs) Deriváty azinyloxy a fenoxy-diarylkarboxylových kyselin, způsob jejich přípravy a použití jako smíšených antagonistů ETA/ETB endotelinových receptorů
MXPA01001246A (en) New carboxylic acid derivatives carrying keto side-chains, their production and their use as endothelin-receptor antagonists

Legal Events

Date Code Title Description
FZDE Discontinued