CA2214800A1 - Chambre d'electroporation en flux et procede associe - Google Patents

Chambre d'electroporation en flux et procede associe

Info

Publication number
CA2214800A1
CA2214800A1 CA002214800A CA2214800A CA2214800A1 CA 2214800 A1 CA2214800 A1 CA 2214800A1 CA 002214800 A CA002214800 A CA 002214800A CA 2214800 A CA2214800 A CA 2214800A CA 2214800 A1 CA2214800 A1 CA 2214800A1
Authority
CA
Canada
Prior art keywords
blood cells
blood
red blood
plasma
erythrocytes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002214800A
Other languages
English (en)
Other versions
CA2214800C (fr
Inventor
Peter M. Meserol
Rita C. Prodell
Jesse L. Acker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maxcyte Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/402,145 external-priority patent/US5720921A/en
Application filed by Individual filed Critical Individual
Priority to CA002363548A priority Critical patent/CA2363548A1/fr
Publication of CA2214800A1 publication Critical patent/CA2214800A1/fr
Application granted granted Critical
Publication of CA2214800C publication Critical patent/CA2214800C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687—Chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3623—Means for actively controlling temperature of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3692—Washing or rinsing blood or blood constituents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D23/00—Control of temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3616—Batch-type treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0429—Red blood cells; Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
    • A61M2205/3382—Upper level detectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3606—General characteristics of the apparatus related to heating or cooling cooled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3673—General characteristics of the apparatus related to heating or cooling thermo-electric, e.g. Peltier effect, thermocouples, semi-conductors

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Electromagnetism (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Automation & Control Theory (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Electrotherapy Devices (AREA)
  • External Artificial Organs (AREA)
  • Apparatuses And Processes For Manufacturing Resistors (AREA)
  • Glass Compositions (AREA)
  • Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)
CA002214800A 1995-03-10 1996-03-11 Chambre d'electroporation en flux et procede associe Expired - Lifetime CA2214800C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002363548A CA2363548A1 (fr) 1995-03-10 1996-03-11 Chambre d'electroporation en flux et procede associe

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/402,145 US5720921A (en) 1995-03-10 1995-03-10 Flow electroporation chamber and method
US490695P 1995-10-06 1995-10-06
US60/004,906 1995-10-06
US08/402,145 1995-10-06
PCT/US1996/003211 WO1996028199A1 (fr) 1995-03-10 1996-03-11 Chambre d'electroporation en flux et procede associe

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002363548A Division CA2363548A1 (fr) 1995-03-10 1996-03-11 Chambre d'electroporation en flux et procede associe

Publications (2)

Publication Number Publication Date
CA2214800A1 true CA2214800A1 (fr) 1996-09-19
CA2214800C CA2214800C (fr) 2002-01-22

Family

ID=26673634

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002214800A Expired - Lifetime CA2214800C (fr) 1995-03-10 1996-03-11 Chambre d'electroporation en flux et procede associe

Country Status (6)

Country Link
EP (1) EP0814855A4 (fr)
JP (2) JP3859709B2 (fr)
KR (1) KR19980702848A (fr)
CN (1) CN1195997A (fr)
AU (1) AU5305096A (fr)
CA (1) CA2214800C (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6773669B1 (en) 1995-03-10 2004-08-10 Maxcyte, Inc. Flow electroporation chamber and method
US7029916B2 (en) 2001-02-21 2006-04-18 Maxcyte, Inc. Apparatus and method for flow electroporation of biological samples
US7141425B2 (en) 2001-08-22 2006-11-28 Maxcyte, Inc. Apparatus and method for electroporation of biological samples
US7771984B2 (en) 2004-05-12 2010-08-10 Maxcyte, Inc. Methods and devices related to a regulated flow electroporation chamber
CN110496276A (zh) * 2013-03-13 2019-11-26 努瓦拉公司 液体输送***和治疗方法

