BRPI1009381A2 - compostos, composição farmacêutica, método para tratar doença ou condição associada com função de trap1 em sujeito em necessidade do mesmo e uso de compostos e composição farmacêutica - Google Patents

compostos, composição farmacêutica, método para tratar doença ou condição associada com função de trap1 em sujeito em necessidade do mesmo e uso de compostos e composição farmacêutica

Info

Publication number
BRPI1009381A2
BRPI1009381A2 BRPI1009381A BRPI1009381A BRPI1009381A2 BR PI1009381 A2 BRPI1009381 A2 BR PI1009381A2 BR PI1009381 A BRPI1009381 A BR PI1009381A BR PI1009381 A BRPI1009381 A BR PI1009381A BR PI1009381 A2 BRPI1009381 A2 BR PI1009381A2
Authority
BR
Brazil
Prior art keywords
compounds
pharmaceutical composition
trap1
subject
need
Prior art date
Application number
BRPI1009381A
Other languages
English (en)
Inventor
Abraham Thomas
Indranil Mukhopadhyay
Nayan Taterao Waghmare
Neelima Khairatkar-Joshi
Sanjay Margal
Sukeerthi Kumar
Original Assignee
Glenmark Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals Sa filed Critical Glenmark Pharmaceuticals Sa
Publication of BRPI1009381A2 publication Critical patent/BRPI1009381A2/pt
Publication of BRPI1009381B1 publication Critical patent/BRPI1009381B1/pt
Publication of BRPI1009381B8 publication Critical patent/BRPI1009381B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
BRPI1009381A 2009-03-23 2010-03-23 compostos, composição farmacêutica e uso de compostos e de composição farmacêutica BRPI1009381B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
IN665MU2009 2009-03-23
US17135509P 2009-04-21 2009-04-21
IN2213MU2009 2009-09-23
US25194409P 2009-10-15 2009-10-15
IN2906MU2009 2009-12-16
US29447010P 2010-01-12 2010-01-12
PCT/IB2010/000930 WO2010109334A2 (en) 2009-03-23 2010-03-23 Thienopyrimidinedione derivatives as trpa1 modulators

Publications (3)

Publication Number Publication Date
BRPI1009381A2 true BRPI1009381A2 (pt) 2016-06-21
BRPI1009381B1 BRPI1009381B1 (pt) 2020-04-14
BRPI1009381B8 BRPI1009381B8 (pt) 2021-05-25

Family

ID=42780205

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI1013705A BRPI1013705A2 (pt) 2009-03-23 2010-03-22 compostos, composição farmacêutica, método de tratamento de doença ou condição associada com função de trap1 e usos de compostos e de composição farmacêutica
BRPI1009381A BRPI1009381B8 (pt) 2009-03-23 2010-03-23 compostos, composição farmacêutica e uso de compostos e de composição farmacêutica

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI1013705A BRPI1013705A2 (pt) 2009-03-23 2010-03-22 compostos, composição farmacêutica, método de tratamento de doença ou condição associada com função de trap1 e usos de compostos e de composição farmacêutica

Country Status (23)

Country Link
US (4) US20120178766A1 (pt)
EP (3) EP2411395B1 (pt)
JP (2) JP2012521406A (pt)
KR (2) KR20110128898A (pt)
CN (3) CN102361874A (pt)
AP (1) AP2948A (pt)
AU (2) AU2010227225A1 (pt)
BR (2) BRPI1013705A2 (pt)
CA (2) CA2756535A1 (pt)
DK (3) DK2411395T3 (pt)
EA (2) EA201190138A1 (pt)
ES (3) ES2424341T3 (pt)
HK (2) HK1166074A1 (pt)
HU (1) HUE024538T2 (pt)
IL (2) IL215177A (pt)
MX (1) MX2011009822A (pt)
PE (2) PE20120834A1 (pt)
PL (3) PL2411395T3 (pt)
PT (3) PT2411395E (pt)
SG (4) SG184767A1 (pt)
SI (3) SI2411395T1 (pt)
WO (2) WO2010109329A1 (pt)
ZA (2) ZA201107649B (pt)

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Publication number Publication date
ZA201107650B (en) 2012-07-25
BRPI1013705A2 (pt) 2016-04-05
CN102361874A (zh) 2012-02-22
EP2411395B1 (en) 2013-05-29
US20130289054A1 (en) 2013-10-31
SG184767A1 (en) 2012-10-30
PT2634191E (pt) 2015-03-04
ES2424342T3 (es) 2013-10-01
EP2411396A2 (en) 2012-02-01
PL2411396T3 (pl) 2013-10-31
ES2424341T3 (es) 2013-10-01
AU2010227230B2 (en) 2015-11-26
BRPI1009381B1 (pt) 2020-04-14
MX2011009822A (es) 2012-01-25
DK2411396T3 (da) 2013-08-05
EA022029B1 (ru) 2015-10-30
JP5612070B2 (ja) 2014-10-22
IL215175A0 (en) 2011-12-29
JP2012521407A (ja) 2012-09-13
ES2532386T3 (es) 2015-03-26
US20150150876A1 (en) 2015-06-04
CN102361877B (zh) 2014-05-07
KR101524337B1 (ko) 2015-05-29
US20120295924A1 (en) 2012-11-22
US8987278B2 (en) 2015-03-24
AU2010227230A2 (en) 2011-10-27
EA201190139A1 (ru) 2012-03-30
AU2010227230A1 (en) 2011-09-22
PT2411395E (pt) 2013-06-06
US9474758B2 (en) 2016-10-25
SI2411395T1 (sl) 2013-07-31
HUE024538T2 (hu) 2016-01-28
IL215177A (en) 2014-01-30
CA2756535A1 (en) 2010-09-30
WO2010109334A3 (en) 2010-11-25
PL2634191T3 (pl) 2015-06-30
SG184769A1 (en) 2012-10-30
AU2010227225A1 (en) 2011-09-15
HK1166073A1 (en) 2012-10-19
IL215177A0 (en) 2011-12-29
EP2411395A1 (en) 2012-02-01
US8507503B2 (en) 2013-08-13
AP2948A (en) 2014-07-31
HK1166074A1 (en) 2012-10-19
WO2010109334A2 (en) 2010-09-30
PL2411395T3 (pl) 2013-10-31
CN103755720A (zh) 2014-04-30
SI2634191T1 (sl) 2015-04-30
IL215175A (en) 2014-01-30
EP2411396B1 (en) 2013-05-29
CN103755720B (zh) 2016-07-06
PT2411396E (pt) 2013-06-06
AP2011005889A0 (en) 2011-10-31
CA2756536C (en) 2015-10-06
JP2012521406A (ja) 2012-09-13
CN102361877A (zh) 2012-02-22
ZA201107649B (en) 2012-07-25
US20120178766A1 (en) 2012-07-12
DK2411395T3 (da) 2013-08-05
KR20110128898A (ko) 2011-11-30
DK2634191T3 (en) 2015-03-23
SG174398A1 (en) 2011-10-28
BRPI1009381B8 (pt) 2021-05-25
EA201190138A1 (ru) 2013-05-30
SI2411396T1 (sl) 2013-07-31
WO2010109329A1 (en) 2010-09-30
AU2010227225A2 (en) 2011-10-06
SG174404A1 (en) 2011-10-28
PE20120834A1 (es) 2012-07-25
EP2634191A1 (en) 2013-09-04
EP2634191B1 (en) 2014-12-24
PE20120775A1 (es) 2012-06-27
KR20120004422A (ko) 2012-01-12
CA2756536A1 (en) 2010-09-30

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