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1161270B1 (fr) * 1999-03-17 2007-01-10 Haemonetics Corporation Systeme de traitement du sang
US7601268B2 (en) * 2003-05-27 2009-10-13 Haemonetics Corporation Continuous blood filtration and method of use
ZA200610508B (en) * 2004-06-12 2009-01-28 Digital Bio Technology Co Ltd Electroporator having an elongated hollow member
WO2006001614A1 (fr) * 2004-06-12 2006-01-05 Digital Bio Technology Co., Ltd. Appareil d'electroporation muni d'un organe creux allonge
KR101084528B1 (ko) * 2008-04-15 2011-11-18 인비트로겐 싱가포르 피티이. 엘티디. 전기천공 장치용 파이펫 팁
CN101857836B (zh) * 2009-11-10 2013-06-12 昆山文曲生物微***有限公司 一种流式电穿孔装置及***
EP2338356A1 (fr) * 2009-12-23 2011-06-29 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt Système de réacteur pour électroporation
GB201012521D0 (en) 2010-07-27 2010-09-08 Univ Strathclyde Integrated perfusion system
CN101928666B (zh) * 2010-07-30 2013-04-03 北京大学 一种流式电穿孔装置及***
US10316335B2 (en) 2013-03-15 2019-06-11 Maxcyte, Inc. Methods and compositions for generating stable transfected cells
CN115737104A (zh) * 2015-03-31 2023-03-07 昂科赛克医疗公司 用于改进的基于组织感测的电穿孔的***和方法
CA2982759A1 (fr) 2015-04-13 2016-10-20 Maxcyte, Inc. Procedes et compositions permettant de modifier l'adn genomique
EP3998335A3 (fr) * 2015-05-08 2022-07-27 Biomagnetic Solutions LLC Appareil et procédé de séparation de cellules immunomagnétique
WO2017176253A1 (fr) * 2016-04-05 2017-10-12 General Electiric Comapny Composition de plaquettes activées ayant un taux de facteur de croissance ajustable
JP7466444B2 (ja) 2017-05-14 2024-04-12 パラゲート メディカル リミテッド 埋入可能流体抽出システム
US10435713B2 (en) * 2017-09-30 2019-10-08 Inscripta, Inc. Flow through electroporation instrumentation
CN108795750A (zh) * 2018-05-28 2018-11-13 深圳先进技术研究院 一种带冷却功能的电穿孔装置
WO2020047504A2 (fr) 2018-08-31 2020-03-05 The Charles Stark Draper Laboratory, Inc. Procédé et appareil de transfection à haut rendement et à haute efficacité de cellules
CN113260697B (zh) * 2018-12-20 2024-07-09 国立大学法人丰桥技术科学大学 电穿孔装置以及外来物质导入细胞的制造方法
US11071860B2 (en) 2019-02-06 2021-07-27 Oncosec Medical Incorporated Systems and methods for detecting fault conditions in electroporation therapy
JP7248721B2 (ja) * 2021-02-17 2023-03-29 ゼネラル・エレクトリック・カンパニイ 成長因子レベルを調節可能な活性化血小板組成物
WO2022224803A1 (fr) 2021-04-22 2022-10-27 富士フイルム株式会社 Dispositif de perforation électrique, procédé d'introduction de matériau bioactif, procédé de production de biomatériau issu de tissu, et biomatériau issu de tissu
WO2023223931A1 (fr) * 2022-05-16 2023-11-23 富士フイルム株式会社 Dispositif d'électroporation et procédé d'électroporation

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6773669B1 (en) 1995-03-10 2004-08-10 Maxcyte, Inc. Flow electroporation chamber and method
US7029916B2 (en) 2001-02-21 2006-04-18 Maxcyte, Inc. Apparatus and method for flow electroporation of biological samples
US7141425B2 (en) 2001-08-22 2006-11-28 Maxcyte, Inc. Apparatus and method for electroporation of biological samples
US7186559B2 (en) 2001-08-22 2007-03-06 Maxcyte, Inc. Apparatus and method for electroporation of biological samples
US7771984B2 (en) 2004-05-12 2010-08-10 Maxcyte, Inc. Methods and devices related to a regulated flow electroporation chamber
US9546350B2 (en) 2004-05-12 2017-01-17 Maxcyte, Inc. Methods and devices related to a regulated flow electroporation chamber
CN110496276A (zh) * 2013-03-13 2019-11-26 努瓦拉公司 液体输送***和治疗方法
CN110496276B (zh) * 2013-03-13 2022-10-14 努瓦拉公司 液体输送***和治疗方法

Also Published As

Publication number Publication date
JP4171755B2 (ja) 2008-10-29
CA2214800C (fr) 2002-01-22
EP0814855A1 (fr) 1998-01-07
EP0814855A4 (fr) 2002-07-17
AU5305096A (en) 1996-10-02
KR19980702848A (ko) 1998-08-05
JP3859709B2 (ja) 2006-12-20
JP2007007430A (ja) 2007-01-18
CN1195997A (zh) 1998-10-14
JPH11502133A (ja) 1999-02-23

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Effective date: 20160311